RSC Advances
·
2013
·Vol. 3
·期 45
·23133-23138
·
IF 2.562
Yang Wang,Yun Xiao,Hangyu Zhou,Wei Chen,Ruikang Tang
A novel versatile system combining chemotherapy and photothermal therapy for cancer cells using CuS NCs is reported. CuS NCs were synthesized by a solid–liquid reaction between Cu2O nanocubes and thiourea. While the hollow nanocage can be used to load anticancer drugs for chemotherapy, the CuS can convert NIR light into heat for photothermal therapy. More importantly, CuS NCs display exceptionally high drug loading capacity of DOX with 500 wt% and release of DOX is pH-controllable, which is a spontaneous process under intracellular conditions. Compared with chemotherapy or photothermal therapy alone, the combination of chemotherapy and phototherapy can significantly improve the therapeutic efficacy. This improvement strategy using multifunctional nanomaterials may be particularly useful in biomedical applications.
研究领域:
肿瘤学
·
纳米医学
·
药物递送
·
转化医学
·
生物材料
✓ 已验证
DOI
高影响因子
MATERIALS RESEARCH BULLETIN
·
2019
·
IF 3.355
Yanqiu Zhang,Sai Xu,Xiangping Li,Jinsu Zhang,Jiashi Sun,Haiping Xia,Ruinian Hua,Baojiu Chen
Novel nanoplatform with excellent photothermal conversion and temperature feedback are preferable in clinical photothermal therapy (PTT). In this work, a hybrid of NaYF 4 :Er 3+ ,Yb 3+ @NaYF 4 upconversion nanoparticles (UCNPs) conjugated with gold nanorods (GNRs) was fabricated in order to achieve effective photothermal conversion and excellent temperature detection. In this nanoplatform, the GNRs as photo-activated nano-heaters could effectively convert the 808 nm photoenergy into heat, meanwhile UCNPs as 980 nm triggered temperature probe could read the temperature in an exact microdomain where the nanocomposite was located at. The effects of excitation source, GNRs concentration and power density on photothermal conversion were investigated. In addition, the difference between eigen temperature of nanoparticles and solution temperature, and the potential for temperature feedback were analyzed under double lasers excitation. Moreover, the photothermal conversion efficiency was experimentally confirmed from thermodynamic analysis. It was found that the nanocomposite can be an excellent nanoplatform for potential application in advanced PTT.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤治疗
·
光热疗法
·
分子影像
·
热疗监测
·
转化医学
✓ 已验证
DOI
高影响因子
Science China-Materials
·
2020
·Vol. 63
·期 6
·1085-1098
·
IF 6.098
Guo Yanxian,Li Yang,Zhang Wolun,Zu Hongru,Yu Haihong,Li Dongling,Xiong Honglian,Hormel Tristan T.,Hu Chaofan,Guo Zhouyi,Liu Zhiming
Research on deep-tissue photothermal therapy (PTT) in the near-infrared II (NIR-II, 1000–1350 nm) region has bloomed in recent years, owing to higher maximum permissible exposure and deeper tissue penetration over that in the near-infrared I (NIR-I, 650–950 nm) region. However, more details need to be uncovered to facilitate a fundamental understanding of NIR-II PTT. Herein, a tumor-targeted therapeutic nanosystem based on NIR-responsive molybdenum oxide (MoO 2 ) nanoaggregates was fabricated. The photothermal conversion capabilities of MoO 2 in the NIR-I and II regions were investigated step by step, from a simple tissue phantom to a three-dimensional cellular system, and further to a tumor-bearing animal model. NIR-II laser exhibited a lower photothermal attenuation coefficient (0.541 at 1064 nm) in a tissue phantom compared with its counterpart (0.959 at 808 nm), which allows it to be more capable of deep-tissue PTT in vitro and in vivo . Depth profile analysis elucidated a negative correlation between the microstructural collapse of tumor tissue and the penetration depth. Moreover, the depth-related tumor ablation was also studied by Raman fingerprint analysis, which demonstrated the major biochemical compositional disturbances in photothermal ablated tumor tissues, providing fundamental knowledge to NIR-II deep-tissue photothermal therapy.
