Heliyon
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2024
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IF 3.4
Yan Zhang,Hua Wei,Pingguang Zhu,Xiaojuan Hao,Jing Chen,Haina Zhang
The adhesion of bacteria to the surface leads to formation of biofilms causing numerous infection problems in implanting medical devices or interventional therapy. Traditional treatment for such problems is generally to administrate patients with antibiotics or antifungal agent. Alternatively, devices are taken out of the body to mechanically destroy the biofilm and re-used by surgery. In this study, a straightforward method was developed to remove biofilms using a MXene-based photothermal hydrogel. The hydrogel consists of dynamic crosslinking network formed by Schiff-base reaction between aldehyde-containing xyloglucan (OXG) and amine-containing MXene (NH 2 -MXene), which showed efficient killing of both gram-positive Staphylococcus aureus ( S. aureus ) and gram-negative Escherichia coli ( E. coli ) bacteria upon near-infrared (NIR) laser irradiation. The NH 2 -MXene/OXG nanocomposite hydrogel showed a high photothermal antibacterial efficiency and stable photothermal conversion, demonstrated by efficient removal of biofilms ex vivo .
研究领域:
生物医学工程
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材料科学
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微生物学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2022
·Vol. 23
·期 18
·10708
·
IF 6.208
Tianlu Li,Yun Zhao,Minfang Chen
Photo-thermal antibacterial properties have attracted much attention in the biomedical field because of their higher antibacterial efficiency. Through fabricating micro-arc oxidation coatings with different treating current densities set on a Mg-Zn-Ca alloy, the present study tried to systematically investigate and optimize the corrosion resistance and photo-thermal antibacterial properties of MAO coatings. The results indicated that different current densities had great influence on the corrosion resistance and photo-thermal property of the MAO coatings, and a current density at 30 A·dm−2exhibited the best corrosion resistance, light absorption capacity at 808 nm, and photo-thermal capability, simultaneously with good antibacterial activity againstStaphylococcus aureus(S. aureus) andEscherichia coli(E. coli). This photo-thermal property of MAO coatings was probably related to the effect of current density on MgO content in the coating that could promote the separation of photo-generated electron carriers and hinder the recombination of photo-generated electron carriers and holes.Keywords:magnesium alloy;micro-arc oxidation;corrosion resistance;photo-thermal therapy;anti-bacteria
研究领域:
材料科学
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生物医学工程
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DOI
PubMed
高影响因子
POLYMER
·
2025
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IF 4.5
Junqi Zhao,Ying Chen,Qing Zhong,Wenjie Chen,Langhuan Huang,Jingxian Zhang,Ming Lu,Guocong Liu,Shaozao Tan
Skin is an important barrier to protect the body from the external environment. Once damaged, the body becomes vulnerable to external bacterial attacks, which induce wound infection, and excessive accumulation of reactive oxygen species (ROS) at the wound site destroys fibroblasts and thus affects the wound healing process. Therefore, in this study, an OD-Gel-CuTA hydrogel dressing with near-infrared (NIR) photothermal antimicrobial properties was prepared using gelatin (Gel), oxidized dextran (ODex), and copper tannic acid nanosheets (CuTA). The composition and morphology of CuTA and the hydrogel were analyzed by XRD, FTIR and SEM. Additionally, the mechanical, antioxidant, NIR photothermal, and antimicrobial properties of the hydrogel were investigated with varying CuTA contents. The results showed that the addition of CuTA endowed the OD-Gel-CuTA hydrogel with good mechanical, antioxidant, and antimicrobial properties. Furthermore, the hydrogel promoted the healing of bacterial-infected wounds, which is potentially applicable to the treatment of bacterial wounds in combination with photothermal therapy.
