THIN SOLID FILMS
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2024
·
IF 2
Xinglei Cui,Long Li,Zhonglian Li,Runhua Li,Yizhuo Wang,Xi Zhu,Zhi Fang
Film deposition with atmospheric pressure plasma jet (APPJ) is an effective approach to enhance surface performances of insulating materials for its high reactivity and flexible operation. However, the plasma-activated precursor will inevitably produce inner-wall contamination in the dielectric tube as it travels through the electrode gap, deteriorating film deposition stability during long-term operation. In this paper, a post-mixing precursor feedthrough is designed to suppress the dielectric tube contamination and improve film deposition stability. The influences of traditional pre-mixing feedthrough and post-mixing feedthrough proposed in this paper on discharge and film deposition stability are compared. The thickness of inner-wall contamination is acquired by image processing technique. The electrical and optical discharge characteristic variations with operation duration are diagnosed to evaluate the discharge stability. The film performance is characterized by the water contact angle (WCA) and flashover voltage. Finally, scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS) measurements are performed for the film physicochemical property variations to explore the mechanism about the effect of precursor feedthrough on film deposition stability. The results indicate that the thickness of the contamination is reduced by 79.9 % for the post-mixing feedthrough after a 30-minute operation. Contamination growth increases the initial discharge voltage and decreases the discharge strength, which is remarkably inhibited for the post-mixing feedthrough. The degradation of WCA and flashover voltage for the post-mixing feedthrough is <10 % after a 30-minute operation. The film physicochemical properties for the post-mixing feedthrough exhibit no spectacular change according to SEM and XPS results. Whereas, the ratio of high-oxidized silicone bonds for the pre-mixing feedthrough is reduced and the degree of cross-linking is drastically decreased. This paper provides a reference for optimizing precursor feedthrough to improve the stability of film deposition with APPJ.
研究领域:
材料科学
·
等离子体物理
·
表面工程
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2018
·Vol. 9
·期 1
·1-10
·
IF 12.353
Li Xinchun,Zhai Tianyou,Gao Pengcheng,Cheng Hongli,Hou Ruizuo,Lou Xiaoding,Xia Fan
Nanochannels with functional elements have shown promise for DNA sequencing, single-molecule sensing, and ion gating. Ionic current measurement is currently a benchmark, but is focused solely on the contribution from nanochannels’ inner-wall functional elements (NIWFE); the attributes of functional elements at nanochannels’ outer surface (NOSFE) are nearly ignored, and remain elusive. Here we show that the role of NOSFE and NIWFE for ion gating can be distinguished by constructing DNA architectures using dual-current readout. The established molecular switches have continuously tunable and reversible ion-gating ability. We find that NOSFE exhibits negligible ion-gating behavior, but it can produce a synergistic effect in alliance with NIWFE. Moreover, the high-efficiency gating systems display more noticeable synergistic effect than the low-efficiency ones. We also reveal that the probe amount of NOSFE and NIWFE is almost equally distributed in our biomimetic nanochannels, which is potentially a premise for the synergistic ion-gating phenomena.
研究领域:
生物物理学
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纳米技术
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 19
·10253
·
IF 4.9
Wei Chen,Qi Yan,Junjiao Yang
Titanium dioxide thin films on the inner wall of quartz tubes were prepared in situ by the sol–gel method. Meanwhile, copper and cerium were loaded onto the surface of the titanium dioxide thin films to enhance photocatalytic activity and broaden the range of light absorption. X-ray diffractometer, X-ray photoelectron spectroscopy, scanning electron microscopy, energy dispersive X-ray spectrum, N2gas adsorption, UV diffuse reflectance spectroscopy, electron paramagnetic resonance, photoluminescene spectroscopy, and so on were used to characterize the structure, morphology, chemical composition, and optical properties of the prepared photocatalyst. Methylene blue (MB) was used as a simulated organic pollutant to study the photocatalytic performance of the photocatalyst, which was a translucent, structurally stable, and reusable high-efficiency photocatalytic catalyst. Under UV lamp irradiation, the MB photodegradation efficiency was 94.5%, which reached 91.2% after multiple cycles.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 40
·33536-33548
·
IF 4.6
Xiaofei Zhang,Mengyuan Lv,Yuyang Wang,Nan Zhang,Di Chen
Tyrosine kinase inhibitors (TKIs) are critical in cancer therapy, but their clinical application is complicated by narrow therapeutic windows and significant interpatient variability in pharmacokinetics. To address this, this study presents an effective pipette-tip solid-phase microextraction (PT-μSPE) method using kapok fiber-derived biochar (KFB) as a green and cost-effective sorbent for the extraction of TKIs in plasma. The KFB was incorporated as an inner-wall coating within a standard pipette tip, minimizing backpressure and enhancing automation compatibility. This PT-μSPE method is optimized for efficiency and sensitivity, with ethanol used as the desorption solvent. The method is coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the determination of TKIs, demonstrating excellent linearity (R2 > 0.99), sensitivity (LOD: 0.022–0.125 ng mL−1), and reproducibility. Furthermore, the method exhibits notable green chemistry characteristics, including minimal solvent usage and environmental sustainability. The proposed method offers a practical, scalable solution for TKI quantification for potential clinical and pharmacokinetic studies, with potential for high-throughput integration into automated systems.
研究领域:
肿瘤学
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药物代谢
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分析化学
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临床药理学
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转化医学
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环境可持续性
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生物医学分析
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产品关联
DOI
PubMed
高影响因子
Nature Protocols
·
2021
·Vol. 16
·期 9
·4201-4226
·
IF 13.491
Gao Pengcheng,Wang Dagui,Che Cheng,Ma Qun,Wu Xiaoqing,Chen Yajie,Xu Hongquan,Li Xinchun,Lin Yu,Ding Defang,Lou Xiaoding,Xia Fan
Solid-state nanochannels (SSNs) provide a promising approach for biosensing due to the confinement of molecules inside, their great mechanical strength and diversified surface chemical properties; however, until now, their sensitivity and specificity have not satisfied the practical requirements of sensing applications, especially in complex matrices, i.e., media of diverse constitutions. Here, we report a protocol to achieve explicit regional and functional division of functional elements at the outer surface (FE OS ) and inner wall (FE IW ) of SSNs, which offers a nanochannel-based sensing platform with enhanced specificity and sensitivity. The protocol starts with the fabrication and characterization of the distribution of FE OS and FE IW . Then, the evaluation of the contributions of FE OS and FE IW to ionic gating is described; the FE IW mainly regulate ionic gating, and the FE OS can produce a synergistic effect. Finally, hydrophobic or highly charged FE OS are applied to ward off interference molecules, non-target molecules that may affect the ionic signal of nanochannels, which decreases false signals and helps to achieve the highly specific ionic output in complex matrices. Compared with other methods currently available, this method will contribute to the fundamental understanding of substance transport in SSNs and provide high specificity and sensitivity in SSN-based analyses. The procedure takes 3–6 d to complete.
研究领域:
纳米技术
·
生物传感器
·
材料科学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
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