ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Hao Li,Sen Xue,Qin Zhang,Feng Chen,Qiang Fu
Cellulose has the advantages of renewability and degradability, while cellulose’s rigid structure and hydrogen bonding limit its dissolution and application. Low-temperature alkali/urea solvents offer a green, low-cost solution but suffer from low solubility, high coagulation costs, and poor fiber strength. In this work, to address these problems, the high specific surface area and surface-rich hydroxyl groups of nano-SiO2 powders were used to modify the low-temperature alkali/urea solvent system. There are two alkali/urea solvent systems: LiOH/urea has better solubility but expensive and NaOH/urea is cheap but of less solubility. In the LiOH/urea system, it was found that the solubility of cellulose could be increased by 60.1% by addition of nano-SiO2 powder, and the gel temperature of the solution remained basically unchanged. By using the phytic acid coagulation system, the strength and elongation of regenerated cellulose fibers could reach 547.6 MPa and 18.7%, respectively. More importantly, in the low-cost NaOH/urea system, nano-SiO2 boosts solubility by 45.2%, regenerated cellulose fibers with 404 MPa strength, and 20.18% elongation by using the H2SO4/Na2SO4 coagulation system. Finally, the mechanism of action of nano-SiO2 is revealed, which provides a new idea for green dissolution and the high-performance regeneration of cellulose.
研究领域:
材料科学
·
高分子科学
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纳米技术
·
绿色化学
✓ 已验证
产品关联
DOI
高影响因子
Processes
·
2022
·Vol. 10
·期 5
·891
·
IF 3.352
Lu Liang,Min Xu,Lei Pan,Zhijiang Zhou,Ye Han
Sugarcane molasses is an agricultural by-product containing sucrose. In this study, the exopolysaccharide (M-EPS) produced byLeuconostoc citreumB-2 in molasses-based medium was characterized, optimized, and its application in set yogurt was investigated. The structure analysis, including gel permeation chromatography, Fourier transform infrared spectroscopy, and nuclear magnetic resonance, revealed that the M-EPS was a linear dextran composed of D-glucose units, which were linked by α-(1→6) glycosidic bonds with 19.3% α-(1→3) branches. The M-EPS showed a lower molecular weight than that produced from sucrose. The M-EPS was added into the set yogurt, and then the water holding capacity, pH, and microstructure of set yogurt were evaluated. Compared with the controls, the addition of M-EPS improved the water holding capacity and reduced the pH of set yogurt. Meanwhile, the structure of the three-dimensional network was also observed in the set yogurt containing M-EPS, indicating that M-EPS had a positive effect on the stability of set yogurt. The results provide a theoretical basis for the cost-effective utilization of sugarcane molasses.Keywords:exopolysaccharide;molasses;structure;optimization;set yogurt
研究领域:
食品科学
·
微生物学
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化学
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Yidong Hu,Fan Yang,Guoliang Ren,Jianguo Li,Qiaodan Hu
Preparation of dense Bi 2 Ti 2 O 7 ceramics with single-phase pyrochlore structure is challenging using the conventional sintering method due to its thermal instability at ≥ 650 °C. Here we synthesized dense and phase-pure Bi 2 Ti 2 O 7 ceramics from a mixture of Bi 2 O 3 and TiO 2 by a novel deep undercooling rapid solidification method using the aerodynamic levitation technique. We reported a surprising discovery that the pyrochlore phase can exist with Bi/Ti ratio varying between 0.9 and 1.1. By a comprehensive investigation on the phase purity, crystal structure, oxidation states and electrical properties, we revealed that the pyrochlore structure is primarily stabilized by the solidification process rather than presence of a large amount of Ti 3+ . With the advantages of being containerless, one-step and fast processing, deep undercooling rapid solidification is an effective and efficient approach to prepare dense Bi 2 Ti 2 O 7 pyrochlores, and can be expanded to other thermally unstable compounds to obtain bulk materials.
