METABOLIC ENGINEERING
·
2025
·
IF 6.8
Shan Yuan,Chao Xu,Miaomiao Jin,Xinglin Jiang,Wei Liu,Mo Xian,Ping Jin
Aldehydes are ubiquitous metabolites in living cells. As reactive electrophiles, they have the capacity to form adducts with cellular protein thiols and amines, leading to potential toxicity. Dynamic regulation has proven to be an effective strategy for addressing the accumulation of toxic metabolites. However, there are limited reports on applying dynamic control specifically to mitigate aldehyde accumulation. In this study, the cinnamaldehyde accumulation in the biosynthesis of cinnamylamine was used as a model to evaluate a two-way dynamic regulation strategy. First, we utilized whole-genome transcript arrays to identify the cinnamaldehyde-responsive promoters: the upregulated promoter P 4 and the downregulated promoter P d . They were then employed as biosensors to dynamically regulate the synthesis and consumption of cinnamaldehyde, mitigating its toxic effects on the host. This strategy successfully reduced cinnamaldehyde accumulation by 50% and increased the production of cinnamylamine by 2.9 times. This study demonstrated a cinnamaldehyde-induced autoregulatory system that facilitated the conversion of cinnamic acid into cinnamylamine without the need for costly external inducers, presenting a promising and economically viable approach. The strategy also serves as a reference for alleviating the inhibitory effects of other toxic aldehydes on microorganisms. Additionally, the biosensors (P d and P 4 ) can respond to a range of aldehyde compounds, offering a rapid and sensitive method for detecting toxic aldehydes in both environmental samples and microorganisms, thus provide a valuable tool for screening strains enhanced aldehyde yield.
研究领域:
合成生物学
·
代谢工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBON
·
2025
·
IF 11.6
Yun Tang,Xuhui Wang,Yalou Xin,Xiaohu Ren,Hudie Yuan,Xianhu Liu,Qiang Chen
Multi-functional electromagnetic wave (EMW) absorption materials are in high demand in the ever-changing application environment of the 5G era. Hydrogels, characterized by their exceptional flexibility, stretchability, and water-induced polarization loss, represent promising candidates for developing multi-functional EMW absorption materials. However, their practical applications are significantly hindered by the single EMW loss mechanism and water evaporation issues. Additionally, the potential for dynamic absorption tunability in hydrogel-based absorbers has yet to be explored. To address these challenges, we developed a multi-functional hydrogel by incorporating graphene oxide (GO) and Fe 3 O 4 into a copolymer network. The oxygen-containing groups on GO interact with water, effectively reducing its polarity and optimizing polarization loss, while the incorporation of Fe 3 O 4 significantly enhances magnetic loss. Consequently, the GO/Fe 3 O 4 hydrogel achieves a minimum reflection loss of −62.97 dB at 10.9 GHz, with an effective absorption bandwidth of 5.89 GHz. Beyond its excellent stretchability (770 %) and strong adhesion to various substrates, the hydrogel also demonstrates self-healing ability under room temperature or photothermal response. Furthermore, surface modification with PDMS enhances its water retention and self-cleaning abilities. Notably, the PDMS-modified GO/Fe 3 O 4 hydrogel possesses the capability to dynamically adjust its absorption frequency by tensile strain, with the maximum adjustable frequency reaching 87 % of the measured band. This study presents a feasible method for developing high-efficiency, multi-functional EMW absorption materials.
