INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Chunchun Wang,Jiayi Guo,Qun Liu,Xu Zeng,Yue Liu,Yanping Deng,Yanli Lin,Xialing Wu,Hongju Deng,Linjing Chen,Wuyin Weng,Yucang Zhang
Accidental bleeding is an unavoidable problem in daily life. To avoid the risk of excessive blood loss, it is urgent to design a functional material that can quickly stop bleeding. In this study, an efficient wound dressing for hemostasis was investigated. Based on the characteristics that Ca 2+ and fish skin collagen (FSC) could activate the coagulation mechanism, hemostatic cotton was prepared by solvent replacement method using CaCl 2 , FSC, soluble starch (SS), and polyvinyl alcohol (PVA) as raw materials. The cytotoxicity test showed the Ca 2+ PVA/FSC-SS hemostatic cottons had good biocompatibility. The activated partial thromboplastin time (APTT) of Ca 2+ PVA/FSC-SS(4) was 35.34 s, which was 22.07 s faster than that of PVA/FSC-SS, indicating Ca 2+ PVA/FSC-SS mediated the endogenous coagulation system. In vitro coagulation test, Ca 2+ PVA/FSC-SS(4) could stop bleeding rapidly within 39.60 ± 5.16 s, and the ability of wound healing was higher than commercial product (Celox). This study developed a rapid procoagulant and hemostatic material, which had a promising application in a variety of environments.
研究领域:
生物材料
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止血
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伤口愈合
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomedical Materials
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2015
·Vol. 10
·期 6
·065022
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IF 3.697
Weiping Wang,Xin Huang,Haiyan Yin,Wenling Fan,Tao Zhang,Lei Li,Chun Mao
In this study, polyethylene glycol acrylate (PEGA) was introduced onto the surface of polysulphone (PSF) membrane to prepare PSF–PEGA membranes through low-temperature plasma technology for haemocompatibility improvement of artificial lungs. The effects of plasma power, PEGA solution concentration and dipcoating temperature on surface modification were systematically investigated. Results of Fourier transform infrared spectroscopy, x-ray photoelectron spectroscopy and PEGA grafting degree confirmed that PEGA was successfully grafted onto the PSF membranes. Contact angle values showed that the hydrophilicity of the PSF–PEGA membrane surface increased by 21.5%. The results of the protein adsorption, platelet adhesion and coagulation tests further showed the excellent haemocompatibility of the modified membrane. Gas exchange tests also revealed that at a porcine blood flow rate of 5 l min−1, O2 and CO2 exchange rates through the PSF–PEGA membrane were 198.6 and 170.9 ml min−1, respectively; approximately this is the gas exchange capacity of commercial respiratory assistance devices.
研究领域:
材料科学
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生物医学工程
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医疗器械
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2016
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IF 1.733
Tingting Xu,Fang Peng,Tao Zhang,Bo Chi,Hong Xu,Chun Mao,Shuaihui Feng
Poly(γ-glutamic acid) (γ-PGA) powder was usually used as hemostatic agent because of its excellent physical properties of water-absorption and water-locking. However, if γ-PGA absorbs enough water, how about its blood compatibility? Here, the other side of the coin was investigated. The anticoagulant properties of γ-PGA were characterized by in vitro coagulation tests, hemolytic assay, platelet adhesion, and platelet activation. Moreover, cytotoxicity experiments of γ-PGA were also carried out by MTT assay. Results indicated that the sufficient water-absorbed γ-PGA has good anticoagulant property and non-cytotoxicity. It means γ-PGA has good anticoagulant property, non-cytotoxicity. If γ-PGA has absorbed enough water, it can be used as an anticoagulation biomaterial. With double effects (coagulation and anticoagulation), the γ-PGA with desirable bioproperties can be readily tailored to cater to various biomedical applications.
研究领域:
生物材料
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止血
·
抗凝
·
生物相容性
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2022
·
IF 5.546
Yaotian Peng,Xiaoyan Feng,Jianming Jiang,Li Ren
Bilirubin, a dangerous toxin may lead to serious brain injury, can be widely removed by hemoperfusion. However, the hemoperfusion adsorbents with higher removal ability, excellent hemocompatibility and biocompatibility still need to be explored. In this work, a novel functionalized polyvinylpyrrolidone (PVP) was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. Then PVP-modified polystyrene-divinylbenzene (PS-DVB-PVP) microspheres were prepared by a one-pot restore-click method. The results showed that the adsorption capacity and rate of microspheres for bilirubin were increased after modification with PVP. In the hemocompatibility and biocompatibility test, the modified microspheres demonstrated higher resistance to human serum albumin (HSA) and excellent hemolysis rate. In order to study the role of PVP in the bilirubin-adsorption process, isotherms were fitted by Langmuir model and Freundlich model, while kinetics data were fitted by pseudo-second-order model and intraparticle diffusion model. In addition, the modified microspheres showed no difference with unmodified microspheres in the coagulation test and exhibited no cytotoxicity to L929 cells. These results showed that our modified microspheres have both excellent hemocompatibility and outstanding biocompatibility, which will not cause hemolysis and coagulation. All these results made them possible to become a new adsorbent for efficient removing bilirubin in hemoperfusion.
研究领域:
材料科学
·
生物医学工程
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化学工程
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生物化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）