Nature Communications
·
2023
·Vol. 14
·期 1
·1-15
·
IF 16.6
Deng Kaicheng,Tang Yao,Xiao Yan,Zhong Danni,Zhang Hua,Fang Wen,Shen Liyin,Wang Zhaochuang,Pan Jiazhen,Lu Yuwen,Chen Changming,Gao Yun,Jin Qiao,Zhuang Lenan,Wan Hao,Zhuang Liujing,Wang Ping,Zhai Junfeng,Ren Tanchen,Hu Qiaoling,Lang Meidong,Zhang Yue,Wang Huanan,Zhou Min,Gao Changyou,Zhang Lei,Zhu Yang
Diagnostic and therapeutic illumination on internal organs and tissues with high controllability and adaptability in terms of spectrum, area, depth, and intensity remains a major challenge. Here, we present a flexible, biodegradable photonic device called iCarP with a micrometer scale air gap between a refractive polyester patch and the embedded removable tapered optical fiber. ICarP combines the advantages of light diffraction by the tapered optical fiber, dual refractions in the air gap, and reflection inside the patch to obtain a bulb-like illumination, guiding light towards target tissue. We show that iCarP achieves large area, high intensity, wide spectrum, continuous or pulsatile, deeply penetrating illumination without puncturing the target tissues and demonstrate that it supports phototherapies with different photosensitizers. We find that the photonic device is compatible with thoracoscopy-based minimally invasive implantation onto beating hearts. These initial results show that iCarP could be a safe, precise and widely applicable device suitable for internal organs and tissue illumination and associated diagnosis and therapy.
研究领域:
生物医学工程
·
光学工程
·
医疗器械
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治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Select
·
2021
·
IF 0
Chenglong Mu,Xiaodan Sun,Kai Yan
Phototherapy is gradually becoming a primary technique for treating tumors due to increased efficacy and less side effects. It largely depends on the photosensitizers. Nevertheless, most of photosensitizers show poor stability, how to encapsulate or load them, especially multiple ones, for effective delivery is of paramount importance. To address the challenge, a hyperbranched polymer was prepared by a reversible addition-fragmentation chain transfer polymerization, which is composed of 2,2,3,3-Tetrafluoropropyl methacrylate (TFPMA), bis(2-methacryloyl)oxyethyl disulfide (DSDMA) and poly(oligo ethylene glycol) methyl ether methacrylate (PEGMA). Benefiting from hydrophobic performance of fluorinated segments, this hyperbranched polymers can load hydrophobic IR780 (9%) and Ce6 (12%) due to self-assembly and hydrophobic-hydrophobic interaction. The final formed composite micelles showed good water dispersity, well biocompatibility, and strong stability. Remarkably, they had good photodynamic and photothemal abilities, enabling them to synergistically induce tumor cell apoptosis by oxidative damage and thermal ablation. This work offers a promising composites and strategy for loading photosensitizers stably and effectively towards cancer therapy.
研究领域:
生物医学工程
·
药剂学
·
肿瘤学
✓ 已验证
DOI
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xiujie Zhao,Yan Ma,Jianhao Di,Yanqi Qiao,Jie Yu,Yongmei Yin,Rimo Xi,Meng Meng
Pyroptosis has been reported to improve the antitumor effect by evoking a more intense immune response and a therapeutic effect. For phototherapy, several photosensitizers have been found to initiate pyroptosis. However, the effect of pyroptosis associated with apoptosis in enhancing the antitumor therapy needs sufficient characterization, especially under long-term treatment. As a NIR photosensitizer, heptamethine cyanines have been discovered for anticancer phototherapy for deep tissue penetration and inherent tumor-targeted capability. However, they are not quite stable for long-term performance. To investigate the effect of pyroptosis along with apoptosis on the anticancer immune responses and phototherapy, here, we chemically modulate the cyanine IR780 to regulate hydrophobicity, stability, and intracellular targeting. Two photosensitizers, T780T-TPP and T780T-TPP-C12, were finally optimized and showed excellent photostability with high photothermal conversion efficiency. Although the cellular uptake of the two molecules was both mediated by OATP transporters, T780T-TPP induced tumor cell death via pyroptosis and apoptosis and accumulated in tumor accumulation, while T780T-TPP-C12 was prone to accumulate in the liver. Ultimately, via one injection-multiple irradiation treatment protocol, T780T-TPP displayed a significant antitumor effect, even against the growth of large tumors (200 mm3).