研究领域:
材料科学
·
电磁学
✓ 已验证
产品关联
DOI
高影响因子
ENERGY AND BUILDINGS
·
2024
·
IF 6.6
Xuemei Zhang,Jianjuan Yuan,Yue Han,Xiangfei Kong
The huge heat loss/gain through windows is the reason for a large amount of energy consumption in buildings. Although using the heat storage capacity of phase change material (PCM) to improve the thermal inertia of windows is an important way to reduce energy consumption, leakage and overheating at noon limit the development of windows containing solid–liquid PCM. Smart windows based on temperature-sensitive hydrogel have aroused great interest due to their excellent ability to dynamically control solar energy. However, current temperature-sensitive hydrogels with single transition temperature and uncontrollable transition speed affect indoor light comfort. Meanwhile, the low heat storage performance of hydrogels limited their energy-saving effect. Therefore, a novel smart window (P3H6) integrating temperature sensitivity and energy storage was constructed by the prepared hydrogel and form-stable PCM. The double-network hydrogel with adjustable temperature band and mechanical enhancement was constructed by acrylamide and N-isopropylacrylamide, which realized the dynamic adjustment of solar energy. The prepared form-stable PCM avoided the leakage problem and improved the heat storage capacity of the window. The comprehensive transmittance of P3H6 can be changed between 3.3 %-62.7 %-2.6 % in a day, which blocked the sunlight from transmitting heat at noon and protected privacy at night. The outdoor experiments showed that P3H6 delayed the inner surface temperature of the window to 32 °C by 1.05 h compared with traditional windows, which reduced the thermal radiation of windows to the room and improved the thermal comfort of indoor personnel. More importantly, the application of P3H6 can reduce the daytime cooling load of buildings by 28.84 %. To sum up, the proposed smart window shows great potential in energy-saving buildings.
研究领域:
材料科学
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能源工程
·
建筑技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Haitang Yang,Yun Tan,Yanwei Zhang,Yihang Xiong,Gaosheng Nie,Heng Luo,Pei He,Junliang Yang,Xiangguo Zhao,Jinchao Tong,Yi Zhang
Maintaining the dynamical microwave synchronization between a target and its background is the key to electromagnetical invisibility in real environment. Herein, we introduce an archetypical paradigm for ultraelastic films of graphene-functionalized ionic gel with tunable microwave-absorbing behaviors. Inspired by the local structural changes during the wing-spreading process of vespertilionids, the experimental and finite element simulations have revealed that proper shape changing of 3D wrinkled structure containing ridge walls with moderate impedance is the effective way to minimize reflected wave and promote energy attenuation. An optimal RL value of −43.6 dB and valid regulatory amplitude of 41.5 dB, covering a microwave-absorbing to shielding state, could be reached with only 0.2% weight fraction of the active ingredient RGO filler. The significant regulatory performance is attributed to the competitive effect between intrinsic dielectric attenuation of silicon nitride modified reduced graphene oxide (RGO-SiN), multiscattering of a 3D wrinkled structure, and evolution of the oriented RGO-SiN.
研究领域:
材料科学
·
电磁学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LAB ON A CHIP
·
2020
·Vol. 20
·期 7
·1227-1237
·
IF 6.774
Chang Chen,Dong Xu,Siwei Bai,Zhihang Yu,Yonggang Zhu,Xiao Xing,Huaying Chen
Inoculation of single cells into separate culture chambers is one of the key requirements in single-cell analysis. This paper reports an innovative microfluidic chip integrating two pneumatic microvalves to screen and print single cells onto a well plate. The upper and lower size limits of cells can be dynamically controlled by regulating the deformation of two adjacent microvalves. Numerical simulations were employed to systematically study the influence of membrane dimensions and pressure on the deflection of a valve. A mathematical model was then modified to predict the size of cells captured by a microvalve at various pressures. The membrane deflection was further studied using confocal imaging. The critical pressure trapping beads of various sizes was experimentally determined. These experiments validated the accuracy of both numerical simulations and the mathematical model. Furthermore, single beads and endothelial cells with the desired size range were screened using dual valves and printed onto well plates with 100% efficiency. Viability studies suggested that the screening process had no significant impact on cells. This device enables dynamic regulation of both the lower and the upper size limits of cells for printing. It has significant application potential in inoculating cells with desired sizes for various fields such as clonal expansion, monoclonality development and single-cell genomic studies.
