Journal of Biophotonics
·
2017
·Vol. 10
·期 12
·1607-1616
·
IF 4.328
Zhihao Han,Liwei Lv,Yi Ma,Zhaohui Wang,Yuxi Liu,Min Zhang,Siwen Li,Yueqing Gu
It is an emerging focus to explore controlled release drug delivery systems for simultaneous cancer imaging and therapy. Herein, we synthesized a photothermal sensitive multifunctional nano-liposome drug delivery system, with doxorubicin wrapped in the hydropholic layer as the therapeutical agent and cypate doped in the hydrophobic layer as the diagnostic agent. A series of in vitro and in vivo characterization demonstrated the stability of synthesized liposome, as the DL% was 9 ± 1.5 and the EE% was 82.7 ± 2.1. And the liposome achieved the functions of target-delivery, enhanced photochemical internalized drug release, and simultaneous chemotherapy and thermal therapy, indicating that this multifunctional nano-liposome is a promising drug delivery system for tumor diagnosis and targeting therapy.
研究领域:
药剂学
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Arabian Journal of Chemistry
·
2024
·
IF 5.3
Wen Liu,Baizhi Su,Hua Song,Xueyun Zhang,Guodong Ren,Xuewei Wang,Lili Yan,Sufang Ma,Lihong Li,Lixia Guo,Shuming Xu,Boye Zhang,Haipeng Diao,Zhifang Wu,Sijin Li,Chengwu Zhang
Staphylococcus aureus has become one of the most common pathogens in clinical tissue infection, and it is easy to form biofilm. Incomplete removal of biofilms often leads to recurrent infections, and more serious is the possibility of bacteria developing drug resistance. Therefore, the effective eradication of refractory biofilms is essential. Herein, a temperature-sensitive hydrogel was prepared by doping the photothermal carbon dots (PTCDs) chelated by Ag + , and the AIPH which could produce alkyl radicals in response to heat into the thermodissolved gelatin. Under the irradiation of 660 nm laser, the PTCDs generated heat to dissolve the hydrogel, and promoted chelation of silver ions in PTCDs for chemical sterilization. Meanwhile, the heat generated by the PTCDs induced the 2,2′-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH) to produce alkyl free radical sterilization, achieving the purpose of photothermal/thermodynamic/chemical synergistic to kill Staphylococci aureus and destroy its biofilm. Therefore, the biocompatible PTCDs@Ag-AIPH hydrogel proposed in this study was a promising composite that could eliminate biofilms and promoted wound healing, showing good potential in future biomedical applications.
研究领域:
材料科学
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纳米技术
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生物医学工程
·
微生物学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Li Hao-Nan,Sun Ze-Yu,Yu Zhen-Jie,Man Kexin,Zhang Chao,Xu Zhi-Kang
Mixed matrix membranes (MMMs) capable of breaking the permeability-selectivity trade-off suffer from the inefficient and disconnected bulky transport channels as well as inferior interfacial compatibility between nanomaterials and polymers. Herein, we propose an original photothermal-triggered in-situ gelation approach to elaborate an original class of MMMs, termed nanofiber-interwoven gel membranes (NIGMs) that feature tunable 3D-interconnected ultrafast transport channels and highly-selective CO 2 -philic gel for boosting CO 2 separation performance. The key design of NIGMs lies in leveraging dual functions of CNT-interwoven skeleton: (1) serving as a photothermal confined reactor that rapidly triggers in-situ gelation of highly-selective CO 2 -philic gel without phase separation-induced interfacial defects to construct defect-free and thickness-controllable NIGMs; (2) functioning as a 3D-interconnected continuous skeleton for providing ultrafast CO 2 transport channels. By orchestrating the distribution and configuration of interwoven nanofibers, the NIGMs possess a boosted CO 2 permeance of 211.0 GPU increased by 1558% over polymeric gel counterparts and an ultrahigh CO 2 /N 2 and CO 2 /CH 4 selectivity of up to 151 and 47 respectively. Our work offers a paradigm shift in developing advanced MMMs beyond gas separation.
研究领域:
材料科学
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化学工程
·
膜技术
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气体分离
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纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2019
·
IF 4.511
Xiaoting Li,Xinhui Wang,Mingli Hua,Haohan Yu,Shaohua Wei,Ao Wang,Jiahong Zhou
Base-pairing is stable under physiological temperature but broken by heating, which is the basic mechanism for nucleic acid amplification in biology. In this manuscript, a simple controlled-drug-release system was prepared on the basis of this rule and its in vivo activity was studied. Poly adenine (poly A), the tail of the synthesized RNA chain, was exploited as gatekeeper of thymine (T)-modified mesoporous silica nanoparticles (MSN-T) based on the simple A-T base-pairing rules. The gate keeper maintains stability to avoid drug (chemotherapy and photothermal therapy drugs) release during the delivery process but is effectively removed by a photothermal effect to trigger drug release at the tumor tissue by near-infrared (NIR) laser irradiation. In vitro and in vivo experiments indicated that the prepared nanomedicine could effectively suppress tumor growth and activate antitumor immunity.
