JOURNAL OF ULTRASOUND IN MEDICINE
·
2024
·
IF 2.1
Xinyu Zhong,Xinghao Zhang,Yuting Cao,Ping Zhou
Objectives This study aimed to explore the interactions between microbubbles and microwave ablation (MWA). Methods The study employed custom-made phantoms (in vitro) and white New Zealand rabbits (in vivo). MWA was performed with or without microbubbles in the phantoms (2 × 10 5 particles mL −1 ) and rabbit livers (intravenous injection of 0.05 mL/kg SonoVue). During the MWA, K-type thermocouple probes were used to monitor the MWA-induced temperature increase. Contrast-enhanced ultrasound imaging (CEUS) was used to monitor and analyze the microbubbles signal intensity. After MWA, the ablation-zone volumes were evaluated and compared between the groups with and without microbubbles. Results In both the phantom models and rabbits, microbubbles showed no significant influence on MWA, including the ablation range and MWA-induced temperature increase. In phantoms and rabbit livers filled with microbubbles, MWA caused the formation of a gradually expanding microbubble-defect region over the ablation time. An increase in the temperature caused microbubble destruction. Conclusions Microbubbles had no significant influence on MWA. However, MWA induced the destruction of microbubbles in a temperature-dependent manner. Thus, the poor thermotolerance of microbubbles is a non-negligible barrier when using CEUS to monitor the ablation range during MWA in real-time.
研究领域:
医学影像学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
Small
·
2016
·Vol. 12
·期 15
·2046-2055
·
IF 8.315
Longfei Tan,Shengping Wang,Ke Xu,Tianlong Liu,Ping Liang,Meng Niu,Changhui Fu,Haibo Shao,Jie Yu,Tengchuang Ma,Xiangling Ren,Hong Li,Jianping Dou,Jun Ren,Xianwei Meng
Combining photothermal therapy (PTT) with clinical technology to kill cancer via overcoming the low tumor targeting and poor therapy efficiency has great potential in basic and clinical researches. A brand-new MoS 2 nanostructure is designed and fabricated, i.e., layered MoS 2 hollow spheres (LMHSs) with strong absorption in near-infrared region (NIR) and high photothermal conversion efficiency via a simple and fast chemical aerosol flow method. Owing to curving layered hollow spherical structure, the as-prepared LMHSs exhibit unique electronic properties comparing with MoS 2 nanosheets. In vitro and in vivo studies demonstrate their high photothermal ablation of cell and tumor elimination rate by single NIR light irradiation. Systematic acute toxicity study indicates that these LMHSs have negligible toxic effects to normal tissues and blood. Remarkably, minimally invasive interventional techniques are introduced to improve tumor targeting of PTT agents for the first time. To explore PTT efficiency on orthotopic transplantation tumors, New Zealand white rabbits with VX 2 tumor in liver are used as animal models. The effective elimination of tumors is successfully realized by PTT under the guidance of digital subtraction angiography, computed tomography, and thermal imaging, which provides a new way for tumor-targeting delivery and cancer theranostic application.
研究领域:
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2023
·
IF 5.2
Yihan Shi,Sheng Ding,Tao Liu,Kexin Hou,Shuhan Liu,Fan Li
Porous carbon spheres (PCS) with different specific surface areas and porous structures were prepared by templated self-assembly method. The as-prepared PCS had uniform radically distributed channels, single cavity and dispersed dendritic pore structures respectively. The whole blood clotting time tests showed the good hemostatic properties of PCS, even better than Celox. It's probably the specific surface area made the difference over the hemostatic performance of PCS. The possible reason is that the higher specific surface area can increase the contact area between PCS and blood, promote blood coagulation rapidly. And the oxygen polar functional groups on the surface of PCS can rapidly stimulate platelets and red blood cells when in contact with blood. Both of the hemolysis rate and cell viability experiments proved that PCS had good biocompatibility. The hemostatic effect of PCS in vivo were preliminary validated on the mouse tail-cutting model and the rabbit liver injury model, and all PCS could efficiently control the caudal and hepatic hemorrhage. Especially, PCS F127 with a pore size of 3 nm and specific surface area of 335 m 2 g −1 showed the best hemostatic efficiency, and it was expected to be an ideal candidate for rapid hemostasis in the battlefield or pre-hospital.
