ADVANCED MATERIALS
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2024
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IF 27.4
Yuan Bai,Gang Tang,Lei Xie,He Lian,Shihao Wang,Chaopeng Liu,Qiao Yu,Jianying Ji,Kailiang Ren,Xiaodan Cao,Cong Li,Lili Zhou,Yizhu Shan,Hongyu Meng,Zhou Li
Flexible films with optimal piezoelectric performance and water-triggered dissolution behavior are fabricated using the co-dissolution–evaporation method by mixing trimethylchloromethyl ammonium chloride (TMCM-Cl), CdCl 2 , and polyethylene oxide (PEO, a water-soluble polymer). The resultant TMCM trichlorocadmium (TMCM-CdCl 3 ) crystal/PEO film exhibited the highest piezoelectric coefficient (d 33 ) compared to the films employing other polymers because PEO lacks electrophilic or nucleophilic side-chain groups and therefore exhibits relatively weaker and fewer bonding interactions with the crystal components. Furthermore, upon slightly increasing the amount of one precursor of TMCM-CdCl 3 during co-dissolution, this component gained an advantage in the competition against PEO for bonding with the other precursor. This in turn improved the co-crystallization yield of TMCM-CdCl 3 and further enhanced d 33 to ≈71 pC/N, exceeding that of polyvinylidene fluoride (a commercial flexible piezoelectric) and most other molecular ferroelectric crystal-based flexible films. This study presents an important innovation and progress in the methodology and theory for maintaining a high piezoelectric performance during the preparation of flexible multi-component piezoelectric crystal films.
研究领域:
材料科学
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物理学
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 20
·7086
·
IF 4.927
Xue-Wei Wei,Cong Chen,Tian-Yu Wu,Li-Hai Cai,Hai-Mu Ye
Co-crystallization plays a crucial role in the integration and regulation of thermal and mechanical properties in polymer blends, but the poor compatibility of the components in the crystal phase has always been a major obstacle to co-crystallization, which puts forward stricter requests for linkage and interaction between different entities. On the basis of the hydrogen-bonding interaction that can promote chain stacking and thus improve miscibility, we propose that crystalline/crystalline blends of 2-ureido-4[1H]-pyrimidinone (UPy)-functionalized poly(butylene succinate) and poly(butylene fumarate) (PBS-UPy/PBF-UPy) where UPy groups with quadruple hydrogen-bonding interaction are employed to connect different chain ends, could inhibit phase separation and improve co-crystallization. PBS-UPy/PBF-UPy blends exhibit complex component-dependent and cooling-rate-dependent co-crystallization behavior. A high level of co-crystallization occurs in the range of PBS-UPy-rich fractions, and the proportion could approach over 98% under optimized conditions with the aid of UPy quadruple hydrogen bonds interaction. This work enriches the understanding of co-crystallization in crystalline/crystalline polymer blends and provides more possibility for the design of structures and properties of polymer materials.Keywords:co-crystallization;polymer blend;hydrogen bond;compatibility
研究领域:
材料科学
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高分子化学
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产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
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2025
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IF 7.3
Qingmeng Xu,Yang Xu,Qiyu Bian,Xiao Huang,Hongjie Luo
Screen coatings serve as important conservation materials for protecting cultural heritage from external influences, particularly during abrupt environmental changes. However, the present conservation materials have the disadvantages of opaque, irreversibility, complex implementation and high cost. In this work, a screen coating with desired properties is simply designed by co-crystallization based on widely used sublimable conservation material, menthol and menthyl lactate. The physic-chemical properties are tuned by changing material types and rations. Co-crystallization products are characterized from phase states, volume change and crystal structure. Menthol/menthyl lactate (90:10) mixture form solid solution which only shows 1 % volume shrinkage during solidification. And, the screen coating can shelter paper sample from water and oxygen. Also it is transparent. The transparency can be attributed to poor crystallinity of the mixture coating, which reduces the light scattering. Also, the coating does not affect sample's mechanical strength after sublimation. Our work opens a way to develop new conservation material with new technology based on widely used conservation material.
