Materials Chemistry Frontiers
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2021
·Vol. 5
·期 23
·8229-8237
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IF 6.482
Junjun Wang,Yize Zhang,Zhi-Peng Yu,Houshi Huang,Lei Chen,Xiaojiao Zhu,Jie Zhang,Lianke Wang,Jianhua Yu,Hongping Zhou
Phototheranostics, the integration of phototherapy and multimodal imaging into one nanoagent, is highly significant for precise cancer treatment, during which how the photo-energy is converted plays a critical role. The Förster resonance energy transfer (FRET) mechanism has opened up a new avenue for diversifying energy conversion, demonstrating great promise for enhanced phototheranostics. Herein, a theranostic nanoagent (HCY–TPA), based on single-molecule FRET, was designed, where the harvested photo-energy was not only transformed into near-infrared fluorescence but also acoustic energy for deep-seated tumor imaging, as well as enhanced thermal and type-I ROS generation for efficient treatment, realizing optimized phototheranostics. Furthermore, the dual cation endowed it with superior mitochondrial targeting ability for precise treatment. In vivo mouse model experiments demonstrated that the proliferation of tumors was effectively inhibited, compared to that by single HCY or TPA, which ultimately demonstrated a synergistic effect in multimodal imaging guiding synergistic cancer treatment.
研究领域:
生物医学工程
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纳米技术
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癌症研究
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分子成像
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产品关联
DOI
高影响因子
Nanoscale
·
2020
·Vol. 12
·期 43
·22173-22184
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IF 6.895
Ziwei Li,Fan Yang,Di Wu,Yanhong Liu,Yang Gao,Haichen Lian,Hongxin Zhang,Zhibin Yin,Aiguo Wu,Leyong Zeng
Metastasis is the main cause of treatment failure in breast cancer, and integrated phototheranostics is a promising strategy to achieve both precision theranostics and metastasis inhibition. In this work, a multifunctional phototheranostic nanoprobe composed of chlorin e6 (Ce6)-conjugated and polydopamine (PDA)-coated gold nanostars (AuNSs) was synthesized for simultaneous photoacoustic (PA) imaging, photothermal therapy (PTT) and photodynamic therapy (PDT). Under the irradiation of near infrared laser, AuNSs@PDA showed enhanced photothermal conversion and amplified PA imaging performance, compared with single AuNSs. By the covalent conjugation of Ce6, the AuNSs@PDA-Ce6 nanoprobe showed robust stability and excellent singlet oxygen (1O2) generation ability. Under the combination of PTT/PDT, the AuNSs@PDA-Ce6 nanoprobes significantly reduced the growth of 4T1 tumors and suppressed their lung metastasis. All the results demonstrated the considerable potential of AuNSs@PDA-Ce6 phototheranostic nanoprobes for precision theranostics and metastasis inhibition of breast cancer.
研究领域:
纳米技术
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癌症研究
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治疗诊断学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
·
IF 9.965
Cunji Gao,Jing Jian,Liuruiqi Luo,Jiawei Liang,Zhilang Li,Maolin Pang,Haobin Cai,Xing-Can Shen
Phototheranostics, a local non-invasive approach that integrates light-based diagnostics and therapeutics, enables precise treatment using nanotheranostic agents with minimal damage to normal tissues. However, ensuring high-efficiency ablation of cancer cells using phototheranostics for one time irradiation is highly challenging. Herein, we designed and synthesized a single-walled carbon nanohorns-based nanotheranostic agent, HA-IR808-SWNHs, by loading IR808, a photosensitizer, conjugated hyaluronic acid (HA) with an amide bond on the surface of single-walled carbon nanohorns (SWNHs) through noncovalent π − π interaction by the sonication method. The HA in HA-IR808-SWNHs improves the water dispersibility of SWNHs and endows SWNHs with targeting capabilities. Importantly, overexpressed endogenous hyaluronidase in cancer cells actively disassembles HA-IR808-SWNHs, forming small HA-IR808 fragments. The fragments exhibit a strong fluorescence signal and can be used to guide programmed photodynamic therapy for sequentially eliminating the residual living cancer cells. The current study confirms that HA-IR808-SWNHs is an endogenous enzyme-responsive nanotheranostic agent that can be employed to precisely track and ablate residual cancer cells in a spatiotemporal manner. The results strengthen the understanding of SWNH functionalization and expand its potential biomedical application, especially in cancer theranostics.
