Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Wang Luping,Zhang Kaiqiang,Hou Kaiyang,Xia Yuguo,Wang Xu
For decades, the prediction of polymer material properties using macromolecular computational methods has faced significant challenges due to the requirement for extensive databases, inefficiencies in computation time, and limitations in predictive accuracy. Herein we discover that the calculated binding energy of supramolecular fragments correlates linearly with the mechanical properties of polyurethane elastomers. This finding suggests that small molecule calculations may offer a more efficient way to predict polymer performance. Experimental validation supports this insight, with the top-performing elastomer exhibiting a toughness of 1.1 GJ m −3 , along with high mechanical strength, transparency, scalability, self-healing capability, and recyclability. Furthermore, this material presents a performance-to-cost ratio double that of commercially available high-performance elastomers, unlocking potential for broader applications where current materials may fall short.
研究领域:
高分子科学
·
材料科学
·
计算化学
·
机械工程
·
大分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2025
·
IF 12.1
Mohamed Nabeel Mattath,Yingying Lu,Ajith Manayil Parambil,Yan Gao,Tian-Ming Yao,Jing-Jing Li,Rui-Min Zang,Song Hu,Shuo Shi
Molecular information coding (MIC) involves biomolecules to encrypt and transmit messages, remains in its early stages of development. This work presents a versatile molecular integration framework and a proof-of-concept multi-level security system that combines Morse code, ASCII code, and Beale's cipher through molecular logic computing, using a molecular dye-oligonucleotide platform (single-stranded DNA, duplex DNA, stem-loop, and G-quadruplex (G-4) structures). This study demonstrates the integration of nanotechnology with crypto-steganographic methods to visualize and decipher codes, embedding elementary logic operations into molecular signal transduction. Additionally, a graphical user interface (GUI) is developed for classifying elementary logic gates using a decision tree algorithm, providing researchers with an accessible tool for rapid prediction. The Morse code-mediated strategy enables static key generation using dots, dashes, and intervals, and dynamic key generation through a polyalphabetic cipher framework. In parallel, ASCII-based logic gate operations facilitate multi-key decryption of decimal values to recover hidden information. Furthermore, a multilayered hybrid cryptographic technique combining Beale's cipher with Morse code implemented via a pangramic codebook, establishes an exceptionally resistant system against brute-force attacks. These methods provide insights into the evolution of communication and highlight the importance of encryption without relying on highly complex materials or sophisticated instruments.
研究领域:
密码工程
·
隐写术
·
分子计算
·
生物信息学
·
纳米技术
·
信息安全
·
基于DNA的数据存储
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2015
·Vol. 7
·期 48
·20749-20756
·
IF 7.394
Siqi Zhang,Kun Wang,Congcong Huang,Ting Sun
Based on the characteristics of magnetic beads and DNA, a simple and universal platform was developed for the integration of multiple logic gates to achieve resettable half adder and half subtractor functions. The signal reporter was composed of a split G-quadruplex DNAzyme and AuNP-surface immobilized molecular beacon molecule. The novel feature of the designed system is that the inputs (split G-quadruplexes) can interact with hairpin-modified Au NPs linked to magnetic particles. Another novel feature is that the logic operations can be reset by heating the output system and by using the magnetic separation of the computing modules. Moreover, the developed half adder and half subtractor are realized on a simple DNA/magnetic bead platform in an enzyme-free system and share a constant threshold setpoint. Due to the diversity and design flexibility of DNA, these investigations may provide a new method for the development of resettable DNA-based arithmetic operations.
研究领域:
生物化学
·
纳米技术
·
分子计算
·
生物工程
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Fang Pu,Jinsong Ren,Xiaogang Qu
Molecular logic gates in response to chemical, biological, or optical input signals at a molecular level have received much interest over the past decade. Herein, we construct “plug and play” logic systems based on the fluorescence switching of guest molecules confined in coordination polymer nanoparticles generated from nucleotide and lanthanide ions. In the system, the addition of new modules directly enables new logic functions. PASS 0, YES, PASS 1, NOT, IMP, OR, and AND gates are successfully constructed in sequence. Moreover, different logic gates (AND, INH, and IMP) can be constructed using different guest molecules and the same input combinations. The work will be beneficial to the future logic design and expand the applications of coordination polymers.
