JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Lanjiao Li,Ying Chen,Rongfei Wei,Siyu Guo,Xiangling Tian,Fangfang Hu,Hai Guo
Near-infrared phosphor-converted light-emitting diodes (NIR pc-LEDs) are playing an increasingly important role in the spectroscopy technology fields. Developing high-performance NIR-emitting phosphors is of immense significance for advancing NIR pc-LEDs. Herein, the approach of cationic substitution of Ca 2+ by Mg 2+ was designed in Ca 4 ZrGe 3 O 12 :Cr 3+ . Remarkably enhanced NIR emission and strikingly improved thermal stability are realized. The luminescence intensity at 423 K compared with that of room temperature ascends from 45.67 % to 72.81 %. Moreover, the representative sample was assembled to a NIR pc-LED with favorable output power and photoelectric conversion efficiency by combining a commercial 470 nm blue chip. The packaged LED demonstrates the feasibility of practical applications in night vision, biological imaging, and fruit detection. The above findings verify the potential prospect of Ca 4- x Mg x ZrGe 3 O 12 :Cr 3+ phosphor for the utilizations in NIR light sources.
研究领域:
材料科学
·
光学工程
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产品关联
DOI
高影响因子
ACS Applied Optical Materials
·
2022
·
IF 0
Hongshi Zhang,Chaojie Li,Jiyou Zhong,Jun Wen,Weiren Zhao
The near-infrared (NIR) phosphor-converted light-emitting diode (pc-LED) is an emerging portable light source and has multifunctional applications based on spectroscopic technology. Nevertheless, it is still difficult to develop broadband NIR materials with strong resistance toward thermal quenching. In this work, a thermally robust broadband NIR phosphor NaGaP2O7:Cr3+ was reported, which has an emission peak located at 793 nm, and the emission spectrum covers 650–1100 nm with a full width at half-maximum (fwhm) of 115 nm. The emission intensity at 150 °C was surprisingly maintained as 85.45% of that at 25 °C, indicating an outstanding ability to resist thermal quenching. A systematic investigation of aspects such as structural rigidity, the band gap of the host, and the electron phonon coupling effect was carried out to understand the mechanism of thermally robust luminescence in this material. Finally, the NaGa0.94Cr0.06P2O7 NIR phosphor and 450 nm InGaN LED chip were combined to produce a prototype NIR light source. This device generates a NIR output power of 44.43 mW and a photoelectric conversion efficiency of 10.4% when driven at 150 mA, demonstrating a good performance of this material for practical applications.
研究领域:
材料科学
·
光学
·
固体物理
✓ 已验证
DOI
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jiangli Song,Hanlian Chen,Rongkai Pan,Fangyu Jin,Jie Tang,Qianqian Huang,Guohua Zhou,Xiumei Song
Understanding the interactions between small molecules and calf thymus deoxyribonucleic acid (ctDNA) is critical for certain aspects of drug discovery. In this study, three 11 H -indeno[1,2-b]quinoxalin-11-one thiosemicarbazones were synthesized and their interaction with ctDNA was examined through various spectroscopic techniques, including ultraviolet (UV) spectroscopy, fluorescence spectroscopy, and circular dichroism (CD) spectrum, and through physicochemical methods, including viscosity measurements. In addition, the effects of these thiosemicarbazone compounds 4a, 4b and 4c on several cancer cell lines were explored. The results of UV absorption, fluorescence quenching and CD experiments indicated that compounds 4a, 4b and 4c primarily bound to ctDNA by an intercalation. This mode of interaction was further corroborated by viscosity measurements. Docked poses of compound 4a revealed that it formed a crucial N position hydrogen bond with the DNA receptor. The chemical structure of compound 4a was further confirmed by X-ray crystallographic analysis. Through biological evaluation, it was found that the in vitro cytotoxicity of three compounds agreed with the order of their binding strength to ctDNA, indicating that the antitumor activity of these compounds correlated with their binding affinity to ctDNA.