研究领域:
材料科学
·
无机化学
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2016
·
IF 2.758
An-Nan Chen,Jia-Min Wu,Meng-Yue Liu,Li-Jin Cheng,Jing-Yan Chen,Huan Xiao,Xiao-Yan Zhang,Chen-Hui Li,Yu-Sheng Shi
Rapid in-situ solidification of SiO 2 suspension under the joint action of releasing calcium ions and shifting pH has been proposed. When the suspension was heated up to 60 ℃, decomposition of calcium iodate which released calcium ions , as well as hydrolysis of diacetate (GDA) which shifted the pH toward the isoelectric point, both contributed to the solidification of suspension. The controlled coagulation of SiO 2 suspension could be realized via controlled release of high valence counter ions and pH shift at 60 ℃ within 30 min, which could considerably shorten the coagulation time compared with present reported results (1–3 h). Green body prepared by heating the SiO 2 suspension with 6.5 g L −1 calcium iodate and 2.0 vol% GDA at 60 ℃ for 30 min shows uniform microstructure with compressive strength of close to 0.3 MPa. SiO 2 ceramics sintered at 1275 ℃ for 3 h possess homogeneous microstructure with bulk density of 2.06 g cm −3 and flexural strength of 40.3 MPa.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Chengkun Liu,Chang Liu,Zhuang Shi,Wei Lu,Zhiyuan Liu,Shihai Liu,Xiaojuan Wang,Xiaoqiang Wang,Fang Huang
This work describes a hemostatic membrane system (or surface coating) based on spray-assisted layer-by-layer electrostatic assemblies of oppositely charged polyphosphate (polyP) and chitosan (Cs). The as-prepared membrane formed a robust micro-stratified porous structure with high flexibility. Both blood clotting test and rodent hepatic severe hemorrhage model revealed the excellent hemostatic performance of the membrane system, benefitting from the robust assembly and synergistic effect of polyP/Cs as well as membrane surface chemistry. Compared to Cs-topped membrane surface, polyP-sprayed one exhibited further improved hemostatic effect via promoting fibrin formation . Besides, comprehensive in vitro and in vivo evaluations demonstrated good biocompatibility and biodegradability of the membrane. The present approach that integrated the hemostasis-stimulating capability of polyP/Cs with facile spraying method is highly scalable and flexible, which is envisioned to be adapted readily for other hemostatic polyelectrolytes and surface functionalization of diverse existing hemostatic products on demand.
研究领域:
生物材料
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医学工程
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
·
2015
·
IF 2.352
Yeyun Fu,Xiaoyan Wang,Yu Zhang,Zonghua Liu,Wei Xue
Cyclodextrins have been extensively used in various biomedical and pharmaceutical applications. In these applications, cyclodextrins administered in vivo would inevitably enter blood stream. However, there is not enough information on the hemocompatibility of cyclodextrins until now. In this study, we investigated the influences of cyclodextrins (α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin) on human blood components and functions in vitro, that is, morphology and lysis of red blood cells, structure and conformation of fibrinogen, complement activation, and blood coagulation. It was found that 10 mg/mL of α- or β-cyclodextrins caused abnormal red blood cell morphology and serious hemolysis, while γ-cyclodextrin at 10 mg/mL did not impair red blood cell membrane morphology and integrity. The three cyclodextrins at up to 10 mg/mL affected the local microstructure but did not change the conformation of fibrinogen. The three cyclodextrins from 0.01 to 1 mg/mL all significantly activated the complement system in a concentration-dependent way. The three cyclodextrins at up to 5 mg/mL in blood plasma did not cause significantly different coagulation times compared with the negative control. In addition, the three cyclodextrins at up to 5 mg/mL in whole blood did not cause abnormal coagulation parameters. These results provide significant information on blood safety of the three cyclodextrins for their biomedical and pharmaceutical applications.
