ACS Applied Materials & Interfaces
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2024
·
IF 8.3
Jinbo Liu,Qiannan Wang,Fuhao Shen,Congcong Zhang,Chang Cheng,Haitao Deng,Enfeng Yang,Xiao Chen,Kefan Fang,Yuan Zhou,Yuan Su,Jing Zhang,Dianyu Wang
Endoscopes, a minimally invasive medical tool, are susceptible to impaired visibility due to the adhesion of biological fluids. However, traditional self-cleaning coatings face limitations in terms of transparency and sustainability, making it difficult to apply them to lenses. Inspired by the phospholipid layer of the eye, a reversible lubricating layer (RL-layer) with low-adhesion and high-transparency properties is reported. Even coagulated blood can be easily removed due to the low surface tension and easy swing of the brushes. In addition, the silicon–oxygen bonds can be cleaved by fluoride ions, thereby achieving reversible modification and showing potential in sustainable usage. To prove the concept, biomimetic endoscopic lenses are employed in vivo experiments. The results indicate that it consistently maintains a clear vision in narrow spaces containing mucus and exhibits excellent biocompatibility. The reversible lubricating layer provides valuable reference significance for self-cleaning coatings in other fields.
研究领域:
医学工程
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材料科学
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生物医学
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产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 3
·421
·
IF 5.719
Rongyuan Cai,Lijun Yin,Qian Huang,Ruiyun You,Shangyuan Feng,Yudong Lu
In this work, we developed a new type of SERS probe, which was composed of glass-SiO2[email protected]@Ag nanoparticles (NPs) three-dimensional Surface-enhanced Raman spectroscopy (SERS) substrate. When the laser passed through the quartz glass sheet, on the one hand, the SiO2NPs supporting the[email protected]@Ag NPs increase the roughness of the substrate surface, resulting in a large number of hot spots among nanoparticles. On the other hand, based on the focusing effect of silicon dioxide nanospheres, the laser can better focus on the surface of nanoparticles in the inverted SERS probe, thus showing better SERS enhancement. Furthermore, the[email protected]@Ag NPs core-shell structure was used with 4-mercaptobenzoonitrile (MBN) as an internal standard molecule, and the quantitative determination of tyrosine and urea was realized by internal standard correction method. The standard working curves of the two had good linear correlation with R2above 0.9555. The detection limits of tyrosine and urea were in the range of 2.85 × 10−10M~7.54 × 10−6M, which confirms that this design can be used for quantitative and specific detection of biological molecules, demonstrating great practical significance for the research of diseases such as skin lesions and endocrine disorders.Keywords:SERS;endoscope;internal standard;tyrosine;urea;sweat
研究领域:
分析化学
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生物医学工程
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材料科学
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产品关联
DOI
PubMed
高影响因子
Photonics
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2022
·Vol. 9
·期 6
·429
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IF 2.536
Zongyu Wu,Ziwen Wang,Haoqiang Xie,Yiming Wang,Haoqi He,Shuming Nie,Jian Ye,Li Lin
Image-guided and robotic bronchoscopy is currently under intense research and development for a broad range of clinical applications, especially for minimally invasive biopsy and surgery of peripheral pulmonary nodules or lesions that are frequently discovered by CT or MRI scans. Optical imaging and spectroscopic modalities at the near-infrared (NIR) window hold great promise for bronchoscopic navigation and guidance because of their high detection sensitivity and molecular/cellular specificity. However, light scattering and background interference are two major factors limiting the depth of tissue penetration of photons, and diseased lesions such as small tumors buried under the tissue surface often cannot be detected. Here we report the use of a miniaturized Raman device that is inserted into one of the bronchoscope channels for sensitive detection of “phantom” tumors using fresh pig lung tissues and surface-enhanced Raman scattering (SERS) nanoparticle tags. The ex vivo results demonstrate not only the feasibility of using Raman spectroscopy for endoscopic guidance, but also show that ultrabright SERS nanoparticles allow detection through a bronchial wall of 0.85 mm in thickness and a 5 mm-thick layer of lung tissue (approaching the fourth-generation airway). This work highlights the prospects and potential of Raman-guided bronchoscopy for minimally invasive imaging and detection of lung lesions.Keywords:bronchoscopy;Raman spectroscopy;endoscopic Raman probe;fluorescence;detection depth
研究领域:
医学影像
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生物光学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Yingmin Zhao,Yunge Liu,Wenwu Shi,He Liu,Jinbo Liu,Lei Zhao,Hongxiao Shi,Saiya Li,Chang Cheng,Shuanggen Wu,Dianyu Wang
Bionic lubricant material received widespread attention in the antifouling field because of its dynamic slippery surface, while the micro-nano structures construction to stable film inevitable pose a compromised optical transparency. In this study, we prepare a biomimetic lubrication material with oil-infused nano-reentrant structure. The nano-reentrant structure of the coating eliminates visible light scattering, resulting in high transparency that was comparable to bare glass. Owing to the nanostructure infused by lubricant increase the capillary force required for the liquid to detach from, this transparent material not only display excellent repellency properties, but also improves the stability of lubricated surfaces. Based on its marvelous biocompatibility, we apply it to the endoscopic lenses. Extensive procedures performed in vivo on porcine stomach showed significantly reduced fouling, resulting nearly 100% clarity. We believe that our coatings provide inspiration for the design of next-generation endoscopes used to in lesion diagnosis and treatment.