研究领域:
生物材料学
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医学
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药剂学
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Yijun Fu,Yue Cheng,Qufu Wei,Yahong Zhao,Wei Zhang,Yumin Yang,Dawei Li
Single function of biomass aerogel restricts its further development, multifunctional biomass aerogel is becoming an urgent need. In this work, multifunctional biomass composite aerogel was prepared by co-modifying MXene and Ag nanowires (AgNWs) on bacterial cellulose/chitosan (BC/CH) composite aerogel through a facile method combining physical mixture, lyophilization and electrostatic adsorption. The as-prepared BC/CH/MXene/AgNWs composite aerogel could be applied as health monitoring sensor and photo-thermal antibacterial material. As a sensor, it showed high sensitivity, short response time, and satisfactory cycling stability for health monitoring. Moreover, the composite aerogel was successfully employed to monitor various human body motions including foot movements, elbow movements, wrist movement, respiration, and throat vibration pronunciation. In addition, the composite aerogel displayed excellent photothermal conversion performance, which could be quickly heated to more than 60 °C in 60 s under NIR laser irradiation (808 nm, 0.6 W/cm 2 ). The BC/CH/MXene/AgNWs composite aerogel showed nearly 100% sterilizing effect due to the synergistic antibacterial effect from common antibacterial role of CH/AgNWs and photo-thermal antibacterial role of MXene. The novel aerogel possesses more response characteristics and better antibacterial property than existing biomass aerogels, which may develop potential application prospect in wearable and implantable bioelectronic material for health monitoring.
研究领域:
材料科学
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生物医学工程
✓ 已验证
DOI
高影响因子
DESALINATION
·
2024
·
IF 8.3
Jingkang Fang,Junkai Gao,Zhongzhi Chen,Mengsheng Xia,Qian Yang,Yan Chen
Silk fibroin (SF) has attracted wide attention due to its excellent biocompatibility and versatile adjustability. The regeneration and reutilization of silk fibroin can efficiently utilize waste cocoons and silk. However, the regenerated SF hydrogels suffer from inadequate mechanical properties and lack inherent antibacterial capabilities, limiting their application in seawater desalination. This study achieved a novel hydrogel (STS@Fe) with photothermal antimicrobial activity, good mechanical property, and excellent durability using a green dual-directional crosslink and meso-reconstruction strategy. The metal-phenolic networks (MPN) were synthesized utilizing the natural plant polyphenol tannic acid (TA) and Fe 3 O 4 nanoparticles. This research incorporated MPN into dissolved and regenerated silk fibroin and sodium alginate solution, enhanced mechanical properties through cryogenic salt precipitation, and prepared STS@Fe hydrogel. The inherent photothermal properties of Fe 3 O 4 nanoparticles and TA complex, coupled with their synergistic effect under near-infrared radiation, can confer excellent photothermal-enhanced antibacterial activity to the fibroin hydrogel. The tensile strength of STS@Fe hydrogel is enhanced 31 times than that of traditional fibroin hydrogel, and its evaporation rate is 4.77 times higher than that of pure water evaporation. The hydrogel has an efficient seawater desalination rate and outstanding antibacterial properties in real seawater conditions. Moreover, The STS@Fe shows effective treatment capabilities for dyeing wastewater and oily saline water.
研究领域:
材料科学
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生物医学工程
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环境科学
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产品关联
DOI
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
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2025
·
IF 8.9
Miaomiao Ma,Yuhong Qi,Qi’an Chen,Zhanping Zhang
Biofouling of underwater equipment caused by marine organisms is a major problem in the marine industry. Although hydrogel exhibits excellent antifouling properties, its mechanical performance greatly limits its practical application. In this work, a suitable marine antifouling hydrogel (PSM) was designed utilizing a polyethylene glycol–modified MXene (Ti 3 C 2 T x -PEG) toughening mechanism and a silica loaded with nitrogen-doped carbon dots (SiO 2 @N-CDs) reinforcement strategy to enhance the durability of the hydrogel. The PSM hydrogel exhibited a fracture strength of up to 1.62 MPa, elongation of 1734 %, and toughness of 17.7 MJ/m 3 . Furthermore, the PSM hydrogel exhibited excellent photothermal antibacterial properties, with antibacterial rates against E. coli and S. aureus reaching 100%. After 180 days of immersion in seawater, the PSM hydrogel morphology remained stable. Because of its long-term durability and effective antifouling properties, our PSM hydrogel can be developed for use in marine ship coatings.
