ACS Applied Materials & Interfaces
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2022
·
IF 10.383
Leilei Lan,Xingce Fan,Shaobo Yu,Juan Gao,Caiye Zhao,Qi Hao,Teng Qiu
Two-dimensional (2D) MXene materials have attracted broad interest in surface-enhanced Raman scattering (SERS) applications by virtue of their abundant surface terminations and excellent photoelectric properties. Herein, we propose to design highly sensitive MXene-based SERS membranes by integrating a 2D downsizing strategy with molecular enrichment approaches. Two types of 2D vanadium carbide (V4C3 and V2C) MXenes are demonstrated for ultrasensitive SERS sensing, and corresponding SERS mechanisms including the effect of 2D vanadium carbide thickness on their electron density states and interfacial photoinduced charge transfer resonance were discussed. A 2D downsizing strategy authorizes nonplasmonic SERS detection with a sensitivity of 1 × 10–7 M. Moreover, the performance can be further upgraded by vacuum-assisted filtration, which enables an ultrarapid molecular enrichment (within 2 min), ultrahigh molecular removal rate (over 95%), and improved sensitivity (5 × 10–9 M). This work may shed light on the MXene-based materials as an innovative platform for nonplasmonic SERS detection.
研究领域:
材料科学
·
光学
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DOI
PubMed
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2017
·Vol. 23
·期 62
·15721-15728
·
IF 5.317
Yuanyuan Hu,Dong Xie,Yang Wu,Nangui Lin,Aixin Song,Jingcheng Hao
Graphical Stacking gels : Factors affecting the self-assembly of supramolecular hydrogels composed of combining 5′-adenosine monophosphate and Ag + are discussed (see figure). The gelation capability was enhanced by increasing the concentration of Ag + or decreasing the pH. The gels are very sensitive to light and have potential applications as photosensitive materials. Supramolecular hydrogels obtained by combining 5′-adenosine monophosphate (AMP) with Ag + were fabricated in this work. Their gelation capability was enhanced by increasing the concentration of Ag + or decreasing the pH. The gels are very sensitive to light, which endows them with potential applications as visible-light photosensitive materials. Coordination between the nucleobase of AMP and Ag + , as well as π–π stacking of nucleobases, are considered to be the main driving forces for self-assembly. The hydrogels successfully achieved the encapsulation and enrichment of biomolecules. Hydrogen bonding between the amino group of guest molecules and silver nanoparticles along the nanofibers drives the enrichment and is considered to be a crucial interaction.
研究领域:
材料科学
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生物化学
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
Advanced Intelligent Systems
·
2023
·Vol. 5
·期 11
·2300386
·
IF 7.4
Jinwei Lin,Kang Xiong,Junyi Hu,Zhengshang Li,Leilei Xu,Jianguo Guan
“On-the-fly” molecule enrichment by micro/nanomotors obviously improves heterogeneous catalysis, trace detection, and environmental monitoring, yet faces challenges of the trade-off between collection range and interaction time. Inspired by the versatile foraging process of predators, this work demonstrates that micromotors doing spontaneous multipattern motion with microvortex can greatly enhance “on-the-fly” enrichment, demonstrated by highly sensitive surface-enhanced Raman scattering detection. It leverages an axis-asymmetric bowl-shaped structure and the nonlinear Ag–AgCl reaction, realizing alternating low-velocity swinging forward and accelerated steering motions for prolonged interaction and large work area. Moreover, the bowl-shaped microstructure bestows a micro-vortex above the Ag side due to the competition of electric potential and pressure gradient, also extending interaction time during the acceleration. Consequently, it exhibits at least an order of magnitude larger enhancement of detection signals than the counterparts. This proof-of-concept study highlights the significance of motion mode and structure design in guiding flow field, offering substantial benefits for applications.
