The aim of this work is to explore the potential application of three-dimensional (3D) needle-punched carbon fiber/poly(ether ether ketone) (CF/PEEK) composites in the field of fractures internal fixation. First, the machinability of 3D needle-punched CF/PEEK composites was explored through mechanical property tests on drilled composite samples; subsequently, the microstrain of composite bone plates at different stages of fracture healing was verified in an in vitro simulation of tibia fracture internal fixation model and compared with titanium alloy bone plates; finally, thinking of the potential debris dropout and exposure of carbon fibers that may occur after implantation of the bone plates in vivo and biocompatibility in vitro tests were conducted. After the above experiments, it can be seen that the composites can still maintain 60% of their ultimate tensile strength and 85% of their ultimate flexural strength after drilling, and the strains in all parts of the composite bone plate are higher than those of the titanium alloy bone plate in all periods of fracture healing, with the maximum being higher than 180%. In addition, debris dropout and exposure of carbon fibers of the composite bone plate will not affect osteoclast activity and will not excessively stimulate immune-inflammation reactions. In this work, we verified 3D needle-punched CF/PEEK composites’ feasibility as bone plates for internal fixation of fractures, providing a direction for the development of composite bone plates.
At present, effective fixation and anti-infection implant materials represent the mainstay for the treatment of open fractures. However, external fixation can cause nail tract infections and is ineffective for fixing small fracture fragments. Moreover, closed reduction and internal fixation during the early stage of injury can lead to potential bone infection, conducive to bone nonunion and delayed healing. Herein, we designed a bone adhesive with anti-infection, osteogenic and bone adhesion fixation properties to promote reduction and fixation of open fractures and subsequent soft tissue repair. It was prepared by the reaction of gelatin (Gel) and oxidized starch (OS) with vancomycin (VAN)-loaded mesoporous bioactive glass nanoparticles (MBGNs) covalently cross-linked with Schiff bases. Characterization and adhesion experiments were conducted to validate the successful preparation of the Gel-OS/ [email protected] (GOVM-gel) adhesive. Meanwhile, in vitro cell experiments demonstrated its good antibacterial effects with the ability to stimulate bone marrow mesenchymal stem cell (BMSCs) proliferation, upregulate the expression of alkaline phosphatase (ALP) and osteogenic proteins (RunX2 and OPN) and enhance the deposition of calcium nodules. Additionally, we established a rat skull fracture model and a subcutaneous infection model. The histological analysis showed that bone adhesive enhanced osteogenesis, and in vivo experiments demonstrated that the number of inflammatory cells and bacteria was significantly reduced. Overall, the adhesive could promote early reduction of fractures and antibacterial and osteogenic effects, providing the foothold for treatment of this patient population.
危险品化学品经营许可证（带存储）