研究领域:
生物化学
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药物化学
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
CELLULOSE
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2022
·Vol. 29
·期 10
·5547-5556
·
IF 6.123
Yan Ning,Zhang Yu-Ting,Chai Xin-Sheng,Lu Zhao-Qing
This paper proposed a derived spectroscopic technique for determining the surface charge of lignocellulosic fiber. In this method, chitosan quaternary ammonium iodide with higher molecule weight was selected to minimize its interaction with the negative charge inside of fiber pores. It was based on spectroscopically measuring the UV absorbance of I − (the counter ion) in the filtrates from a set of solutions that containing the fixed amount of fibers and the different amount of cationic polymer (from under- to over-saturation). By plotting the derived absorbance at 245 nm versus the volume of chitosan addition, a transition point is determined, from which the fiber surface charge can be calculated. The results showed that the present method has a good measurement precision (RSD < 3.24%) and accuracy (relative differences < 3.11%, when compared with the conductivity titration method). It is suitable to be used for determining the surface charge of lignocellulosic fibers.
研究领域:
材料科学
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分析化学
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2024
·
IF 4.3
Ying Chen,Rongfei Wei,Lanjiao Li,Xiangling Tian,Fangfang Hu,Hai Guo
High-performance near-infrared (NIR) light sources are highly sought after in advanced spectroscopy techniques, driving the development of NIR phosphor-converted light-emitting diodes (pc-LEDs). Escalating the luminescence intensity and thermal stability of NIR-emitting phosphors, which is a core component of NIR pc-LEDs, is of paramount importance. Herein, chemical unit cosubstitution and cosolvent addition tactics were implemented to simultaneously boost the NIR luminescence performance of the synthesized phosphors. The replacement of [Sc3+-Sc3+] for [Ca2+-Zr4+] in Ca4ZrGe3O12:Cr3+ likely reduces the antisite defects and offers a more rigid crystal structure. As a result, the emitting intensity is reinforced significantly, along with a remarkable improvement in thermal stability, acquiring 65% of the initial luminescence at 423 K compared with 42% for the primal sample. Moreover, the introduction of H3BO3 further enhances NIR luminescence while maintaining a favorable thermal resistance. The encapsulated NIR pc-LED carries an impressive output power of 71.8 mW at 300 mA and a conversion efficiency up to 15.6% at 10 mA. The practical presentations in food checking, imaging, and detection manifest that Ca3.5ScZr0.5Ge3O12:Cr3+,H3BO3 is a promising material for spectroscopy-based technologies.
研究领域:
材料科学
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光学
·
无机化学
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2025
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IF 6.7
Yanyan Lu,Yu Qiao,Haoming Bao,Kang Chen,Yi Wei,Qian Zhao,Guo Kang Leon,Hongwen Zhang,Xing Yi Ling,Weiping Cai
To address the challenges of precise identification and real-time monitoring of hazardous chemicals, this work proposes and develops surface-plasmon-enhanced dual spectroscopies (SPEDS). This technique combines highly recognizable surface-enhanced Raman spectroscopy (SERS) with real-time plasmon-mediated differential ultraviolet–visible spectroscopy (P-DUS). The feasibility of this technique is demonstrated by successfully acquiring SPEDS signals of thiourea with a plasmonic gold colloidal system. By combining SPEDS with machine learning algorithms, we achieve accurate identification and precise quantification of chemicals, with accuracies of 98.2 and 98.6%, respectively, significantly outperforming single P-DUS (63.2 and 95.1%) and SERS (80.3 and 86.5%). Additionally, we demonstrate the universality and expandability of SPEDS through other plasmonic nanostructures of various shapes and surface modifications. Using a CuS-coated Au nanoarray, we demonstrate multiple 8-h monitoring sessions of Hg2+ with good anti-interference and robust quantification, thereby highlighting the practical potential of SPEDS in real-world applications. These results position SPEDS as a cutting-edge and multifunctional chemical sensing platform, unlocking transformative possibilities for advancing environmental monitoring, industrial safety, and public health.