研究领域:
生物医学工程
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材料科学
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光学
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产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2023
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IF 6.6
Xiaodan Gong,Haojie Yu,Li Wang,Jian Hu,Luming Wang,Chengjiang Li
Foggy surfaces can damage the optical performance of devices and even cause adverse consequences like safety concerns in some cases. Various antifogging coatings have been proposed to relieve this trouble. Nevertheless, most coatings suffer from temporary fog-repellency features due to hygroscopic swelling behavior and detachable interface. Herein, we reported an antifogging coating with persistent fogging prevention via the introduction of the amphiphilic polymer and interfacial layer. With the aid of benzophenone (BP) groups, both bulk crosslinking and interfacial bonding were achieved to prevent relatively macroscopic motions of coating from the substrate under extreme conditions. In virtue of the minor swelling and interfacial adhesion, the coating could preserve the fog-free behavior after 50-cycle antifogging tests and even aging for 90 days under harsh conditions. Notably, both in vitro (pig larynx) and vivo (living rabbit) outcomes indicated excellent fog-repellency of the polymer-coated endoscope.
研究领域:
材料科学
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高分子化学
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生物医学工程
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产品关联
DOI
高影响因子
American Journal of Translational Research
·
2025
·Vol. 17
·期 7
·5475
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IF 1.6
Bin Shi,Wen Yu,Bei Qi,Huifang Liu,Rui Jiang
Objective: To evaluate the efficacy of endoscopic minimally invasive surgery (EMIS) in improving olfactory function and quality of life among patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Methods: A cohort of 117 patients diagnosed with CRSwNP between January 2020 and June 2024 were included in this retrospective study. Patients were assigned to either a control group (n=50, treated with conventional endoscopic sinus surgery [ESS]) or a research group (n=67, treated with EMIS). Comprehensive assessments were conducted, including treatment efficacy, safety profile, olfactory function, nasal ventilation (airway resistance), nasal status, stress biomarkers, and quality of life. Results: Compared to the control group, the research group showed significantly better outcomes in terms of: (1) overall therapeutic efficacy, (2) postoperative safety profile (lower postoperative complication rates), (3) olfactory function recovery, (4) nasal ventilation and functional status, (5) quality of life improvement, and (6) reduced surgical stress response (all P<0.05). Conclusion: EMIS significantly improves olfactory function and quality of life in patients with CRSwNP, offering clinical advantages over conventional ESS and supporting its broader clinical application.
研究领域:
耳鼻喉科学
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神经外科
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临床医学
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DOI
PubMed
高影响因子
Advanced Science
·
2023
·Vol. 10
·期 14
·2206699
·
IF 15.1
Hao Dong,Xubin Zheng,Chen Cheng,Libin Qian,Yaoxuan Cui,Weiwei Wu,Qingjun Liu,Xing Chen,Yanli Lu,Qing Yang,Fenni Zhang,Di Wang
Advanced machine intelligence is empowered not only by the ever-increasing computational capability for information processing but also by sensors for collecting multimodal information from complex environments. However, simply assembling different sensors can result in bulky systems and complex data processing. Herein, it is shown that a complementary metal-oxide-semiconductor (CMOS) imager can be transformed into a compact multimodal sensing platform through dual-focus imaging. By combining lens-based and lensless imaging, visual information, chemicals, temperature, and humidity can be detected with the same chip and output as a single image. As a proof of concept, the sensor is equipped on a micro-vehicle, and multimodal environmental sensing and mapping is demonstrated. A multimodal endoscope is also developed, and simultaneous imaging and chemical profiling along a porcine digestive tract is achieved. The multimodal CMOS imager is compact, versatile, and extensible and can be widely applied in microrobots, in vivo medical apparatuses, and other microdevices.