研究领域:
纳米技术
·
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Qi Ao,Lin Jiang,Xinglai Tong,Ying Song,Xiaoxiao Lv,Jun Tang
Efficient and stable catalysis has always been the core concept of enzyme catalysis in industrial processes for manufacturing. Here, we constructed molecular enrichment accelerators to synergistically enhance enzyme activity and stability by assembling enzyme surface grafted polymer and cyclodextrin . At 40 °C, the enzyme activity of CalB-PNIPAM 212 /β-CD was 2.9 times that of CalB-PNIPAM 212 . The enzyme activity of CalB-PNIPAM 428 /γ-CD had reached 1.61 times that of CalB . At the same time, the stability of CalB-PNIPAM 212 /β-CD and CalB-PNIPAM 428 /γ-CD are slightly better than that of CalB under high temperature, organic solution and extreme pH conditions. The synergistic increase in activity and stability of the lipase-polymer assembly was achieved due to the structure of assembly, in which the role of cyclodextrin could enrich substrate affecting molecular diffusion. In addition, the lipase-polymer assembly proved to be an efficient catalyst for biodiesel synthesis, with a biodiesel conversion 1.4 times that of CalB at 60 °C. Therefore, this simple and low-cost lipase-polymer assembly provides new possibilities for the construction of high-efficiency industrial biocatalytic catalysts.
研究领域:
生物化学
·
工业酶学
·
催化工程
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Ruiyuan Zhang,Liang Yu,Hongjun You,Rui Hao,Jixiang Fang
Surface-enhanced Raman scattering (SERS) possesses the advantage that directly detects target analytes in solution with high specificity and sensitivity without complicated pretreatment procedures. It remains a challenge in most practical applications to achieve molecule sensitivity in any highly diluted solutions. Here, we develop a robust and practical molecular enrichment strategy that can effectively confine analyte molecules and Au nanoparticles together in a short time into a small-sized sensitive region on a needle tip, based on the Leidenfrost phenomenon and capillary force . In this strategy, the Leidenfrost evaporation phenomenon maintains the analytes droplet in a Cassie state based on a levitating force, and at the same time, a hung needle tip anchors the droplet based on the capillary force. After 1–2 min quick evaporation, more than 98% Au nanoparticles and analytes can be condensed into an around 0.5 mm small size area on the needle tip. Due to the significant enrichment capability and reproducibility, the SERS measurement enables to achieve the limit of detection (LOD) down to 0.08 nM (at an S/N ratio of 3) for crystal violet (CV) molecules and to nM level for several types of pesticide molecules (glyphosate, carbendazim , thiram and choline) in ethanol solution. The strategy was also applied to the detection of CV molecules in mixture pigments solution, thiram in spiked environment water samples, with good selectivity and sensitivity. In addition, using the high thermal conductivity substrate without additional surface modification, this enrichment SERS detection may open the possibility of universal applications due to its facile and cost-effective. The accurate site of the needle tip offers great practical potentials for on-site identification by using a handheld Raman spectrometer.
研究领域:
分析化学
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纳米技术
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传感器技术
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DOI
高影响因子
Nano Energy
·
2022
·
IF 19.069
Lingjun Zhang,Jianfeng Sun,Yurui Fang,Yingzhou Huang,Hengyu Guo,Zhong Lin Wang
Attracting target molecules in solution to electromagnetic hot spots is one of the most important problems in the application of surface-enhanced Raman spectroscopy (SERS). In this work, an ultrasensitive SERS detection system with electrokinetic preconcentration is proposed, in which triboelectric nanogenerator (TENG) is employed to provide the electrostatic driving force for molecular enrichment on SERS substrate. During TENG operation, an electric field is generated in solution and provides sufficient driving force for the movement of target molecules. Thanks to the unique output characteristics of TENG, effective enrichment of molecules in triboelectric preconcentration (TEPC) is achieved in 30 s, which exhibits much higher efficiency compared to the enrichment in 10 min with a DC source. Moreover, the TEPC assisted SERS detection system exhibits excellent sensitivity with the limit of detection (LOD) at 10 −15 M. Furthermore, a self-powered TEPC assisted SERS system is designed, which could use environmental mechanical energy and realize outdoor real-time sensitive detection .
