BIOMACROMOLECULES
·
2012
·
IF 5.479
Bei Feng,Hongbin Tu,Huihua Yuan,Hongju Peng,Yanzhong Zhang
In tissue engineering research, there has recently been considerable interest in using electrospun biomimetic nanofibers of hybrids, in particular, from natural and synthetic polymers for engineering different tissues. However, phase separation between a pair of much dissimilar polymers might give rise to detrimental influences on both the electrospinning process and the resultant fiber performance. A representative natural-synthetic hybrid of gelatin (GT) and polycaprolactone (PCL) (50:50) was employed to study the phase separation behavior in electrospinning of the GT/PCL composite fibers. Using trifluoroethanol (TFE) as the cosolvent of the two polymers, observation of visible sedimentation and flocculation from dynamic light scattering analysis of the GT/PCL/TFE mixture both showed that phase separation does occur in just a few hours. This consequently led to gradually deteriorated fiber morphologies (e.g., splash, fiber bonding, and varied fiber size) over time during electrospinning GT/PCL. Quantitative analysis also indicated that the ratio of GT to PCL in the resultant GT/PCL fibers was altered over time. To address the phase separation related issues, a tiny amount (<0.3%) of acetic acid was introduced to improve the miscibility, which enabled the originally turbid solution to become clear immediately and to be single-phase stable for more than 1 week. Nanofibers thus obtained also appeared to be thinner, smooth, and homogeneous with enhanced performance in wettability and mechanical properties. Given the versatility and widely uses of the electrospun GT/PCL and other similar natural-synthetic hybrid systems in constructing tissue-engineered scaffolds, this work may offer a facile and effective approach to achieve finer and compositionally homogeneous hybrid nanofibers for effective applications.
研究领域:
生物材料学
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组织工程学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
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2017
·Vol. 123
·期 6
·1-4
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IF 1.455
Wen Xiaoyu,Pan Xiaona,Wu Libin,Li Ruinan,Wang Dan,Zhang Jinqiu,Yang Peixia
Lamellar tin deposits were prepared by galvanostatical electroplating from the aqueous acidic-sulfate bath, with gelatin and benzalacetone dissolved in ethanol (A BA+EtOH ) as additive, and their morphologies were investigated by scanning electron microscopy. Cathodic polarization curves revealed that the absorbability of A BA+EtOH on the cathode surface was higher than that of gelatin. X-ray diffraction analysis indicated preferred orientations of tin growth led to the formation of lamellar structure and distortion of tin lattice. The growth mechanism of lamellar tin was also discussed.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Chenping Li,Juncheng Zhu,Shihao Qiao,Yuxin Yang,Hongjie Dai,Hai Chen,Liang Ma,Yuhao Zhang,Hongxia Wang
Gelatin based nanoparticles was prepared by sodium trimetaphosphate (STMP) for stabilizing and fabricating high internal phase emulsions (HIPEs), and cyanophycin and capsanthin were single/dual-encapsulated in emulsion systems. The characterization of FTIR, XRD, TGA, zeta potential, particle sizes, dilatation rheology and AFM indicated that the phosphate groups of STMP could react with side chain groups of gelatin and chitosan to form nanoparticles, and enhance the thermal resistance. The nanoparticles could form strong membrane on the oil-water interface, which prevents stratification and precipitation of HIPEs, and promotes high centrifugation stability and freezing-thawing stability. The functional HIPEs with single encapsulation of medium-content cyanophycin or capsanthin have excellent colors, shear thinning performance, structure reversibility, mechanical strength, elasticity and strong network systems with small emulsion droplets; however, the mixed purple HIPEs illustrated the relative weak network structure and the low final strain recovery rates with the enlarged emulsion droplets. On another hand, the simultaneous load of cyanophycin and capsanthin in emulsion systems could produce bright purple HIPEs based on Subtractive Color Principle, and HIPEs possess the outstanding rheological characteristics and the structured systems with small emulsion droplets. The outstanding extrudability and excellent combinational 3D printability of functional HIPEs suggest the great potential in personalized, innovative food production.
