Contrast Media & Molecular Imaging
·
2018
·
IF 2.934
Shengjuan Luo,Jinsong Ding,Peiqi Wang,Zheng Wang,Xiaoqian Ma,Cejun Yang,Qi Liang,Pengfei Rong,Wei Wang
Perfluorooctyl bromide (PFOB) enclosed nanoparticles (NPs) as ultrasonic contrasts have shown promising results in the recent years. However, NPs display poor contrast enhancement in vivo. In this work, we used the copolymers poly(lactide-co-glycolide) carboxylic acid (PLGA-COOH) and poly(lactide-co- glycolide) poly(ethylene glycol) carboxylic acid (PLGA-PEG-COOH) as a shell to encapsulate PFOB to prepare a nanoultrasonic contrast agent. The NPs were small and uniform ( nm with a polydispersity index of ) with a complete shell nuclear structure under the transmission electron microscopy (TEM). In vitro, when concentration of NPs was ≥10 mg/ml and clinical diagnostic frequency was ≥9 MHz, NPs produced intensive enhancement of ultrasonic gray-scale signals. NPs could produce stable and obvious gray enhancement with high mechanical index (MI) (MI > 0.6). In vivo, the NPs offered good ultrasound enhancement in tumor after more than 24 h and optical imaging also indicated that NPs were mainly located at tumor site. Subsequent analysis confirmed that large accumulation of fluorescence was observed in the frozen section of the tumor tissue. All these results caused the conclusion that NPs encapsulated PFOB has achieved tumor-selective imaging in vivo.
研究领域:
医学影像学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2012
·Vol. 127
·期 1
·402-409
·
IF 1.289
Haohua Ye,Zhanxiong Li,Guoqiang Chen,Dan Fan
Bis (1H, 1H, 2H, 2H-perfluoro-octyl)methylenesuccinate (FOM)/ethyl acrylate (EA)/methyl methacrylate (MMA) copolymer (FOME) latexes, FOM/butyl acrylate (BA)/MMA copolymer (FOMB) latexes, and FOM/octyl acrylate (OA)/MMA copolymer (FOMO) latexes were synthesized by continuous emulsion polymerization. Solution polymerization was also carried out to prepare FOMB. The influences of fluorine content and curing conditions on the surface properties of polymer films were discussed. The water and oil repellency of cotton fabrics treated with the FOM copolymers was better than that of conventional poly(fluoroalkyl acrylate)s containing the same fluorinated chain. The polymer films or the treated fabrics were characterized by Fourier transform infrared, scanning electron microscope, atomic force microscopy, thermogravimetric analysis, x-ray photoelectron spectrometry, and wide angle x-ray diffraction. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci, 2013
研究领域:
材料科学
·
纺织化学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 15
·7924-7931
·
IF 2.936
Yanling Wang,Yongfei Li,Qian Wang,Qiang Li,Yue Zhang,Lin Yuan
The wettability of a rock’s surface is a vital factor for gas flow and fracturing fluid backflow. As a result of this, novel and effective gas wetting alteration agents are required. In this work, a gas-wetting alteration agent, N,N-bis(perfluorooctyl)imine acetate sodium, was synthesized and characterized by different methods. The wettability of a rock’s surface was evaluated by contact angle and imbibition measurements, the Owens two-liquid method and glass capillary tube rise testing. The results showed that after treatment with 0.5 wt% N,N-bis(perfluorooctyl)imine acetate sodium the contact angles of water and n-hexadecane on the surface of the rock increased from 36° and 0° to 140° and 119°, respectively. The surface free energy rapidly reduced from primeval 72 mN m−1 to 3.4 mN m−1 after treatment with 0.3 wt% N,N-bis(perfluorooctyl)imine acetate sodium. These values agreed with the imbibition measurements and the results of the glass capillary tube rise testing. Moreover, analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) showed that the roughness of the rock surface significantly increased. The above results fully proved that the wettability of the rock surface is altered from its original water-wetting or oil-wetting to gas-wetting. Furthermore, thermal analysis demonstrated that the gas-wetting alteration agent has good thermal stability, which indicates its great potential to be used as a gas-wetting alteration agent for unconventional gas reservoirs under high temperature conditions.