研究领域:
生物工程
·
细胞生物学
·
微流体技术
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产品关联
DOI
PubMed
高影响因子
Energy & Environmental Materials
·
2022
·Vol. 6
·期 3
·e12353
·
IF 13.443
Boqiu Luo,Jin Wen,Hao Wang,Size Zheng,Rui Liao,Wenjing Chen,Omid Mahian,Xiaoke Li
Solar-driven hydrogel evaporator used for water purification demonstrates great potential in seawater desalination and domestic sewage treatment. However, much uncertainty still exists about the most efficient design to obtain cost-effective drinkable water. In this paper, a natural rich biomass Nicandra physalodes (Linn.) Gaertn. polysaccharide was introduced into the polyvinyl alcohol network to control the water distribution during evaporation and build a low-cost hybrid hydrogel solar evaporator with a total material cost of $7.95 m −2 . The mixed evaporator works stably in a long-span acid–base range (pH 1–14) and salinity range (0–320 g kg −1 ). Its daily water purification capacity can reach 24.4 kg m −2 with a water purification capacity of 3.51 kg m −2 h −1 under sunlight. This paper provides a new possibility for a highly efficient and cost-effective water desalination system with guaranteed water quality by focusing on the dynamic regulation of water molecules at the evaporation interface.
研究领域:
材料科学
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环境科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Weiting Huang,Jueying Yang,Chunlei Long,Jingjing Yuan,Lizhi Lin,Yang Lv,Lijie Li,Yu Chen
κ-Carrageenan (KC) hydrogels are processed from a natural polysaccharide with abundant sources, simple preparation, and superior biocompatibility, which are widely used in the food industry and biomedical applications. Due to fixed water content and loose structure, KC hydrogels crosslinked by hydrogen bonding exhibit inflexible and inferior mechanical properties that considerably restrict their application potential. This study presents a comprehensive investigation of the Hofmeister effect for dynamically modulating KC hydrogels, combining multi-scale mechanistic analysis with versatile applications. The mechanical strength of KC hydrogels was reversibly tuned from 0 to 444 kPa and the hydrogel volume swelling ratio was varied from 0.7 to 1.3 times the original volume. Through a series of characterizations and molecular dynamics simulations, we elucidate the underlying mechanisms via three complementary perspectives: aggregation behavior of molecular chains, microstructural anisotropy, and molecular-level hydrogen bonding interactions. The Hofmeister effect confers dynamic shape tunability properties, regulable volume properties, and adjustable mechanical properties on KC hydrogel, positioning it as a potential shape-regulation material and also rendering it a suitable solution sieve and a probe to measure softness and hardness. The exploration of the Hofmeister effect on KC hydrogels establishes a generalizable framework for understanding Hofmeister effects in natural polymer hydrogels while significantly expanding their potential in intelligent materials.
研究领域:
材料科学
·
生物医学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Materials Technologies
·
2022
·Vol. 7
·期 7
·2101381
·
IF 8.856
Gaoping Xu,Bo Wang,Shanshan Song,Zichen Ren,Dongqi Liu,Leipeng Zhang,Yao Li
There is a need to develop next generation devices for dual-dynamic regulation of thermal radiation and electromagnetic interference (EMI) shielding to allow the precise operation of electronic components. Here, a novel, stretchable, and self-healing electrochromic device with unprecedented dynamic tunability of thermal emittance and electromagnetic interference is developed, which exhibits the thermal emittance modulation (Δε) of 0.37 and 0.43 at 8–14 µm under different voltages and strains, respectively. Additionally, by tuning the strain, the device can achieve the change of EMI shielding efficiency (SE) of 16.1 dB due to the increase of the transmittance for electromagnetic wave between the interleaving of the fibers. Moreover, the device exhibits outstanding mechanical stability (98.7% retention of Δε at 8–14 µm and 97.7% retention of EMI SE after bending for 300 cycles), a remarkable stretching stability (99.2% retention of Δε at 8–14 µm and 98.2% retention of EMI SE after stretching for 50 cycles) and the self-healing performance (99.8% retention of Δε at 8–14 µm and 99.6% retention of EMI SE after the self-healing). These results indicate that the device have excellent tunability for EMI shielding and thermal management in communication, military, and smart electronics.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Zhen Meng,Dongqing Liu,Shiqi Xing,Yongqiang Pang,Yan Jia,Mingyang Li,Mei Zu,Zi Wang,Tianwen Liu,Haifeng Cheng
Tunable microwave absorbers have gained significant interest due to their capability to actively control microwaves. However, the existing architecture-change-based approach lacks flexibility, and the active-element-based approach is constrained by a narrowband operation or small dynamic modulation range. Here, a novel electrically tunable microwave absorbing device (TMAD) is demonstrated that can achieve dynamic tuning of the average reflection amplitude between −13.0 and −1.2 dB over a broadband range of 8–18 GHz enabled by reversible metal electrodeposition. This reversible tunability is achieved by electrodepositing silver (Ag) layers with controlled morphology on nanoscopic platinum (Pt) films in a device structure similar to a tunable Salisbury screen, employing Ag electrodeposited on Pt films as the modifiable resistive layer. Furthermore, this TMAD possesses a simple device architecture, excellent bistability, and multispectral compatibility. Our approach offers a new strategy for dynamically manipulating microwaves, which has potential utility in intelligent camouflage and communication systems.
