OPTICS LETTERS
·
2022
·Vol. 48
·期 1
·139-142
·
IF 3.56
Zhenyu Ma,Jing Sun,Sijie Zhou,WenJun Shan,Yunxiang Yan,Yunxiang Yan,Yongjun Liu
A novel, to the best of our knowledge, type of compact pH fiber sensor combined with a hydrogel based on the whispering gallery mode (WGM) is proposed and integrates a liquid crystal (LC) microdroplet in a capillary in a compact structure as small as 180 µm. In the research, the hydrogel performs both as a supporting frame and a responsive material that causes morphological deformation of the LC microdroplet with pH variation. Moreover, a new phenomenon of pH-induced LC refractive index variation is observed and applied in the pH measurement, so that the acid itself can also lead the LC microdroplet structure transition. Thus, the WGM method is applied to detect the composite effect simultaneously to improve the sensing capability. The sensitivity of the sensor in the pH range from 4.55 to 6.86 reaches 3.19 nm/pH. The response time is short, within 60 s. The simple and compact structure of the sensor reduces the cost and enhances the stability, which is of great potential for biomedical pH measurement.
研究领域:
生物医学工程
·
光学工程
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DOI
PubMed
高影响因子
Analytical Methods
·
2024
·Vol. 16
·期 48
·8380-8389
·
IF 2.7
Zhuoxing Wu,Bolin Yu,Huien Gong,Yiquan Tang,Jiaxian Chen,Yingying Jian,Danmei Wei,Hongyun Meng,Chunhua Tan
The concentration of formaldehyde in the environment must be precisely monitored, as it is closely linked to human health. In this paper, a decaboryl derivative formaldehyde fluorescent probe (M1) was synthesized for the first time by introducing a 5-amino-isoquinoline group into a decaborane parent. Using theoretical calculations, 1H-NMR, 11B-NMR, HR-MS, and FT-IR, the molecular structure of the probe was determined and its response mechanism to formaldehyde was examined. The fluorescence response of the probe to formaldehyde was then tested, revealing an augmented response to formaldehyde in a solution of 0–600 μM, with a detection limit of 4.18 × 10−6 M. The results show that the formaldehyde fluorescence probe has the advantages of good linearity, strong anti-interference and high sensitivity. On this basis, a fiber optic formaldehyde fluorescence sensor based on an M1/PMMA thin film was constructed in this paper. This fiber optic fluorescence sensor, with its high selectivity, low detection limit, online and remote monitoring, and other advantages, was successfully applied to the detection of formaldehyde in both food and aqueous solutions, with results that were reliable compared to those of acetone. The detection limit of formaldehyde increased to 6.9 × 10−8 M. The potential for its utilization in the chemical, biological, environmental, and other formaldehyde detection fields is quite promising.
研究领域:
环境科学
·
分析化学
·
生物医学工程
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DOI
PubMed
高影响因子
APPLIED OPTICS
·
2019
·Vol. 58
·期 17
·4806-4811
·
IF 1.973
Jianyang Hu,Dongying Fu,Chunli Xia,Sibang Long,Chunlian Lu,Weimin Sun,Yongjun Liu
A novel, to the best of our knowledge, liquid crystal (LC) biosensor, based on an optical fiber Mach–Zehnder interferometer (MZI), is proposed. The proposed optical fiber MZI consists of two single-mode fibers and a tapered photonic crystal fiber (PCF). The PCF is coated with 4′-pentyl-biphenyl-4-carboxylic acid (PBA)-doped 4-cyano-4′-pentylbiphenyl (5CB). Being a pH-sensitive material, PBA can manipulate LC molecules to different orientations according to their pH values. When the orientation of LC molecules changes with varying pH, the effective refractive index of the cladding modes also is accordingly affected. Enzymatic reactions of penicillinase can release H+, which causes the decrease of the pH. Therefore, the enzymatic reactions of penicillinase can be sensed by monitoring the peak shift in the interference spectrum. The effects of the tapered diameter on the sensitivity of the sensor were experimentally investigated as well.