研究领域:
肿瘤学
·
免疫学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Zhuge Deli,Li Li,Sun Xueying,Liang Hui,Jin Chenjie,Lu Ailing,Gao Wenli,Zhong Yutong,Li Wenlu,Chen Sihao,Wang Fang,Yan Linzhi,Meng Weiyang,Lin Xiaoji,Zhang Xufei,Liu Yong,Li Yuanfeng,Zhao Yingzheng,Zhang Xiang,Chen Mengchun,Chen Yijie
Phototherapy holds great potential for treating cancer and infections but faces limitations related to photosensitizer accumulation, tissue penetration, and diminished photo-conversion efficiency, particularly in deep-seated tumors and infections. Here, a biomimetic phototherapeutic nanodisc platform consisting of erythrocyte membranes and the photosensitizer IR780 is developed. With the advantages of the ultra-small size and exceptional biosafety of cell membrane-derived nanodiscs, this platform facilitates efficient accumulation and deep tissue penetration at disease sites. Upon near-infrared (NIR) irradiation, IR780 delivered via the nanodisc exhibits enhanced photothermal conversion efficiency, markedly inhibiting tumor growth in an orthotopic 4T1 breast cancer model and reducing bacterial load in a methicillin-resistant Staphylococcus aureus (MRSA) skin infection model. Furthermore, the nanodisc platform demonstrates outstanding biocompatibility in mice. In conclusion, this nanodisc system significantly extends the functional potential of cellular nanodiscs, presenting a promising strategy to address the challenges of photosensitizer delivery and biosafety in phototherapeutic applications.
研究领域:
生物医学工程
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肿瘤学
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微生物学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2020
·Vol. 8
·期 23
·6515-6525
·
IF 6.183
Chengyuan Zhu,Zhaoyang Ding,Zhengxi Guo,Xiaolu Guo,Aijia Yang,Zhilang Li,Bang-Ping Jiang,Xing-Can Shen
Second near-infrared (NIR-II) window responsive phototheranostic agents have a precise spatiotemporal potential for the diagnosis and treatment of cancer. In this study, a full-spectrum responsive ZrO2-based phototheranostic agent was found to achieve NIR-II photoacoustic (PA) imaging-guided tumour-targeting phototherapy. Initially, the ZrO2-based phototheranostic agent was fabricated through NaBH4 reduction to form boron-doped oxygen-deficient zirconia (ZrO2−x-B), an amino-functionalised SiO2 shell and a further covalent connection with hyaluronic acid (HA), namely, ZrO2−x-B@SiO2-HA. In the ZrO2−x-B@SiO2-HA system, the oxygen vacancy and boron doping resulted in full-spectrum absorption, enabling a high NIR-II photothermal conversion, high-resolution PA imaging ability and a remarkable production of reactive oxygen species (ROS). The surface modification of HA provided ZrO2−x-B@SiO2-HA with water dispersibility and a targeting capability for CD44 overexpressed cancer cells. Furthermore, in vitro and in vivo experiments showed that NIR-II activated ZrO2−x-B@SiO2-HA had a targeted photothermal/photodynamic effect for cancer elimination under the real-time guidance of NIR-II PAs. Hence, ZrO2−x-B@SiO2-HA displays a precise NIR-II radiation-activated phototheranostic potential for PA imaging-guided cancer-targeting photothermal/photodynamic therapy.
研究领域:
生物医学工程
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癌症研究
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材料科学
·
成像技术
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Fanqi Meng,Lei Chen,Haoran Chen,Meili Shen,Guangyi Wang,Yulei Chang
Combined phototherapy with other therapeutic strategies can improve the therapeutic outcomes of tumors and reduce the side effects. However, shaping multiple modalities for combination therapy remains challenging. Herein, multiple stimuli-responsive drug-loaded micelles are presented, which are self-assembled from cypate-conjugated pH-sensitive poly(ethylene glycol)–poly(2-(diisopropylamino) ethyl methacrylate)–poly(2-aminoethyl methacrylate hydrochloride) and redox-responsive poly(glycidyl methacrylate)–poly(propylene sulfide) copolymer and loaded with chemo agents doxorubicin (DOX) and sorafenib (SRF, also a ferroptosis inducer) for enhanced tumor therapy. The DOX and SRF chemo drugs were encapsulated into the hydrophobic core of PPS and PDPA to enable multiple stimuli-responsive controlled drug delivery. In vivo and in vitro experiments are carried out to investigate the potential application for controlled drug release and systemic chemo-phototherapy. This study highlights the rational design of cypate-based drug-loaded micelles, offering multiple stimuli-responsive drug releases and synergistic photo-, ferro-, and chemotherapy in colorectal cancer.