研究领域:
材料科学
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生物材料
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止血剂
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2022
·Vol. 11
·期 6
·1331-1343
·
IF 7.571
Wenjie Huang,Juan Wu,Zhenhua Huang,Dong Zhang,Fangping Chen,Changsheng Liu
Uncontrolled bleeding remains one of the direct causes of high mortality. There is an urgent need for developing emergency hemostats capable of coping with uncontrolled bleeding. The commercial starch-based hemostatic powder (PerClot®) requires compression during application, which limits its application in hemostasis of irregular and non-compressed wounds. Herein, a boronic acid-modified thiol starch sponge (St-SP sponge) with self-gelling properties was developed for hemorrhage control. The results show that the St-SP sponge could quickly absorb blood, self-gel and self-heal to seal the bleeding sites. In addition, the St-SP sponge can rapidly initiate the coagulation cascade and promote the adhesion and aggregation of erythrocytes and platelets. The St-SP sponge exhibited significantly improved in vitro and in vivo hemostatic abilities as compared with PerClot. Notably, the St-SP sponge attained complete hemostasis without any compression in 61.5 s and made a great difference compared to PerClot (169 s) for the irregular wound constructed on the rabbit liver. In addition, the St-SP sponge had good hemocompatibility and cytocompatibility. It turns out that the newly developed St-SP sponge is a promising material for first-aid hemostasis of irregular and non-compressed wounds.
研究领域:
材料科学
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生物医学工程
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止血
·
急诊医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Jinzhi Shi,Kai Shi,Qi Dong,Junfeng Yang,Yingshan Zhou,Peng Ma,Sha She,Fan Yang,Zuojiong Gong
Enriching erythrocytes and platelets in seconds and providing a fast seal in bleeding sites is vital to fatal hemorrhage control. Herein, hydrophilic chitosan fibrous mats (CECS-D mats) are fabricated by introducing hydrophilic carboxyethyl groups and subsequent catechol groups onto chitosan fibers. Due to strong hydrophilicity, CECS-D mats exhibit rapid liquid-absorption capacity, especially instantaneous absorptivity to the rabbit blood, which can achieve erythrocyte and platelet aggregations quickly by concentrating blood, thus promoting the formation of blood clots. Furthermore, the mats are self-oxidated to form quinone-amine adducts or quinone multimers by adjusting pH conditions, which not only provides tissue adhesion but also induces erythrocyte aggregation and platelet adhesion, further enhancing the seal and triggering quick closure to achieve fast hemostasis. Therefore, the mats reveal superior hemostatic performance in rabbit liver and spleen models over CECS mats and gauze. Especially in the fatal femoral artery injury model of rabbits, the mats reduce the blood loss by ∼75% and shortened the bleeding time by ∼50% compared with CECS mats, which have been reported to have the same hemostatic effect as commercialized Celox products in a swine femoral artery injury model. Besides, the mats are cytocompatible and degradable as well as antibacterial. This chitosan mat is a promising hemostatic material for fatal hemorrhage control.
研究领域:
生物材料
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止血
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组织工程
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2020
·
IF 0
Chen Bai,Pengcheng Hu,Nianlong Liu,Guodong Feng,Di Liu,Yi Chen,Ming Ma,Ning Gu,Yu Zhang
To elevate the accurate diagnosis of tumors, nanomaterial-based magnetic resonance imaging (MRI) contrast agents are being rapidly developed. In this paper, we report the large-scale synthetic method of Fe3O4 nanoparticles by high-temperature thermal decomposition and their application as time-dependent T1–T2 dual-modal MRI contrast agents in rabbit hepatic tumors. The Fe3O4 nanoparticles are modified with bull serum albumin (BSA), which provides excellent biocompatibility and colloidal stability. These nanoparticles also exhibit a high r1 value of 6.99 mM–1 s–1 and a low r2 value of 24.11 mM–1 s–1 at a clinically relevant magnetic field (3.0 T). In in vivo experiments, after intravenous administration with these nanoparticles, the rapid T2-weighted effect can be acquired within 5 min and the slow T1 contrast enhancement at the tumor site appears at 90 min. The explanation of this phenomenon is possibly due to the different accumulation rates and states of the nanoparticles in different tissues. In normal liver tissue, the nanoparticles can be quickly phagocytosed by a reticuloendothelial system and accumulated in the liver. These accumulated nanoparticles aggregate, improving the T2-weighted effect and reducing the T1-weighted effect. However, because of an enhanced permeation and retention effect, the nanoparticles are delivered into tumor tissue gradually and dispersedly, which takes a longer time to generate the T1-weighted effect at the tumor site. In summary, these Fe3O4 nanoparticles have significant potential to improve the diagnostic accuracy and sensitivity in MRI.