研究领域:
传感器技术
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生物医学工程
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微机电系统
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产品关联
DOI
PubMed
高影响因子
Small Science
·
2024
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IF 11.1
Fangzhou Jin,Zhiyuan Xu,Wei Wang,Zhongyuan Cheng,Yang Wu,Zesen Li,Enlai Song,Xu Yue,Yong Kang Zhang,Wei Li,Youzhen Feng,Donglin Cao,Dongmei Zhang,Minfeng Chen,Xiangran Cai,Yang Ran,Bai-Ou Guan
Efficient delivery of photons to visceral organs is critical for the treatment of deep-seated tumors taking advantage of photo theranostics. Optical fiber can be regarded as a direct and facile photon pathway for targeting tumor lesion. However, current fiber theranostic strategies rely on the spatially separated optical fibers to realize diagnosis and therapy independently, resulting in low compactness, poor continuity of medical process, and incompatibility with current medical technologies. Herein, an integrated fiber-optic theranostic (iFOT) probe is developed that merges tumor microenvironment sensing and photothermal therapy by functionalizing the fiber with graphene/gold nanostar hybrid materials and hypoxic-responsive fluorophores. The iFOT probe can quickly detect the hypoxia of xenograft tumors of mice with high sensitivity. The tumors can be photothermally killed on-site through the same fiber probe tightly followed by detection, which presents a high cure rate. More importantly, the iFOT is highly adaptable to the conventional medical imaging and endoscopic techniques, which facilitates the imaging-assisted navigation and manipulation by use of the interventional trocar. The proposed strategy can be used as an effective endoscopic and interventional tool for tackling deep-situated tumor and may open a revolutionized pathway to bridge separate diagnosis and therapy process in the current stage.
研究领域:
生物医学工程
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癌症研究
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纳米技术
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医学成像
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产品关联
DOI
高影响因子
Acta Biomaterialia
·
2024
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IF 9.4
Kaidi Ding,Wenlong Cong,Ying Liu,Changtong Song,Haoyang Mi,Chuntai Liu,Yuhong Ma,Changyu Shen
Endoscopic surgery is an effective and common clinical practice for chronic sinusitis. Nasal packing materials are applied in nasal surgery to prevent hemorrhage and promote wound healing. In this study, a degradable polyurethane foam dressing is successfully developed as a promising nasal packing material with good biocompatibility and antibacterial capability. Specifically, quaternized chitosan (QCS) serves as the crosslinker instead of polyols to offer polyurethane foam (PUF-QCS) antibacterial capability. The PUF-QCS2.0 % (with 2.0 wt% QCS) exhibits satisfactory liquid absorption capacity (19.4 g/g), high compressive strengths at both wet (14.5 kPa) and dry states (7.7 kPa), and a good degradation rate (8.3 %) within 7 days. Meanwhile, PUF-QCS2.0 % retains long-term antibacterial activity for 7 days and kills 97.3 % of S. aureus and 91.8 % of E. coli within 6 hours in antibacterial testing. Furthermore, PUF-QCS2.0 % demonstrates a positive hemostatic response in the rabbit nasal septum mucosa trauma model by reducing hemostatic time over 50.0 % and decreasing blood loss up to 76.1 % compared to the commercial PVA nasal packing sponge. Importantly, PUF-QCS also exhibits a significant antibacterial activity in nasal cavity. This nasal packing material has advantages in post-surgery bleeding control and infection prevention. Statement of Significance The performance of a nasal packing sponge requires good mechanical properties, fast and high liquid absorption rate, effective degradability and strong antibacterial activity. These features are helpful for improving the postoperative recovery and patient healing. However, integrating these into a single polyurethane foam is a challenge. In this study, quaternized chitosan (QCS) is synthesized and used as a chain extender and antibacterial agent in preparing a degradable polyurethane foam (PUF-QCS) dressing. PUF-QCS undergoes partial degradation and exhibits effective broad-spectrum antibacterial activity in 7 days. The reduction of postoperative bleeding and infection observed in the animal experiment further demonstrates that the PUF-QCS developed here outperforms the existing commercial nasal packing materials.
研究领域:
生物材料
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生物医学工程
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药剂学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）