SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Fang Zhang,Jiaman Liang,Yang Liu,Qiuju Zhou,Yushuang Hong,Xianping Chen,Kejun Tan
Perfluorooctanoic acid (PFOA) and Perfluorooctane sulfonate (PFOS) are two typical perfluorinated compounds (PFCs) that poss potential ecological toxicity . In this work, a fluorescence and resonance light scattering (RLS) dual-readout strategy for the detection of PFCs at picomole level based on the water-soluble CdTe quantum dots (CdTe QDs) has been proposed. It is found that the CdTe QDs exhibit a quenching in the presence of PFCs and thus serve as useful probes for PFCs. The linear ranges are 0.032 – 10.0 nM with a limit of detection(LOD) of 32.02 pM for PFOA and 0.044 – 15.0 nM with a LOD of 43.96 pM for PFOS, respectively. Meanwhile, PFCs can form complexes with CdTe QDs in acid medium , resulting in remarkable RLS signals. The enhanced RLS intensities are in proportion to the concentrations of PFOA and PFOS, respectively. And the linear ranges are 0.048 – 5.0 nM with a LOD of 47.78 pM for PFOA, and 0.057 – 5.0 nM with a LOD of 56.72 pM for PFOS, respectively. This dual-mode detection increases the reliability of the measurement. The proposed method is simple, sensitive and cost-effective, with potential applications in environmental monitoring and assessment.
研究领域:
环境科学
·
分析化学
·
毒理学
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 20
·16752-16757
·
IF 3.201
Yanming Miao,Xiaojie Sun,Qi Yang,Guiqin Yan
A majority of traditional array sensors combine several sensing units, which can hardly be miniaturized. In order to solve the deficiency, it is suggested to design a sensing unit, which can obtain multidimensional information. Herein, taking the three-dimensional (3D) optical properties including phosphorescence (Ph), fluorescence (FL) and resonance light scattering (RLS) of the Mn–ZnS quantum dots (QDs) as signals, single-unit 3-signal mucopolysaccharide (MPS) sensors on the basis of Mn–ZnS QD/poly(diallyldimethylammonium chloride) (PDC) nanohybrids (Mn–ZnS+ QDs) were built with positively-charged poly(diallyldimethylammonium chloride) (PDC) as a receptor. These 3D sensors took advantage of the static interactional difference between Mn–ZnS+ QDs and different mucopolysaccharides (MPSs), and utilized different responses of Ph, FL and RLS to differentiate and identify four MPSs including heparan sulfate (Hep), hyaluronic acid (Hya), dermatan sulfate (Der) and chondroitin sulfate (Cho). Since the static interactional difference can be discriminated in virtue of the linear discriminating analysis, single-unit 3D sensors were constructed for differentiating MPSs of different types and concentrations. The three-dimensional sensor can still identify and analyze the target mucopolysaccharide in the presence of biological sample matrix, showing its good application prospects.
研究领域:
生物化学
·
分析化学
✓ 已验证
DOI
高影响因子
ANALYTICAL SCIENCES
·
2016
·Vol. 32
·期 7
·757-762
·
IF 1.174
Wang Chengke,Chen Dan,Wang Qingqing,Wang Qiuxia
In this work, an aptasensor-based resonance light-scattering (RLS) method was developed for the sensitive and selective detection of acetamiprid. The ABA (acetamiprid binding aptamer)-stabilized gold nanoparticles (ABA-AuNPs) were used as a probe. Highly specific single-strand DNA (ssDNA, i.e , aptamers) that bind to acetamiprid with high affinity were employed to discriminate other pesticides, such as edifenphos, kanamycin, metribuzin et. al. The sensing approach is based on a specific interaction between acetamiprid and ABA. Aggregation of AuNPs was specifically induced by the desorption of the ABA from the surface of AuNPs, which caused the RLS signal intensity to be enhanced at 700 nm. The alteration of AuNPs’ aggregation has been successfully optimized by controlling several conditions. Under the optimal conditions, the RLS intensity changes ( I/I0 ) of AuNPs were linearly correlated with the acetamiprid concentration in the range of 0–100 nM. The detection limit is 1.2 nM (3σ). This method had also been used for acetamiprid detection in lake water samples.
