Nanomaterials
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2021
·Vol. 11
·期 1
·169
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IF 5.076
Jing Lv,Qing-Xian Yue,Rui Ding,Qi Han,Xin Liu,Jia-Long Liu,Hui-Jie Yu,Kang An,Hai-Bin Yu,Xiao-Dong Zhao
Metal engineering structures are commonly covered and protected by coatings. However, the early local corrosion under the coatings and at defects is difficult to detect and discover. Visibility to the naked eye means that corrosion has already developed and expanded. Therefore, it is practical significant to detect the early corrosion of coated metal. Based on the formation of iron ions and anodic acidification in the local corrosion process, iron ions and proton responsive fluorescent rhodamine B acylhydrazone on-off probes are prepared by newly improved methods and denoted as RBA. RBA are loaded on the surface and in the lattice cage of zeolite (ZEO) to protect RBA from premature exposure to the corrosive environment and fluorescence quenching. In corrosive environments, the RBA loaded on the surface are released and complex with iron ions in the environment to activate fluorescence characteristics. Simultaneously, due to the cation exchange of ZEO, iron ions enter the lattice cage of ZEO and combine with RBA in the lattice cage to turn on fluorescence. When applied in epoxy coatings, the RBA/ZEO effectively indicate the occurrence of corrosion under the coatings and at defects, and accurately locate the corrosion site. Nano-scale ZEO (or RBA/ZEO) fill the micropores such as pinholes and defects of the coatings, and increase the difficulty of diffusion and penetration of corrosive media into the coatings. The application of RBA/ZEO functional filler not only do not weaken the main anti-corrosion performance of the coatings, but also significantly improve it.Keywords:corrosion detection;chemical probe;zeolite;fluorescence
研究领域:
材料科学
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化学工程
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DOI
PubMed
高影响因子
Processes
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2021
·Vol. 9
·期 1
·170
·
IF 2.847
Xiupei Yang,Fangming Tian,Shaohua Wen,Hua Xu,Lin Zhang,Jie Zeng
A cost-effective and environmentally friendly method was formulated for rapid dopamine (DA) detection that was based on the fluorescence (FL) quenching of carbon quantum dots (C-dots). Upon adding DA to the C-dots’ solution, we noticed a regular reduction in their fluorescence intensity. The effects of pH, amount of C-dots, reaction temperature and time on the determination of DA were investigated. Under the optimized experimental conditions, trace amounts of DA could be analyzed. Furthermore, dopamine hydrochloride injection and human urine samples with and without spiked DA were analyzed using the developed sensing system. The procedure was validated following the guidelines of the European Medicines Agency (EMA) in terms of the following: calibration range (0.3–100 μM), linearity (R2= 0.9991), limit of detection (LOD) (93 nM). Recoveries of dopamine with spiked samples at three different levels were between 95.0 and 105.9%, and the relative standard deviations (RSDs) were within 2.68% (n = 6). This method is simple and suitable for the determination of dopamine in pharmaceuticals and human urine for clinical application. Compared with previous reports, the proposed method offers great advantages including ease of C-dot sensor preparation (one-pot synthesis), environmentally friendly sample preparation by using either water or phosphate buffer solution only, a short response time and selectivity.Keywords:carbon quantum dots;dopamine;fluorescence quenching;yet photochemical probe
研究领域:
分析化学
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医学检测
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DOI
高影响因子
Nature Chemical Biology
·
2015
·Vol. 11
·期 12
·904-905
·
IF 12.996
Macarron Ricardo
Wassermann, A.M. et al. Nat. Chem. Biol. doi:10.1038/nchembio.1936 (19 October 2015).Article CAS Google Scholar Polishchuk, P.G. et al. J. Comput. Aided Mol. Des. 27, 675–679 (2013).Article CAS Google Scholar Huggins, D.J. et al. ACS Chem. Biol. 6, 208–217 (2011).Article CAS Google Scholar Baell, J.B. & Holloway, G.A. J. Med. Chem. 53, 2719–2740 (2010).Article CAS Google Scholar Leeson, P.D. & Springthorpe, B. Nat. Rev. Drug Discov. 6, 881–890 (2007).Article CAS Google Scholar Download references
研究领域:
药物化学
·
化学生物学
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PubMed
高影响因子
JOURNAL OF MATERIALS RESEARCH
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2024
·
IF 2.7
Qiao Xinxin,Bian Ruihan,Li Shu,Zhu Jialei,Wang Fuqin,Liu Chang