研究领域:
生物传感
·
光学工程
·
生物化学
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DOI
PubMed
高影响因子
IEEE SENSORS JOURNAL
·
2024
·
IF 4.3
Hao-Yuan Cao,Dandan Wei,Yingying Hu,Bin Liu,Yue Fu,Juan Liu,Xing-Dao He,Jinhui Yuan,Wenbo Xiao,Qiang Wu
In this paper, a high sensitivity U-shape single mode- tapered four core-single mode (STFS) optical fiber biosensor is proposed and investigated for tumor necrosis factor-alpha (TNF-α) detection in both Phosphate Buffered Saline (1x) (PBS) and diluted serum. The surface of U-shape STFS biosensor is immobilized with TNF-α antibody (10 μg/mL), which will specifically bind with target TNF-α. The results demonstrate a Hill curve relationship between wavelength shift and TNF-α concentration (from 10
1
to 10
4
pg/mL diluted in PBS). The lowest concentration of TNF-α detected in the experiment is 10 pg/mL, with an average wavelength shift of 0.389 nm. The average wavelength fluctuation of the sensor in PBS is 0.099 nm, and the corresponding limit of detection (LOD) is 4.35 pg/mL. Results for the detection of TNF-α in blood sample is also presented. It is found that the deviation of detected TNF-α concentrations (13.00–15.03 pg/mL, calibrated by measured results in PBS) is -0.7%~14.7% compared to standard TNF-α concentration of 13.09 pg/mL in blood. This biosensor, with its simple structure and high sensitivity, has the potential to serve as a valuable reference in disease diagnosis and medical drug usage, offering promising application prospects.
研究领域:
生物医学工程
·
光学传感
·
分子诊断
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Yan-nan Wang,Jin Li,Zhenyu Yuan,Fanli Meng
An optical fiber triethylamine (TEA) gas sensor based on a hollow malposition structure (HMS) platform with CQDs@BiOBr gas-sensing layer is proposed. The CQDs@BiOBr gas-sensing material is coated onto the surface of the hollow core fiber (HCF) using a dip-coating method. The misaligned structure is designed to guide light transmission within the cladding of the HCF and excite the evanescent field. The heterojunction formed between CQDs and BiOBr enhances the separation efficiency of electron-hole pairs, improving the transfer speed of charge carriers during the gas adsorption process. Experimental results show that the sensitivity of sensor at room temperature is 3.53 pm/ppm, which is 2.43 times higher compared to a sensor coated with BiOBr alone. Additionally, the response and recovery times of sensor are 12 s and 36 s, respectively, with a limit of detection (LOD) of 5.67 ppm. DFT calculations provide insight into the electronic transfer pathways and electron cloud distribution during the gas adsorption process, further validating the crucial role of the CQDs@BiOBr heterojunction in enhancing gas-sensing performance. The proposed optical fiber TEA gas sensor shows significant potential for applications in environmental monitoring and industrial safety.
研究领域:
光学工程
·
材料科学
·
化学
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DOI
高影响因子
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
·
2024
·
IF 5.6
Qi Wang,Hao-Yue Wang,Nuerguli Kari
Rapid and incredibly sensitive analyte detection is crucial in a variety of settings, including medical diagnostics. However, conventional surface plasmon resonance (SPR) sensors cannot effectively solve the issue of low sensitivity when assaying trace analytes. In this work, the rare Earth oxide Lu2O3 is first introduced to modify fiber optic SPR sensor. By utilizing the inherent advantages of Lu2O3, including high dielectric constant, high breakdown field strength, and high photoelectric conversion efficiency, the electric field around the sensor is effectively increased and high sensitivity detection is achieved. Experimental results show sensitivity of the sensor modified with Lu2O3 nanomaterial reaches 12133.78 nm/RIU in the interval of 1.3614–1.3756. The hexagonal boron nitride (h-BN) is subsequently introduced to further enhance electric field using the charge transfer mechanism. The sensitivity reaches 15065.92 nm/RIU, 3.96 times better than conventional U-shaped fiber SPR sensors. The sensor is compact designed with high sensitivity. There is significant potential for improving the sensitivity aspect of analyte detection.
