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A novel mitochondria-targeting fluorescent probe for hydrogen sulfide in living cells

Wei Shi,Miaobo Pan,Hao Qiang,Qianqian Qiu,Wenlong Huang,Haiyan Lin,Hai Qian,Liang Ge

A novel mitochondria-targeting fluorescent probe compound S-N 3 for hydrogen sulfide (H 2 S) in living cells has been designed and synthesized in this study. This article contained the chemosynthesis and some studies on bioactivity of the target compound in living cells. Compound S-N 3 is easy to synthesize and can remain stable under the effect of pH, system and photostability. In addition, it shows low cytotoxicity in cell imaging. And it can react with H 2 S highly selective in PBS or FBS solution, which would cause the obvious increase in fluorescence intensity. Therefore, the low-cost detection method for H 2 S is allowed for monitoring the quantity of H 2 S existed in the mitochondria.