研究领域:
材料科学
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生物医学工程
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海洋科学
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产品关联
DOI
高影响因子
Materials Today Communications
·
2024
·
IF 3.7
Yang Liu,Run Liu,Wenxian Nie,Leiting Yu,Shaoyuan Lyu,Qi Han,Yun Zhao,Minfang Chen
In this study, a composite coating of polycaprolactone layer and polydopamine-cyclodextrin (β-CD)/naringenin (NG) was prepared on the surface of a micro-arc oxidized (MAO) pretreated magnesium alloy by a two-step method. The findings demonstrate that the composite coating exhibits favorable corrosion resistance, biocompatibility, photo-thermal antimicrobial, and bone-enhancing characteristics. Compared with the MAO coating, the corrosion rate of the composite coating was significantly reduced from about 0.087 mm/y to 0.066 mm/y. The antimicrobial efficiency of the coating against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) under 808 nm laser irradiation was found to reach 93 % and 99 %, respectively. Furthermore, in vitro cytotoxicity assays, dead and live cell staining, and immunoblotting analysis showed that the coating exhibited favorable biocompatibility and osteogenic activity. This novel coating may have good application prospects in the treatment of osteoporosis-related fractures.
研究领域:
材料科学
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生物医学工程
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
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IF 8.2
Han Yin,Jingqi Zhao,Hanyu Zhong,Nanxi Zhu,Yiyi Zhang,Jiyao Li,Jun Luo,Kunneng Liang,Bo Han,Jiaojiao Yang
Current treatments for skin infections employing single-agent antimicrobials have demonstrated pronounced limitations. Here, we have engineered an efficient antibacterial composite consisting of MXene and poly(vinyl alcohol) electrospun fibrous membranes, which are further functionalized with outer membrane vesicles (OMVs) using a tannic acid (TA) bridge. Upon near-infrared irradiation, OMVs augment the photothermal properties of MXene due to their “bedquilt effect”. Meanwhile, the temperature rise facilitates active antibacterial substance release by increasing the permeability of the OMVs. The synergistically enhanced antimicrobial ability of the OMVs and photothermal materials achieves a potentiated antibacterial effect, resulting in a near 100% antibacterial efficacy in vitro and in vivo. This multifunctional, antibiotic-free dressing membrane, which integrates photothermal and biological antibacterial properties, presents a promising therapeutic strategy for the management of skin wound infections.
研究领域:
材料科学
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医学
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生物工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Yilin Ding,Zhipeng Sun,Zilin Wu,Yulin Zhang,Jiuzhi Ma,Huitong Luo,Xiaodong Cao
Bacterial infections and complex microenvironments induce cellular oxidative stress and cellular senescence severely affect chronic wound healing. However, the antibacterial effect of most dressings is single, which is only against the wound-breeding bacteria but cannot resist further invasion of bacteria in the environment into the wound. Few dressings can simultaneously fulfill antibacterial, antifouling, oxidative stress regulation, and cellular protection. Therefore, a Janus patch (SBMA/OHA/GelMA/TA-CeO 2 @HA (HGT-C@HA)) is prepared, in which the top superhydrophilic SBMA zwitterionic layer resists bacterial adhesion, and CeO 2 coated with hyaluronic acid (HA) is loaded into the bottom gel as the functional center. After immersion in tannic acid (TA), Ce-TA chelate formation in situ confers photothermal antimicrobial properties to the hydrogel. It is further validated that HA-coated CeO 2 enable the dressing to obtain higher antioxidant properties by regulating the proportion of Ce 3+ on the nanoparticle surface, which protects cells from the high glucose and high H 2 O 2 environment and effectively inhibits intracellular DNA damage to mitigate cellular senescence. In vivo experiments illustrate that the material significantly accelerated wound healing and improved the quality of wound healing, demonstrating the significant potential of this dressing in diabetic wound healing.
研究领域:
生物材料学
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医学
·
纳米医学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Yuanhong Zhou,Ziyuan Zong,Mohamed S. Selim,Xiang Chen,Zhifeng Hao
The problem of antibiotic misuse leading to bacterial resistance is a significant challenge currently faced. The rapid adaptability and evolutionary capabilities of microorganisms have caused strains that were initially sensitive to antibiotics to gradually become resistant, posing a threat to traditional antibacterial treatments. Therefore, the search for antibacterial treatment methods, especially those less likely to induce resistance, has become crucial. Photodynamic antibacterial therapy is an emerging method with efficient antibacterial and selective effects, reducing the risk of resistance. A two-dimensional nanocomposite material, modified with quaternized ruthenium complexes on MXene, has been developed. The minimum inhibitory concentrations against Escherichia coli and Staphylococcus aureus were found to be 23.4 and 29.0 μg/mL, respectively, under xenon lamp irradiation with a light power intensity of 100 mW/cm2 for 20 min. The bactericidal effects of the Q/Ru-MXene composite system were quantitatively and qualitatively confirmed through plate counting and live/dead staining. This system integrates the chemical antibacterial properties of quaternary ammonium salts, the photodynamic antibacterial effects of ruthenium complexes, and the photothermal antibacterial properties of MXene. The simultaneous application of these three therapeutic approaches allows for the development of a chemical/photodynamic/photothermal antibacterial strategy that can attack bacteria on multiple levels, enhancing treatment efficacy, slowing down the development of bacterial resistance, and adapting better to different types of infections. Research and the application of this comprehensive strategy have the potential to bring breakthroughs and innovations to the field of antibacterial treatment.