研究领域:
石油工程
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2021
·Vol. 19
·期 1
·1-14
·
IF 10.435
Qin Bing,Jiang Mengshi,Li Xiang,Shi Yingying,Zhang Junlei,Luo Zhenyu,Luo Lihua,Lu Yichao,Liu Xu,Wang Sijie,Du Yongzhong,Qiu Yunqing,Lou Yan,You Jian
Background Gene therapy shows great promise for a broad array of diseases. However, we found that hypoxic tumor microenvironment (TME) exerted significant inhibitory effects on transfection efficiency of a variety of gene vectors (such as Lipo 2000 and PEI) in an oxygen-dependent manner. Solid tumors inevitably resulted in acute hypoxic areas due to the rapid proliferation of tumor cells and the aberrant structure of blood vessels. Thus, the hypoxic TME severely limited the efficiency and application of gene therapy.Methods In our previous study, we constructed endoplasmic reticulum-targeted cationic liposomes, PAR-Lipo, which could effectively deliver genes and ensure high transfection efficiency under normoxia. Unsatisfactorily, the transfection efficiency of PAR-Lipo was rather poor under hypoxia. We believed that reoxygenation was the most direct and effective means to rescue the low transfection under hypoxia. Hence, we fabricated liposomes modified with perfluorooctyl bromide (PFOB@Lipo) to load oxygen and deliver it to tumor sites, which effectively alleviated the hypoxic nature of tumor. Then PAR-Lipo were applied to mediate high-efficiency delivery of tumor suppressor gene pTP53 to inhibit tumor progression.Results The results showed that such staged strategy augmented the expression of P53 protein in tumors and extremely suppressed tumor growth.Conclusion This work was the first attempt to utilize an oxygen nanocarrier to assist the therapeutic effect of gene therapy under hypoxia, providing a new reference for gene therapy in malignant tumors.Graphical Abstarct
研究领域:
癌症研究
·
基因治疗
·
纳米技术
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER COMPOSITES
·
2025
·
IF 4.7
Tengyang Zhang,Jie Fei,Jifeng Yan,Zhaoxi Gou,Peng Cheng,Lehua Qi
At low temperature (−60°C), increased brittleness and surface grease adhesion promote significant adhesive wear in the composites. 1H,1H,2H,2H-perfluorooctane trichlorosilane (PFOTS) was coated onto carbon fibers to enhance the tribological performance at low temperature of the composites. Compared to the original material, the shear strength of the modified sample was increased by 31.9% to 20.16 MPa, while the wear rate under −60°C was decreased significantly by 87.5% to 1.72 × 10 −8 cm 3 /J. The low-temperature adhesive wear mechanisms were first revealed by combining experimental measurements with molecular dynamics simulations, and the simulations further clarified how a PFOTS coating modifies the tribological response of the material.
研究领域:
材料科学
·
复合材料工程
·
表面科学
·
摩擦学
·
低温工程
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2017
·
IF 3.684
Hui Dai,Guang-Zhong Yin,Fang-Jia Zhao,Zhong-Xuan Bian,Yu-Jie Xu,Wen-Bin Zhang,Xia-Ran Miao,Hui Li
Hierarchical assembly of macromolecules has been central in creating complex nanostructures . In this work, polystyrene- block -poly (perfluorooctylethyl acrylates) (PS- b -PFOA) diblock copolymers were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and shown to assemble into hierarchical structures in bulk with the interplay of nanophase separation and crystallization. The molecular weights were determined by gel permeation chromatography (GPC) and 1 H NMR spectra. The phase-separated nanostructures of these block copolymers were investigated via small-angle X-ray scattering (SAXS) and wide-angle X-ray diffraction (WAXD) in reciprocal space and by transmission electron microscopy (TEM) in real space. The results showed that well-ordered lamellar morphologies were formed in the bulk of samples with volume fraction of PFOA ( f PFOA ) around 0.390–0.538. Within the PFOA layers, the side chains were found to further crystallize, forming crystalline layers with thicknesses about twice that of the length of fluorinated side-chains. The SAXS patterns from sheared samples further show that the orientation of crystalline layers was perpendicular to the lamellar layers formed by micro-phase separation.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2022
·
IF 6.76
Feihong Ye,Liping Li,Jianyin Xu,Lu Zhou
Synthesization of 1H,1H,2H,2H-Perfluorooctyltrimethoxysilane through solvent-free hydrosilylation of 1H,1H,2H-perfluoro-1-octene with trimethoxysilane was efficiently conducted over the RuCl 3 ·3H 2 O catalyst. The synergistic action of Ru 3+ as the active center and the strong electronegativity of Cl − to attract the electron of the electron-donating group –OCH 3 in trimethoxysilane, activated the Si-H and thus promoted the reaction. The influences of different reaction conditions including feed order, feed ratio, catalyst dosage, reaction temperature and reaction time on the reaction yield were fully investigated, to conclude the optimized condition to achieve a yield of 86.80% was the feed of 1.2 mol trimethoxysilane per mole of 1H,1H,2H-perfluoro-1-octene, together with the addition of 9.56 × 10 −4 mol RuCl 3 ·3H 2 O per mole of trimethoxysilane, at 80 °C for 4 h; while the additive of CuCl to RuCl 3 ·3H 2 O catalyst could further improve the reaction yield at 50℃. Finally, after understanding the activity of Ru with different valence state, the reaction mechanism was also proposed.
