RSC Advances
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2022
·Vol. 12
·期 33
·21135-21144
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IF 4.036
Yirong Xia,Wei Ni,Xintong Wang,Yanyan Wang,Ximing Huang
The health benefits of drinking tea stem from it being rich in polyphenols and other physiologically-active substances. Thus, exploring the synergistic effect between polyphenols and a variety of physiologically-active substances can contribute to our understanding of how tea benefits health. In this work, we have studied the interactions between catechin and theanine, exploring the synergetic antioxidant mechanism of the two molecules. Electrochemical characterization results showed that the oxidation peak current of catechin decreased gradually with the concentration of theanine, which is due to theanine spontaneously binding to catechin through intermolecular hydrogen bonds and forming molecular clusters via two hydrogen bonds. The binding constant is 4.75 at room temperature. The molecular clusters reduce the diffusion coefficient of catechin in solution, leading to the slow release of its antioxidant capacity (ability to effectively inhibit free radical oxidation reactions). Density functional theory calculations were also performed and verified the binding behavior. In identifying the synergistic effect between catechin and theanine on the antioxidant capacity of tea, this study adds to our understanding of the efficacy of tea polyphenols.
研究领域:
食品科学
·
生物化学
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DOI
高影响因子
MOLECULAR IMAGING AND BIOLOGY
·
2023
·Vol. 25
·期 5
·875-886
·
IF 3.1
Hui Xin,Wang Yanxing,Li Wenjing,Yuan Ying,Tao Xiaofeng,Lv Ruichan
In this research, we designed a novel NIR II luminescence imaging probe with targeting effect to accurately track oral squamous cell carcinoma (OSCC) cells. Massive gene expression data were processed by weighted gene co-expression network analysis to establish a network of relationships between genes. After clustering, correlation of clinical information, and gene functional enrichment analysis, MMP1 was predicted to be a biomarker/therapeutic target for OSCC cells. To obtain rare-earth probes with better luminescence in the NIR II region, we adjusted the doping ratio of the rare-earth element (Nd, Gd, Er, and Yb) fraction of the Nd-Mn molecular cluster to optimize its luminescence properties. The results of in vitro targeting experiments showed that Nd-Mn-MMP1Ab can target Cal-27 cells, demonstrating at the cellular level that the MMP1 gene is a biomarker for oral cancer, which also proves that the cancer targets predicted by the bioinformatics approach are correct.
研究领域:
生物信息学
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癌症研究
·
分子影像学
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2020
·
IF 2.463
Xiao-Qi Jia,Yi Li,Chun-Xia Zhang,Yan-Cai Gao,Yuqing Wu
Due to the importance of ethanol-water solutions in many fields the different supramolecular clusters involved in this binary system is studied in detail by using fluorescence spectroscopy , at different concentration and incubation time after mixing. Two-dimensional (2D) correlation analysis is performed on the concentration-dependent mixtures (10–100%) at each incubation time, which find that the correlation intensity of emission peak at 330 nm for (H 2 O) m (EtOH) n not only related to the concentration but also gradually increase with the incubation time. Such results indicate that the cluster of (H 2 O) m (EtOH) n is the most stable one because it tends to be formed with longer incubation time. In addition, the correlation results indicate that at low concentration range of 10–45%, the dominated cluster is (H 2 O) m (EtOH) corresponding to a peak at 373 nm; while at high concentration range of 80–100%, the main cluster is (H 2 O)(EtOH) n corresponding to an emission peak at 308 nm; however, the most stable cluster of (H 2 O) m (EtOH) n , corresponding to the peak at 330 nm, not only predominate at the concentration range of 50–75% but also exist in all mixture at longer incubation time. Therefore, the present study provides a new approach to clarify the different supramolecular clusters in ethanol-water mixtures, which would be applied to other binary solution system.