研究领域:
文物保护
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材料科学
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有机化学
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文化遗产保护
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表面工程
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Chen Wang,Zewei Hu,Wei Lou,Mingjie Huang,Wei Xiang,Tao Zhou,Juan Mao,Xiaohui Wu
This study has demonstrated that the Fenton fluidized bed (FFB) technology could successfully immobilize As ions on the iron-crystallized (IC) carriers, with simultaneous crystallization of ferric and mineralization of organic pollutants. It was found that rapid fluidized immobilization of aqueous As(V) on the IC carriers was through surface favorable bidentate complexion, while the adsorptive removal of As(III) was rather slow. Adding Fe 3+ caused competitive complexion and inhibited the As(V) immobilization. However, effective oxidative crystallization of Fe(II) and As(III) in FFB would take place. With the simultaneous generation of As(V) and Fe(III) by rapid •OH oxidation, two different crystalline precursors would be formed on the IC carriers, leading to efficient co-crystallization of As(V)/Fe(III). Recursive Fe(III) crystallization in the FFB continuously provided essential surface hydroxyl groups for capturing As(V), inducing layer-by-layer co-crystallized immobilization As(V)/Fe(III). The long-term continuous-flow treatment of a practical As(III)-containing industrial organic wastewater exhibited effective/stable co-crystallizations of As(V)/Fe(III), as well as COD removal. The FFB technology is expected to be a good option in treating complex industrial wastewater containing heavy metal and recalcitrant organic pollutants.
研究领域:
环境科学
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化学工程
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废水处理
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DOI
高影响因子
Nanoscale Advances
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2021
·Vol. 3
·期 17
·5053-5061
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IF 4.553
Jian Qu,Xin Zhang,Shuyan Zhang,Zhongjie Wang,Yejian Yu,Huajun Ding,Zhiyuan Tang,Xiangjun Heng,Ruiqi Wang,Su Jing
Time-dependent evolutive afterglow materials can increase the security level by providing additional encryption modes in anti-counterfeiting and data encryption. The design of carbon-based materials with dynamic afterglow colors is attractive but formidably challenging. In this study, a facile two-component co-crystallization strategy is designed for the first time to obtain N,S-co-doped carbon dots@isophthalic acid (CDs@IPA) and N,S-co-doped carbon dots@melamine (CDs@MA). CDs@IPA and CDs@MA all exhibiting time-dependent evolutive RTP colors from orange via yellow to green over 1 s, especially that the green afterglow time of CDs@IPA can reach 6 s (τavg = 582 ms). Studies show that the time-dependent RTP colors originated from two primary emissive centers, low-energy emission of CDs and high-energy emission of host matrix activated by CDs. Due to their distinguishable RTP colors with differentiated lifetimes, the ratios of two RTP emissive bands changed with time during the decay process, resulting in the continuous RTP colors variation in real-time. This two-component carbon dot-based co-crystallization strategy may open a new avenue for the development of time-dependent afterglow color materials.
研究领域:
材料科学
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化学
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产品关联
DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
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2025
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IF 8
Meng Li,Dongxia Hu,Dian Zhang,Guangya Xu,Di Wu,Chengcheng Gao,Linghan Meng,Xiao Feng,Weiwei Cheng,Zhenjiong Wang,Yuling Yang,Xiaozhi Tang
Oleanolic acid (OA) is a common pentacyclic triterpenoid and has been used to relieve metabolic-related diseases. However, its low water solubility severely limits its clinical application. In this study, OA was encapsulated by a cyclodextrin metal–organic framework material (CD-MOF) using the co-crystallization method to obtain the OA and CD-MOF inclusion complex (OA@CD-MOF). The OA@CD-MOF was characterized using scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis, which proved that OA was successfully loaded into the CD-MOF. Molecular docking data revealed that OA tends to occupy the cyclodextrin dimolecular cavity outside the CD-MOF. The formation of OA@CD-MOF significantly increased the apparent water solubility of OA to 269.27 ± 19.40 μg/mL. Further zebrafish experiments showed that the OA@CD-MOF exhibited better anti-steatosis, anti-lipid accumulation, and anti-oxidative stress activities than OA. Overall, this study presents a promising approach for delivering OA, enhancing its bioavailability in vivo and mitigating metabolic-related diseases such as non-alcoholic fatty liver disease.
