JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Xinmei Sha,Yidan Zhang,Yue Li,Runxuan Chen,Haotong Zhang,Demei Meng,Hai Chen,Rui Yang
Ferritin is a cage-like protein with modifiable outer and inner surfaces. To functionalize ferritin with preferable carrier applications, caffeic acid was first covalently bound to the soybean ferritin outer surface to fabricate a caffeic acid–ferritin complex (CFRT) by alkali treatment (pH 9.0). A decreased content of free amino acid (0.34 μmol/mg) and increased polyphenol binding equivalent (63.76 nmol/mg) indicated the formation of CFRT (ferritin/caffeic acid, 1:80). Fluorescence and infrared spectra verified the binding of caffeic acids to the ferritin structure. DSC indicated that the covalent modification enhanced the thermal stability of CFRT. Besides, CFRT maintained the typically spherical shape of ferritin (12 nm) and a hydration radius of 7.58 nm. Moreover, the bioactive colorant betanin was encapsulated in CFRT to form betanin-loaded CFRT (CFRTB), with an encapsulation rate of 15.5% (w/w). The betanin stabilities in CFRTB were significantly improved after heat, light, and Fe3+ treatments, and its red color retention was enhanced relative to the free betanin. This study delves into the modifiable ferritin application as nanocarriers of dual molecules and gives guidelines for betanin as a food colorant.
研究领域:
纳米技术
·
生物技术
·
食品科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Lingyu Han,Ruiyi Zhai,Bing Hu,Peter A. Williams,Jixin Yang,Cunzhi Zhang,Nuo Dong,Tingting Li
Micelles are nano-architectured structures capable of encapsulating hydrophobic substances in aqueous solutions, thereby improving their stability, solubility, and bioavailability to control the release of bioactive compounds. In this study, the sodium alginate backbone was modified via a hydrophobic modification scheme where octyl chains were covalently attached to the alginate chains via esterification reactions. Fourier-transformed infrared spectrometry (FTIR), 1 H nuclear magnetic resonance ( 1 H NMR), X-ray diffraction (XRD), and thermal gravimetric analysis (TGA) were used to characterize the structure of the sodium alginate derivatives of varying molar mass (ALG-C8). Fluorescence spectroscopy, surface tension measurements, and dynamic light scattering (DLS) were employed to assess the self-assembly performance of ALG-C8. The three methods produced consistent results, indicating that self-assembly decreased with higher molar mass. The self-assembled ALG-C8 micelles were utilized to encapsulate fucoxanthin. The loading capacity (LC) and encapsulation efficiency (EE) were determined using UV–Vis spectrophotometry. The molar mass of ALG-C8 has a key influence on fucoxanthin loading and release behavior. The ALG-C8 molecules with the lowest molar mass produced micelles with the smallest hydration diameter, resulting in the highest LC and EE. Furthermore, the release of fucoxanthin is significantly influenced by the pH and ionic strength of the medium. ALG-C8 micellar-like aggregates exhibit resistance to low pH and high ionic strength environments, releasing encapsulated material at the target site under alkaline conditions. Therefore, synthesized ALG-C8 is a potential candidate for preparing pH-responsive self-assembled micellar-like aggregates, enabling targeted delivery and gradual release of hydrophobic functional food components.
研究领域:
材料科学
·
药学
·
食品科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2024
·
IF 2.3
Xuena Zhang,Xuehan Wang,Juan Xu,Ting Wang
Drospirenone (DROP) is a highly effective, low-toxicity, safe new generation progestin that counteracts estrogen-related sodium retention, is well tolerated, and has a positive effect on premenstrual syndrome (PMS). However, the low water solubility of DROP and its chemical instability resulted in low bioavailability. In this study, we developed a two-step delivery system to enhance drospirenone’s solubility and stability. We prepared a drospirenone liposome complex to optimize the encapsulation process and achieve an encapsulation efficiency of (84.9 ± 0.73) %, with an 878-fold increase in solubility under optimal conditions. To address the instability of high drug-loading liposomes, we immobilized the drospirenone liposome inclusion complex using a cellulose-based hydrogel. The system achieved uniform loading of liposomes in the hydrogel, as confirmed by SEM and FTIR analysis. 0.5 g hydrogel can be loaded with up to 96.48 mg drospirenone, and the encapsulation efficiency is (80.4 ± 1.17%). It was indicating the potential for wider application of drospirenone with enhanced water solubility and improved stability. At the same time, it also provides support for sustained-release systems or large dose drug delivery.
