ANNALS OF BIOMEDICAL ENGINEERING
·
2022
·Vol. 50
·期 9
·1038-1052
·
IF 4.219
Du Zhibo,Li Zhijie,Wang Peng,Wang Xinghao,Zhang Jiarui,Zhuang Zhuo,Liu Zhanli
Intracranial pressure (ICP) during the interaction between blast wave and the head is a crucial evaluation criterion for blast-induced traumatic brain injury (bTBI). ICP variation is mainly induced by the blast wave transmission and skull deformation. However, how the skull deformation influences the ICP remains unclear, which is meaningful for mitigating bTBI. In this study, both experimental and numerical models are developed to elucidate the effect of skull deformation on ICP variation. Firstly, we performed the shock tube experiment of the high-fidelity surrogate head to measure the ICP, the blast overpressure, and the skull surface strain of specific positions. The results show that the ICP profiles of all measured points show oscillations with positive and negative change, and the variation is consistent with the skull surface strain. Further numerical analysis reveals that when the blast wave reaches the measured point, the peak overpressure transmits directly through the skull to the brain, forming the local positive ICP peak, and the impulse induces the local inward deformation of the skull. As the peak overpressure passes through, the blast impulse impacts the nearby skull supported by the soft and incompressible brain tissue and extrudes the skull outward in the initial position. The inward and outward skull deformation leads to the oscillation of ICP. These numerical analyses agree with experimental results, which explain the appearance of negative and positive ICP peaks and the synchronization of negative ICP with surface strain. The study has implications for medical injury diagnosis and protective equipment design.
研究领域:
生物力学
·
医学工程
·
创伤医学
✓ 已验证
DOI
高影响因子
Journal of Nanotechnology
·
2025
·Vol. 2025
·期 1
·4522421
·
IF 4.1
Samir Ali Abd El-Kaream,Maye Mohammad Ragab Ahmad El-Soukkary,Hagar Mohamed Mohamed,Amal Saleh Mohamed Soliman,Sohier Mahmoud El-Kholey,Awatef Mohamed El-Sharkawy
Background: Shockwave–photodynamic therapy (SWPDT) is a novel approach to cancer treatment that combines photodynamic therapy (PDT) and shockwave–dynamic therapy (SWDT) with sensitizers. Although several novel sensitizers for SWPDT have been successfully synthesized, not all of them are being used to their full potential. The tumor microenvironment’s degradation, the sensitizers’ limited capacity to transfer deeply intratumorally, and their restricted tumor-targeting specificity all contribute to their low antitumor efficacy. To provide an advanced strategy for cancer treatment, this study was conducted with the aim of shockwave (SW)-assisted drug administration of berries-conjugated carbon dots (CDs) nanoparticles for in vitro and in vivo SW–photodynamic bladder cancer (BLCA) treatment. Materials and Methods: This study was conducted on BLCA (T-24) human cells in vitro and on Swiss albino mice in vivo, where the mice were administered only N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) without receiving any treatment for inducing BLCA. The treatment protocol for the BLCA induction study was initiated after the mice BLCA began, and it involved daily administration of Berries-CDsNP with or without SW and/or laser (IRL) exposure for 3 minutes over a 2-week period. We used Berries-CDsNP as SWPDT sensitizer (SWPS), with IRL and SW serving as two sources of energy. Results: The results demonstrated that CDs could be employed as an efficient delivery system for berries to the target BLCA cells. Furthermore, Berries-CDsNP is a potential SWPS that can be highly successful in treating BLCA-T-24 in vitro when combined with SWPDT (cell viability was declined, cell cycle was arrested, and cell death was induced; in a dose-dependent manner, the population of cells during the G0/G1 phase increased, an increase in the Pre-G cell population, autophagic cell death, apoptosis early/late phases, and necrosis were observed) and in vivo (BBN-induced BLCA mice) induction of antiproliferative apoptotic (Bax, p53, TNF-alpha, Caspase-3, and Caspase-9) genes, suppression of antiangiogenic (VEGF) and antiapoptotic (Bcl2) genes, efficiently eliminating cancer cells, restoring deteriorated parameter, enhancing the functions of the kidneys (urea and creatinine) and liver (ALT and AST), conserving redox status homeostasis via regaining antioxidant balance (GPx, GSH, GR, GST, SOD, CAT, and TAC), and lowering oxidative stress (MDA). This process can be connected to sensitization of berries upon the SW and photochemical SWPDT activation mechanism and the antioxidant potential of nonactivated berries. Conclusion: Our research findings indicate that the Berries-CDsNP shows significant potential as an innovative and effective delivery strategy for SWPDT-activated BLCA treatment.