研究领域:
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
HOLZFORSCHUNG
·
2020
·Vol. 74
·期 8
·799-809
·
IF 1.826
Yu Wang,Zuwu Tang,Shengchang Lu,Min Zhang,Kai Liu,He Xiao,Liulian Huang,Lihui Chen,Hui Wu,Yonghao Ni
Wood is a natural, abundant, renewable resource, which is easily processed, has beautiful texture and good mechanical strength, and is widely used for furniture, flooring, decor and building construction. However, wood is vulnerable to moisture and microorganisms, resulting in deformation, cracks, mold and degradation, which causes aesthetic problems and/or shortens the service life of wood products. In this paper, superhydrophobic wood (wood-F) was fabricated by grafting poly(2-(perfluorooctyl)ethyl methacrylate) (PFOEMA) onto wood by atom transfer radical polymerization (ATRP). Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) with an energy-dispersive X-ray spectroscopy (EDS) showed that PFOEMA was successfully grafted onto wood. The resultant wood-F exhibited excellent water resistance with a contact angle (CA) of 156° and hysteresis of 4°. The modified wood also showed abrasion resistance, self-cleaning ability and anti-mold properties, all of which are desirable for various wood products.
研究领域:
材料科学
·
木材科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers of Chemical Science and Engineering
·
2022
·Vol. 16
·期 11
·1606-1615
·
IF 4.803
Liu Zihan,Luo Yang,Ning Lianchao,Liu Yong,Zhang Ming
The increasing applications of seawater desalination technology have led to the wide usage of polyamide reverse osmosis membranes, resulting in a large number of wasted reverse osmosis membranes. In this work, the base nonwoven layer of the wasted reverse osmosis membrane was successfully modified into the hydrophobic membrane via surface deposition strategy including TiO 2 and 1H,1H,2H,2H-perfluorooctyltrichlorosilane (PFOTS), respectively. Various techniques were applied to characterize the obtained membranes, which were then used to separate the oil—water system. The optimally modified membrane displayed good hydrophobicity with a contact angle of 135.2° ± 0.3°, and its oil—water separation performance was as high as 97.8%. After 20 recycle tests, the oil—water separation performance remained more than 96%, which was attributed to the film adhesion of the anchored TiO 2 and PFOTS layer on the surface. This work might provide a new avenue for recycling the wasted reverse osmosis membrane used in oily wastewater purification.
研究领域:
环境工程
·
材料科学
·
水处理
✓ 已验证
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2019
·
IF 7.015
Yunzhe Jiang,Chuanyao Liu,Yanhong Li,Aisheng Huang
This work reports the preparation and post-synthetic modification of COF named BTADHBD with perfluorooctyltriethoxysilane (POTS) to obtain a superhydrophobic COF coating. Through post-synthetic modification, the water contact angle (CA) of BTADHBD is increased from 83.7° to 153.2° without change of crystals morphology and structure. BTADHBD COF coating was prepared on the stainless steel net (SSN) through repeated growth, followed by post-synthetic modification using (±)-glycidol (Glc) and POTS to obtain the SSN-supported superhydrophobic BTADHBD@Glc@POTS coating with a water CA of 152.1°. The superhydrophobic BTADHBD@Glc@POTS coating showed high water-resistance, self-cleaning property and oil/water separation performance using simply gravity as driving force. For various oil/water mixtures, the oil/water separation efficiency was always up to 99.5% with oil flux above 70 L/(m 2 ·s). For 50 successive cycles of oil/water separation, the high oil/water separation efficiency (above 99.5%) remained unchanged, which is very promising for oil/water separation.
