Small
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2014
·Vol. 10
·期 21
·4270-4275
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IF 7.514
Kaiwen Chang,Zhihe Liu,Haobin Chen,Lan Sheng,Sean Xiao-An Zhang,Daniel T. Chiu,Shengyan Yin,Changfeng Wu,Weiping Qin
Graphical Stable full-color fluorescence patterning are achieved by multicolor polymer-dot inks. The fluorescent patterns show extraordinary stability upon various treatments, offering a superior combination of bright fluorescence, excellent photostability, chemical resistance, and eco-friendship.
研究领域:
材料科学
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光学
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环境科学
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DOI
PubMed
高影响因子
Advanced Materials Technologies
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2024
·
IF 6.4
Fangzhen Hu,Chenkai Cao,Sancan Han,Ding Wang,Xi Chen
Transferring the concept of chemical-driven responses into artificial intelligence technology holds the key to mimicking olfactory for neuromorphic computing of chemical recognition. Currently, artificial olfactory systems are designed based on chemical sensor arrays. Time-dependent responses of the sensor arrays are processed by artificial neural networks for recognition. However, the sensors generate instantly volatile responses, and algorithms for the processing of the time-dependent responses have not been involved. The recognition accuracy and speed are severely impeded. A sensor array can only achieve an accuracy of 90% after at least 5 training epochs. Herein an artificial olfactory chemical-resistant synapse consisting of 3D hierarchical WO 3 @WO 3 nanofibers are demonstrated. The nanofibers exhibit persistent resistance responses through chemical exposures due to the strong chemisorption of water molecules. Typical synaptic behaviors including paired-pulse facilitation, long-term −1 short-term memory, and learning experience have been achieved. Next, a recurrent neural network that is committed to processing the time-dependent data is used to identify gas-phase chemicals of 3-hydroxy-2-butanone, triethylamine, and trimethylamine. Training-free gas recognition has been realized by a WO 3 @WO 3 nanofiber synapse only, in which the accuracy is above 90% at the first epoch. The results have great potential to satisfy stringent performance requirements on artificial perception systems.
研究领域:
材料科学
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神经形态计算
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人工智能
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产品关联
DOI
高影响因子
E-POLYMERS
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2017
·Vol. 17
·期 4
·333-340
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IF 0.949
Jun Song,Mei Liu,Zhanping Yang,Songwei Xu,Bowen Cheng,Pengfei Fei
Commercial cellulose diacetate with a degree of substitution (DS) of 2.45 was partly deacetylated to cellulose acetate (CA) with different DSs by acid-catalyzed hydrolysis and then reacted with 1-naphthoyl chloride (NpCl) to synthesize CA naphthoate (CANp). Fourier transform infrared and 1 H-NMR were used to characterize the chemical structure of CANp. The DS of naphthoate moiety (DS CANp ) could be varied from 0.18 to 0.98 by adjusting the molar ratio of –OH in CA unit to NpCl, the DS of CA (DS CA ), and the reaction time and temperature. When DS CA was 2.01 and the molar ratio was 1:6, the maximum DS CANp of the product was achieved after a reaction at 80°C for 2 h. With the increase of DS CANp , the thermal stability decreased slightly whereas the anti-ultraviolet property was enhanced. Moreover, the obtained films containing CANp exhibited good ultraviolet resistance as well as chemical resistance.