研究领域:
材料化学
·
超分子化学
·
分子计算
·
纳米技术
·
发光材料
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2017
·
IF 6.32
Jiao Yang Lu,Xin Xing Zhang,Wei Tao Huang,Qiu Yan Zhu,Xue Zhi Ding,Li Qiu Xia,Hong Qun Luo,Nian Bing Li
The most serious and yet unsolved problems of molecular logic computing consist in how to connect molecular events in complex systems into a usable device with specific functions and how to selectively control branchy logic processes from the cascading logic systems. This report demonstrates that a Boolean logic tree is utilized to organize and connect “plug and play” chemical events DNA, nanomaterials, organic dye, biomolecule, and denaturant for developing the dual-signal electrochemical evolution aptasensor system with good resettability for amplification detection of thrombin, controllable and selectable three-state logic computation, and keypad lock security operation. The aptasensor system combines the merits of DNA-functionalized nanoamplification architecture and simple dual-signal electroactive dye brilliant cresyl blue for sensitive and selective detection of thrombin with a wide linear response range of 0.02–100 nM and a detection limit of 1.92 pM. By using these aforementioned chemical events as inputs and the differential pulse voltammetry current changes at different voltages as dual outputs, a resettable three-input biomolecular keypad lock based on sequential logic is established. Moreover, the first example of controllable and selectable three-state molecular logic computation with active-high and active-low logic functions can be implemented and allows the output ports to assume a high impediment or nothing (Z) state in addition to the 0 and 1 logic levels, effectively controlling subsequent branchy logic computation processes. Our approach is helpful in developing the advanced controllable and selectable logic computing and sensing system in large-scale integration circuits for application in biomedical engineering, intelligent sensing, and control.
研究领域:
生物电化学
·
分子计算
·
生物传感器
·
纳米生物技术
·
生物医学工程
·
分析化学
·
逻辑电路
·
安全装置
✓ 已验证
DOI
高影响因子
Research
·
2025
·
IF 10.7
Jie Zhou,Jiao Yang Lu,Zhi Xin Xie,Dong Hua Wang,Bin Sheng He,Wei Tao Huang
Polymetallic nanomaterials have important development potential by integrating the properties and advantages of their components. However, their preparation paradigm urgently needs to be updated to make full use of their characteristics to realize their multifaceted applications. In this study, multifunctional trimetallic gold–silver–chromium nanocomposites (Au–Ag–Cr NCs) were successfully synthesized, and their polymetallic plasmonic absorption properties were used in a variety of applications, from multimode and multianalyte sensing, advanced arithmetic, and reversible logic to long-text information protection. Au–Ag–Cr NCs with Au or Ag nanoparticles anchored on Cr nanobelts were synthesized using Au–Cr nanoseeds, Ag + , ascorbic acid as the reductant, and sodium dodecylbenzenesulfonate as the stabilizer. The resulting Au–Ag–Cr NCs exhibited multichannel sensing ability for 2 analytes (Hg 2+ and hypochlorite), with remarkably improved selectivity and sensitivity when analyzing combined channels. Multiresponsiveness of Au–Ag–Cr NCs to diverse substance combinations underpins input–output mapping relationships, enabling advanced molecular logic computations (such as arithmetic and reversible logic). By digitizing its intrinsic sensing and response mechanisms, advanced molecular information protection (including encoding, encryption, and information concealment) for extended text were successfully implemented. This work not only offers novel insights into the design and multifunctionality of multicomponent nanocomposites but also paves the way for a new paradigm in molecular information technology that integrates sensing, logic processing, and information security.
研究领域:
纳米材料科学
·
传感器与传感技术
·
分子计算
·
信息安全
·
等离激元学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）