CHEMOSPHERE
·
2022
·
IF 8.943
Jianlong Wang,Shizong Wang,Chuanhong Chen,Jun Hu,Shijun He,Yuedong Zhou,Huanzheng Zhu,Xipo Wang,Dongming Hu,Jian Lin
The effective treatment of hospital sewage is crucial to human health and eco-environment, especially during the pandemic of COVID-19. In this study, a demonstration project of actual hospital sewage using electron beam technology was established as advanced treatment process during the outbreak of COVID-19 pandemic in Hubei, China in July 2020. The results indicated that electron beam radiation could effectively remove COD, pathogenic bacteria and viruses in hospital sewage. The continuous monitoring date showed that the effluent COD concentration after electron beam treatment was stably below 30 mg/L, and the concentration of fecal Escherichia coli was below 50 MPN/L, when the absorbed dose was 4 kGy. Electron beam radiation was also an effective method for inactivating viruses. Compared to the inactivation of fecal Escherichia coli , higher absorbed dose was required for the inactivation of virus. Absorbed dose had different effect on the removal of virus. When the absorbed dose ranged from 30 to 50 kGy, Hepatitis A virus (HAV) and Astrovirus (ASV) could be completely removed by electron beam treatment. For Rotavirus (RV) and Enterovirus (EV) virus, the removal efficiency firstly increased and then decreased. The maximum removal efficiency of RV and EV was 98.90% and 88.49%, respectively. For the Norovirus (NVLII) virus, the maximum removal efficiency was 81.58%. This study firstly reported the performance of electron beam in the removal of COD, fecal Escherichia coli and virus in the actual hospital sewage, which would provide useful information for the application of electron beam technology in the treatment of hospital sewage.
研究领域:
环境科学
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生物学
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医学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2021
·
IF 9.229
Cuicui Su,Yumin Ye,Haofeng Qiu,Yabin Zhu
Biofilm formation on indwelling medical devices is a major cause of hospital-acquired infections. Monofunctional antibacterial surfaces have been developed to resist the formation of biofilms by killing bacteria on contact, but the adsorption of killed bacterial cells and debris gradually undermines the function of these surfaces. Here, we report a facile approach to produce an antibacterial surface that can regenerate its function after contamination. The self-regenerating surface was achieved by sequential deposition of alternating antibacterial and biodegradable layers of coating using a solvent-free initiated chemical vapor deposition method. As the top antibacterial layer gradually loses its killing ability due to the accumulation of debris, the underlying biodegradable layer degrades, shedding off the top surface layers and exposing another fresh antibacterial surface. Urinary catheters coated with monofunctional and self-regenerating antibacterial coatings both showed more than 99% bacterial killing ability at the initial antibacterial test, but the monofunctional surface lost its killing ability after continued exposure to concentrated bacterial solution, whereas the self-regenerating surfaces regained strong bacterial killing ability after prolonged exposure. Employing poly(methacrylic anhydride) and its copolymers with varied composition as the degrading layer, the degradation kinetics can be well-tailored and the self-regeneration duration spanned from minutes to days. The designed self-regenerating antibacterial surfaces could provide an effective approach to resist biofilm formation and extend the service life of indwelling medical devices.