研究领域:
肿瘤学
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药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2021
·Vol. 9
·期 6
·2313-2321
·
IF 6.843
Yuchu He,Cong Cong,Shuxian Zhao,Zhuo Li,Desong Wang,Jianmin Gu,Lanxiang Liu,Dawei Gao
The gaseous microenvironment (GME) of tumors is rapidly becoming a new concern for nanotechnology-mediated oncotherapy. Here, we constructed a tumor/near-infrared (NIR) light-responsive nanoplatform to generate O2 and NO for remodeling the GME of tumors and phototherapy. The biocompatible and pyrolytic polydopamine was used to load indocyanine green, NONOate, and MnO2 NPs as a nanoenzyme (PINM). Then, HA was modified on the PINM to form the final nanoplatform (PINMH). PINMH can target tumors favorably due to the modification of HA. Under the NIR light irradiation, PINM converts the light and O2 to hyperpyrexia (58.5 °C) and cytotoxic 1O2. MnO2 NPs catalyze the H2O2 overexpressed in tumors to O2, which increases the amount of 1O2. Moreover, NONOate decomposes to NO (100 μM) under hyperpyrexia, thus leading to the gas therapy. The results verified that the responsive nanoplatform with precise gaseous regulation and phototherapy exhibited a superior anti-tumor effect (V/V0 = 1.2) and biosafety. In addition, PINMH can be tracked in real-time via magnetic resonance imaging. In this study, an intelligent nano-platform integrated with diagnosis and treatment was developed, which used the phototherapy technology to reshape GME and achieve good anti-tumor effects, aiming to provide an innovative and reasonable strategy for the development of tumor treatment.
研究领域:
肿瘤学
·
纳米医学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Hean Zhang,Ming Qiu,Qianling Cui,Yufeng Luo,Lidong Li
Viscosity is a key parameter of mitochondria and related to several diseases. To design a probe acting both the mitochondria-targeted viscosity sensor and photosensitizer is meaningful for diagnosis and therapies. Herein, we report a ratiometric viscosity sensor with dual-emission mediated by excitation energy transfer (EET) effect, which can detect the mitochondrial viscosity and serve as an efficient photosensitizer to eradicate cancer cells. The probe comprises of a blue-emitting imidazole moiety as the energy donor and a green-emitting boron dipyrromethene (BODIPY) core as the energy acceptor, respectively. Via viscosity-modulated EET effect, the dual-emissive probe can sensitively detect the medium viscosity in a ratiometric model. Directed by imidazole as targeting factor, the probe can specifically accumulate in mitochondria and ratiometrically determine the intracellular viscosity increase induced by Nystatin treatment. Furthermore, it also exhibits light-triggered reactive oxygen species (ROS) generation including singlet oxygen and superoxide radical, which can efficiently kill the cancer cells under white light illumination. Thus, this work provides a versatile and promising candidate for disease diagnosis and phototherapy.
研究领域:
生物物理学
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生物化学
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癌症研究
·
光疗
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
Science Advances
·
2024
·Vol. 10
·期 10
·
IF 11.7
Mian Chen,Qiuju Han,Mengmeng Zhang,Ying Liu,Lu Wang,Fengmin Yang,Qian Li,Zhenping Cao,Chunhai Fan,Jinyao Liu
Synergistic phototherapy stands for superior treatment prospects than a single phototherapeutic modality. However, the combined photosensitizers often suffer from incompatible excitation mode, limited irradiation penetration depth, and lack of specificity. We describe the development of upconversion dual-photosensitizer–expressing bacteria (UDPB) for near-infrared monochromatically excitable combination phototherapy. UDPB are prepared by integrating genetic engineering and surface modification, in which bacteria are encoded to simultaneously express photothermal melanin and phototoxic KillerRed protein and the surface primary amino groups are derived to free thiols for biorthogonal conjugation of upconversion nanoparticles. UDPB exhibit a near-infrared monochromatic irradiation-mediated dual-activation characteristic as the photothermal conversion of melanin can be initiated directly, while the photodynamic effect of KillerRed can be stimulated indirectly by upconverted visible light emission. UDPB also show living features to colonize hypoxic lesion sites and inhibit pathogens via bacterial community competition. In two murine models of solid tumor and skin wound infection, UDPB separately induce robust antitumor response and a rapid wound healing effect.
研究领域:
生物医学工程
·
纳米技术
·
光疗
·
分子生物学
·
癌症研究
·
传染病
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Exploration
·
2024
·
IF 0
Heng Guo,Linlin Shi,Zengliang Shi,Yue He,Yizhi Zhu
Yellow light-emitting diodes (LEDs) with a wavelength of 570–590 nm can reduce the excitability of peripheral nerves and the sensitivity of the skin, stimulate collagen synthesis, and tighten the skin, which plays an important role in skin rejuvenation. In general, commercial LEDs are made of phosphor excited by ultraviolet chips. It is very important for the development of yellow light emitters with high luminous efficiency, good stability, and environmental protection. For the first time, a simple organic structural unit (2-methylimidazole, 2-MIM) was used to collect a mixture of two metal precursors (CsI and CuI) and successfully synthesized an all-inorganic lead-free yellow light CsCu 2 I 3 powder in water. The prepared CsCu 2 I 3 powder exhibited excellent optical properties and considerable stability. Finally, a phosphor-converted LED (pc-LED) device was fabricated via the CsCu 2 I 3 phosphor coated on a 310 nm ultraviolet chip. The pc-LED device's electroluminescence spectra may be a good fit for the blood's absorption regions. Therefore, this work provides a facile method for the synthesis of novel lead-free metal halide CsCu 2 I 3 powder in eco-friendly solvents. In addition, the stable and efficient CsCu 2 I 3 powder shows promising exciting potential applications in photoluminescence and phototherapy fields.