研究领域:
物理化学
·
光谱学
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DOI
高影响因子
Journal of Physical Chemistry Letters
·
2021
·
IF 6.475
Li Liu,Keliang Pan,Ke Xu,Xitian Peng,Jin Z. Zhang
Mn2+-doped amino lead halide molecular clusters (MCs) are synthesized using amine (e.g., n-octylamine, or butylamine) as passivating ligand and MnX2 (X = Cl or Br) as the Mn2+ doping source at room temperature. Their optical properties are investigated with UV–visible absorption, photoluminescence (PL), and PL excitation spectroscopy. The Mn2+ precursor plays a vital role in the synthesis of Mn2+-doped MCs. MnCl2 seems to facilitate the incorporation of Mn. The MnCl2 doping causes electronic absorption blue shift and leads to a spin-forbidden 4T1 → 6A1 Mn d-electron emission. With the help of time-resolved PL, Fourier transform infrared, and electron paramagnetic resonance results, a model is proposed to explain the formation mechanism. We suggest that Mn2+ doping replaces Pb2+ is assisted by Cl– ions that replace Br– ions. This study demonstrates the possibility of doping MCs and has important implications in gaining new fundamental insight into the growth mechanisms of perovskite nanostructures.
研究领域:
材料科学
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无机化学
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光学光谱学
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纳米技术
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凝聚态物理
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Jinzhou Li,Lili Wang,Tianning Wang,Jiuli Chang,Dapeng Wu,Fang Xu,Kai Jiang,Zhiyong Gao
Efficient and durable nonprecious catalysts for the oxygen evolution reaction (OER) are crucial for practical water electrolysis for hydrogen production. A self-supported OER catalytic electrode with sufficient exposure of the catalyst and tight anchoring onto the current collector is vital for the catalytic activity and stability, and is therefore deemed to be a preferable tactic to enhance water electrolysis performance. Herein, a polyoxometalate (POM) molecular cluster-mediated electroplating and activation tactics are proposed to design a self-supported molybdenum nickel oxide (MoNiO x ) catalytic electrode for the OER. The MoNiO x active layer can anchor tightly onto the Ni foam current collector with sufficient surface exposure and high structural stability, therefore enabling high alkali OER catalytic efficiency (222 mV at 10 mA cm −2 ) and robust durability (only slight decay in catalytic efficiency upon 12 days of chronopotentiometry ( V - t ) test). Moreover, the easily processable electroplating and active protocol can serve as a general approach to prepare other OER catalytic electrodes by altering the reactants and current collectors. The current work paves a facile and universal way to design a highly active and durable molybdenum (Mo) based hybrid catalytic electrode for OER via molecular cluster-assisted electroplating and activation treatment.
研究领域:
电化学
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材料科学
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催化
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能源存储与转换
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DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Fang Cheng-Dong,Huang Ying,Sun Yi-Fan,Sun Peng-Fei,Li Ke,Yao Shu-Yang,Zhang Min-Yi,Fang Wei-Hui,Chen Jia-Jia
Understanding the Li-ions conduction network and transport dynamics in polymer electrolyte is crucial for developing reliable all-solid-state batteries. In this work, advanced nano- X-ray computed tomography combined with Raman spectroscopy and solid state nuclear magnetic resonance are used to multi-scale qualitatively and quantitatively reveal ion conduction network of poly(ethylene) oxide (PEO)-based electrolyte (from atomic, nano to macroscopic level). With the clear mapping of the microstructural heterogeneities of the polymer segments, aluminium-oxo molecular clusters (AlOC) are used to reconstruct a high-efficient conducting network with high available Li-ions (76.7%) and continuous amorphous domains via the strong supramolecular interactions. Such superionic PEO conductor (PEO-LiTFSI-AlOC) exhibites a molten-like Li-ion conduction behaviour among the whole temperature range and delivers an ionic conductivity of 1.87 × 10 −4 S cm −1 at 35 °Ϲ. This further endows Li electrochemical plating/stripping stability under 50 μA cm −2 and 50 μAh cm −2 over 2000 h. The as-built Li|PEO-LiTFSI-AlOC|LiFePO 4 full batteries show a high rate performance and a capacity retention more than 90% over 200 cycling at 250 μA cm −2 , even enabling a high-loading LiFePO 4 cathode of 16.8 mg cm −2 with a specific capacity of 150 mAh g −1 at 50 °Ϲ.