研究领域:
生物医学工程
·
光学传感
·
材料科学
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产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2019
·Vol. 8
·期 1
·132-138
·
IF 6.641
Rui Wang,Qing Wu,Xiantao Jiang,Taojian Fan,Jia Guo,Cong Wang,Feng Zhang,Yali Gao,Meng Zhang,Zhengqian Luo,Han Zhang
Two-dimensional (2D) InSe has recently attracted increasing attention due to its outstanding electrical transport property, excellent photo-response, and direct band gap characteristics. In this contribution, few-layer InSe was successfully fabricated via a facile liquid phase exfoliation (LPE) method. Compared with other 2D materials, the photothermal response measurements demonstrate that InSe has excellent photothermal conversion efficacy. A novel Vernier-cascaded photothermal fiber sensor with high sensitivity that takes advantage of the photothermal effect of few-layer InSe has been proposed and demonstrated for the first time. The experimental results have shown that the photothermal optical sensitivity and spectral shifts of the MZI (Mach–Zehnder interferometer)–MKR (microfiber knot ring) Vernier sensor and the Vernier part are 0.126 nm mW−1, 12.22 nm and 0.0047 nm mW−1, 0.49 nm, respectively. A maximum sensitivity amplification factor of ∼26.8 is realized. Our present work can provide more possibilities of 2D materials that can be utilized towards cascade sensors.
研究领域:
材料科学
·
光学工程
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DOI
高影响因子
ANALYST
·
2025
·
IF 3.3
Yang Li,Yikan Zhao,Zhihao Yi,Shitong Han
Timely and accurate diagnosis of RNA viruses, represented by the SARS-CoV-2, is the foundation for protecting people from health threats. Currently, direct detection of viral RNA genes remains the most accurate method. Herein, a rapid, ultrasensitive, and no heating equipment required CRISPR/Cas13a based evanescent wave fluorescence biosensing platform for quantitative detection of the SARS-CoV-2 gene is reported. The collateral effect of CRISPR/Cas13a for RNA is combined with a self-driven enzyme-free hybridization chain reaction (HCR) as a signal amplification step. When the initiator RNA strand is cleaved by Cas13a, the downstream signal amplification induced by HCR is blocked, and a multiple crRNA strategy is used to enhance the cleavage efficiency. The newly designed HCR assemblies are captured by the cDNA-modified optical fiber and generate a higher-intensity fluorescence signal induced by the evanescent field. The CRISPR/Cas13a-HCR evanescent wave fluorescence biosensing platform is capable of detection of SARS-CoV-2 with a LOD of 0.47 copies per μL and the detection time is within 35 min. The spike recovery tests in saliva and high specificity have demonstrated the potential of this method for point-of-care diagnosis. This method is also suitable for the detection of other RNA viruses, without the need to alter any design of the HCR component, and only the corresponding crRNA needs to be replaced.
研究领域:
生物技术
·
医学诊断
·
病毒学
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DOI
PubMed
高影响因子
Nanoscale
·
2024
·Vol. 16
·期 6
·3113-3120
·
IF 5.8
Hongxin Zhang,Xuegang Li,Xue Zhou,Yanan Zhang,Yong Zhao
As a low-density lipoprotein, tributyrin plays an essential role in food safety and human health. In this study, a novel lipase-conjugated carbon nanotube (CNT) surface plasmon resonance (SPR) fiber-optic sensor is used to specifically detect tributyrin for the first time. In this work, CNTs can be used as an amplifying material to significantly increase the sensitivity of SPR sensors due to their high refractive index and large surface area. CNTs can also be used as an enzyme carrier to provide abundant carboxyl groups for the specific binding of lipases. Covering the surface of the sensor with CNTs can not only enhance the performance of the sensor, but also provide sufficient detection sites for subsequent biomass detection, reduce the functionalization steps, and simplify the sensor preparation process. The experimental results demonstrate that the refractive index sensitivity of the traditional multimode fiber (MMF)–single mode fiber (SMF)–MMF transmissive optical fiber sensor is 1705 nm RIU−1. After covering the sensor with CNTs, the sensitivity is 2077 nm RIU−1, and the sensitivity has been improved very well. In addition, there are abundant functional groups on CNTs, which can provide abundant binding sites. Conjugating lipase on carbon nanotubes helps to achieve linear detection in the range of 0.5 mM to 4 mM tributyrin, with a sensitivity of 4.45 nm mM−1 and a detection limit of 0.34 mM, which is below the 2.26 mM detection standard and meets food safety monitoring requirements. Compared with other sensors, the optical fiber biosensor proposed in this study expands the concentration detection range of tributyrin. Furthermore, the sensor also has good stability, anti-interference performance and specificity. Therefore, the sensor proposed in this paper has good application prospects in the fields of food safety and biomedicine.