研究领域:
肿瘤学
·
药理学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Nanoscale
·
2018
·Vol. 11
·期 3
·1423-1436
·
IF 7.233
Rong Chen,Qun Chen,Huan Qin,Da Xing
Drug delivery to a tumor site with an insufficient microvascular network remains a challenge due to the size preference for transport in terms of circulation and distribution. In this work, an integrated nano-therapeutic parcel disintegrable by a photoacoustic shockwave was developed. Nano-therapeutic particles with red absorbance are packaged into a larger parcel to generate a longer circulation half-life and improved accumulation in tumor tissue. Pulse-laser irradiation is absorbed by the nanoparticles and it generates a photoacoustic shockwave. This triggers a liquid–gas phase transition of the nano-parcel, leading to the high-efficiency release of smaller nanoparticles, thus achieving excellent therapeutic diffusion with improved uniformity. This results in a highly effective therapeutic effect, as demonstrated with both in vitro and in vivo tumor models. Compared to previously reported work, this approach has the distinctive advantage of precisely controllable therapeutic release that is independent of the physiological environment in the tumor and it is less limited than a UV-based release mechanism. In addition, the concept of photoacoustic shockwave-based nanoparticle release can be extended over a wide wavelength range, including microwaves, to match specific needs and achieve optimal therapeutic depth. The results demonstrate that the proposed strategy holds great potential for improved tumor therapy efficacy.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 4
·1537-1549
·
IF 3.5
Chen Yongjin,Li Yaru,Fu Jianbo,Zhang Mi,Ren Hui,Jiao Qingjie
Aluminum hydride (AlH 3 ), as a potential new metal fuel, has attracted extensive attention in the field of hydrogen storage materials, propellants and energetic materials due to its excellent properties. In this paper, a new organic liquid phase reduction method was used to prepare AlH 3 , and the microstructure and composition of the prepared samples were characterized by SEM–EDS, XRD, FT-IR, XPS, etc. The main crystal phase of the prepared AlH 3 was α-AlH 3 , with high quality and no other impurities. The thermal decomposition behavior and non-isothermal reaction kinetics of AlH 3 were investigated by TG-DSC. The results show that there are three exothermic stages in the heating process of AlH 3 : dehydrogenation of AlH 3 , first oxidation of Al, and second oxidation of Al. The activation energy of the dehydrogenation of AlH 3 is 77.8675 kJ/mol (Kissinger method) and 81.4862 kJ/mol (Ozawa method), respectively. The morphology evolution of AlH 3 particles during the heating process (300–3000 K) was simulated using a reaction kinetics method based on the ReaxFF force field. The response behavior of AlH 3 in the instantaneous high-temperature detonation environment was investigated using the high-energy laser-induced shock wave technique. Under the impact of a high-energy laser (1006 mJ), the AlH 3 sample undergoes an ultra-fast reaction and generates a large amount of plasma. The expansion of the plasma pushes the surrounding air to form a supersonic shock wave and propagates forward. The shock wave propagation velocity of AlH 3 is 690.99 m/s in the range of 2.1–12.35 μs, and the higher the laser energy, the faster the shock wave propagation velocity. This study provides the basis for the application of AlH 3 . Graphical Abstract
研究领域:
氢存储材料
·
推进剂
·
高能材料
·
材料科学
·
化学工程
·
物理学
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2022
·Vol. 14
·期 11
·4073-4081
·
IF 8.307
Liming Liu,Fanchu Zeng,Yujie Li,Wenjing Li,Hui Yu,Qingxing Zeng,Qun Chen,Huan Qin