研究领域:
药剂学
·
药物递送系统
✓ 已验证
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2017
·
IF 4.159
Hong Wang,Guangxing Zhang,Xueqin Ma,Yanhua Liu,Jun Feng,Kinam Park,Wenping Wang
Poly (lactide-co-glycolide) (PLGA) microparticles are widely used for controlled drug delivery. Emulsion methods have been commonly used for preparation of PLGA microparticles, but they usually result in low loading capacity, especially for drugs with poor solubility in organic solvents . In the present study, the nanocrystal technology and a water-soluble polymer template method were used to fabricate nanocrystal-loaded microparticles with improved drug loading and encapsulation efficiency for prolonged delivery of breviscapine . Breviscapine nanocrystals were prepared using a precipitation-ultrasonication method and further loaded into PLGA microparticles by casting in a mold from a water-soluble polymer. The obtained disc-like particles were then characterized and compared with the spherical particles prepared by an emulsion-solvent evaporation method. X-ray powder diffraction (XRPD) and confocal laser scanning microscopy (CLSM) analysis confirmed a highly-dispersed state of breviscapine inside the microparticles. The drug form, loading percentage and fabrication techniques significantly affected the loading capacity and efficiency of breviscapine in PLGA microparticles, and their release performance as well. Drug loading was increased from 2.4% up to 15.3% when both nanocrystal and template methods were applied, and encapsulation efficiency increased from 48.5% to 91.9%. But loading efficiency was reduced as the drug loading was increased. All microparticles showed an initial burst release, and then a slow release period of 28 days followed by an erosion-accelerated release phase, which provides a sustained delivery of breviscapine over a month. A relatively stable serum drug level for more than 30 days was observed after intramuscular injection of microparticles in rats. Therefore, PLGA microparticles loaded with nanocrystals of poorly soluble drugs provided a promising approach for long-term therapeutic products characterized with preferable in vitro and in vivo performance.
研究领域:
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 26
·15762-15768
·
IF 3.108
Zideng Gao,Long Pang,Haojie Feng,Shunyi Wang,Qiuyun Wang,Mengyao Wang,Yining Xia,Shuwen Hu
Encapsulation of pesticides with polymeric materials is a promising approach to improve the efficacy of pesticide application and reduce the potential risks of pesticides to the environment and humans. In this study, a novel imidacloprid microcapsule was prepared by depositing a polydopamine (PDA) layer on imidacloprid via oxidative self-polymerization followed by a polyurea (PU) layer on PDA via copolymerization. No organic solvent or surfactant was used in the preparation process. The entrapment rate of imidacloprid was determined to be 47.28 ± 0.87%, and the pesticide loading of microcapsule was 68.36 ± 1.13%. Several characterization assays, such as Fourier infrared transform analysis, thermogravimetric analysis and contact angle analysis, were conducted to confirm the encapsulation of imidacloprid. Dynamic light scattering showed that the microcapsule size ranged from hundreds of nm to several μm, which was similar to the results obtained by scanning electron microscopy. The microcapsule had a stable dispersion up to one month in the aqueous solution. Moreover, the microcapsule was able to release imidacloprid in a sustainable manner, as the release was much slower than the non-encapsulated imidacloprid.
研究领域:
农业化学
·
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Feng Cao,Meiyu Zheng,Wenjuan Zhang,Yangguang Wang,Shengmin Lu
Naringin (NR) has the drawbacks of poor water solubility and low bioavailability, which restricts its applications. The NR-loaded pectin-alginate nanoparticles (PANPs) were prepared by the ion gel method. When the complex polysaccharide concentration, mass ratio of pectin to sodium alginate , molar concentration of CaCl 2 and NR addition were 1 %, 2:1, 0.03 mol/L and 5 mg/mL, respectively, the encapsulation efficiency of PANPs to NR was highest with a value of 79.23 %. Furthermore, multi-factor stability investigation revealed that the NR-loaded PANPs suspension was stable at pH 3–8, NaCl concentration of less than 400 mmol/L, and temperature of less than 75 °C. The NR-loaded PANPs suspension maintained good stability during a storage period of 30 days, and the retention rate of PANPs to NR was as high as 82.51 % at the 30th day, indicating that PANPs had a positive protective role on NR over a longer storage period. The findings might provide a theoretical basis and practical guidance for further exploiting naringin as a functional food ingredient using composite hydrogel encapsulation.