研究领域:
化学传感
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环境科学
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纳米技术
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数据分析
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产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Huan-Yu Sui,Dong Chen,Jia-Ping Huang,Zhe-Ying Hu,Lu Hu,Jie-Hua shi,Shao-Liang Jiang
Approval in 2019 was granted for the highly selective, targeted agent lorlatinib, which primary target is ROS1 and ALK. The purpose of this work was to examine the binding mechanism between lorlatinib (LOR) and HAG employing multispectral and molecular modeling techniques. Fluorescence data demonstrated that LOR quenched HAG fluorescence as a static quenching, interecalated into the hydrophobic cavity of HAG with a moderate affinity. Thermodynamic and competitive experiments pointed out that LOR bound with HAG primarily through hydrogen bonding, hydrophobic, and van der Waals forces. Circular dichroism, three-dimensional and synchronous fluorescence spectroscopic studies noted that the secondary structure of HAG and microenvironments around tyrosine (Tyr) and tryptophan (Trp) residues were altered due to binding with LOR. The contribution of each energy involved in binding process of LOR and HAG has been analyzed by molecular simulation techniques. Besides, the environmental conditions with metal ions have also been studied. The present study is expected to provide a theoretical basis for further studying the metabolism of LOR in vivo, which may help to gain a deeper understanding of the general pharmacological activity of the drug.
研究领域:
药理学
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生物化学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Xuewa Jiang,Shaoyan Yi,Pingping Shen,Richa Raj,Jian Zhang,Haixia Ge
Chronic low-grade inflammation, driven by elevated levels of circulating high mobility group box1 (HMGB1), plays a crucial role in the pathogenesis of multiple chronic diseases. Glycyrrhetinic acid (GA) and isoliquiritigenin (ISL) are representative metabolites in licorice, exhibit potent regulatory effects on HMGB1-mediated chronic inflammation. In this research, we investigated the interactions of GA and ISL with HMGB1 using multi-spectroscopy, surface plasmon resonance (SPR), and molecular docking. Fluorescence spectroscopy revealed that GA or ISL binds to HMGB1, leading to static fluorescence quenching of the protein. Additionally, the binding of GA or ISL altered the microenvironment of tryptophan and decreased the α-helix content of HMGB1 to varying extents. Dynamic light scattering (DLS) showed that GA induced aggregation of the HMGB1 complex into large particles, while ISL reduced the particle size of HMGB1. SPR analysis confirmed that GA and ISL bound reversibly to HMGB1 with K d values of 53.0 ± 3.6 and 16.3 ± 0.5 μM, respectively. Molecular docking further elucidated the binding modes and sites of GA and ISL on HMGB1, showing that GA binds to the B-box and ISL binds to the A-box of HMGB1, with hydrogen bonding and hydrophobic interactions as the primary driving forces. Isobologram analysis demonstrated that the combination of GA and ISL exhibited a significant synergistic inhibitory effect on HMGB1-induced inflammation on RAW264.7 cells, with an optimal combination ratio of 1:1. This study reveals that GA and ISL synergistically exert anti-inflammatory effect by modulating HMGB1 conformation, offering new insights into licorice extracts for preventing chronic inflammatory diseases.
研究领域:
药理学
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生物化学
·
分子生物学
·
免疫学
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药物化学
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产品关联
DOI
PubMed
高影响因子
Plant Methods
·
2017
·Vol. 13
·期 1
·1-11
·
IF 3.51
Zhang Heng,Chen Zhenyi,Li Taihao,Chen Na,Xu Wenjie,Liu Shupeng
Background
Flos Chrysanthemi , as a part of Chinese culture for a long history, is valuable for not only environmental decoration but also the medicine and food additive. Due to their voluminously various breeds and extensive distributions worldwide, it is burdensome to make recognition and classification among numerous cultivars with conventional methods which still rest on the level of morphologic observation and description. As a fingerprint spectrum for parsing molecular information, surface-enhanced Raman scattering (SERS) could be a suitable candidate technique to characterize and distinguish the inter-cultivar differences at molecular level. Results SERS spectra were used to analyze the inter-cultivar differences among 26 cultivars of Chinese ornamental Flos Chrysanthemum . The characteristic peaks distribution patterns were abstracted from SERS spectra and varied from cultivars to cultivars. For the bands distributed in the pattern map, the similarities in general showed their commonality while in the finer scales, the deviations and especially the particular bands owned by few cultivars revealed their individualities. Since the Raman peaks could characterize specific chemical components, those diversity of patterns could indicate the inter-cultivar differences at the chemical level in fact. Conclusion In this paper, SERS technique is feasible for distinguishing the inter-cultivar differences among Flos Chrysanthemum . The Raman spectral library was built with SERS characteristic peak distribution patterns. A new method was proposed for Flos Chrysanthemum recognition and taxonomy.