研究领域:
分析化学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2018
·
IF 2.746
Qian Chen,Panpan Zhu,Jie Xiong,Lixia Gao,Kejun Tan
In this study, a simple, fast and cost-effective triple-channel optical assay for the determination of PFOS has been developed. The carbon quantum dots (CDs) were prepared by one-pot hydrothermal method and employed as probe for sensing PFOS. CDs react with PFOS to form ground-state complex, which brings about the intensity changes of three signals including fluorescence, UV–vis absorption and resonance light scattering (RLS). And the changes of the fluorescence and absorption signals can be used for the visual detection of PFOS. And there is a certain relationship between the three-signal changes with the concentration of PFOS, respectively. The proposed assay exhibits good selectivity and sensitivity with a limit of detection (LOD) of 18.27 nmol/L in the fluorescence signal. Fluorescence lifetime , transmission electron microscopy (TEM) images, Fourier transform infrared (FTIR) and zeta potential were investigated for the mechanism study. Furthermore, this promising approach was also successfully applied to PFOS sensing in real water samples with RSD ≤ 2.09%.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2013
·Vol. 15
·期 9
·1-9
·
IF 2.175
Chen Zhanguang,Wang Zhen,Chen Xi,Xu Haixiong,Liu Jinbin
In this contribution, novel chitosan-stabilized gold nanoparticles (AuNPs) were prepared by mixing chitosan with citrate-reductive AuNPs under appropriate conditions. The as-prepared chitosan-stabilized AuNPs were positively charged and highly stably dispersed in aqueous solution. They exhibited weak resonance light scattering (RLS) intensity and a wine red color. In addition, the chitosan-stabilized AuNPs were successfully utilized as novel sensitive probes for the detection of heparin for the first time. It was found that the addition of heparin induced a strong increase of RLS intensity for AuNPs and the color change from red to blue. The increase in RLS intensity and the color change of chitosan-stabilized AuNPs caused by heparin allowed the sensitive detection of heparin in the range of 0.2–60 μM (~6.7 U/mL). The detection limit for heparin is 0.8 μM at a signal-to-noise ratio of 3. The present sensor for heparin detection possessed a low detection limit and wide linear range. Additionally, the proposed method was also applied to the detection of heparin in biological media with satisfactory results.
研究领域:
纳米技术
·
分析化学
·
生物传感器
✓ 已验证
DOI
PubMed
高影响因子
TALANTA
·
2020
·
IF 5.339
Li Jun Gong,Yuan Fang Li,Hong Yan Zou,Cheng Zhi Huang
Heparin (Hep) is a mucopolysaccharide sulfate anticoagulant drug widely used in clinic and thus the quantification of Hep concentration is of great significance. In this work, a simple resonance light scattering (RLS) method for the determination of Hep concentration using plasmonic copper selenide nanoparticles (Cu 2-x Se NPs) was developed. The positively-charged Cu 2-x Se NPs capped by cetyltrimethyl ammonium bromide (CTAB) were aggregated by negatively-charged Hep, consequently inducing a significant enhancement in the RLS signals of plasmonic Cu 2-x Se NPs. Under the optimal reaction conditions, the increased RLS intensity is linearly correlated with the concentrations of Hep in the range of 0.01–0.60 μg mL −1 (R 2 = 0.999), with a low detection limit (LOD) of 4.0 ng mL −1 (3σ). This method offered a simple, sensitive and selective strategy for determining Hep, which can be further successfully applied to quantify Hep in the heparin sodium injection.
研究领域:
分析化学
·
生物医学工程
·
药物分析
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2017
·
IF 4.162
Sifang Lv,Feng Chen,Chunyan Chen,Xiaoming Chen,Hang Gong,Changqun Cai
We report a rapid and facile resonance light scattering (RLS) technique that utilizes CdTe quantum dots (CdTe QDs) probe to detect microRNA-122. The RLS sensor is ingeniously designed with P1 and P2 , two cDNA sequence probes with partially complementary sequences to miRNA-122. The amine-modified P1 and P2 are coupled to the surface of QDs to form functional QDs-P1 and QDs-P2 conjugates, which are collectively referred to as QDs-P. The cDNAs hybridize with the target miRNA to rapidly induce the self-assembly of QDs probe and change RLS intensity. The proposed technique can detect miRNA-122 within 40 min. RLS intensity is enhanced in proportion with miRNA-122 concentrations of 0.16–4.80 nM and has a low detection limit of 9.4 pM. In addition, the assay satisfactorily detects miRNAs in human serum samples. Thus, the assay has considerable potential for the analysis of other interesting tumor makers.
研究领域:
生物化学
·
分子生物学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROSCOPY LETTERS
·
2015
·
IF 0.852
Yunfei He,Lifu Liao,Canhui Xu,Shijun Li,Rurong Wu,Yanyan Yang
The formation of a manganese (II) coordination supramolecular polymer was studied by resonance light scattering spectra for manganese (II) detection. Bis-sulfosalophen (a ditopic tetradentate Schiff base ligand) and bis-phenanthroline-glutaraldehyde (a ditopic bidentate ligand) were prepared for the construction of the supramolecular polymer. In a procedure of manganese (II) detection, manganese (II) ion reacts with bis-sulfosalophen to form a binuclear manganese (II) complex. The binuclear complex then self-assembles with bis-phenanthroline-glutaraldehyde to form the supramolecular polymer, resulting in the production of strong resonance light scattering signal. The amount of manganese was detected by measuring the resonance light scattering intensity. Under optimal conditions, a linear range was found to be 0.5–50.0 ng/mL, with a detection limit of 0.1 ng/mL. The method has been successfully applied to determine manganese in vegetable and tea samples with relative standard deviations of less than 5% and recoveries of 95.8–105.7%.
