POLYMER
·
2015
·
IF 3.562
Xue Jiang,Chun Feng,Guolin Lu,Xiaoyu Huang
A homopolymer strategy was developed to synthesize temperature and pH/CO 2 stimulus-responsive homopolymers. A new class of acrylamide monomers bearing oligo(ethylene glycol) unit and N,N -diethylaminoethyl group were designed and prepared through Aza-Michael addition reaction followed by amidation with acryloyl chloride using amino group as a linkage to connect oligo(ethylene glycol), N,N -diethylaminoethyl, and polymerizable double bond groups together. Subsequently, the corresponding homopolymers containing oligo(ethylene glycol) unit and N,N -diethylaminoethyl group in each repeated unit were prepared via RAFT polymerization with controlled molecular weights and relatively narrow molecular weight distributions . The lower critical solution temperature (LCST) of homopolymer was examined to be influenced by molecular weight, salt concentration, and pH value of aqueous solution. The LCSTs of homopolymers could be tuned in a wide temperature window by changing pH value of aqueous solution and it increased with the decrease of pH value. Particularly, CO 2 gas as a unique pH stimulus can also reversibly adjust the solubility of homopolymer without the addition of acids or bases.
研究领域:
高分子化学
·
智能材料
·
药物递送
·
生物医用材料
·
刺激响应材料
✓ 已验证
DOI
高影响因子
Advanced Healthcare Materials
·
2024
·Vol. 13
·期 22
·2400439
·
IF 10
Lihao Zhang,Lehao Ren,Yufei Chen,Yue Cao,Sunlong Li,Weipeng Lu,Yaoyuan Jia,Yachun Li,Cihui Liu,Chen Li,Qian Dong
Soft-bodied aquatic organisms have exhibited remarkable capabilities in navigating and moving within liquid environments serving as a profound inspiration for the development of bionic robots with intricate movements. Traditional rigid components are being replaced by stimulus-responsive soft materials such as hydrogels and shape memory polymers, leading to the creation of dynamically responsive soft robots. In this study, the development of a bionic robot inspired by the shape of an octopus and the adsorptive properties of its tentacles, specifically tailored for targeted stimulation and pH sensing in the cervix, are presented. This approach involves the design of a soft, water-based Janus adhesive hydrogel patch that adheres to specific parts of the cervix and responds to pH changes through external stimuli. The hydrogel patch incorporates inverse opal microstructures mimicking the legs of an octopus, to facilitate efficient and stable locomotion, unidirectional transport of biofluids, and pH-responsive behavior. This miniature bionic robot showcases controlled adhesion and precise unidirectional fluid transport highlighting its potential for targeted stimulus response and pH sensing in the uterine cervical tract. This breakthrough opens new avenues for medical applications within the expanding field of soft-bodied robotics.
研究领域:
软体机器人
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生物医学工程
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刺激响应材料
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仿生学
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pH传感器
·
水凝胶技术
✓ 已验证
DOI
高影响因子
LANGMUIR
·
2016
·
IF 3.993
Yajie Wang,Pengyao Xing,Shangyang Li,Mingfang Ma,Minmin Yang,Yimeng Zhang,Bo Wang,Aiyou Hao
This paper reports an interesting type of self-assembly systems based on dynamic covalent bonds. The systems are pH-responsible and reversible, which could be utilized for controlling the morphology transformation of the assemblies. In alkaline conditions, the amine group of 11-aminoundecanoic acid (AUA) can connect with the aldehyde group of benzaldehyde (BA) or 1-naphthaledhyde (NA) by dynamic covalent bond to form a small organic building block accompanied by the morphological transformation from vesicles to fibers. When pH is lowered to a neutral value, the dynamic covalent bonds (imine bonds) can be hydrolyzed, leading to the dissociation of fibers and appearance of spherical aggregates. The transformation was confirmed reversible as fibers appeared again when the pH was changed back to alkaline value. In addition, a reversibly controlled gel was designed based on the nanofiber formation. NaCl, which is capable of greatly enhance the nanofiber density and cross-linking, was used to induce the growth of free-standing gel from free-flowing nanofiber system, and the resultant gel was proven to be pH-reversible.
研究领域:
超分子化学
·
材料科学
·
纳米技术
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刺激响应材料
·
软物质
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
·
2017
·Vol. 105
·期 9
·2451-2460
·
IF 3.076
Chu Gong,Meng Shan,Bingqiang Li,Guolin Wu
An injectable dual redox responsive diselenide-containing poly(ethylene glycol) (PEG) hydrogel was successfully developed by combining the conceptions of injectable hydrogels and dual redox responsive diselenides. In the first step, four-armed PEG was modified with N -hydroxysuccinimide (NHS)-activated esters and thereafter, crosslinked by selenocystamine crosslinkers to form injectable hydrogels via the rapid reaction between NHS-activated esters and amino groups. The cross-sectional morphology, mechanical properties, and crosslinking modes of hydrogels were well characterized via scanning electron microscope (SEM), rheological measurements, and Fourier transform infrared spectra, respectively. In addition, the oxidation- and reduction-responsive degradation behaviors of hydrogels were observed and analyzed. The model drug, rhodamine B, was encapsulated in the hydrogel. The drug-loaded hydrogel exhibited a dual redox responsive release profile, which was consistent with the degradation experiments. The results of all experiments indicated that the formulated injectable dual redox responsive diselenide-containing PEG hydrogel can have potential applications in various biomedical fields such as drug delivery and stimuli-responsive drug release. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2451–2460, 2017.
研究领域:
生物医学工程
·
药物递送
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高分子科学
·
刺激响应材料
·
组织工程
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Likai Hou,Zhongjun Liang,Xu Fan,Jian Yu,Fubing Bao
Many soft coiled actuators are mimic the desirable structures of plant tendril. Here, we present a facile microfluidic spinning method to fabricate self-coiling Janus microfiber actuator with tunable morphology, spontaneous coiling performance and reversible traction property. By adjusting the component of hydrogel Janus fiber in a microfluidic spinning device with theta-shaped channels, tens of hundreds of homogeneous coils can be spontaneously and rapidly generated due to asymmetric contraction upon dehydration process, and three different forms of coiled fibers with various screw diameters are presented. Furthermore, the coiled Janus microfiber with hygroscopic properties possesses a reversible coiling/uncoiling performance under humidity gradients, which can serve as a micro-actuator to lift a certain weight with enough tensile strain and long-range tractive displacement. In addition, local reversible coiling/uncoiling morphing is achieved under water contact and near infrared light optothermal stimulations. As a verification of this coiled microfiber actuator, a smart switch is designed to control different colored LED lights for sensing an ambient moisture content.
研究领域:
生物医学工程
·
软体机器人
·
功能高分子材料
·
微纳制造
·
生物传感器
·
刺激响应材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）