研究领域:
材料科学
·
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Zhihua Song,Jinqiu Liu,Deyang Zhang,Yumeng Wang,Wen Lin,Yi Bi,Hongbo Wang,Maryam Arabi,Jinhua Li,Jiping Ma,Yan Wang,Lingxin Chen
Up to now, the chromatographic separation and analysis of highly polar compounds are still challenging because of low retention ability and selectivity of conventional stationary phases (SPs). Developing new SPs to achieve high-resolution and high-efficiency separation of polar compounds is of great importance for health and medicine, food safety, environmental protection, etc. . Herein, an influential multi-step modification strategy (modification with 1H,1H,2H,2H-perfluorooctyltriethoxysilane on the silica twice and end-capped with trimethylchlorosilane once) is introduced to prepare C8F13-SiO 2 SP. The physical properties of C8F13-SiO 2 SP, including morphologies, pore structures and carbon content were fully characterized by various instrumental techniques. The packed HPLC column with C8F13-SiO 2 SP exhibited high column efficiency, good peak shape (tailing factors for most analytes are between 0.9 and 1.3), and resolution for simultaneous separation of ginsenosides, sulfonamides, nucleosides , and benzoylurea insecticides (BUs); meanwhile, the retention mechanism of typical reversed-phase liquid chromatography (RPLC) mode was observed. A column efficiency of 30,220 plates/m for separation of ginsenoside Re was obtained. Furthermore, the resulting columns benefit from the advantages of supreme reproducibility, repeatability and stability. Importantly, the chromatographic properties (e.g. column efficiencies, chromatographic peak shapes, retention ability and resolution) of the C8F13-SiO 2 SP for the polar analytes were superior to those of the commercial SPs (including commercial amino-modified silica SP, diol-modified silica SP and commercial PFP-SiO 2 SP). Thus, the C8F13-SiO 2 SP is able to satisfy the strict requirements of highly polar compounds separation.
研究领域:
分析化学
·
色谱学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2022
·Vol. 128
·期 4
·1-10
·
IF 2.983
Li Lin,Shi Tao,Zhang Yuan,Ma Xiaoyong,Xue Sen,Li Wenyan,Peng Huaqiao,Wei Yongqiang,Zhang Aimin,Zhao Chengshou
Superhydrophobic aluminum alloy is fabricated through a chemical etching combined with surface modification. The surface modification step consists of a cyclic assembly of phytic acid (PA) and a metal ion (Ce or Fe) followed by surface modification with a low-surface-energy material (perfluorooctyltriethoxysilane, PFTS). With the optimized fabrication parameter, the sample integrated with Ce ion, denoted as Al-PA-Ce-PFTS, shows the best superhydrophobicity with CA of 169.6° ± 0.8° and SA of < 1°, followed by the sample integrated with Fe ion, denoted as Al-PA-Fe-PFTS (CA = 164.9° ± 2.1° and SA < 1°). Both samples determine excellent non-wettability. Through studying the dynamic behavior of water droplets on the surfaces of Al-PA-Ce-PFTS and Al-PA-Fe-PFTS, it reveals that both samples show excellent anti-adhesion ability. Electrochemical tests with 3.5 wt.% NaCl solution indicates that the anti-corrosion performance of superhydrophobic aluminum alloy surfaces is much better than that of the untreated aluminum surface. The freezing of water droplets on Al-PA-Ce-PFTS and Al-PA-Fe-PFTS is much slower than that of the untreated aluminum surface. Some water droplets can remain unfrozen at − 5 °C for over 60 min on the surfaces of Al-PA-Ce-PFTS and Al-PA-Fe-PFTS.
研究领域:
材料科学
·
表面化学
·
腐蚀工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）