研究领域:
材料科学
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电化学
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电池技术
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高分子科学
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产品关联
DOI
PubMed
高影响因子
Lipids in Health and Disease
·
2024
·Vol. 23
·期 1
·1-17
·
IF 3.9
Tan Cuiyu,Huang Shuqiang,Xu Liying,Zhang Tongtong,Yuan Xiaojun,Li Zhihong,Chen Miaoqi,Chen Cairong,Yan Qiuxia
Background Changes in the oxidative stress and lipid metabolism (OSLM) pathways play important roles in polycystic ovarian syndrome (PCOS) pathogenesis and development. Consequently, a systematic analysis of genes related to OSLM was conducted to identify molecular clusters and explore new biomarkers that are helpful for the diagnostic of PCOS. Methods Gene expression and clinical data from 22 PCOS women and 14 normal women were obtained from the GEO database (GSE34526, GSE95728, and GSE106724). Consensus clustering identified OSLM-related molecular clusters, and WGCNA revealed co-expression patterns. The immune microenvironment was quantitatively assessed utilizing the CIBERSORT algorithm. Multiple machine learning models and connectivity map analyses were subsequently applied to explore potential biomarkers for PCOS, and nomograms were employed to develop a predictive multigene model of PCOS. Finally, the OSLM status of PCOS and the hub genes expression profiles were preliminarily verified using TUNEL, qRT‒PCR, western blot, and IHC assays in a PCOS mouse model. Results 19 differential expression genes (DEGs) related to OSLM were identified. Based on 19 DEGs that were strongly influenced by OSLM, PCOS patients were stratified into two distinct clusters, designated Cluster 1 and Cluster 2. Distinct differences in the immune cell proportions existed in normal and two PCOS clusters. The random forest showed the best results, with the least cross-entropy and the utmost AUC (cross-entropy: 0.111 AUC: 0.960). Among the 19 OSLM-related genes, CXCR1, ACP5, CEACAM3, S1PR4, and TCF7 were identified by a Bayesian network and had a good fit with PCOS disease risk by the nomogram (AUC: 0.990 CI: 0.968–1.000). TUNEL assays revealed more severe DNA damage within the ovarian granule cells of PCOS mice than in those of normal mice ( P < 0.001). The RNA and protein expression levels of the five hub genes were significantly elevated in PCOS mice, which was consistent with the results of the bioinformatics analyses. Conclusion A novel predictive model was constructed for PCOS patients and five hub genes were identified as potential biomarkers to offer novel insights into clinical diagnostic strategies for PCOS.
研究领域:
生殖医学
·
分子生物学
·
免疫学
·
生物信息学
·
病理学
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产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Si Sun,Fangzhen Tian,Huanhuan Qiao,Qi Xin,Xinxu Zhang,Nan Song,Yuxing Yan,Ling Liu,Yili Wang,Lijie Zhang,Ke Chen,Jiang Yang,Shu Zhang,Jianning Zhang,Yonghui Li,Hao Wang,Xiao-Dong Zhang
Type 2 diabetes mellitus is the most prevalent disease in the world, with one-tenth of the population suffering from the disease, and the most critical challenges are its complications that induce high disability and mortality rates. The state-of-the-art therapeutic agents can manage glucose but fail to prevent renal failure as well as neurodegeneration with immunosuppression. Herein, we developed a deep learning design strategy that exploits the ‘size-fitting effect’ to engineer an atomic-precision metal cluster for preventing diabetic complications by targeting metabolic abnormality and immunosuppression. The designed AuZn cluster achieves almost 100% α-amylase inhibition and 88% α-glucosidase inhibition, resulting in the normalized glycated hemoglobin and sustained glucose control. The intrinsic redox properties reduce oxidative stress damage, promoting β-cell regeneration and metabolic stress alleviation. Consequently, the renal function, the most prevalent complications, shows that glomerular filtration can be restored to normal levels without urinary protein, while the clinical dulaglutide is not show any improvement. The key marker during early neurocognitive disorders, the amyloid precursor protein (APP) induced by complications, can be effectively suppressed, and diabetes induced organelle degeneration in neurons can be restored.
研究领域:
糖尿病研究
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纳米医学
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代谢性疾病
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免疫学
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神经退行性疾病
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氧化还原生物学
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药物设计
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生物医学中的深度学习
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）