JOURNAL OF APPLIED POLYMER SCIENCE
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2014
·Vol. 132
·期 5
·
IF 1.64
Jinku Xu,Pengfei Yang,Leilei Zhang,Guanghua Huo
Transparent silicone hydrogels with interpenetrating hydrophilic/hydrophobic networks were simultaneously synthesized on the basis of the radical polymerization of the methacrylic monomer of 3-methacryloxypropyl tris(trimethylsiloxy) silane (TRIS)/ N,N -dimethylacrylamide (DMA) and the addition polymerization of hydroxyl-grafted polysiloxane (HPSO)/isophorone diisocyanate. The curing temperature was set at 80°C by a differential scanning calorimetry study. The polymerization process was studied by in situ Fourier transform infrared spectroscopy. The results indicate that the curing time was about 4.5 min, and the addition polymerization had a faster rate than radical polymerization. Then, the radical polymerization rate increased rapidly, and this led to instant curing. The interpenetrating polymer network (IPN) silicone hydrogels were characterized by swelling kinetics and dynamic mechanical thermal analysis. The results show that all of the hydrogels reached swelling equilibrium at about 4 h in water, and the IPN silicone hydrogels with a hydrophobic network of HPSO indicated a slower water transport than that of the copolymerization hydrogel of DMA and TRIS. The hydrophobic network was finely dispersed in the hydrophilic network, and the increasing hydrophobic network of HPSO decreased the glass-transition temperature of the IPN silicone hydrogels. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41399.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2013
·
IF 1.7
Jinku Xu,Leilei Zhang,Yongchun Zhang,Tianduo Li,Guanghua Huo
Hydrogels with interpenetrating network (IPN) can overcome thermodynamic incompatibility and obtain transparent materials with limited phase separation. In this report, hydroxyl-grafting polysiloxane (HPSO) was synthesized and transparent silicone hydrogels with interpenetrating network were simultaneously prepared based on radical polymerization of methacrylic monomer of 3-methacryloxypropyl tris(trimethylsiloxy)silane/N,N-dimethylacrylamide and addition polymerization of HPSO/isophorone diisocyanate. The silicone hydrogels were characterized by dehydration kinetics, tensile tester, light transmittance, ion permeability, oxygen permeability, and lysozyme deposition. The results show that increasing the proportion of hydrophobic network of HPSO in the IPN silicone hydrogel decreases equilibrium swelling ratio, ion permeability, Young’s modulus, and lysozyme deposition; on the contrary, increased tensile strength, elongation at break and oxygen permeability. Puerarin and ketoconazole were used as models to evaluate the drug loading and in vitro release behavior of the silicone hydrogels. It is revealed that the amount of loaded drugs in the hydrogel decreases with the increase of HPSO network in the hydrogels. All the silicone hydrogels exhibit extended release behavior, especially for ketoconazole, the in vitro release is divided into two phases corresponding to the rapid release at initial 24 h and relatively slow release from 125 to 360 h.
研究领域:
材料科学
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药剂学
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眼科学
✓ 已验证
DOI
高影响因子
POLYMER
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2015
·
IF 3.562
Miao-Miao Xun,Ya-Ping Xiao,Ji Zhang,Yan-Hong Liu,Qi Peng,Qian Guo,Wan-Xia Wu,Yong Xu,Xiao-Qi Yu
A series of polycationic gene delivery vectors were synthesized via Michael addition from low molecular weight PEI and linking compounds with various heteroatom compositions . Agarose gel electrophoresis results reveal that these polymers can well condense plasmid DNA and can protect DNA from degradation by nuclease. The formed polyplexes , which are stable toward serum, have uniform spherical nanoparticles with appropriate sizes around 200–350 nm and zeta-potentials about +40 mV. In vitro experiments show that these polymers have lower cytotoxicity and higher transfection efficiency than 25 KDa PEI. Furthermore, the title materials exhibit excellent serum tolerance. With the present of 10% serum, up to 19 times higher transfection efficiency than PEI was obtained, and no obvious decrease of TE was observed even the serum concentration was raised to >40%. Flow cytometry and confocal microscopy studies also demonstrate the good serum tolerance of the materials.