研究领域:
微生物学
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材料科学
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医学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Ruiyao Wang,Chongyi Li,Yuxi Zhang,Dan Zeng,Dandi Fan
Bacterial infection is the most common problem in wound healing, and the severe inflammatory response it triggers can significantly increase associated complications and delay the healing process. Consequently, developing effective antimicrobial wound dressings presents a substantial challenge. Herein, a versatile hydrogel namely PVA/POA-MX@Mg 2+ was fabricated on the basis of Polyvinyl alcohol (PVA), phenyl boric acid (PBA)-grafted oxidized hyaluronic acid (POA), and magnesium coated MXene nanosheets (MXene@Mg 2+ ). The hydrogel features reversible borate ester bonds for automatic repair and self-healing, adapting to complex wounds, while residual aldehyde groups enhance its adhesiveness. It was observed that increasing the proportion of aldehyde groups in the hydrogel system enhances its adhesion continuously, with the strength reaching up to 45 kPa. Besides, the PVA/POA-MX@Mg 2+ hydrogel exhibits excellent electrical conductivity, and effective photothermal antibacterial properties under near-infrared (NIR) light irradiation, achieving antibacterial efficiencies of approximately 97.6 % against E. coli and 99.1 % against S. aureus. Furthermore, the photothermal capabilities of the hydrogel significantly enhance the healing of bacterial-infected wounds when combined with NIR stimulation. On day 14, treatment using the PVA/POA-MX@Mg 2+ hydrogel under NIR irradiation resulted in a wound healing rate of 99.6 %. This improvement is attributed to the hydrogel’s potent anti-inflammatory effects, promotion of cell proliferation, and facilitation of angiogenesis. This study underscores the pivotal role of multifunctional two-dimensional (2D) MXene@Mg 2+ nanocomposites in treating infected wounds. In summary, the PVA/POA-MX@Mg 2+ hydrogel demonstrates high antibacterial efficiency, suitable conductivity, excellent self-healing properties, and favorable biocompatibility, making it a promising candidate for wound healing dressings in treating infected skin wounds.
研究领域:
生物材料学
·
医学工程
·
皮肤修复研究
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Hua Wei,Houchao Jing,Can Cheng,Yaqing Liu,Jingcheng Hao
Severe skin wounds arising from burns, cancers, and accidents can damage the entire tissue structure, resulting in permanent somatosensory dysfunction in patients. Although emerging hydrogel dressings have shown clinical potential for accelerating wound repair, the use of an individual material to synchronously restore the tissue structure and sensory function of defective skin remains a challenge. Herein, a multifunctional hydrogel that combines electroconductive polydopamine-capped graphene nanosheets (PrGOs) embedded in a dynamically crosslinked dual-polysaccharide (xyloglucan and chitosan) matrix network is presented. The fabricated hydrogels have an adjustable modulus that can be matched to skin tissue at the wound site, owing to the dynamic Schiff-based crosslinking as well as the facile photo-triggered secondary crosslinking. Furthermore, the photothermal activity of PrGO can elevate the local temperature up to ≈50 °C, significantly restraining bacterial growth. These two factors jointly promote the regeneration of skin tissue. Tissue adhesion of hydrogels is also reported that offers a conformable and robust interface that can detect and quantify human movement and physiological signals to mimic the human skin somatosensory system. This hydrogel offers an effective one-stone-for-two-birds material that simultaneously achieves tissue regeneration and multi-signal sensing, promoting the restoration and/or replacement of the structure and function of damaged skins.
研究领域:
生物医学工程
·
材料科学
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）