研究领域:
生物医学工程
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材料科学
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DOI
PubMed
高影响因子
Frontiers of Environmental Science & Engineering
·
2022
·Vol. 16
·期 10
·1-12
·
IF 6.048
Liang Jinhui,Luo Yuchen,Li Benhang,Liu Shiqi,Yang Liansheng,Gao Peng,Feng Li,Liu Yongze,Du Ziwen,Zhang Liqiu
Progesterones are ubiquitous in hospital wastewater (HWW) with concentrations much higher than those of estrogens and androgens. To ensure that these water systems are safe to use, disinfection is crucial during HWW treatment by providing “front line” defense against biological contaminations. Here, five disinfection processes, namely, chlorine (Cl 2 ), chlorine dioxide (ClO 2 ), ozone (O 3 ), ultraviolet (UV)), and UV/chlorine (UV/Cl 2 ), were selected to investigate their removal efficiencies for progesterones in primary filtration and secondary biological treatment effluents. There were 61 natural and synthetic progesterones detected in HWW, with the natural progesterones being the main components with a concentration of 845.51 ng/L and contributing to 75.08% of the total progesterones. The primary filtration treatment presented insignificant removal effects on the progesterones, while the secondary biological treatment significantly reduced the progesterone content by biodegradation. The order of removal efficiencies of total progesterones by different disinfection processes was UV/Cl 2 > Cl 2 > O 3 > ClO 2 > UV. UV/Cl 2 showed the highest removal efficiency against progesterones mainly due to the activation of Cl 2 by ultraviolet (UV) photolysis, which helps open the heterocyclic, aromatic, and phenolic rings, thus accelerating progesterone degradation. In addition, the removal efficiencies of natural progesterones in the five disinfection processes were higher than those of synthetic progesterones (progesterone derivatives, 19-nortestosterone derivatives, and 17α-hydroxyprogesterone derivatives).
研究领域:
环境科学
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医学
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生物学
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DOI
高影响因子
WATER RESEARCH
·
2024
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IF 11.4
Haichuan Zhang,Jiawei Li,Shanshan Ye,Xiyang Zou,Rongxin Fei,Xinyu Hu,Ji Li
The electro-peroxone (EP) process encounters two inherent challenges in wastewater treatment: sluggish O 2 /O 3 transfer and substantial ozone waste. To overcome these limitations, we introduced micro-nano bubbles (MNBs) aeration to enhance O 2 /O 3 dissolution and diffusion, ultimately aiming to improve the removal of trace pharmaceutical contaminants from hospital wastewater. In the MNBs aeration system, the ozone transfer coefficient ranging from 0.536 to 0.265 min −1 , significantly surpassing that of conventional aeration (0.220 to 0.090 min −1 ) by approximately 2 to 4.5 times. Consequently, the EP process under MNBs aeration significantly enhanced ozone-resistant ibuprofen (IBU) removal, achieving a removal rate of 98.4 ± 1.5 %, far exceeding the 47.3 ± 4.7 % observed with conventional aeration. This significant improvement was attributed to the heightened production of hydroxyl radicals (•OH), reaching 0.97 × 10 −9 M s, compared to only 0.28 × 10 −9 M s in conventional aeration. The mechanism behind the enhanced •OH production in the MNBs-EP process relied primarily on two factors: improved O 2 /O 3 dissolution due to high internal pressure/large surface and enhanced O 3 /H 2 O 2 activation from high collapse energy. These factors together contributed to the robust oxidation capability of the MNBs-EP system. As a result, over 97 % removal efficiency was achieved for five representative pharmaceutical pollutants (sulfamethoxazole, ribavirin, norfloxacin, tetracycline and ampicillin) in just 1 min. Furthermore, when applied to real hospital wastewater, the MNBs-O 3 -E treatment system reduced all 15 detected trace pharmaceutical compounds to below 10 ng L −1 and achieved 14 types of pollutants with removal rates of over 85 % within 15 min, resulting in an ultrahigh total removal rate of 98.6 %, from an initial total concentration of 2108 ng L −1 to less than 30 ng L −1 . Thus, micro-nano aeration endowed the EP process as a promising advanced oxidation system for rapid and highly-effective removal of trace pharmaceutical contaminants from hospital wastewater.
