The presence of lead as an environmental pollutant is widespread. However, safe and effective treatments for the resulting intestinal and liver damage from high levels of lead exposure remain limited. The study aimed to investigate the protective effects of dietary fiber and polyphenols in whole grain wheat flour on lead-induced mice. The results indicated that the daily intake of 12 mg of polyphenols, 0.5 g of dietary fiber, and their combination effectively reduced blood and liver lead accumulation by approximately 50 % in mice exposed to lead, while also mitigating lead-induced oxidative stress though a reduction in malondialdehyde levels and an enhancement in antioxidant enzyme activities including superoxide dismutase, catalase, and glutathione peroxidase. Furthermore, all three treatments enhanced cytokine secretion with the combined treatment exhibiting the highest efficacy. Specifically, the combination treatment decreased tumor necrosis factor-α and interleukin 1β by 56.78 %, 47.86 % in intestinal tissue while increasing increased interleukin 4 and interleukin 10 by 81.84 %, 145.14 %. Additionally, it promoted the expression of tight junction proteins like Zonula occludens-1, Occludin and Claudin-1. The study presented a potential strategy for alleviating liver and intestinal tract damage from high-dose lead exposure.
Cold atmospheric plasma (CAP) has shown great promise in mycotoxin degradation. This study compared the degradation efficiency of CAP against DON in the solid phase, aqueous solution, and wheat grains, as well as their degradation pathway and cytotoxicity of degradation products. The degradation efficiency of liquid DON by 12-W and 3.5-min CAP was 95%, while the maximum degradation rate of solid DON was only 56% after 40-W CAP treatment for 20 min. The major individual degradation products of solid and liquid-phase DON were C 15 H 19 NO 9 and C 15 H 18 O 7 . There were also four same degradation products, namely C 14 H 16 O 4 , C 15 H 18 O 6 , C 15 H 18 O 8 , and C 15 H 20 O 5 . The cytotoxicity of solid and liquid-phase DON on human kidney cells was significantly decreased after CAP treatment. Additionally, the degradation rate of 30-min CAP at 10 W against DON in wheat grains was 61%. The pasting and gluten quality of whole wheat flour was altered after CAP treatment.
危险品化学品经营许可证（带存储）