In the paper, a high-performance electrode was reported for the determination of uric acid (UA) and dopamine (DA) by loading nanocomposites Fe 2 O 3 /poly-neutral red (PNR)/partially reduced graphene oxide (rGO) on glassy carbon electrode (GCE). The nanocomposites Fe 2 O 3 /PNR/rGO were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectrometer (FTIR), and electrochemical impedance spectroscopy (EIS). Under the optimized condition, the peak currents of UA and DA showed good linear relationships with their concentrations in the range of 1 × 10 –6 to 1 × 10 –3 mol L −1 and 3 × 10 –7 to 9 × 10 –5 mol L −1 , respectively. The recovery rates were 93.0–102.0% and 99.2–104.6% for detecting DA from medical injections and human specimens, including urine and serum, respectively, 95.5–105.0% for UA from urine and serum samples. Obviously, this Fe 2 O 3 /PNR/rGO/GCE is expected to be used in production quality control and clinical test. Graphical abstract
研究领域:
分析化学
·
生物医学工程
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DOI
高影响因子
ANALYTICAL CHEMISTRY
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2018
·
IF 6.042
Shuo Wu,Wenjuan Tu,Yanqiu Zhao,Xiuyun Wang,Jie Song,Xinlan Yang
A ruthenium(II) bipyridyl derivative photoelectrochemical probe, Ru-1, is synthesized and coupled with TiO2 nanoparticles (Ru-1/TiO2) for the specific recognition and highly sensitive photoelectrochemical (PEC) detection of Hg2+ in a series of biofluids. The probe is designed with a chromophore, a thiocyanate recognition unit, a π-conjugated photoelectron-transfer pathway, and a phosphonate anchor. TiO2 nanoparticles with strong affinity to phosphonate and suitable conduction band energy are used as intermediate layers to increase the Ru-1 adsorption amount and amplify the photocurrent response. Under irradiation, the Ru-1/TiO2/fluorine-doped tin oxide (FTO), with strong visible light-harvesting capacity, aqueous stability, and efficient photoelectron transfer, shows a high and stable photocurrent response. In the presence of Hg2+, however, the specific Hg2+ and NCS coordination changes the photophysical properties of Ru-1, imposing the probe with a wider band gap, a weaker absorbance, and a poorer photoelectron and hole separation efficiency, thus resulting in a significant photocurrent decrease. On the basis of the Hg2+-induced photocurrent change, the Ru-1/TiO2/FTO shows good selectivity and high sensitivity toward the PEC detection of Hg2+, with wide linear ranges from 10–12 to 10–7 and 10–7 to 10–3 g/mL, and a low limit of detection of 0.63 pg/mL. The PEC probe is recyclable and accurate for selective detection of Hg2+ in urine, serum, and cell extracts. The whole analysis can be completed within 15 min. These good analytical performances indicate that the PEC method might have great potential for the onsite detection of small molecules in biosystems.
研究领域:
分析化学
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环境科学
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生物医学
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DOI
PubMed
高影响因子
Sustainable Materials and Technologies
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2023
·
IF 9.6
Jinghan Guo,Yalin Wu,Yanhui Li,Shuangying Li,Zhi Li,Jingwen Niu,Chunmao Chen,Qingxiang Zhou
A creative electrochemical probe utilizing molecularly imprinted modified magnetic carbon dots was designed and fabricated. Carbon dots are a new kind of green, pollution-free, cheap and easy to obtain nanomaterials . The combination of Fe 3 O 4 and carbon dots improved the defect of ferric oxide being easy to aggregate, and their co-modification significantly enhanced the electrochemical activity of the electrode. Cyclic voltammetry and differential pulse voltammetry were executed to evaluate the electrochemical behavior of the co-modified electrode surface and performance of the probe. The constructed probe exhibited excellent selectivity and sensitivity for determining bisphenol AP in plastic products. The introduction of molecularly imprinted polymers endowed the sensor excellent selectivity, ensuring specific recognition of bisphenol AP. The fabricated sensor demonstrated a good two-stage linear range of 0.07–0.3 μM and 0.3–10 μM, and the detection limit was 0.027 μM. The constructed probe was validated to detect bisphenol AP in self-heating hot pot, instant noodle bucket and disposable plastic cup, and satisfactory results were achieved. These results indicated that the fabricated sensor was a cheap, rapid, and selective sensing-platform for detecting bisphenol AP, and could be employed as a reliable routine tool.