研究领域:
纳米技术
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医学成像
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生物医学工程
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癌症研究
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药理学
✓ 已验证
产品关联
DOI
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
·
IF 8.025
Fenghua Wang,Jiahua Sun,Hui Shi,Jie Zhou,Xiaoke Ma,Xiaolu Song,Xianhao Su,Lei Liu
Hemostasis and anti-infection are crucial for emergency treatment of severe trauma. Developing functional biomaterial with efficient hemostasis, antibacterial activity and wound healing is of great social significance and clinical value to fast stop bleeding and save lives, but it is still challenged. Here we designed a series of multifunctionalized SA/PDA cryogels by using two-step cross-linking of dopamine and sodium alginate. The resulting interpenetrating network structure had good swelling ratio, excellent mechanical and shape memory properties. Compared with cotton gauze and gelatin sponge, the cryogels exhibited excellent activation of coagulation cascade, more blood cells and platelet adhesion . Due to the action of polydopamine, the cryogel also showed good antioxidant activity and photothermal antibacterial ability assisted by near-infrared radiation, as well as better wound healing performance than gelatin sponge and Tegaderm™ film. Moreover, in the tests of mouse tail docking model, rat femoral artery hemostasis model and non-compressible rabbit liver defect model, the treatment by SA/PDA cryogels presented less blood loss and shorter hemostasis time than cotton gauze and gelatin sponge. Therefore, SA/PDA cryogels with simple preparation process, low cost, and good biocompatibility would be applied in the variety of great clinical applications in bleeding control, anti-infection and wound healing, etc.
研究领域:
生物材料
·
止血
·
抗菌材料
·
伤口愈合
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2023
·
IF 6.1
Qinsheng Chen,Qinwei Lu,Lianglong Zhang,Chenhan Zhang,Jingxian Zhang,Yu Gu,Qingxia Huang,Huiru Tang
Consistent retention time ( t R ) of metabolites is vital for identification in metabolomic analysis with ultrahigh-performance liquid-chromatography (UPLC). To minimize inter-experimental t R variations from the reversed-phase UPLC-MS, we developed an endo genous r etention- i ndex (endoRI) using in-sample straight-chain acylcarnitines with different chain-length ( L C , C0–C26) without additives. The endoRI-corrections reduced the t R variations caused by the combined changes of mobile phases , gradients, flow-rates, elution time, columns and temperature from up to 5.1 min–0.2 min for most metabolites in a model metabolome consisting of 91 metabolites and multiple biological matrices including human serum, plasma, fecal, urine, A549 cells and rabbit liver extracts. The endoRI-corrections also reduced the inter-batch and inter-platform t R variations from 1.5 min to 0.15 min for 95 % of detected features in the above biological samples. We further established a quantitative model between t R and L C for predicting t R values of acylcarnitines when absent in samples. This makes it possible to compare metabolites’ t R from different t R databases and the UPLC-based metabolomic data from different batches.
研究领域:
分析化学
·
代谢组学
·
生物化学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xiao Yang,Xiaoqin Si,Luqi Pan,Xujian Li,Zhixiao Ji,Changcan Shi
In pre-hospital care, achieving rapid and effective hemostasis for arterial rupture and visceral perforation wounds remains a critical challenge. Herein, we have developed a macroporous sponge with double-network structure using foaming technique, chemical and physical crosslinking reactions, and lyophilization. The prepared sponge not only demonstrates outstanding water absorption and water-triggered shape recovery capacity, but also exhibits significantly enhanced mechanical properties due to the construction of double-network structure. Simultaneously, the sponge shortens blood clotting time (from 1354.3 ± 41 s to 473.0 ± 28 s) by concentrating blood components and regulating coagulation pathways. Particularly, the sponge possesses excellent 3D printability and can be additively manufactured through DIW technique while maintaining favorable physical properties and procoagulant potential. Animal experiments have shown that sponges prepared by different processing method exhibit desirable hemostatic performance in SD rat/rabbit liver volume defect and artery complete transection hemorrhage. The construction of double-network provides promising avenue for developing high-performance sponge for massive and noncompressible hemorrhage, and the proposed DIW printing strategy for hemostatic sponge may revolutionize processing methods and provide a potentially feasible approach for designing and preparing customized sponges.
研究领域:
材料科学
·
生物医学工程
·
止血
·
组织工程
·
增材制造
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2022
·
IF 11.322
Caili Lv,Xiaosong Zhou,Peng Wang,Jianchao Li,Zhenxu Wu,Zixue Jiao,Min Guo,Zongliang Wang,Yu Wang,Liqiang Wang,Peibiao Zhang
Massive bleeding from deep penetrating wounds and bacterial infections are serious challenges for clinical and outdoor wound management. In this study, different molar ratios of chitosan (CS) and dopamine (DA) were covalently combined with sodium alginate (SA) through EDC/NHS to form complexes. Then, the cross-linking reaction was performed to form a sponge by adding sodium periodate. The CS 3 /SA/DA 1 compress sponge has rapid blood-triggered recovery properties that can quickly expand to block wounds and prevent bleeding. The CS 3 /SA/DA 1 has better coagulation ability than commercial gelatin sponges and gauze in a mouse liver injury/leg vein model and lethal incompressible hemorrhage model of a rabbit liver defect. The outstanding advantages of CS 3 /SA/DA 1 in degradation performance , antibacterial properties , antioxidation, hemocompatibility , cytocompatibility and histocompatibility present great application prospects in incompressible wound hemostasis.
研究领域:
生物材料
·
伤口愈合
·
止血
·
抗菌材料
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）