研究领域:
环境科学
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水处理技术
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高级氧化工艺
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产品关联
DOI
PubMed
高影响因子
Journal of Energy Storage
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2024
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IF 8.9
Lezhi Zhang,Yuan Shi,Hongzhi Cui
Patient recovery is influenced by thermal comfort. Traditional air conditioning systems often overload due to fluctuating occupancy, requiring innovative technologies. Phase change materials offer an efficient solution by reducing energy consumption. This study introduces an innovative phase change composite (PCC) specifically designed for hospital wards. The PCC, formulated from delignified wood and octadecane, aims to enhance indoor temperature regulation, thereby mitigating the energy-intensive dependence on traditional air conditioning systems commonly employed in hospitals. By applying surface carbonization technology, the adsorption performance of the wood was optimized, while the phase change material (PCM) was encapsulated within a polymerizable low eutectic solvent system consisting acrylic acid (AA) and choline chloride (ChCl). This encapsulation process guaranteed antibacterial properties, mechanical stability, and sustainability of materials. Notably, the sample treated at 400 °C (SCW-OD-400) exhibited remarkable thermal management capabilities, undergoing a phase change at approximately 26 °C. With a high latent heat of 191.7 J/g and impressive photo-to-thermal conversion efficiency, this material can increase temperatures by 17.4 °C within 240 s under simulated sunlight, making it a promising candidate for temperature regulation in hospital wards. The findings of this research offer a promising new temperature control strategy for medical settings, paving the way for future hospital construction enhancements.
研究领域:
材料科学
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能源技术
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医学工程
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产品关联
DOI
高影响因子
Analytical Methods
·
2013
·Vol. 5
·期 5
·1150-1154
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IF 1.855
Sheng Liu,Xian-Zheng Wu,Zi-Hui Gao,Fang Jiao
A mini-solid phase extractor (MSPE) was designed and applied in the on-site determination of trace levels of chloramphenicol. The results showed that 1.5 g of the macroporous XAD-16 resin was suitable for capturing chloramphenicol from 500 mL of solution. Methanol was used as the eluent to desorb chloramphenicol from the resin. Chloramphenicol was determined by HPLC at 278 nm with a mobile phase of 0.01 mol L−1 oxalic acid–acetonitrile (40 : 60 v/v), the retention time was around 5.07 min. The detection scope of chloramphenicol was between 0.004 and 0.120 mg L−1. Using the MSPE, chloramphenicol in surface water and hospital sewage was determined with recoveries of 96 to 108% and RSDs of less than 6.8%. The MSPE achieved a rapid on-site preconcentration of chloramphenicol and avoided the inconvenient transportation and storage of large volumes of water sample.
研究领域:
环境分析化学
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药物残留监测
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水环境污染
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样品前处理技术
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DOI
高影响因子
ENVIRONMENTAL MONITORING AND ASSESSMENT
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2020
·Vol. 192
·期 6
·1-11
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IF 1.903
Zagui Guilherme Sgobbi,de Andrade Leonardo Neves,Moreira Natália Columbaro,Silva Thaís Vilela,Machado Gabriel Pinheiro,da Costa Darini Ana Lúcia,Segura-Muñoz Susana Inés
Multidrug resistance mediated by β-lactamase in Gram-negative bacilli is a serious public health problem. Sewers are considered reservoirs of multiresistant bacteria due to presence of antibiotics that select them and favor their dissemination. The present study evaluated the antibiotic resistance profile and β-lactamases production in Gram-negative bacilli isolates from hospital sewage and urban wastewater treatment plants (UWWTP) in Brazil. Bacteria were isolated and identified with biochemical tests. Antibiotic susceptibility testing was performed by the disk-diffusion method and detection of extended-spectrum β-lactamase and carbapenemases by enzymatic inhibitor and conventional PCR. Differences in resistance to amoxicillin clavulanic, aztreonam, cefepime, and cefotaxime were observed in hospital sewage compared with urban sewage ( p < 0.05). The multidrug-resistant phenotype was observed in 33.3% of hospital sewage isolates ( p = 0.0025). β-lactamases genes were found in 35.6% of isolates, with the most frequent being bla KPC and bla TEM (17.8%), and bla SHV and bla CTX-M (13.3% and 8.9%, respectively). The data obtained are relevant, since the bacteria detected are on the priority pathogens list from the World Health Organization and hospital sewage could be released untreated into the municipal collection system, which may favor the spread of resistance. Changes in hospital sewage discharge practices, as well as additional technologies regarding effluent disinfection in the UWWTP, can prevent the spread of these bacteria into the environment and negative impact on water resources.