研究领域:
纳米医学
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癌症治疗
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药物递送系统
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光热疗法
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Hongtao Zhang,Shiguo Yuan,Boyuan Zheng,Peng Wu,Kai Zheng,Li Ye,Zihang Chen,Xiuming He,Jing Wang,Xinchun Yang,Huige Hou,Xiaofei Zheng,Huajun Wang,Jian Guan
The progression of osteoarthritis (OA) is driven by a complex interplay of pathological mechanisms, including oxidative stress imbalance, inflammatory cascade amplification, and irreversible cartilage degradation, which pose significant challenges for effective therapeutic intervention. Conventional single-stimulus responsive drug delivery systems often exhibit insufficient sensitivity under complex pathological conditions, whereas multi-modal stimulation strategies significantly enhance the precision and controllability of drug release. In this study, a photothermally-triggered multimodal controlled-release nano-system (MoS 2 -LS@QZTL) was innovatively developed to address these challenges. At the initial stage of treatment, the exposure of leonurine (Leo) was triggered via photothermal effects, followed by reactive oxygen species (ROS) scavenging and polarization of synovial macrophages toward the M2 phenotype. This process modulated the inflammatory microenvironment in osteoarthritis, thereby creating an optimal immune environment for cartilage repair. In the second stage, the damaged cartilage is specifically targeted via negative charge recognition, with subsequent acid-triggered degradation enabling controlled release of Zn 2+ and Ca 2+ to orchestrate osteochondral microenvironment remodeling and tissue regeneration. Furthermore, the nanocomposite platform exhibits excellent lubrication performance, effectively minimizing interosseous friction to prevent progressive inflammatory deterioration and osteoclasia. This study establishes a pioneering approach by orchestrating multidimensional physicochemical and biological regulatory mechanisms to achieve spatiotemporal synchronization between inflammatory microenvironment modulation and cartilage regeneration.
研究领域:
纳米技术
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生物医学工程
·
药剂学
·
炎症生物学
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组织工程
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骨科
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2018
·
IF 4.37
Wentao Deng,Juhui Qiu,Shaoting Wang,Zhi Yuan,Yuefeng Jia,Hailin Tan,Jiru Lu,Ruqiang Zheng
In this study, we performed the characterization and synthesis of biocompatible and targeted albumin and graphene oxide (GO) dual-carrier paclitaxel (PTX) nanoparticles for photothermal-triggered tumor therapy. PTX absorbed on GO nanosheets as cores were coated with human serum albumin (HSA), following surface conjugation with monoclonal antibodies (mAb) against vascular endothelial growth factor (VEGF; denoted as mAbVEGF) via polyethylene glycol linker to form targeted nanoparticles (PTX-GHP-VEGF). The spherical nanoparticles were 191±5 nm in size with good stability and biocompatibility. GO functioned as the first carrier and a near infrared absorber that can generate photothermal effects under 5-minute 808-nm laser irradiation to thermal trigger the release of PTX from the second carrier HSA nanoparticles. The mechanism of thermal-triggered drug release was also investigated preliminarily, in which the heat generated by GO induced swelling of PTX-GHP-VEGF nanoparticles which released the drugs. In vitro studies found that PTX-GHP-VEGF can efficiently target human SW-13 adrenocortical carcinoma cells as evaluated by confocal fluorescence microscopy as well as transmission electron microscopy, and showed an obvious thermal-triggered antitumor effect, mediated by apoptosis. Moreover, PTX-GHP-VEGF combined with near infrared irradiation showed specific tumor suppression effects with high survival rate after 100 days of treatment. PTX-GHP-VEGF also demonstrated high biosafety with no adverse effects on normal tissues and organs. These results highlight the remarkable potential of PTX-GHP-VEGF in photothermal controllable tumor treatment.