研究领域:
分析化学
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材料科学
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环境科学
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DOI
高影响因子
Petroleum Science
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2023
·
IF 5.6
Zhong-Zheng Xu,Ming-Wei Zhao,Yi-Ning Wu,Jia-Wei Liu,Ning Sun,Zi-Zhao Wang,Yi-Ming Zhang,Lin Li,Cai-Li Dai
The membrane method based on adaptive wettability shows great advantages in oil-water separation. At present, researches focus on the excellent application performance of the membrane material, while the quantitative analysis of interactions in oil-water separation is rarely recognized. Herein, we constructed an adaptable wettability membrane with multiple polymer networks by polydopamine (PDA) and mussel-inspired amphiphilic polymer. Based on the Owens three-probe liquid method, the surface energy of the modified membrane was verified to meet the adaptive wettability conditions, with surface energies ( γ S ) of 147.6 mJ m −2 (superhydrophilic/underwater superoleophobic) and 49.87 mJ m −2 (superhydrophobic/superoleophobic), respectively. The adhesion or repulsion of the membrane to the oil phase under different conditions during the separation process was quantified by the chemical probe AFM technique. In addition, the oil-water selective separation mechanism was further analyzed in a simplified membrane microchannel model. The results show that the different wetting produces capillary additional pressure in opposite directions, resulting in different energies to be overcome when the oil or water passes through the microchannels, thus achieving selective separation.
研究领域:
材料科学
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环境科学
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界面化学
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DOI
高影响因子
FOOD CHEMISTRY
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2025
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IF 9.8
Kaiyu Jiang,Wei Gong,Yu-Xuan Liang,Juncai Tu,Jinjin Li,Weiman Gao,Xiuping Dong,Beiwei Zhu
To investigate the effects of processing temperatures on α, β-unsaturated aldehyde-mediated modifications of cod protein, a clickable probe, 4-(2-Propyn-1-yloxy)-2-butenal (yne-ACR), was developed to simulate α, β-unsaturated aldehyde modifications on cod protein in simulated processing systems (25 °C, 90 °C, and 180 °C). Processing at 180 °C resulted in a 3-fold increase in the hydrophobicity, while modifications under thermal processing had limited effects on the content of free nucleophilic amino acids. However, modification at 180 °C significantly increased the content of carbonylated proteins to 14.7 nmol/mg protein. Cod protein modified during thermal processing (90 °C and 180 °C) exhibited superior emulsifying and foaming properties than those subjected to heating alone. Cod protein processed at 90 °C exhibited 757 identified modified components, representing the highest number among the three processing temperatures, and thermally induced structural changes in cod protein facilitated multiple modifications on a single peptide. These findings provide new tools and insights for the study of food protein modification.
研究领域:
食品科学
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生物化学
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DOI
PubMed
高影响因子
SN Applied Sciences
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2021
·Vol. 3
·期 5
·1-14
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IF 0
Xiao Li,Li Chunqing,He Xiantinglv,Cheng Xinjian
It is of scientific and practical significance to sense and to remove heavy metal ions in the environment. In this work, four BODIPY-based fluorescent polymeric probes with the ability to sense and separate Fe 3+ ions have been prepared via thiol-ene click reaction. The polymers have good thermal stability. Meanwhile, the results show that they have selective recognition capabilities only for Fe 3+ , which are mainly manifested as significant quenching of fluorescence and color modulation under visible light. The sensitivity is good, and the limit of detection reaches as low as 0.14 µM. They can also be used as reversible chemical probes to detect Fe 3+ . Therefore, the click reaction provides us with a facile method for preparing fluorescent polymer probes.
研究领域:
环境科学
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材料科学
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分析化学
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DOI
REACTIVE & FUNCTIONAL POLYMERS
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2021
·
IF 3.975
Wenmei Tan,Wei Shi,Sheng Ding,Zhengfeng Xie
Using renewable substances as the raw materials, and through relatively greener synthetic processes to implement the preparation of novel functional polymers is an idea that accords with the concept of “sustainable development” and is highly desirable in nowadays polymer science. In this study, apigenin (as renewable phenol) and furfurylamine (as renewable amine) were selected to prepare bio-based benzoxazine derivative (AP-f) through Mannich reaction . Using AP-f and diphenylmethane-based diisocyanide (IC) as reactants, a type of cross-linked, semi-aromatic polyamide derivative (Bio-PA) was successfully prepared via benzoxazine-isocyanide mechanochemistry (BIC-MC) by ball milling manner. Chemical structure , elemental composition , micro morphology and stacking state properties of Bio-PA were systematically characterized here. Multiple Pb(II)-affinitive molecular fragments (phenolic hydroxyl , tertiary amine and amide) were integrated into the structure of Bio-PA. Based on this, the application of Bio-PA as “enrichment-type” Pb(II) electrochemical probe was explored subsequently. The results showed that the introduction of Bio-PA significantly improved the response of Pb(II), and the modified electrode (Bio-PA/Nafion/GCE) illustrated satisfactory detection sensitivity and selectivity.