研究领域:
食品科学
·
材料科学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Lei Chen,Die Zhang,Ling-Feng Wei,Wei-Jia Zhu,Xiao-Qin Yan,Rui Zhou,Zia-ud Din,Wen-Ping Ding,Tie-Zheng Ma,Jie Cai
We report a self-assembly method for the fabrication of multilayer-starch-based microgels used for anthocyanin encapsulation. Alcohol-heating treatment and ionization reactions were employed to reduce the crystallinity of starch and introduce ionic groups on the molecule to further cross-link it with sodium trimetaphosphate and produce a starch microgel. The molecular interactions between the starch and the anthocyanins facilitated the anthocyanin encapsulation and the starch-microgel/anthocyanin complexes with one, two, and three self-assembled layers were obtained. The Lay-1 microgel exhibited an encapsulation efficiency of 50.1% when the anthocyanin concentration, cross-linking starch concentration, contact time, and temperature were 0.25 mg/mL, 1.5 mg/mL, 3 h, and 40 °C, respectively. An increase in the number of layers resulted in a more compact microgel structure with the zeta potential presenting variations upon structural changes. Furthermore, the encapsulated anthocyanins presented a slow release from Lay-1, while the multilayered microgels (Lay-2 and Lay-3) displayed outstanding encapsulation stability. This study gives an insight on the encapsulation and release of anthocyanins by starch microgels, and provides a novel strategy for the design of starch-based encapsulation materials presenting great stability.
研究领域:
材料科学
·
食品科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Ziman Hu,Songnan Li,Shaokang Wang,Bin Zhang,Qiang Huang
Cyclodextrin (CD)-metal-organic frameworks (MOFs) are developed as a new type of food-acceptable multi-porous material, which shows a great potential for controlled volatile compound release. This study aimed to synthesize CD-MOFs from potassium nitrate, crystallized with α-cyclodextrin (α-CD), β-CD or γ-CD, and their complex capacities were further evaluated using menthol encapsulation. Compared with CD , all the CD-MOFs had highly ordered crystal structures and more regular shapes. β-CD-MOF showed better thermal stability, with an initial thermal degradation temperature of 253 °C, higher than the other two CD-MOFs. The CD-MOFs were used for menthol encapsulation and the resulting menthol concentration within the inclusion complexes (ICs) was determined. The menthol concentration in ICs followed the order: β-CD-MOF > β-CD > γ-CD-MOF > γ-CD > α-CD ≥ α-CD-MOF. The menthol content and encapsulation efficiency of β-CD-MOF were 21.76% (w/w) and 22.54% (w/w) respectively, significantly higher than those of other reported solid materials, such as amylose, CD and V-type starch.
研究领域:
材料科学
·
化学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2018
·
IF 5.089
Mingyu Ji,Xinyu Sun,Xiaoban Guo,Wenjin Zhu,Jiulin Wu,Li Chen,Jianhua Wang,Mingmao Chen,Cui Cheng,Qiqing Zhang
As a natural preservative, cinnamaldehyde (CA) has a bright application prospect. However, CA is sensitive to light and can be easily oxidized. What's more, its water solubility is poor. These properties greatly limit its application. In this study, CA/sodium alginate (SA)/chitosan (CS) nanoparticles (CA/SA/CS NPs) were prepared by using SA and CS as wall materials, and CA as core material. The single factor experiment showed that the optimal CA/SA/CS NPs can be obtained when the mass ratio of SA to CS was 5.5/1, SA to CaCl 2 was 5/1, SA to CA was 1/2, and the pH of CS solution was 5.0. Under this condition, the average size of the prepared nanoparticles was 455.2 nm, polymer dispersity index (PDI) value was 0.189, zeta potential was −40.8 mV, and the encapsulation efficiency was 72.92%. The scanning electron microscopy (SEM) and atomic force microscopy (AFM) images confirmed the formation of nanoparticles, which were spherical or ellipsoidal in shape. The fourier transform infrared spectroscopy (FTIR) and multifunctional polycrystalline X-ray diffraction (XRD) spectra indicated that CA was encapsulated in the nanoparticles. Furthermore, in vitro release experiments showed that CA/SA/CS NPs had the function of sustained release. In summary, SA/CS NPs can be used as a promising carrier for CA.