研究领域:
药理学
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材料科学
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代谢疾病研究
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产品关联
DOI
PubMed
高影响因子
POLYMER
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2021
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IF 4.43
Xue-Wei Wei,Lu-Lu Yang,Yi Li,Xiaoyu Meng,Li-Hai Cai,Qiong Zhou,Hai-Mu Ye
Blending is a convenient method to regulate the crystallization behavior and thus the performance of polymer materials, but poor compatibility in crystalline phase for different components remarkably depresses the co-crystallization capability, which poses a great challenge to effective regulation of the properties for crystalline/crystalline blends. In this work, the co-crystallization between two kinds of polyester with similar chain structure, poly(butylene succinate) (PBS) and poly(butylene fumarate) (PBF) is investigated and found to be dependent on the blending ratio and crystallization condition. A new type of co-crystal is only discovered in the PBS-rich blends ( i.e. , PBS/PBF-6/4 and PBS/PBF-8/2), and, further, it is proved as the isomorphism between PBS and PBF by employing various characterizations of differential scanning calorimeter and Fourier transformation infrared spectrometer and X-ray diffractometer. Both the enhancing cooling rate and the increasing PBS content benefit the growth of isomorphic co-crystal, and, its fraction in the blend of PBS/PBF-8/2 can reach as high as ∼75% during a fast cooling rate of 40 °C/min. In addition, the changes of Gibbs free energy for including butylene fumarate unit into PBS-type crystal and including butylene succinate unit into PBF-type crystal are respectively calculated as −0.96 and 1.94 kJ/mol, revealing the intrinsic thermodynamic driving force for the forming of isomorphism and clarifying why isomorphism only occurs in the PBS-rich blends. Finally, a summary of the crystallization behavior of PBS/PBF blend is reasonably sketched, which will help design the crystalline/crystalline blends with desired structure and performance.
研究领域:
材料科学
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高分子化学
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2025
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IF 3.9
Pengpeng Yang,Wenbo Li,Shushu Li,Qingshi Wen,Chenglun Tang,YongLiang Yan,Fengxia Zou,Keke Zhang
Cordycepin shows anticancer activity in vitro but minimal in vivo activity due to its short plasma half-life. To address this, the cocrystallization technique was used to prolong its release and protect it from deamination by adenosine deaminase. In this study, multiple simulation methods were combined to identify potential cocrystal formers (CCFs). Based on the simulation results, one binary salt (cordycepin-oxalic acid) and two binary cocrystals (cordycepin-gallic acid and cordycepin-vanillic acid) were successfully screened by the mechanochemical method. The new multicomponents were characterized by several techniques. In vitro dissolution experiments showed that the binary salt has a significant sustained-release effect. This study proposes a strategy using binary cocrystals/salts to achieve sustained release and increase the half-life of cordycepin, offering potential for its in vivo application.
研究领域:
药学
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材料科学
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计算化学
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药物递送
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生物物理学
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产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
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2022
·Vol. 40
·期 6
·602-610
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IF 3.815
Wei Xue-Wei,Zhao Xin-Xin,Li Yi,Meng Xiao-Yu,Zhou Qiong,Ye Hai-Mu
Co-crystallization of different monomeric units fundamentally contributes to the versatile and tunable performance of random copolymers. At present, the crystallization manners of random binary copolymers have been divided into three categories: isomorphism, isodimorphism and comonomer exclusion. Each category, however, has its own advantages and disadvantages. Therefore, it is challenging to design and prepare random copolymer sharing the advantages of isomorphism and isodimorphism through a new co-crystallization manner beyond the ones already exist. On the basis of previous study on poly(alkylene succinate- ran -alkylene fumarate) whose co-crystallization can be extensively and finely regulated by simply varying the chemical structure of alkylene, random copolymers of poly(propylene succinate- ran -propylene fumarate) (PPSF) are synthesized using 1,3-propanediol as the diol source. The thermal properties and crystal structure of PPSF are investigated, and, intriguingly, it is proved that PPSF is an isodimorphism system while displays similar composition-dependent thermal properties and crystallinity as isomorphism. That is, PPSF exhibits a novel co-crystallization behavior that has rarely been discovered, which would combine the advantages of both isomorphism and isodimorphism. Consequently, PPSF could be termed as a new-type, special composition-dependent polymorphism. Besides, the altering of PPS-like to PPF-like crystal structure of PPSF when changing chain composition has been proved to originate from the shift of dominant inter-segment interaction from van der Waals forces to strong hydrogen-bonding interaction. This work enriches the co-crystallization manner of random copolymers, leading to more diverse performance design of polymer materials.
研究领域:
高分子化学
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材料科学
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产品关联
DOI
高影响因子
Matter
·
2025
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IF 17.5
Wanjie Bai,Haotian Li,Huijie Liu,Xianheng Wang,Zhipeng Gu,Ye Yang,Yiwen Li
Black color is the most typical feature of natural and synthetic melanins, which results from the complex packing and chemical disorder of the molecular structure within melanins. From nature and beyond nature, breaking through the black color boundary, expanding the scope of inherent functions, and establishing clearer structure-function relationship of melanin is necessary but hard due to the inherent chaos structure caused by random covalent coupling and supramolecular assembly. Herein, starting from melanin-inspired monomers, we chose and assembled typical organic acceptor molecules (TCNB/TCNQ) with melanin-inspired donor molecules to prepare a series of colorful melanin-inspired pigments through the co-crystallization strategy. The resulting colorful melanin-inspired pigments exhibited multiple colors and different rod-like morphologies compared with many melanin-like polymers. Particularly, green DHI/TCNQ powder presented excellent photothermal efficiency (∼69.8%) for antibacterial application. This work would provide new structure-function tailoring strategy toward the design of melanin-like polymers with highly ordered structures and desirable properties.