研究领域:
分析化学
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纳米技术
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生物传感
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产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2014
·
IF 4.258
Shao-Ting Wang,Wei Huang,Yi-Fan Deng,Qiang Gao,Bi-Feng Yuan,Yu-Qi Feng
The metal oxide affinity chromatography (MOAC) materials have been extensively used for extraction of phosphate compounds in the past decade. Actually, some of these materials also possess adsorption affinity towards cis -diol-containing compounds, which was seldom explored in separation field so far. Here we present the proof-of-concept study to evaluate the feasibility of expanding MOAC for specific capture of cis -diol biomolecules. Benefitting from the high commercialisation of the metal oxide materials, such MOAC strategy possesses several advantages, like synthesis-free, low cost and high expandability. Firstly, the recognition of adenosine against 2′-deoxyadenosine was performed using zirconium oxide and cerium oxide, two typical commercial MOAC materials. The results showed that efficient adsorption and elution could be achieved easily by pH switching from basic to acidic. The isotherm curves demonstrated the adsorption process fitted well with Freundlich isotherm model and was spontaneous at room temperature (Δ G 0 < 0) with an exothermic nature (Δ H 0 < 0). Afterwards, the highly efficient and selective enrichment of various model cis -diol biomolecules, including ribonucleosides, glycopeptides and glycoproteins, was achieved using this MOAC strategy. Finally, the endogenous ribonucleosides and modified ribonucleosides were successfully purified from human urine sample, which demonstrated the potential application of MOAC materials in the enrichment of target compounds from complex biological samples. Besides the excellent performance of extraction for cis -diol-containing compounds, equally important is that these materials are commercially available with low cost, which makes the MOAC a promising strategy for the study of cis -diol biomolecules in metabolomics and proteomics.
研究领域:
分析化学
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生物化学
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代谢组学
·
蛋白质组学
✓ 已验证
DOI
高影响因子
TALANTA
·
2025
·
IF 6.1
Panjie Li,Jiaxin Chen,Yalin Xie,Caijun Wu,Yan Zhao,Xiaojun Luo
Surface-enhanced Raman spectroscopy (SERS), an ultrasensitive molecular fingerprinting technique, requires substrates that synergistically integrate electromagnetic field amplification (via plasmonic hotspots) and analyte enrichment (through nanoscale molecular confinement). Although metal nanoparticles (NPs) generate hotspots, their practical utility is hindered by chemical instability, poor reproducibility, and weak analyte affinity. Covalent organic frameworks (COFs), with designable porosity, ultrahigh surface areas, and stability, offer a promising platform to address these limitations. By combining COFs with noble metals, the molecular enrichment capability of COFs and the plasmonic effects of metals can be synergistically exploited. However, conventional synthesis strategies (chemical reduction, pre-synthesis anchoring) suffer from complex multi-step processes, reducing agent dependence, and irregular deposition of metal NPs on the COF matrix, which compromise SERS performance. Our study proposed a sulfur-rich COF leveraging Au–S soft acid-base interactions to achieve in situ reduction of Au 3+ to Au 0 within COF matrices. Three synthesis approaches−chemical reduction, physical adsorption, and in-situ reduction−were systematically compared, with the in-situ method demonstrating superior SERS enhancement and reproducibility due to the confinement of large-area and high-density NPs. The optimized COF/Au composite enabled ultrasensitive detection of letrozole at 6.07 × 10 −8 g/mL, leveraging COF-inherent Raman peaks for internal calibration. This work provides an innovative solution for developing next-generation SERS sensors with acceptable sensitivity, anti-interference capability, and reproducibility.
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DOI
PubMed
高影响因子
LANGMUIR
·
2021
·
IF 3.882
Xiao Xiao,Yan Qiao,Zhirui Xu,Tongyue Wu,Yunxue Wu,Zhe Ling,Yun Yan,Jianbin Huang
Enzyme-instructed self-assembly is an increasingly attractive topic owing to its broad applications in biomaterials and biomedicine. In this work, we report an approach to construct enzyme-responsive aqueous surfactant two-phase (ASTP) systems serving as enzyme substrates by using a cationic surfactant (myristoylcholine chloride) and a series of anionic surfactants. Driven by the hydrophobic interaction and electrostatic attraction, self-assemblies of cationic–anionic surfactant mixtures result in biphasic systems containing condensed lamellar structures and coexisting dilute solutions, which turn into homogeneous aqueous phases in the presence of hydrolase (cholinesterase). The enzyme-sensitive ASTP systems reported in this work highlight potential applications in the active control of biomolecular enrichment/release and visual detection of cholinesterase.
研究领域:
材料科学
·
生物技术
·
生物材料
·
生物医药
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）