研究领域:
聚合物科学
·
可持续化学
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环境化学
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电化学
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DOI
高影响因子
TALANTA
·
2023
·
IF 6.1
Hong Zhang,Bo Li,Ruiying Wang,Qiannan Miao,Xiaomin Cui,Lei Shang,Rongna Ma,Liping Jia,Chuan Li,Fenghua Li,Shuijian He,Wei Zhang,Huaisheng Wang
To design highly efficient electrochemistry system was important for construct simple and sensitive biosensors, which was crucial in clinical diagnosis and therapy. In this work, a novel electrochemistry probe N,N′-di (1-hydroxyethyl dimethylaminoethyl) perylene diimide (HDPDI) with positive charges was reported to show two-electron redox behavior in neutral phosphate buffer solution between 0 and -1.0 V. And K 2 S 2 O 8 in solution could significantly increase the reduction current of HDPDI at −0.29 V, which was interpreted with cyclic catalysis mechanism of K 2 S 2 O 8 . Moreover, HDPDI as electrochemical probe and K 2 S 2 O 8 as signal enhancer was used to design aptasensors for protein detection. Thrombin was used as target model protein. Thiolate ssDNA with thrombin-binding sequence was immobilized on gold electrode to selectively capture thrombin and adsorb HDPDI. The thiolate ssDNA without binding with thrombin was with random coil structure and could adsorb HDPDI through electrostatic attraction interaction. However, the thiolate ssDNA binding with thrombin became G-quadruplex structure and hardly adsorbed HDPDI. Thus, with increasing the concentration of thrombin, the current signal stepwisely decreased and was taken as detection signal. Compared with other aptasensors based on electrochemistry molecules without signal enhancer, the proposed aptasensors exhibited wider linear response for thrombin between 1 pg mL −1 and 100 ng mL −1 with lower detection limit 0.13 pg mL −1 . In addition, the proposed aptasensor showed good feasibility in human serum samples.
研究领域:
分析化学
·
生物化学
·
生物医学工程
·
临床诊断
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DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 6
·1837-1845
·
IF 4.58
Wu Jing,He Junlin,Zhang Yuchan,Zhao Yilin,Niu Yazhen,Yu Chao
The authors describe a nanocomposite prepared from gold nanoparticles, branched polyethylenimine and carboxylated multiwalled carbon nanotubes (AuNP/b-PEI/c-MWCNTs), and its application to a highly sensitive electrochemical immunosensor for the soluble CD40 ligand (sCD40L), a biomarker of acute coronary syndrome (ACS). It is known that c-MWCNTs possess a remarkably good electrochemical conductivity that can improve the sensitivity of an immunosensor, but their tendency towards aggregation is an obstacle. The use of b-PEI can substantially decrease the tendency towards aggregation. AuNPs with their large specific surface and good electrical conductivity were used to load the antibody. The nanocomposite was characterized by transmission electron microscopy, atomic force microscopy, energy dispersive spectroscopy, electrochemical impedance spectroscopy, and cyclic voltammetry. When using hexacyanoferrate as an electrochemical probe (best detected at 0.18 V vs. SCE), the electrode displays a linear response in the 10 fg mL −1 to 100 pg mL −1 sCD40L concentration range, and a lower detection limit of 3 fg mL −1 . The electrode is regenerable. It was applied to the determination of sCD40L in spiked serum samples, and the results agreed well with an ELISA.
Schematic of a highly sensitive electrochemical immunosensor for the detection of soluble CD40 ligand (sCD40L), a biomarker for the acute coronary syndrome (ACS). It is based on the use of a nanocomposite consisting of gold nanoparticles, branched polyethylenimine and carboxylated multiwalled carbon nanotubes (AuNPs/b-PEI/c-MWCNTs).
研究领域:
电化学
·
生物传感器
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纳米技术
·
心脏病学
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DOI
高影响因子
危险品化学品经营许可证（带存储）