Resistance to either radiation or chemotherapy remains a complex and stubborn obstacle in cancer therapy and is responsible for a significant portion of the treatment failure. While the underlying mechanisms of the resistance are often associated with multiple factors, direct destruction of mitochondria is likely to ensure the ultimate death of the cell. Herein, a strategy of precise mitochondrial destruction using a photoacoustic (PA) shockwave was proposed to overcome chemoresistance and radiation resistance in cancer therapy. A nanoparticle featuring mitochondria-targeting and high near-infrared absorbance is constructed. The nanoparticle was found to indiscriminately localize in the mitochondria of both parental and its corresponding resistant tumor cells due to the mitochondrial transmembrane potential. By absorbing a controllable amount of energy from a pulsed laser, the nanoparticle could generate a mechanical PA shockwave that physically damages the mitochondria leading to the opening of apoptotic pathways and thus yielding a precision antitumor effect. The cell-killing efficiency was validated in vitro and in vivo. The results demonstrate that a PA shockwave can result in undifferentiated killing of the resistant tumor cells via destruction of mitochondria. Given the critical importance of resistant tumor cells, although at its preliminary stage, the proposed modality may open a new window in cancer therapy.
研究领域:
肿瘤学
·
生物医学工程
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Research and Technology-JMR&T
·
2023
·
IF 6.4
Dong Ma,Cheng Wang,Wenlong Xu,Shiyu Jia,Fangfang Qi
A novel shear thickening gel with micro-scale hard/soft interface structure and low reaction temperature was proposed in this article. The gel was named TH and used as core material within Kevlar fabrics. Storage modulus of TH was proved to increase by around two orders with increasing of shear frequency, and dynamic properties indicated that TH could dissipate or store more energy. TH can adhere with Kevlar fabrics well and satisfactorily fulfill the gap between fabrics. As a result, shock wave peak pressure and positive impulse decreased markedly. Wavelet decomposition analysis show that high frequency energy was filtered by protection materials. Meanwhile, impact resistance test suggested the existence of TH changed the stress propagation routes and avoided pulling out for Kevlar fabrics. Samples filled with TH demonstrated a better shock wave mitigation ability and impact resistance. Energy dissipation structures with TH have a promising prospect in the application of defending area.
研究领域:
材料科学
·
机械工程
·
复合材料
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2025
·
IF 14.2
Chuanyi Liu,Wenlong Xu,Cheng Wang,Dong Ma,Zhihui Zeng,Na Wu
In industrial explosion accidents, mechanical shock waves and flame thermal radiation are the main destructive factors, posing serious threat to life and property. Current designs mainly focus on one of these factors, so it is necessary to develop protective materials against both destructive factors. TPP (Triphenyl phosphate) - SiO 2 Aerogel synergistically modified polyurea composites were developed in this work, which process excellent mechanical shock wave mitigation performance and enhanced flame retardancy. The mechanical shock wave mitigation experiments were conducted on Multi-purpose Shock Cannon (MSC), Human Tissue Equivalent Target (HTET) and full-scale human head model, which comprehensively evaluated the protective performance of polyurea composites for the human body. The flame retardancy was assessed through thermal conductivity, LOI, thermal gravimetric and small flame experiment. The combustion residue was analyzed using SEM, EDS, Raman spectroscopy, and XPS technologies, revealing flame retardant mechanism of TPP-SiO 2 Aerogel synergistically modified polyurea composites. The results showed that the TPP-SiO 2 Aerogel synergistically modified polyurea composites achieved the highest mitigation ratios of overpressure peak and acceleration peak at 13.20% and 60.87%, respectively, superior to those of fiber-enhanced polymer composites (Fiber-PE, Fiber-PA6, Fiber-ASA), single filler polyurea, wood and PLA plastic. The flame retardancy was effectively improved, with the highest LOI reaching 24.9%, far higher than that of pure polyurea (19.6%). It particularly enhanced the carbonization performance of polyurea composites during combustion, eliminating burning material dropping phenomenon. The thermal insulation performance was also elevated, with the lowest thermal conductivity reduced by 58.6% compared to pure polyurea.