研究领域:
材料科学
·
纳米技术
·
药学
·
食品科学
✓ 已验证
产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2019
·
IF 5.839
Ben Niu,Ping Shao,Peilong Sun
The development of carotenoid-enriched functional foods is limited by the low stability of these bioactive compounds . The main objective of this study was to improve the stability of β-carotene through its encapsulation within emulsion-electrosprayed particles. Further, the particles with higher encapsulation efficiency was incorporated in meal replacement bar and investigated for their impact on bar quality and β-carotene content after bar baking. Ultrasonic power had a significant effect on the properties of emulsion, which are important to the properties of the particles. Moreover, the morphology of solidification product is related to the applied voltage connected to the spinneret and collector. The highest encapsulation efficiency, up to 39 ± 4%, was exhibited in the electrosprayed particles obtained from the emulsions prepared using a power of 360 W. β-Carotene and encapsulates incorporated bar retained their sensory characteristics and almost similar to control. Moreover, the encapsulation structures increased the stability of β-carotene after incorporated meal replacement bar.
研究领域:
食品科学
·
营养学
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2016
·
IF 2.76
Wenhua Lv,Shuangni Zhao,Hui Yu,Na Li,Vasil M. Garamus,Yiyin Chen,Peihao Yin,Rongguang Zhang,Yabin Gong,Aihua Zou
This study was aimed at preparing a stable nanostructure lipid carriers for Brucea javanica oil (BJO/NLCs) using the high-pressure homogenization (HPH) method. The obtained BJO/NLCs exhibited a particle size of approximately 180 nm and were quite stable during 30 days of storage. The entrapment efficiency (EE) and drug loading (DL) of BJO/NLCs were good, with values of up to 99.2% and 10.4%, respectively. The polydispersity index (PDI) and zeta potential values of BJO/NLCs were 0.17 and −31.2 mV, respectively. BJO/NLCs exhibited spherical or elongated particles when viewed by transmission electron microscopy (TEM). Small-angle X-ray scattering (SAXS) further confirmed that the internal structures of blank NLCs and BJO/NLCs were arranged into lamellar phases. Anti-tumor activity was studied using the MTT assay; the BJO/NLCs showed improved cytotoxicity to A549 cells. Taken together, these results indicate that this newly designed BJO/NLCs delivery system has the potential to exhibit improved BJO bioavailability.
研究领域:
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2017
·Vol. 22
·期 11
·1801
·
IF 2.861
Jianfei He,Zong-Ping Zheng,Qin Zhu,Fengxian Guo,Jie Chen
In this study, the encapsulation mechanism of oxyresveratrol and β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) was studied. As this research shows, oxyresveratrol and two cyclodextrins (CDs) were able to form inclusion complexes in a 1:1 stoichiometry. However, the interaction with HP-β-CD was more efficient, showing up as higher encapsulation constant (KF) (35,864.72 ± 3415.89 M−1). TheKFvalues exhibited a strong dependence on temperature and pH, which decreased as they increased. From the thermodynamic parameters (ΔH0, ΔS0, and ΔG0) of the oxyresveratrol loaded β-CD (oxyresveratrol-β-CD) and HP-β-CD (oxyresveratrol-HP-β-CD), it could be seen that the complexation process was spontaneous and exothermic, and the main driving forces between oxyrsveratrol and CDs were hydrogen bonding and van der waals force. Besides, molecular docking combined with1H-NMR were used to explain the most possible mode of interactions between oxyresveratrol and CDs.Keywords:oxyresveratrol;encapsulation constant;pH;temperature;thermodynamic parameters;molecular docking
研究领域:
药剂学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）