研究领域:
食品安全
·
生物医学工程
·
分析化学
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产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2024
·Vol. 16
·期 5
·780-785
·
IF 2.7
Simin Hong,Mingming Yan,Yuan Feng,Huifang Chen,Ben Xu,Chunliu Zhao,Juan Kang
Ethanol plays a critical role in the modern chemical industry, food production, and medical research. Given its wide applications, the detection of ethanol concentration is very necessary. In this paper, a fibre device for rapid ethanol detection is proposed. The sensing head was fabricated with multimode fibre. The hydrogel was photo-cured on the fibre tip from polyethylene glycol diacrylate (PEGDA). In the hydrogel, rhodamine 6G (R6G) was immobilized as the fluorescent indicator. The sensor was designed based on the swelling behaviour of the hydrogel in liquid. The transparency of the hydrogel was modulated by the component of the water–ethanol mixture, thus, the fluorescence intensity of R6G was monitored for the determination of ethanol. Within the range of 0–62.2 vol%, the detection limit (LOD) was 0.4 vol%. A detailed comparison with other detection methods showed that the proposed sensor has the advantages of being single-ended, low LOD, cost-effective, and easy to prepare. It has great potential for on-site ethanol detection applications.
研究领域:
化学传感器
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Xuegang Li,Pengqi Gong,Xue Zhou,Shankun Wang,Yingxuan Liu,Yanan Zhang,Linh V. Nguyen,Stephen C. Warren-Smith,Yong Zhao
An advanced multi-parameter optical fiber sensing technology for EGFR gene detection based on DNA hybridization technology is demonstrated in this paper. For traditional DNA hybridization detection methods, temperature and pH compensation can not be realized or need multiple sensor probes. However, the multi-parameter detection technology we proposed can simultaneously detect complementary DNA, temperature and pH based on a single optical fiber probe. In this scheme, three optical signals including dual surface plasmon resonance signal (SPR) and Mach-Zehnder interference signal (MZI) are excited by binding the probe DNA sequence and pH-sensitive material with the optical fiber sensor. The paper proposes the first research to achieve simultaneous excitation of dual SPR signal and Mach-Zehnder interference signal in a single fiber and used for three-parameter detection. Three optical signals have different sensitivities to the three variables. From a mathematical point of view, the unique solutions of exon-20 concentration, temperature and pH can be obtained by analyzing the three optical signals. The experimental results show that the exon-20 sensitivity of the sensor can reach 0.07 nm nM −1 , and the limit of detection is 3.27 nM. The designed sensor gives a fast response, high sensitivity, and low detection limit, which is important for the field of DNA hybridization research and for solving the problems of biosensor susceptibility to temperature and pH.
研究领域:
生物医学工程
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
Laser & Photonics Reviews
·
2024
·
IF 9.8
Changrui Liao,Haoqiang Huang,Mengqiang Zou,Ying Wang,Shangben Jiang,Dezhi Zhu,Jiabin Huang,Jiajun Guan,Famei Wang,Cong Zhao,Mengjie Zheng,Weijia Bao,Dejun Liu,Xiaoyu Weng,Liwei Liu,Junle Qu,Yiping Wang
Optical fiber hydrogen (H 2 ) sensors have garnered attention for avoiding explosion hazards in flammable gas environments. Conventional optical fiber sensors rely on electron beam sputtering and chemical coating for functionalization, but these methods may not achieve precise functionalization of intricate structures. Based on 4D printing principles, an H 2 -sensitive ink containing methacrylate groups modified palladium (Pd) nanoparticles (NPs) is reported, with a printing resolution of 200 nm. Then, a fiber-tip clamped-beam H 2 sensor is fabricated with the femtosecond (Fs) laser-induced two-photon polymerization (TPP) technique. The sensor exhibits compact dimensions and fast responses, only 2.64 s for a 4.0 vol.% H 2 concentration. A high sensitivity of roughly 165 pm % −1 is achieved as the H 2 concentration increases from 0% to 5.5 vol.%. This study demonstrates that H 2 -sensitive microstructures can be flexibly achieved by TPP of H 2 -sensitive inks, offering a solution for achieving on-chip direct laser writing of integrated H 2 microsensors.
研究领域:
材料科学
·
光学工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）