研究领域:
材料科学
·
电磁学
·
通信工程
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·
IF 19
Hulin Zhang,Xiang Zhang,Wenhai Sun,Mingjun Chen,Yingjun Xiao,Zhenmin Ding,Dukang Yan,Jianbo Deng,Zitong Li,Jiupeng Zhao,Yao Li
Smart windows that incorporate photothermal modulators (PMs) can independently regulate solar transmittance and infrared (IR) emissivity to improve building comfort and reduce energy consumption. Herein, a novel all-solid-state variable IR emissivity device (VED) is first designed and fabricated with a high visible irradiation transmittance ( T ′ vis = 0.79) and solar irradiation transmittance ( T ′ sol = 0.75) using an ITO/SiO 2 /ITO Fabry–Perot cavity structure. The VED exhibits different IR emissivity (ɛ) values at positive (ɛ P = 0.80) and negative (ɛ N = 0.38) bias, allowing for dynamic regulation of radiation by controlling the electrical conductivity of the indium tin oxide (ITO) layer. Furthermore, an all-solid-state PM with a structure of ITO/SiO 2 /ITO/Glass/ITO/NiO/ZrO 2 /Li/WO 3 /ITO, which is capable of independently regulating solar transmittance (Δ T' sol = 0.31) and IR emissivity (Δɛ 2.5–25 µm = 0.42), is fabricated. The multi-mode smart window incorporating PMs can achieve “bright,” “dark,” “warm,” and “cool” modes, making them suitable for deployment in diverse climate zones. The innovative smart window holds a massive potential for use in reducing building energy consumption.
研究领域:
材料科学
·
能源技术
·
建筑环境工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2017
·
IF 4.233
Huilin Li,Dandan Men,Yiqiang Sun,Dilong Liu,Xinyang Li,Liangbin Li,Cuncheng Li,Weiping Cai,Yue Li
We developed an interesting route for preparing a poly (acrylamide- co -acrylic acid) (P(AAm- co -AA)) hydrogel microsphere with a coating of Au nanospheres (hydrogel microsphere @ Au nanospheres) through self-assembly based on electrostatic interaction. The fabricated composites could be used as highly sensitive enhanced Raman scattering substrates. The nanogaps between adjacent Au nanospheres were dynamically tuned by volume changes in the hydrogel microspheres in the semiwet state under different pH conditions. At pH 6, the hydrogel microsphere @ Au nanospheres demonstrated highly sensitive SERS with an enhancement factor of 10 9 . The product could detect very low concentrations of analytes up to 10 −12 M 4-aminothiophenol (4-ATP) molecules. This paper proposes a new method for detecting trace amounts of environmental organic pollutants by dynamically tuning the SERS enhancement in the semiwet testing state.
研究领域:
纳米材料科学
·
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Yu Wang,Wei Wei,Kai Qu,Yulin Shi,Li Li,Xuhong Guo,Yanfeng Gao
The development of a green and environmentally friendly window system is always the upmost target among other requirements for modern buildings. Here, a smart window with a dynamic regulation mode was fabricated by integrating a functional layer of natural polymer thermoresponse starch (TRS) and a joule heating film (JHF) of highly transparent silver nanowires (AgNWs)/cellulose. With cellulose, the mismatch of refractive index between air and AgNWs was significantly overcame, resulting in a JHF with high visible transmittance. The excellent joule heating performance of the JHF endowed the smart window system with a dynamic regulation mode driven by a low input of voltage (5.0 V) and increased energy efficiency. This smart window displayed excellent solar modulation property of 17.9% with high average luminous transmittance of 57.8%, representing a remarkable pavement for a new type of smart window.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）