研究领域:
纳米技术
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癌症诊疗学
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生物医学工程
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材料科学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Protocols
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2025
·
IF 16
Yan Dingyuan,Li Xue,Wang Huanhuan,Li Bin,Wang Wei,Liao Yuhui,Tang Ben Zhong,Wang Dong
Phototheranostics, which allows simultaneous diagnosis and therapy, offers notable advantages in terms of noninvasiveness, controllability and negligible drug resistance, presenting a promising approach for disease treatment. By integrating second near-infrared (NIR-II, 1,000–1,700 nm) phototheranostic agents characterized by aggregation-induced emission (AIE) and cell membranes with specific targeting capacity, we have developed a versatile type of biomimetic nanoparticle (NP) for precise phototheranostics of pulmonary tuberculosis (TB). Coating the phototheranostic agents with preactivated macrophage membranes results in the formation of biomimetic NPs, which exhibit specific binding to TB through a lesion–pathogen dual-targeting strategy, allowing the accurate detection of Mycobacterium tuberculosis via NIR-II fluorescence imaging and precise photothermal therapy using the irradiation of a 1,064 nm laser. In comparison with traditional treatments, small individual granulomas (0.2 mm in diameter) in TB-infected mice are visualized, and improved antibacterial effects are achieved upon NP administration. Here we present a standardized workflow for the synthesis of the NIR-II AIE agents, their use for the fabrication of the biomimetic NPs and their in vitro and in vivo applications as phototheranostics against M. tuberculosis . The preparation and characterization of the NIR-II AIE agents requires ~8 d, the synthesis and characterization of the phototheranostic NPs requires ~8 d, the validation of in vitro targeting capacity and photothermal eradication requires ~26 d, and the in vivo NIR-II fluorescence imaging and imaging-guided photothermal therapy requires ~74 d. All procedures are straightforward and suitable for clinicians or researchers with prior training in organic synthesis and biomedical engineering.
研究领域:
生物医学工程
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纳米技术
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传染病学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Beibei Shan,Yaxuan Lu,Chao Zheng,Ming Li
The structural symmetry is of great importance for optical and chemical behaviors of a complex plasmonic nanostructure system. However, the influence of structural symmetry breaking has been rarely studied in metal–semiconductor heterostructures for cancer phototheranostics. Herein, we present a systematic investigation on cancer phototheranostics of plasmonic Au-Cu 2-x Se nanocrystals (GCS NCs) with different structural symmetries. These GCS NCs are capable of photoacoustic (PA)/computed tomography (CT) diagnostic imaging for tumor visualization and chemodynamic therapy (CDT)/photothermal therapy (PTT) of cancer. We theoretically and experimentally demonstrate much superior near-infrared II (NIR-II) plasmonic and photothermal properties from Janus-GCS NCs because of much stronger plasmonic coupling effects compared with concentric and non-concentric GCS core/shell structures. In addition, more efficient OH production via the combined Fenton-like effects and photocatalytic reaction is evidenced for Janus-GCS NCs with a further enhancement upon the NIR-II laser irradiation. Janus-GCS NCs as a multifunctional theranostic nanoplatform have been demonstrated for highly efficient PA/CT imaging-guided CDT/PTT synergistic cancer therapy in vivo with efficient glutathione depletion. This study highlights the importance of structural symmetry in plasmonic metal–semiconductor heterostructures for cancer phototheranostics.
研究领域:
材料科学
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纳米技术
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癌症研究
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生物医学工程
✓ 已验证
DOI
高影响因子
ACS Nano
·
2024
·
IF 15.8
Jiayi Bian,Yingjie Xu,Minghao Sun,Zerui Ma,Hao Li,Changrui Sun,Fei Xiong,Xiaopeng Zhao,Wenjing Yao,Yue Chen,Yuanyuan Ma,Xikuang Yao,Shenghong Ju,Wenpei Fan
Accurate imaging and precise treatment are critical to controlling the progression of pancreatic cancer. However, current approaches for pancreatic cancer theranostics suffer from limitations in tumor specificity and invasive surgery. Herein, a pancreatic cancer-specific phototheranostic modulator (AuHQ) dominated by aggregation-induced emission (AIE) luminogens-tethered gold nanoparticles is meticulously designed to facilitate prominent fluorescence-photoacoustic bimodal imaging-guided photothermal immunotherapy. Once reaching the pancreatic tumor microenvironment (TME), the peptide Ala-Gly-Phe-Ser-Leu-Pro-Ala-Gly-Cys (AGFSLPAGC) linkage within AuHQ can be specifically cleaved by the overexpressed enzyme Cathepsin E (CTSE), triggering the dual self-assembly of AuNPs and AIE luminogens. The aggregation of AuNPs mediated by enzymatic cleavage results in potentiated photothermal therapy (PTT) under near-infrared (NIR) laser irradiation, induced immunogenic cell death (ICD), and enhanced photoacoustic imaging. Simultaneously, AIE luminogen aggregates formed by hydrophobic interaction can generate AIE fluorescence, enabling real-time and specific fluorescence imaging of pancreatic cancer. Furthermore, coadministration of an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with AuHQ can address the limitations of PTT efficacy imposed by the immunosuppressive TME and leverage the synergistic potential to activate systemic antitumor immunity. Thus, this well-designed phototheranostic modulator AuHQ facilitates the intelligent enzymatic dual self-assembly of imaging and therapeutic agents, providing an efficient and precise approach for pancreatic cancer theranostics.
研究领域:
生物医学工程
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癌症治疗
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纳米技术
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成像科学
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免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）