研究领域:
药学
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纳米技术
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癌症研究
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生物医学工程
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Huan Li,Ke Yang,Luo Hai,Zefeng Wang,Yuze Luo,Lidan He,Wenhua Yi,Junqin Li,Caiyun Xu,Le Deng,Dinggeng He
Well-designed nanocatalysts capable of generating free radicals have recently shown promising potential for treating bacterial biofilm infections. However, the biofilm microenvironments such as hypoxia and over-expressed glutathione (GSH) seriously limit their biomedical applications. To address these issues, we herein construct a dual free radical nanogenerator (MnO 2 /GOx/AIBI) by loading glucose oxidase (GOx) and thermal-labile azo initiator (AIBI) onto the flower-like MnO 2 with high loading capacity for the hypoxia-irrelevant treatment of biofilm-associated bacterial infections. On the one hand, MnO 2 /GOx/AIBI nanocomposites can generate hydroxyl radicals by glucose-fueled cascade catalytic reactions between GOx and MnO 2 for efficient O 2 – and H 2 O 2 -self-supplying chemodynamic therapy (CDT). On the other hand, MnO 2 can provide local photonic hyperpyrexia, which not only triggers the O 2 -independent generation of alkyl radicals for photothermal dynamic therapy (PTDT), but also enhances the CDT efficacy by accelerating the release of Fenton-type Mn 2+ . Besides, MnO 2 can degrade GSH over-expressed in the infection sites, improving the synergistic CDT/PTDT therapeutic effectiveness by redox dyshomeobasis. The hybrid MnO 2 /GOx/AIBI nanocatalysts exhibit satisfactory in vitro and in vivo antibacterial and antibiofilm performances with minimal toxic side effects. Taken together, the developed hypoxia-irrelevant dual-mode synergistic antibacterial nanoplatform can effectively overcome the interferences of biofilm microenvironments, showing a promising potential for future biomedical applications.
研究领域:
纳米技术
·
生物医学工程
·
抗菌治疗
·
生物化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 12
·4908-4918
·
IF 3.069
Yitong Wang,Ling Wang,Luxuan Guo,Maiomiao Yan,Lei Feng,Shuli Dong,Jingcheng Hao
We report a multifunctional drug delivery platform (Au NR@SiO2/Ce@Dox@PDA@aptamer, abbreviated as PP-Dox nanocomposites) for enhancing non-small cell lung cancer (NSCLC) treatment with controlled drug release, magnetic targeting and specific cancer cell targeting. The platform is composed of polydopamine (PDA) as gatekeepers, gold nanorods (Au NRs) as local photothermal generators, S6 aptamers as targeting ligands and magnetic mesoporous silica nanoparticles (mSiO2) containing high payloads of Ce with cross-linking ligands as drug containers and magnetic targeting agents. Upon uptake into cells or stimulation under a near-infrared (NIR) laser, pH and photothermally triggered drug release was observed. When target cancer cells are absent, the cellular uptake of PP-Dox nanocomposites is suppressed and displays poor treatment effect. However, when target cancer cells are present, more PP-Dox nanocomposites enter into cells because of the specific recognition between aptamers and targeted cells, resulting in an excellent treatment effect. Furthermore, the magnetic field and photothermal effect also supply a more effective therapeutic outcome than chemotherapy alone. We believe that the PP-Dox multifunctional platform has great potential in targeted cancer therapy for enhancing therapeutic efficiency.
研究领域:
纳米技术
·
癌症研究
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2020
·
IF 10.317
Jing Wang,Yanzhou Chang,Hui Luo,Wenxiao Jiang,Ligeng Xu,Tianfeng Chen,Xueqiong Zhu
Low tumor mutational burden and absence of T cells within the tumor sites are typical characteristics of “cold immune tumors” that paralyzes the immune system. The strategy of reversing “cold tumors” to “hot tumors” infiltrated high degree of T cells in order to activate anti-tumor immunity has attracted lots of attentions. Herein, immunogenic core–shell [email protected] NPs is fabricated by gold-selenium coordination bond to realize nanoparticles-mediated local photothermal-triggered immunotherapy. As expected, incorporation of gold nanostars (AuNSs) with improved photothermal stability and conversion efficiency promotes the disintegration and transformation of selenium nanoparticles (SeNPs), thus leading to enhanced cancer cells apoptosis by producing higher hyperthermia. Moreover, the results of in vivo experiments demonstrate that the synergy between SeNPs-mediated chemotherapy and AuNSs-induced photothermal therapy not only generated a localized antitumor-immune response with excellent cancer killing effect under the presence of tumor-associated antigens, but also effectively reprogrammed the tumor associated macrophages (TAMs) from M2 to M1 phenotype with tumoricidal activity to devour distant tumors. Without a doubt, this study not only provides a potent strategy to reverse the immunosuppressive tumor microenvironment , but also offers a new insight for potential clinical application in tumor immunotherapy.
研究领域:
纳米技术
·
免疫疗法
·
肿瘤学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）