研究领域:
生物化学
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分子生物学
·
基因治疗
✓ 已验证
产品关联
DOI
高影响因子
DESIGNED MONOMERS AND POLYMERS
·
2017
·
IF 1.139
Miao Sun,Chunxiao Yin,Yanan Gu,Yun Li,Zhirong Xin
A series of tertiary amine-based hyperbranched poly(amine-ester)s have been synthesized by Michael addition polymerization of trifunctional monomer, TMEA and difunctional monomer, diacylates in chloroform, and the resultant polymers were subsequently treated with mercaptoethenol or 1-dodecanethiol for improving stability in storage. The caption efficiency of mercaptoethanol is much better than that of 1-dodecanthiol. Kinetic study reveals that the thiol group is consumed faster than the acrylate group when the polymerization with feed molar ratio of diacrylate/TMEA = 2/1 was carried out. At initial polymerization, monomer conversion increases fast, but the molecular weights increase slowly and sharp increase of the molecular weight occurs at the final polymerization. The hyperbranched polymers were well characterized by 1H NMR spectra and TD-SEC, and DBs of the polymers obtained are between 0.6 and 0.82, as well as the molar ratios of diacrylate/TMEA in the hyperbranched polymers are between 1.60 and 1.82. The fluorescence efficiency and quantum yields of HypET20, HypHT24 and HypDT24 has the following sequence: HypET20 > HypHT24 > HypDT24.
研究领域:
高分子化学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2021
·
IF 3.171
Xingzheng Liu,Chuanbo Fu,Manting Wang,Jiexin Wang,Haikui Zou,Yuan Le,Jianfeng Chen
Poly (ethylene glycol)-poly ( n -butyl cyanoacrylate) (PEG-PBCA) is a remarkable drug delivery carrier for permeating blood-brain barrier. In this work, a novel high-gravity procedure was reported to intensify Knoevenagel condensation-Michael addition polymerization of PEG-PBCA. A series of PEG-PBCA containing different block ratios were synthesized with narrow molecular weight distribution of polydispersity indexes less than 1.1. Furthermore, the reaction time reduced 60% compared to conventional stirred tank reactor process. Chemical structures of as-prepared polymers were characterized. In vitro drug delivery performance was evaluated. The cytotoxicity of PEG-PBCA to brain microvessel endothelial cells (BMVEC) decreases with the extension of the PEG chain and the shortening of the PBCA chain. The polymer cellular uptake to BMVECs was better after improving hydrophilicity by PEG block. Results of blood-brain barrier permeability demonstrated that medium length of PBCA chain and short PEG chain are favorable for hydrophobic Nile red permeation, while long PEG chain and short PBCA chain are beneficial to delivery water-soluble doxorubicin hydrochloride (Dox). The average apparent permeability coefficient increased 1.7 and 0.25 times than that of raw Nile red and Dox, respectively. High-gravity intensified condensation polymerization should have great potential in brain drug delivery system.
研究领域:
药剂学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
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2016
·Vol. 6
·期 27
·22908-22916
·
IF 3.289
Jianwen Tian,Xiaohui He,Jingyin Liu,Xiaodan Deng,Defu Chen
Palladium(II) and copper(II) chloride complexes bearing bulky 9,10-dihydro-9,10-ethanoanthracene-11,12-diimine ligands were synthesized and sufficiently characterized by elemental and spectroscopic analysis along with X-ray diffraction analysis. The X-ray diffraction demonstrated that palladium(II) complexes (C1–C2) and copper(II) complexes (C3–C4) were four-coordinated. All these complexes displayed catalytic activities up to 105 gpolymer molMt−1 h−1 for norbornene vinyl-addition polymerization on treatment with excess methylaluminoxane (MAO). The parameters of the reaction conditions, the type of metals and steric effects of coordinative ligands had influences on the catalytic properties. C2 was selected as a catalyst precursor for the copolymerization of norbornene (NB) with 2-butyloxymethylene norbornene (BN), which exhibited catalytic activities up to 1.1 × 105 gpolymer molPd−1 h−1 and produced copolymers with relatively high molecular weights. The fraction of BN in the copolymer could reach up to 9.8–62.1% by controlling the monomer feed ratio range from 10–80%. The achieved vinyl-addition type poly(NB-co-BN) displayed high thermal stability and was soluble in common organic solvents, such as CHCl3 and THF.
研究领域:
高分子化学
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配位化学
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催化化学
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有机金属化学
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功能高分子材料
✓ 已验证
DOI
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
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2016
·
IF 0.963
Rongpeng Liu,Bing Zhang,Liqiang Wan,Farong Huang,Lei Du
The kinetics for the reaction of diazide (4,4′-biphenyl dibenzyl azide) and diyne (dipropargyl bisphenol A) catalyzed by CuBr-PMDETA (N, N, N′, N″, N″-pentamethyldiethylenetriamine) was studied in this paper by means of nuclear magnetic resonance spectra (1H-NMR) and differential scanning calorimetry (DSC). 1H-NMR was carried out to analyze solution polymerizations under different CuBr-PMDETA ratios in DMSO-d6. The results showed that CuBr-PMDETA catalytic system was easy to be oxidation under ambient condition. However, different CuBr-PMDETA ratios influenced the catalytic efficiency and the optimal ratios were found in nitrogen gas. DSC was carried out to analyze bulk polymerizations. The results showed that the apparent activation energy (Eα) calculated by Kissinger's method was 69.2 kJ/mol, which was confirmed by Friedman's method. The two tests indicated that the catalyzed polymerization of diazide and diyne was a second order reaction.