研究领域:
材料科学
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有机化学
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光热治疗
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高分子化学
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超分子化学
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2025
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IF 4.7
Chao Hao,Changping Fan,Lanting Gao,Mingyue Yin,Xue Jiang,Chenchen Wang,Xingyin Wang,Chaoyang Yin,Guisen Zhang,Jian Zhang
The present study aimed to prepare and evaluate a sustained-release microsuspension (MSP) of the antischizophrenic drug risperidone (RIS) via cocrystallization with kaempferol (KAE) (RIS-KAE-MSP). Cocrystal solvates of RIS and KAE in solvent systems of ethanol (EtOH), methanol (MeOH) and ethyl acetate (EA) were successfully prepared by solvent evaporation method. Cocrystal solvates prepared from 3 different solvent systems were characterized in detail using single-crystal X-ray diffraction (SCXRD), Hirshfeld surface analysis (HSA), Gas chromatography (GC), Karl Fischer titration (KFT), powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and Fourier transform infrared (FT-IR) spectroscopy. SCXRD successfully confirmed that RIS-KAE·0.4EtOH·2.6H₂O and RIS-KAE·MeOH are solvates. The dissolution rates of RIS from cocrystal solvates at pH 6.8 in 12 hours were 9.4-fold (RIS-KAE·0.4EtOH·2.6H₂O), 11.8-fold (RIS-KAE·MeOH) and 7.4-fold (RIS-KAE·EA·H₂O) lower than that of free RIS, showing significant sustained release behaviors. Furthermore, RIS-KAE·0.4EtOH·2.6H 2 O was prepared into microsuspensions (MSP), denoted as RIS-KAE-MSP, for I.M. injection. Pharmacokinetic (PK) results indicated that plasma RIS of RIS-KAE-MSP were still detectable by liquid chromatography-mass spectrometry (LC-MS) for as long as 45 days. In conclusion, cocrystallization with insoluble coformers is a promising strategy for long-term sustained release of RIS.
研究领域:
药剂学
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药理学
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晶体工程
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药物递送
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分析化学
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2025
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IF 4.7
Yue-Ming Yu,Lu Liu,Fan-Zhi Bu,Zhi-Long Zhao,Zhi-Yong Wu,Yan-Tuan Li
The combination of cardiotonic milrinone (MLN) and diuretics furosemide (FSM) is used to treat refractory heart failure clinically. However, the compatibility and stability issues of both limit the curative effect. For highlighting the superiority of cocrystallization technology in regulating drug performances, further getting new understanding for developing dual-drug cocrystals to realize their combination at the molecular level, a cocrystallization-driven drug-drug bidirectional optimization tactic is presented. By cocrystallizing MLN and FSM into the same lattice, for one thing, the in vitro/vivo properties of MLN can be optimized, and the photostability of FSM is raised simultaneously, thereby enhancing the bioavailability, and creating a prerequisite for the bidirectional optimization and the combination of these two drugs at the molecular level. Based on this, the dual-drug cocrystal MLN-FSM is successfully assembled and thoroughly characterized by multiple techniques. The evaluations of in vitro/vivo properties involving theory and experiment methods exhibit that the garnered cocrystal has achieved the simultaneous improvements in solubility and permeability versus pure MLN; meanwhile, the cocrystal formation also prominently enhances the stability of FSM relative to FSM itself. Interestingly, these bidirectional optimized in vitro properties change into in vivo pharmacokinetic strengths effectively, showcasing the raised bioavailability and extended half-life, thus laying a solid foundation for exerting the combined effect of the two drugs at the molecular level. Therefore, this research provides the first dual-drug cocrystal solid form with clinical combination drugs to treat cardiac failures, also offers innovative insights into leveraging the advantages of the cocrystallization-driven strategy for fulfilling the co-treatment of clinical combination drugs from the molecular levels.
研究领域:
药学
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晶体工程
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药物传递
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药物化学
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药理学
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DOI
高影响因子
危险品化学品经营许可证（带存储）