研究领域:
材料科学
·
光学
·
生物医学工程
✓ 已验证
DOI
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Jia-Jun Qian,Jing-Xuan Guo,Meng-Chao Wang,Li-Jian Chen,Xu Zhao,Xiu-Ping Yan
Bacterial infections significantly impede wound healing and threaten global public health. Porphyrin covalent organic frameworks (COFs) have shown promise as phototherapy antibacterial materials. However, the inherent π–π stacking interactions between the monomers also lead to aggregation and quenching of photosensitizers, thereby reducing the production of singlet oxygen ( 1 O 2 ) and compromising their antibacterial efficacy. Herein, we designed and prepared a novel cationic porphyrin-based COFs nanoplatform (TAPP-VIO), utilizing photosensitive TAPP and cationic VIO as structural units. This multifunctional nanoplatform is specifically tailored for targeted phototherapy and chemotherapy against bacterial infections. Upon irradiation, TAPP unit in TAPP-VIO generates heat and 1 O 2 , which effectively disrupt bacterial structure and cause cell death. The incorporation of VIO unit introduces electrostatic repulsion between layers, mitigating π-π stacking effects and enhancing 1 O 2 production. Additionally, the positive charge imparted by the VIO unit enables TAPP-VIO to bind efficiently to negatively charged bacterial surfaces, immobilizing the bacteria and reducing their motility, thereby improving the overall efficacy of phototherapy . Under identical experimental conditions and concentrations, TAPP-VIO exhibits a 1 O 2 generation capacity that is 179% higher than that of nonionic porphyrin COF. Moreover, the temperature increase induced by TAPP-VIO is 85% of that observed with nonionic porphyrin COF (TAPP-MMA-Da), which is conducive to enhancing the phototherapeutic effects while minimizing heat-induced damage to healthy tissues. In summary, our study presents a straightforward approach to developing non-antibiotic antibacterial nanoagents, and the as-prepared TAPP-VIO is a promising candidate drug suitable for clinical trials in the future.
研究领域:
生物医学工程
·
抗菌材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
·
2021
·
IF 8.947
Chenyu Liu,Hengjun Zhou,Simiao Yu,Hailiang Chen,Ning Wang,Weihe Yao,An-Hui Lu,Weihong Qiao
Controlled-release drug carriers in cancer therapy are the most ideal way to reduce toxicity and improve drug efficacy . Since light stimulation is precise and operable, most multi-stimulation response carriers utilize phototherapy to enhance release efficiency. However, phototoxicity severely limits the application of phototherapy. Herein, we designed and synthesized a Cou-ONB lipid with sensitive fluorescence feedback and multi-stimulus response. COBL liposomes prepared from Cou-ONB lipids will passively aggregate at the tumor and guide phototherapy by fluorescence. More importantly, it can reflect the drug release effect in vivo through its own sensitive fluorescence changes, further enabling precise phototherapy and reducing phototoxicity. In this paper, the multi-stimulus superimposed response and precise fluorescence-guided performance of COBL liposomes were investigated at the molecular, liposome, cellular, and animal levels. Finally, tumor treatment experiments showed that the d -COBL-UV group had the best tumor suppression effect (5.3-fold). This paper highlights a real-time fluorescence-guided multi-stimulus superposition strategy and provides a design idea to precisely implement exogenous stimuli by displaying the degree of drug release, aiming to achieve less toxic and more efficient cancer therapy through timely and precise multi-stimulation. Statement of significance Multi-stimulus responsive drug carriers have been extensively developed in the last decade. Visual guidance is an important tool to achieve precision medicine and precise control of drug release. However, the available visualization materials are more aimed at directing stimulation at the optimal moment. There is little discussion on when to stop exogenous stimulation and how to minimize the damage of stimulation to the patient. Here, we provide a Cou-ONB lipid that not only responds to multiple stimuli, but also provides sensitive feedback on its own dissociation with a fluorescent signal so that physicians can adjust exogenous stimuli in a timely manner. This paper provides insights to facilitate precision drug delivery systems, providing viable design ideas for precise, efficient, and less toxic cancer therapies.
研究领域:
生物医学工程
·
药理学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）