Yalan Wu,Shengjun Wu,Xin-an Huang,Qingping Zeng,Tao Deng,Fang Liu
Primaquine (PMQ), an important anti-malarial drug, has been recommended by the World Health Organization (WHO) for the treatment of life-threatening infections caused by P. vivax and ovale. However, PMQ has unwanted adverse effects that lead to acute hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. There is a need to develop simple and reliable methods for PMQ determination with the purpose of dosage monitoring. In early 2019, we have reported an UV-Vis and naked-eye based approach for PMQ colorimetric quantification. The detection was based on a Griess-like reaction between PMQ and anilines, which can generate colored azo products. The detection limit for direct measurement of PMQ in synthetic urine is in the nanomolar range. Moreover, this method has shown great potential for PMQ quantification from human serum samples at clinically relevant concentrations. In this protocol, we will describe the technical details regarding the syntheses and characterization of colored azo products, the reagent preparation, and the procedures for PMQ determination.
Solar ultraviolet (UV) radiation, a primary cause of skin cancer and erythema, poses irreversible risks to human health, underscoring the urgent need for advanced solar UV detector. Herein, we present a novel intrinsically flexible UVA detector featuring real-time monitoring, high performance and recyclability. This breakthrough is achieved through engineered oriented composite fabrics combining main-chain azobenzene-thermoplastic polyurethane elastomers (Az-TPU) with piezoelectric poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] nanogenerators. The molecular architecture employs azobenzene groups and 4,4′-methylene diphenyl diisocyanate (MDI) as hard segment, while polytetramethylene ether glycol (PTMG) forms the soft segment. The physical cross-linking network and homogeneous microphase-separated structure enables the fabrics to generate substantial internal stress, resulting in superior photoelectrical conversion capabilities. The device we report achieves an 80 ms response time and maintains excellent linear correlation (R 2 = 0.997) across a broad light intensity range (0.05–50 mW·cm −2 ). Remarkably, the fabric achieves dynamic UV light monitoring when subjected to a tensile strain of 10%. Integrated with Bluetooth communication, the device enables real-time data transmission to mobile devices for continuous UVA intensity and dose monitoring throughout daily sunlight exposure. With demonstrated capability for solar UVA measurement, this technology presents significant industrial potential for wearable solar UV monitoring systems.
危险品化学品经营许可证（带存储）