研究领域:
分析化学
·
超分子化学
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2016
·Vol. 8
·期 45
·8042-8048
·
IF 1.915
Zhen Cheng,Fang Zhang,Xianping Chen,Lingling Du,Chutong Gao,Kejun Tan
A simple, highly sensitive and selective assay method has been developed for the determination of perfluorooctane sulfonate (PFOS), a kind of emerging persistent organic pollutant, which is bio-accumulative, resistant to degradation and toxic. It was found that PFOS can form complexes with protonated Janus Green B (JGB) through electrostatic interaction in pH 5.8 citric acid–sodium citrate (CA–NaCA) buffer medium resulting in a remarkable enhancement of the resonance light scattering (RLS) intensity of the system. The study shows that the maximum scattering wavelength is located at 319.0 nm and the enhanced RLS intensities are in proportion to the concentration of PFOS in the range of 0.05–9.0 μmol L−1 (R2 = 0.9958), with a detection limit of 5.6 nmol L−1 (3σ). Under the same experimental conditions, various perfluorinated compounds (PFPrA, PFBA, PFPeA, PFHeA, PFHpA, PFOA, PFNA, and PFBS) and JGB interactions were studied and the scattering signal changes very little. Based on the above discussion, a simple, highly sensitive and selective resonance light scattering analysis method was established for the detection of PFOS. In this work, the optimum reaction conditions were investigated. The reaction mechanism between JGB and PFOS was also studied by the absorption spectrum, scanning electron microscopy (SEM), the combination ratio and so on. This method is successfully applied to the selective detection of PFOS in environmental water samples with RSD ≤2.7%.
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2017
·Vol. 409
·期 11
·2839-2846
·
IF 3.431
Wang Chengke,Wang Chengen,Wang Qingqing,Chen Dan
In this paper, a resonance light scattering (RLS) method was developed for detecting kanamycin with high sensitivity and selectivity. Here, aptamer specific to kanamycin was utilized for recognizing and competitively binding with kanamycin, and gold nanoparticles (GNPs) were used as probes. After adding kanamycin into solutions containing aptamer and GNPs, the GNPs would aggregate in the presence of NaCl, which resulted in the RLS signal intensities enhanced dramatically. Based on this phenomenon, kanamycin can be detected in the range of 10 to 600 nM with a limit of detection as 1 nM, which is more sensitive than many other instrumental methods, especially the commonly used UV-visible spectroscopic method. Furthermore, we demonstrated that this method can be used for detecting kanamycin in milk samples with satisfactory results, which is meaningful for solving food safety problems.
研究领域:
分析化学
·
食品安全
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Applied Spectroscopy
·
2023
·Vol. 89
·期 6
·1232-1240
·
IF 0.7
Yang Jing,Li Qian,Xu Canhui,Li Yujie,Nie Lizhen,Liu Chen,Xiao Xilin,Nie Changming,Zhou Xin,Liao Lifu
The resonance light scattering method was used to study the coordination-driven self-assembly reaction of zinc with a bipolar tetradentate ligand and a bipolar bidentate ligand to form a supramolecular polymer. The bipolar tetradentate ligand was N,N’-bis(pyridoxal phosphate)-o-tetraminobiphenyl synthesized by the reaction of pyridoxal phosphate with biphenyltetramine, and the bipolar bidentate ligand was bis-phenanthroline-glutaraldehyde synthesized by the reaction of glutaraldehyde with 5-aminophe-nanthroline. The formation of the supramolecular polymer causes signal enhancement of resonance light scattering. Based on this, we established a new method for the determination of zinc by resonance light scattering. Under optimized experimental conditions, the zinc concentration in the range of 0.3–30 ng/mL showed a good linear relationship with the resonance light scattering intensity of the system. The detection limit of the method is 0.1 ng/mL. Using this method to determine the content of zinc in food, the recovery rate of standard addition is between 95 and 107%, and the relative standard deviation is less than 3.68%.
研究领域:
分析化学
·
食品科学
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2015
·
IF 2.353
Ai Ping Li,Jing Dong Peng,MingQiong Zhou,Jin Zhang
A simple, fast, costless, sensitive and selective method of resonance light scattering coupled with HPLC was established for the determination of 6-mercaptopurine in human urine sample. In a Britton–Robinson buffer solution of pH 5.5, the formation of coordination complex between 6-mercaptopurine and metal palladium (II) led to enhance the RLS intensity of the system. The RLS signal was detected by fluorescence detector at λ ex = λ em = 315 nm. The analytical parameters were provided by the coupled system, the linear of 6-mercaptopurine response from 0.0615 to 2.40 μg L − 1 and the limit of detection (S/N = 3) was 0.05 μg L − 1 . The presented method has been applied to determine 6-mercaptopurine in human urine samples which obtained satisfactory results. Moreover, the reaction mechanism and possible reasons for enhancement of RLS were fully discussed.
研究领域:
分析化学
·
药物分析
·
医学检验
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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