研究领域:
医学
·
药理学
✓ 已验证
DOI
高影响因子
BIOMATERIALS
·
2012
·
IF 7.404
Dagen Zhong,Yanpeng Jiao,Yi Zhang,Wei Zhang,Nan Li,Qinhua Zuo,Qian Wang,Wei Xue,Zonghua Liu
As a synthetic polycation , polyethylenimine (PEI) is currently one of the most effective non-viral gene carriers. For in vivo applications, PEI will enter systemic circulation and interact with various blood components and then affect their individual bio-functions. Up to now, overall and systematic investigation on the interaction of PEI with multiple blood components at cellular, membrane, and molecular levels is lacking, even though it is critically important for the in vivo safety of PEI. To learn a structure–activity relationship, we investigated the effects of PEI with different molecular weight (MW) and shape (branched or linear) on key blood components and function, specifically, on RBC aggregation and morphological change, platelet activation , conformation change of albumin (as a representative of plasma proteins), and blood coagulation process. Additionally, more proteins from plasma were screened and identified to have associations with PEI by a proteomic analysis. It was found that, the PEIs have severe impact on RBC membrane structure , albumin conformation, and blood coagulation process, but do not significantly activate platelets at low concentrations. Furthermore, 41 plasma proteins were identified to have some interaction with PEI. This indicates that, besides albumin, PEI does interact with a variety of blood plasma proteins, and could have unexplored effects on their structures and bio-functions. The results provide good insight into the molecular design and blood safety of PEI and other polycations for in vivo applications.
研究领域:
生物医学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2025
·
IF 5.7
Chuanjuan Chen,Yicheng Zhang,Siqi Chen,Qinhui Chen
Hemostatic dressings are a simple and effective method for managing bleeding emergencies. Based on the blood coagulation process, hemostatic dressings work optimally by aggregating hemocytes, releasing coagulation factors, and sealing blood in a sequential manner. Janus materials, which have different components compartmentalized, have the ability to independently perform multiple functions. In this study, a Janus nonwoven fabric (BG-PNIPAM) with thermo-sensitivity on one side, designed to consistent with the physiological process of coagulation, was created. When utilized for hemostasis, the poly(N-isopropylacrylamide) (PNIPAM) side of Janus BG-PNIPAM undergoes a phase transition within 1 minute. Prior to this, it adsorbs blood in injured site and aggregate hemocytes to form primary thrombus; Afterwards, it plays a sealing role to decrease blood loss. During this process, the bioactive glass (BG) side continuously releases SiO44- and Ca2+ to activate coagulation factors and accelerate the cascade reaction. The phase transition and hydrophilic/hydrophobic transition are triggered by body temperature and rapidly completed just like a click on the switch. Animal studies have demonstrated that Janus BG-PNIPAM shows superior hemostatic performance compared to nonwoven fabric and commercial QuikClot® gauze. Furthermore, its biosafety profile provides assurance for potential clinical applications in the future.
研究领域:
材料科学
·
医学
·
生物工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2024
·
IF 5.5
Yuzhen Wang,Xiao Yang,Ziwei Yang,Hangbin Xia,Xiaoqin Si,Jiahui Hao,Dongxue Yan,Huili Li,Ke Peng,Jie Sun,Changcan Shi,Huaqiong Li,Wenzhong Li
The development of a natural, additive-free, absorbable sponge with procoagulant activity for noncompressible hemostasis remains a challenging task. In this study, we extracted high molecular weight keratin (HK) from human hair and transformed it into a hemostatic sponge with a well-interconnected pore structure using a foaming technique, freeze-drying, and oxidation cross-linking. By controlling the cross-linking degree, the resulting sponge demonstrated excellent liquid absorption ability, shape recovery characteristics, and robust mechanical properties. The HK10 sponge exhibited rapid liquid absorption, expanding up to 600% within 5 s. Moreover, the HK sponge showed superior platelet activation and blood cell adhesion capabilities. In SD rat liver defect models, the sponges demonstrated excellent hemostatic performance by sealing the wound and expediting coagulation, reducing the hemostatic time from 825 to 297 s. Furthermore, HK sponges have excellent biosafety, positioning them as a promising absorbable sponge with the potential for the treatment of noncompressible hemostasis.