研究领域:
材料科学
·
安全工程
·
燃烧学
✓ 已验证
产品关联
DOI
高影响因子
CHINESE MEDICAL JOURNAL
·
2018
·
IF 1.596
Yuan Zhou,Li-Li Wen,Han-Dong Wang,Xiao-Ming Zhou,Jiang Fang,Jian-Hong Zhu,Ke Ding
Background: The increasing frequency of explosive injuries has increased interest in blast-induced traumatic brain injury (bTBI). Various shock tube models have been used to study bTBI. Mild-to-moderate explosions are often overlooked because of the slow onset or mildness of the symptoms. However, heavy gas cylinders and large volume chambers in the model may increase the complexity and danger. This study sought to design a modified model to explore the effect of moderate explosion on brain injury in mice. Methods: Pathology scoring system (PSS) was used to distinguish the graded intensity by the modified model. A total of 160 mice were randomly divided into control, sham, and bTBI groups with different time points. The clinical features, imaging features, neurobehavior, and neuropathology were detected after moderate explosion. One-way analysis of variance followed by Fisher’s least significant difference posttest or Dunnett’s t 3-test was performed for data analyses. Results: PSS of mild, moderate, and severe explosion was 13.4 ± 2.2, 32.6 ± 2.7 ( t = 13.92, P < 0.001; vs. mild group), and 56.6 ± 2.8 ( t = 31.37, P < 0.001; vs. mild group), respectively. After moderate explosion, mice showed varied symptoms of malaise, anorexia, incontinence, apnea, or seizure. After bTBI, brain edema reached the highest peak at day 3 (82.5% ± 2.1% vs. 73.8% ± 0.6% , t = 7.76, P < 0.001), while the most serious neurological outcomes occurred at day 1 (Y-maze: 8.25 ± 2.36 vs. 20.00 ± 4.55, t = −4.59, P = 0.048; 29.58% ± 2.84% vs. 49.09% ± 11.63%, t = −3.08, P = 0.008; neurologic severity score: 2.50 ± 0.58 vs. 0.00 ± 0.00, t = 8.65, P = 0.016). We also found that apoptotic neurons (52.76% ± 1.99% vs. 1.30% ± 0.11%, t = 57.20, P < 0.001) and gliosis (2.98 ± 0.24 vs. 1.00 ± 0.00, t = 14.42, P = 0.021) in the frontal were significantly higher at day 3 post-bTBI than sham bTBI. Conclusions: We provide a reliable, reproducible bTBI model in mice that can produce a graded explosive waveform similar to the free-field shock wave in a controlled laboratory environment. Moderate explosion can trigger mild-to-moderate blast damage of the brain.
研究领域:
神经科学
·
创伤
·
实验模型
·
病理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Xiaoming Luo,Haiyang Gong,Ziling He,Peng Zhang,Limin He
The acoustic parameters and operating conditions that determine efficiency of oil recovery from oily sludge are studied. Based on this, the mechanism of ultrasonic disintegration of oily sludge is analyzed. The results show that lower frequency ultrasound results in larger and more energetic cavitation bubbles that are more effective in the desorption of oil from solid particles. Moreover, acoustic intensity and treatment time that correspond to maximal oil recovery are found. Increasing the ratio of water to sludge and pH can reduce the slurry viscosity and facilitate the formation of HSiO 3 − , respectively, which improves the oil recovery efficiency. Moreover, Triton X-100 has better oil solubilizing effects than SDBS. After ultrasonic treatment, small amounts of asphaltenes are more stable on solid particles than other components. The heteroatoms such as S, N, and O in asphaltenes form hydrogen bonds with hydroxyl groups on the surface of the particles, impeding the desorption of oil. Mechanical effects such as shock waves and micro jets due to acoustic cavitation can break the hydrogen bonds between asphaltenes and solid particles, thereby facilitating oil recovery from oily sludge.
研究领域:
环境工程
·
化学工程
·
超声学
·
废物管理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）