研究领域:
材料科学
·
有机化学
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产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2025
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IF 4.8
Dandan Zhou,Xiaoxiao Li,Wencun Liu,Mingjun Zhang,Ying Cheng,Zhousong Xu,Jian Gao,Yiyang Wang
Liver cancer, a highly aggressive malignancy, continues to present significant challenges in therapeutic management due to its pronounced chemoresistance. This resistance, which undermines the efficacy of conventional chemotherapy and targeted therapies, is driven by multifaceted mechanisms, with increasing emphasis placed on the protective role of the tumor microenvironment (TME). The hepatocellular carcinoma extracellular matrix (ECM), a primary non-cellular component of the TME, has emerged as a critical regulator in cancer progression and drug resistance, particularly in hepatocellular carcinoma cell (HCC). In this study, a hybrid biomimetic hydrogel was engineered by integrating decellularized hepatocellular carcinoma matrix (DHCM) with gelatin methacrylate (GelMA) precursors. This composite DHCM/GelMA hydrogel was designed to replicate the physicochemical and functional properties of the hepatocellular carcinoma ECM, thereby offering a biomimetic platform to explore the interactions between HCCs and their microenvironment. Leveraging a custom-designed microfluidic 3D printing platform, we achieved high-throughput fabrication of HCC-encapsulated DHCM/GelMA microgels, characterized by enhanced uniformity, biocompatibility, and scalability. These microgels facilitated the construction of hepatocellular carcinoma microtissues, which were subsequently employed for chemoresistance studies. Our findings revealed that DHCM/GelMA microgels closely mimic the hepatocellular carcinoma tumor microenvironment, effectively recapitulating key features of ECM-mediated drug resistance. Mechanistic studies further demonstrated that DHCM significantly upregulates the expression of Aquaporin 3 (AQP3) in the encapsulated HCCs. This upregulation potentially activates mTOR signaling-associated autophagy pathways, thereby enhancing chemoresistance in HCCs. These biomimetic models provide a robust and versatile platform for studying the underlying mechanisms of drug resistance and evaluating therapeutic interventions. This innovative approach highlights the potential of DHCM/GelMA microgels as a transformative tool in cancer-associated tissue engineering and anticancer drug screening. By enabling detailed investigations into the role of ECM in chemoresistance, this study contributes to advancing therapeutic research and offers promising strategies to overcome drug resistance, ultimately improving clinical outcomes in liver cancer treatment.
研究领域:
生物医学工程
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肿瘤学
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药理学
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DOI
PubMed
高影响因子
Journal of Translational Medicine
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2025
·Vol. 23
·期 1
·1-18
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IF 7.5
Li Xing,Zhang Wansong,Fang Yitong,Sun Tianhu,Chen Jian,Tian Ruilin
Background Glioblastoma (GBM) patients frequently develop resistance to temozolomide (TMZ), the standard chemotherapy. While targeting cancer metabolism shows promise, the relationship between metabolic perturbation and drug resistance remains poorly understood.Methods We performed high-throughput CRISPR interference screens in GBM cells to identify genes modulating TMZ sensitivity. Findings were validated using multiple GBM cell lines, patient-derived glioma stem cells, and clinical data. Molecular mechanisms were investigated through transcriptome analysis, metabolic profiling, and functional assays.Results We identified phosphoglycerate kinase 1 (PGK1) as a key determinant of TMZ sensitivity. Paradoxically, while PGK1 inhibition suppressed tumor growth, it enhanced TMZ resistance by inducing metabolic stress. This activated AMPK and HIF-1α pathways, leading to enhanced DNA damage repair through 53BP1. PGK1 expression levels correlated with TMZ sensitivity across multiple GBM models and patient samples.Conclusion sOur study reveals an unexpected link between metabolic stress and chemoresistance, demonstrating how metabolic adaptation can promote therapeutic resistance. These findings caution against single-agent metabolic targeting and suggest PGK1 as a potential biomarker for TMZ response in GBM.
研究领域:
癌症生物学
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分子生物学
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基因组学
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转化医学
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DOI
PubMed
高影响因子
ACS Omega
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2022
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IF 4.132
Guoqing Wu,Dongjiu Zhang,Wei Xu,Hongjun Zhang,Likun Chen,Yongchao Zheng,Yi Xin,Hong Li,Yan Cui
Chemical warfare agents (CWAs) can be absorbed in polymeric coatings through absorption and permeation, thus presenting a lethal touch and vapor hazards to people. Developing a highly impermeable polymer coating against CWAs, especially against organophosphate CWAs (OPs), is challenging and desirable. Herein, fluorinated epoxy (F-EP) and epoxy (EP) coatings with different cross-link densities were prepared to resist OPs. The effects of the polymer coating structure, including cross-link density, chemical composition and free volume, on the chemical resistance to dimethyl methylphosphonate (DMMP, Soman simulant) were investigated in detail. Meanwhile, the chemical resistance to Soman and VX was examined. The results reveal that the cross-link density is a critical factor in determining the chemical resistance of the coatings. Highly cross-linked EP and F-EP coatings with dense and solid cross-linked networks can fully bar DMMP and OPs permeation during the test time. At low or medium cross-link densities, the EP coating with a lower retention of DMMP exhibited a higher resistance than the F-EP coating due to the lower interaction with DMMP and smaller free-volume holes and lower relative fractional free volume. These results suggest that increasing the cross-link density is a reasonable approach to control the chemical resistance of polymer networks against OPs.
研究领域:
材料科学
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高分子化学
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化学工程
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环境科学
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产品关联
DOI
PubMed
高影响因子
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