研究领域:
食品科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS & DESIGN
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2019
·
IF 5.77
Weiming Chen,Yong Xu,Yanqun Liu,Zongxin Wang,Yaqiang Li,Gening Jiang,Xiumei Mo,Guangdong Zhou
The fabrication of three-dimensional (3D) electrospun fibrous scaffolds with customizable shapes and large pores is a challenging task. In this study, for the first time, one-dimensional (1D) gelatin/poly (lactic- co -glycolic acid) (PLGA) electrospun fibers were processed into inks suitable for 3D printing. By combining 3D printing and freeze drying, electrospun fiber-based inks were successfully fabricated into 3D-printed scaffolds (3DP) with precisely controlled shapes and large pores, in addition to fibrous surface morphologies similar to that of a native extracellular matrix (ECM). The 3DP exhibited good elasticity and water-induced shape memory, and was found to be superior to 3D-printed scaffolds fabricated using pure gelatin fibers and freeze-shaped scaffolds fabricated using non-fibrous gelatin/PLGA powder. Moreover, 3DP combined with chondrocytes achieved satisfactory cartilage regeneration in vivo . The novel strategy of 3D printing electrospun fibers established in this study provides a research model for the design and fabrication of multiple scaffolds for various tissue regeneration applications.
研究领域:
生物材料学
·
组织工程学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Hesheng Wang,Linna Wang,Silong Jia,Qiyuan Feng,Limin Guo,Shaoying Zhang,Youwei Yu
Conventional petroleum-based food packaging faces sustainability challenges due to limited water resistance and mechanical strength. To address this, we developed an octenyl succinic anhydride (OSA)-modified gelatin film crosslinked with vanillin (OGV), enhancing its potential for food packaging applications. Infrared and X-ray spectroscopy confirmed the successful modification of gelatin and forming a Schiff base structure with vanillin. Thermal analysis showed that the modification and crosslinking enhanced the film's thermal stability. The results demonstrated that OSA modification and vanillin crosslinking significantly enhanced the mechanical strength of OGV films, increasing tensile strength from 19.50 MPa to 43.04 MPa. Additionally, OGV films exhibited excellent water vapor barrier properties, with the water contact angle increasing from 76.6° to 91.1°, along with superior UV-blocking capacity and notable antimicrobial activity against E. coli and S. aureus . Furthermore, applying OGV films to fresh-cut green peppers effectively reduced weight loss (by 9.23 % after 10 days), preserved chlorophyll and ascorbic acid content, and inhibited lipid peroxidation, thereby extending shelf life. These findings highlight the potential of this bio-based film as an effective and sustainable alternative for food packaging applications.
研究领域:
食品科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2024
·Vol. 13
·期 19
·2304444
·
IF 10
Haihua Wang,Mengxi Wang,Jingheng Wu,Shilei Zhu,Yanan Ye,Yushan Liu,Ke Li,Ruyue Li,Yuhang Zhang,Meng Wei,Xin Yang,Leixin Meng
Conventional hemostatic agents face challenges in achieving rapid hemostasis and effective tissue repair due to limited hemostatic scenarios, suboptimal efficacy, and inadequate adhesion to wet tissues. Drawing inspiration from nature-sourced materials, a gelatin-based adhesive hydrogel (AOT) is designed, easily prepared and quick to form, driven by Schiff base and multiple hydrogen bonds for applications in arterial and liver bleeding models. AOT exhibits exceptional adhesion to wet tissues (48.67 ± 0.16 kPa) and displays superior hemostatic properties with reduced blood loss and hemostatic time compared to other hydrogels and conventional hemostatic materials. Moreover, AOT exhibits good biocompatibility and biodegradability. In summary, this easily prepared adhesive hydrogel has the potential to supplant traditional hemostatic agents, offering a novel approach to achieve swift sealing of hemostasis and facilitate wound healing and repair in broader application scenarios, owing to its unique advantages.