研究领域:
植物学
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分析化学
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光谱学
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分子系统学
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中药鉴定
✓ 已验证
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Yining Li,Yanping Jiang,Qiaojuan Zhang,Yiwen Zhao,Li Zhang,Gang Song,Kunlun Huang,Zhiyi Yao
In this report, we have established a novel approach for the rapid detection of folic acid (FA) with a water soluble perylene bisimide-based probe in 100% aqueous media. The sensing performance and mechanism of this probe were investigated systematically using spectroscopic techniques. After optimizing conditions, the limit of detection in this assay is as low as 29.2 nmol/L and linear operation range is from 0.1 to 1.2 μmol/L. It relies on the supramolecular recognition between the probe and FA under the synergistic effects of non-covalent interactions such as electrostatic, hydrophobic and π−stacking interactions. Monitoring the FA concentrations in real-world samples is also confirmed.
研究领域:
分析化学
·
超分子化学
·
生物化学
✓ 已验证
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Yiling Zhou,Yaru Liao,Jing Bai,Xinlei Xia,Zhihua Wu,Xin Li,Ping Tong,Hongbing Chen,Anshu Yang
This study aimed to investigate the effects of active soybean isoflavones on the structure and potential allergenicity of glycinin, a major allergen, in soybean. The interaction mechanism between two active soybean isoflavones, namely, genistein (Gen) and daidzein (Dai), and glycinin were investigated using a series of spectral techniques. The structure of the isoflavone-glycinin complexes was characterized by SDS-PAGE and spectral techniques. In addition, the potential allergenicity of the isoflavone-glycinin complexes and their digestion products in vitro was measured via Western blot and enzyme-linked immunosorbent assay. Results showed that Gen and Dai effectively quenched the intrinsic fluorescence of glycinin largely through static quenching. Dai interacted with glycinin through hydrogen bonding and van der Waals forces, while Gen relied on hydrophobic interactions with glycinin. Furthermore, the neutral complex of daidzein-glycinin (Dai-G) exhibited weaker IgE binding ability compared with the glycinin samples. These findings provided new insights into the molecular mechanisms that underlay the immunomodulatory effects of soybean isoflavones and their potential applications in food allergy prevention and management.
CAS / MDL:
研究领域:
食品科学
·
过敏与免疫学
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2024
·
IF 4.8
Qi Sun,Guangqing Mu,Peng Sun,Qing Zhao,Xiaomeng Wu,Fanhua Kong
Casein (CN) is the primary factor leading to allergic reactions in infants to bovine milk, severely limiting the intake of bovine milk formula by allergic infants. This study investigates the conformational changes and regulation of linear epitopes during the hydrolysis of CN by five proteases derived from microbial and plant sources using multiple spectroscopic techniques combined with LC/MS-MS. The results showed that the IgE inhibition rates for SD (subtilisin hydrolysate), PD (papain hydrolysate), BD (bromelain hydrolysate), KD (proteinase K hydrolysate), and FD (ficin hydrolysate) were 43.19%, 41.99%, 35.45%, 48.15%, and 14.80%, respectively. The differences in antigenic residues remaining after hydrolysis by different proteases mainly result from the varying degrees of structural alteration of CN and the hydrolysis allergic epitope regions. This study provides theoretical basis for understanding the mechanism by which proteases reduce the allergenicity of CN. It also offers new insights into the development of multienzyme combinatorial hydrolysis strategies.
研究领域:
食品科学
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免疫学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）