研究领域:
生物医学工程
·
材料科学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2022
·Vol. 22
·期 4
·2100491
·
IF 5.859
Manshan Xie,Zhiwen Zheng,Shiheng Pu,Yong-Guang Jia,Lin Wang,Yunhua Chen
Developing nanocomposite hydrogel with multi-functions including adjustable mechanical property, tissue-adhesion, and blood coagulation property to accelerate wound healing is highly desirable in surgical application. Here a macroporous adhesive nano-enabled hydrogel constructed from gelatin methacryloyl stabilized air-in-water emulsions incorporated with dopamine-grafted-gelatin (GelDA) and Laponite nanoclay is reported. The hydrogel exhibits interconnected macroporous structure. The physical/chemical cross-linked network formed among the various components contributes to the good mechanical strength of hydrogel, which could be further regulated by adjusting the concentration of Laponite nanoclay. Furthermore, the nanocomposite macroporous hydrogel is endowed with self-healing properties and tissue adhesion by the intermolecular hydrogen bonds, ionic interactions among Laponite nanoclay and polymers, as well as the catechol functional groups. The in vitro studies demonstrate that the macroporous hydrogel has good biocompatibility and could significantly reduce blood clotting time, which is expected to be applied for the rapid sealing and hemostasis of bleeding wounds.
研究领域:
生物材料
·
医学工程
·
组织工程
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Wan Peng,Yefeng Jiang,Yang Zhang,Youjin Lai,Yiming Zhu,Huixia Wang,Zilin Kan,Pingsheng Liu
Bleeding control by traditional hemostatic materials poses a risk of continuing oozing bleeding, while existing self-gelling hemostatic powders still face challenges in simultaneously achieving robust wound sealing and effectively accelerating blood coagulation. Herein, we reported acrylic acid/methacrylic acid/2-aminoethyl methacrylate copolymer (PAMA) and chitosan (CS) as a new type of self-gelling composite powder (PAMA-CS) for acute bleeding wound sealing with reduced blood leakage. Upon rapid blood absorption, PAMA-CS powders could quickly form an adhesive hydrogel that strongly binds to bleeding tissues, exhibiting high burst pressure tolerance (up to 452.6 mmHg) for wound sealing to prevent bleeding. The incorporation of chitosan endowed significantly enhanced liquid uptake ability and accelerated blood coagulation (clot index of 77.92 % within 30 s) to the PAMA-CS powder. Based on the synergistic effect of tight adhesive sealing and accelerating intrinsic blood coagulation, PAMA-CS powders could achieve effective hemostasis within 20 s for acute bleeding liver and stomach on rats, outperforming commercial hemostatic chitosan powders. Combined with rapid hemostasis, tight & stable wound sealing, and favorable biodegradation, PAMA-CS powders may serve as a promising hemostatic candidate for emergency bleeding control and wound closure.
研究领域:
生物材料学
·
医学工程
·
创伤修复
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Yuan Li,Rui Yang,Rui Zhang,Bing Cao,Pei Li
Insoluble polyimides (PIs) are ideal materials for organic nanofiltration membranes. However, the membranes have to be prepared using soluble polyamic acid and then converted to PIs via chemical or thermal imidization. The low imidization degree of chemical imidization makes PI membranes easily hydrolyzed in water. On the contrary, a thermally imidized PI has a higher imidization degree and better chemical stability. However, the high imidization temperature (300 °C) often induces pore collapsing, membrane brittleness, and low flux. To overcome the drawbacks of thermal imidization, we developed a dual-coagulant bath method to prepare macrovoid-free poly(4,4′-oxydiphenylene pyromellitimide) membranes. The size, distribution, and connectivity of membrane pores were well controlled by tuning the compositions of the dope and the first coagulant. A series of thermally imidized flat-sheet PI membranes with macrovoid-free structures were prepared. These membranes exhibited good mechanical properties and stable nanofiltration performance in N,N-dimethylformamide solvent. This implied that the membranes were qualified for the separation process under harsh organic environments.
研究领域:
材料科学
·
分离工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）