研究领域:
纳米医学
·
光热治疗
·
癌症治疗学
·
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Fugong Qi,Zhenwen Yang,Jinfeng Zhang,Ying Wang,Qiwen Qiu,Huijun Li
Modified metal oxides with narrow band gaps have attracted great interest in photothermal applications because of their wide optical absorption range. To tune wide band gap metal oxides into visible and near-infrared responsive materials, we deploy a unique interfacial reaction-induced defect engineering approach, which enables us to effectively modify the electronic structure of metal oxides by introducing oxygen vacancy defects. This approach reduced the band gap of zirconia from 5.47 to 1.38 eV, accompanied by a color change to black. More importantly, it is not limited by the size of the metal oxides, and bulk black zirconia was successfully obtained for the first time. It has been demonstrated that the prepared black zirconia can be applied as an effective photothermal therapy agent in vitro. Additionally, the interfacial reaction-induced defect engineering approach has been successfully extended to enhance the optical absorption of other metal oxides.
研究领域:
材料科学
·
纳米技术
·
光热治疗
·
缺陷工程
·
光学材料
✓ 已验证
DOI
高影响因子
Science China-Materials
·
2020
·Vol. 64
·期 2
·430-439
·
IF 6.098
Wu Jialong,Wu Yongwei,He Zepeng,Li Zihua,Huang Huahua,Chen Yongming,Liang Guodong
Herein, a facile and highly efficient synthetic method to prepare organic photothermal materials with high photo-stability and outstanding photothermal performance is reported. Through direct polymerization of commercial aromatic monomers in the presence of anhydrous aluminium chloride and dichloromethane, four kinds of conjugated microporous polymers (CMPs) were obtained. Detailed structural analysis confirmed that the resultant CMPs possessed abundant micropores with an extended π-conjugated skeleton. Under near-infrared (NIR) light irradiation (808 nm, 1.0 W cm −2 ), all the CMPs showed fast heating-up behavior with their maximum temperatures higher than 150°C. Moreover, the efficiency of photothermal conversion ( η ) of the CMPs was found to increase linearly with the increase in the number of conjugated benzene rings within the monomer. Poly-TPE from tetraphenylethylene (TPE) and Poly-TP from o -terphenyl (TP) showed high η values of over 47%. Poly-TPE was additionally used as a photothermal filler to remotely and spatially control the shape recovery of thermal-sensitive shape memory polymers (SMPs), while its introduction (1 wt%) had little influence on the thermal and mechanical properties of the polymer matrixes. Owing to their excellent NIR photothermal performance as well as a one-step synthetic preparation, these CMPs may be promising photothermal materials for practical applications.
研究领域:
材料科学
·
聚合物化学
·
光热治疗
·
智能材料
·
纳米技术
✓ 已验证
DOI
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Minqin Huang,Erhao Wang,Xiuju Li,Zhiying Wei,Tiantian Wang,Ao Wang,Li Yang
In this study, a fascinating nanoplatform, possessing fluorescent imaging, hyperthermia-amplified reactive oxygen species (ROS) generation, and calcium-overloaded comediated multimodal therapeutic effects toward breast malignancy, was innovatively constructed. Accordingly, engineering this accurate targeting theranostic scheme can be used for efficacious ablation of breast carcinoma. Because Cu and Ca ions can induce ROS generation and cytoplasmic overaccumulation, respectively, here, a Cu–Ca-based nanoplatform was designed by adsorbing indocyanine green (ICG) through the relatively high specific surface area and Arg-Gly-Asp peptide (RGD) decorating by covalent conjugation. Upon the internalization of breast tumor cells, biodegradation was triggered under an intracellular weak acid microenvironment; the released ICG molecules allowed for near-IR (NIR) II fluorescent imaging and photothermal production. Importantly, Cu ions in the nanoplatform guaranteed more efficient Fenton-like reaction-mediated chemodynamic therapy under NIR laser exposure. Meanwhile, the virus-like hollowed Cu–Ca (VhCu-Ca) nanoplatform created an artificial calcium-overloading stress in the cytoplasm. In vitro and in vivo studies have demonstrated that our proposed Cu–Ca-based nanoplatform integrated the advantages of breast tumor targeting, NIR II fluorescent imaging, and efficient ablation via synergistic treatments. Therefore, this multimode nanoplatform developed a facile and versatile strategy for the diagnosis and suppression of breast tumors.
研究领域:
纳米医学
·
癌症诊疗一体化
·
生物医学工程
·
活性氧研究
·
光热治疗
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）