研究领域:
生物材料学
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医学工程
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创伤修复
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 139
·期 37
·e52882
·
IF 3.057
Shuaishuai Cheng,Xiaoyuan Duan,Yiwen Cui,Chaobo Liang,Zhiyi Zhang,Guizhe Zhao,Yaqing Liu
The development of high-performance green rubber materials with excellent comprehensive properties is very important for the environment and resources. Graphene has excellent electrical, mechanical, and thermal properties and is regarded as the most promising functional filler for rubber composites. In this work, a facile and efficient strategy was used to prepare graphene rubber materials with balanced integrated properties by chemical modification of graphene oxide (GO) with gelatin (Gel). Gel molecules as bridges could not only connect with GO by chemical bonds, but also physically entangle with natural rubber (NR) molecules. The optimized dispersibility of GO and the enhanced interfacial interaction between GO and NR together enable graphene rubber to exhibit excellent integrated properties, such as tensile strength of 29.7 MPa and heat build-up of 1.9°C only at 1 phr of Gel-rGO (G-rGO) content. Additionally, finite element simulation was used to evaluate the temperature field distribution of graphene rubber tires, and the temperature of the NR/Gel-rGO (NR/G-rGO) tread was 17.3°C lower than that of NR/GO. This work will provide effective strategies for the preparation of high-performance graphene rubber materials.
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2023
·
IF 5
Wentong Lu,Hongyan Tang,Yakun Li,Jincheng Wang,Jibo Sun
In this work, a type of natural microspheric soil conditioner, PZ(Fe)/GL-SA-Urea, was prepared by emulsion cross-linking and sharp-hole coagulation bath methods. Gelatin (GL) and sodium alginate (SA) were selected as the outermost shell, and the prepared FeOOH was loaded on pickling zeolite (PZ) to improve the loading ratio of urea. The embedding performance and sustained release behavior of the microspheres showed that when the concentration of urea was 1.5%, the embedding rate reached 37.63%, and the cumulative release rate reached 68% within 100 h, indicating that the microsphere had good encapsulation and sustained release abilities. In addition, the water retention and swelling behaviors of the microspheres can be obtained by controlling the content of added GL. Furthermore, antibacterial and planting experiments revealed that the microspheres had excellent antibacterial effects and can effectively improve soil quality and promote crop growth. Therefore, the PZ(Fe)/GL-SA-Urea microsphere soil conditioners possess good application properties and provide fresh solutions to improve soil quality and raise crop yields.
研究领域:
农业科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
3D Printing and Additive Manufacturing
·
2023
·
IF 3.1
Liang Cheng,Qianqian Tang,Yangyang Zhang,Xiaoyong Cheng,Anqi Miao,Junjie Su,Shiyu Wu,Fuzhou Niu,Lijiu Zhang,Yuping Duan,Qian Gao,Guangli Liu,Runhuai Yang
Hydrogels, as soft smart materials, have been widely used in the manufacturing of responsive biomedical structures. The manufacturing process of smart hydrogels is critical for their application; however, the production efficiency and precision of the extrusion-based 3D printing method for the fabrication of responsive structures of gelatin-based hydrogels have not been extensively studied. In this study, a gelatin-based shape memory hydrogel was designed and prepared with the addition of sodium alginate, tannic acid, and sodium iron ethylene diamine tetra acetic acid to improve its mechanical strength and photothermal properties. The printability of the hydrogel based on extrusion-based 3D printing was studied under different mixture ratios of hydrogel components. The appropriate printing parameters and formulas of the hydrogel were investigated to determine the structural strength of printing structures. Furthermore, the shape memory properties of printed structures under different printing conditions were studied. The biomedical applications of the shape memory behavior of printed structures were explored. The proposed hydrogels and manufacturing process allow the realization of 3D printed shape memory smart hydrogel structures and provide details and solutions for the design and integration of multifunctional hydrogels.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2018
·
IF 3.974
Jie Meng,Xiaoyan Lin,Jian Zhou,Ruigang Zhang,Yan Chen,Xiaoyan Long,Ran Shang,Xuegang Luo