研究领域:
高分子化学
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有机化学
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材料科学
·
化学动力学
✓ 已验证
DOI
高影响因子
MACROMOLECULES
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2023
·
IF 5.5
Dianyu Dong,Yuzhang Zhu,Wangxi Fang,Jian Jin
Ultrathin membranes by interfacial polymerization can efficiently purify high-salinity water, but the variety beyond classic polyamide is limited yet. Based on the modular and rapid feature of click chemistry, this work for the first time reports a “clickable” IP strategy to prepare polythioether ultrathin membranes for ion separation. Multiple sets of multifunctional thiol and alkene/alkyne monomers are proven to react at the water–oil interface via thiol–ene/yne addition polymerization. In particular, triallyl cyanurate-DL-dithiothreitol and triallyl isocyanurate-DL-dithiothreitol ultrathin membranes prepared on polyether sulfone substrates reach the separation accuracy of nanofiltration with rejections to Na2SO4 of over 95%. Their surfaces remain negatively charged in both acidic and alkaline environments, and thioether linkages even stand the challenge of long-term acid treatment with high concentration. This strategy would thus motivate growing attempts at developing new-type ultrathin membranes for ion removal or desalination.
研究领域:
材料科学
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化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2021
·
IF 3.171
Xionghui Liu,Jianfeng Du,Yu Ye,Yuchuan Liu,Shun Wang,Xianyu Meng,Xiaowei Song,Zhiqiang Liang,Wenfu Yan
Nitrogen-rich porous organic polymers have shown great potentials in gas adsorption/separation, photocatalysis , electrochemistry, sensing and so on. Herein, 1,2,3-triazole functionalized triazine-based porous organic polymers (TT-POPs) have been synthesized by the copper-catalyzed azide-alkyne cycloaddition (Cu-AAC) polymerization reactions of 1,3,5-tris(4-azidophenyl)-triazine with 1,4-diacetylene benzene and 1,3,5-triacetylenebenzene, respectively. The characterizations of N 2 adsorption at 77 K show TT-POPs possess permanent porosity with BET surface areas of 666 m 2 ·g −1 (TT-POP-1) and 406 m 2 ·g −1 (TT-POP-2). The adsorption capacities of TT-POPs for CO 2 , CH 4 , C 2 H 2 and C 2 H 4 , as well as the selective separation abilities of CO 2 /N 2 , CO 2 /CH 4 , C 2 H 2 /CH 4 and C 2 H 4 /CH 4 were evaluated. The gas selective separation ratio of TT-POPs was calculated by the ideal adsorbed solution theory (IAST) method, wherein the selective separation ratios of C 2 H 2 /CH 4 and C 2 H 4 /CH 4 of TT-POP-2 was 48.4 and 13.6 (298 K, 0.1 MPa), which is comparable to other adsorbents (5.6–120.6 for C 2 H 2 /CH 4 , 10–26 for C 2 H 4 /CH 4 ). This work shows that the 1,2,3-triazole functionalized triazine-based porous organic polymer has a good application prospect in natural gas purification.
研究领域:
材料科学
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化学工程
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环境科学
✓ 已验证
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2021
·Vol. 32
·期 9
·3495-3504
·
IF 3.665
Kun Cong,Jiyu He,Rongjie Yang
TPU and flame-retardant TPU (FR-TPU) were prepared through a polyaddition reaction with polytetramethylene ether glycol (PTMEG) and 4,4′-methylene-bisphenyl-isocyanate (MDI) by reactive extruding. 1,4-Butanediol (BDO) and diethyl bis(2-hydroxyethyl) amino methyl phosphonate (DBAMP) were used as the chain extender in different ratios, respectively, to obtain TPU and flame-retardant TPU (FR-TPU)with adjusted molecular weight and mechanical properties. The resulting TPU and FR-TPU were characterized by FTIR, DSC, TGA, and NMR. A kinetic model based on the data from extrusion process was used to depict the polymerization of TPU. These reactions carried out without any solvent and the residual water showed that the polymerization with BDO could be achieved in 20 minutes, instead, that with DBAMP in 55 minutes while with a similar molecular weight. These results point out that Twin Screw Extrusion Reaction (TSER) is a suitable and convenient way to produce a variety of polymers.
研究领域:
材料科学
·
高分子化学
·
化学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）