A novel gelatin/PVA composite nanofiber band loaded with bayberry tannin (GPNB-BT) was prepared by electrostatic spinning and crosslinking for extraction of uranium (VI) from simulated seawater. The influential factors of tannin loaded on the nanofiber band were investigated in detail. Surface morphology and fiber diameter of GPNB-BT were studied by Scanning Electron Microscopy (SEM). Functional groups of GPNB-BT were investigated by Fourier Transform Infrared Spectrometer (FTIR). The adsorption process and mechanism of uranium on GPNB-BT was characterized by Energy Dispersive X-ray (EDX) and X-ray Photoelectron Spectroscopy (XPS). The results revealed that the BT had been stably solidified on the GPNB. Compared with other tannin-immobilized membranes, the nano-network structure of GPNB-BT with 200–400 nm diameter of fibers can promote solidification of tannins and improve adsorption capacity of GPNB-BT for uranium. The maximum adsorption capacity of the GPNB-BT for uranium is 170 mg/g at the optimal pH of 5.5 in 80 mg/L of initial uranium concentration and 1.4 μg/g even at extremely low initial concentration of 3 μg/L in the simulated seawater for 24 h. The GPNB-BT with good hydraulic properties, floatability and adsorption capacity for uranium is expected to be widely used in separation and enrichment of uranium in seawater and radioactive waste water.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF FOOD ENGINEERING
·
2025
·
IF 5.8
Yuxiao Mao,Hosahalli S. Ramaswamy,Junde Ren,Hongyue Li,Tao Song,Ting Xiao,Sinan Zhang,Yong Yu,Songming Zhu
To develop a model food for the large yellow croaker (LYC, Larimichthys crocea ) muscle subjected to liquid nitrogen spray freezing (LNSF), the effects of temperature and concentrations of gelatin (5%, 10%, and 15%, w/w), sodium chloride (0%, 3%, 6%, and 9%), and sucrose (0%, 3%, 6%, and 9%) on thermal properties of frozen gelatin gels were investigated. Thermal conductivity ( k ) and diffusivity ( α ) significantly decreased ( P < 0.05) with increasing gelatin concentration and decreasing sodium chloride content. Adding sucrose significantly decreased k but raised α . Increasing the concentrations of all three components reduced the volumetric heat capacity ( C pV ). The gelatin gel with 16% gelatin and 4% sucrose was selected as the model food because its thermal properties most closely matched those of LYC muscle. At depths of 5, 15, and 25 mm, the total LNSF freezing durations for gels (164.78, 167.01, and 167.40 min) were similar to those for fish muscles (167.67, 169.47, and 168.93 min), validating that the developed model food effectively simulated the freezing characteristics of real food. The significant decrease in cross-sectional area from 1538.63 to 850.90 μm 2 and area uniformity index from 2.507 to 1.612 with decreasing freezing temperature from -20 to -100 °C demonstrated that rapid freezing generated uniformly distributed fine ice crystals. This phenomenon indicated that the model food could simulate the quality changes in fish muscle with LNSF freezing temperature. In summary, adjusting the component content of gelatin gels can be used to develop model foods for aquatic products to optimize LNSF freezing protocols.
研究领域:
食品科学
·
生物物理学
✓ 已验证
DOI
高影响因子
Cell Reports Physical Science
·
2024
·
IF 7.9
Mengnan Cao,Fang Liu,Xinzhu Huo,Shouxin Liu,Jian Li,Shujun Li,Tony D. James,Zhijun Chen
Covalently embedding natural phosphors into a polymer matrix is a particularly appealing approach for producing sustainable room-temperature phosphorescent (RTP) materials. However, the fabrication of such RTP materials remains challenging. Additionally, naturally degradable RTP materials have been scarcely reported although they are crucial for sustainability. Here, we report methacrylated lignosulfonate as a phosphor, which is then covalently embedded within methacrylated gelatin by polymerization. The as-obtained Lig@Gel exhibits phosphorescence of ∼110 ms. Moreover, the Lig@Gel displays excellent biodegradability in a natural soil environment. Life cycle assessment indicates that 10 out of 14 environmental impact categories of our Lig@Gel are approximately 60%–100% lower than those of traditional luminescent materials. As a demonstration of applicability, Lig-RhB@Gel with red afterglow emission is prepared via loading Lig@Gel with rhodamine B (RhB) using an energy-transfer strategy. The as-prepared Lig@Gel and Lig-RhB@Gel could be employed as functional anti-counterfeiting coatings for fibers and paper.
研究领域:
材料科学
·
环境科学
·
生物化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）