研究领域:
微生物学
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公共卫生
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环境科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2023
·
IF 15.1
Jie Li,Ye Du,En-Yu Zhao,Yanni Jiang,Zhongjuan Wang,Heng Zhang,Peng Zhou,ZhaoKun Xiong,Bo Lai
Traditional Fe(VI) treatment process does not fully utilize the fresh iron flocs. This study proposed a novel Fe(VI) flocs recycling process. The flocs were recycled into the front-end reactor and the flocculation effluent further reacted with Fe(VI). Compared with Fe(VI) alone, the COD Cr of the secondary effluent of hospital wastewater decreased from 74.9 to 59.4 mg/L and TP decreased from 0.36 to 0.10 mg/L at the dosage of 20 mg/L Fe(VI). However, the enhanced removal of NH 3 -N and TOC by the flocs recycling process is limited. The Fe(VI) flocs recycling process also strengthened the removal of luminescent bacterial acute toxicity, from 0.52 ± 0.01 in secondary effluent to 0.17 ± 0.01 mg-ZnSO 4 /L. Compared with polymeric ferric chloride and ferric chloride (FeCl 3 ), Fe(VI) showed the best performance on purifying wastewater in the flocs recycling process. Compared with FeCl 3 , the C O bond contents in flocs from Fe(VI) changed more obviously. Flocs from Fe(VI) have a smaller average particle size than those from FeCl 3 , which may result in better adsorption capacity of Fe(VI) flocs. In conclusion, the flocs recycling process not only taken full use of the Fe(III) flocs and reduced the iron sludge, but also strengthened the purification of the wastewater without additional Fe(VI) dosing.
研究领域:
环境科学
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水处理工程
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产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2025
·
IF 4.8
Jianhui Gao,Deliang Liu,Zhiqiang Lin,ZhouYang,Zhuojun He,Xiafei Dai,Pengfei Zhao,Hongzhou Lu,Mingbin Zheng
Respiratory pathogens transmitted via clinical textiles represent a major source of hospital-acquired infections, yet current antibacterial fabric strategies are limited by poor durability and weak bacterial inhibition. Here, we reported a molecular-level strategy for the fabrication of copper-doped antibacterial cotton textiles (Cu@textile) via a simple immersion of common cotton in a Cu(II)- saturated NaOH solution. This process enabled stable coordination between the copper ions and cellulose hydroxyl groups, forming stable Cu-O bonds throughout the fiber matrix. Structural and spectroscopic analyses confirmed uniform copper integration and chemical bonding. The resulting Cu@textile exhibited potent, broad-spectrum antibacterial activity against key respiratory pathogens, including Pseudomonas aeruginosa, Acinetobacter baumannii, and Mycobacterium tuberculosis, with > 99% sterilization efficiency. Mechanistic studies revealed this efficacy as copper-induced reactive oxygen species (ROS) production and bacterial membrane disruption. This accessible and scalable antimicrobial textile eliminates the need for specialized equipment or nanoparticle synthesis, and may represent a strategic intervention to reduce bacteria propagation and contact infection risks in healthcare settings.
研究领域:
微生物学
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生物材料
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感染控制
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纺织科学
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纳米医学
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分子生物学
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公共卫生
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产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
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2022
·
IF 8.943
Weiyingxue Yang,Chuixiu Huang,Xiantao Shen
Pharmaceuticals in hospital effluents, often discharged into the public sewage network without sufficient treatment, have shown negative impacts to the human health and aquatic environment. However, the conventional adsorbents used to remove these micropollutants had several deficiencies, including slow uptake kinetics and poor selectivity . To overcome these challenges, water-compatible Janus MIP particles (J-MIPs) with mouth-like openings were synthesized using seeded interfacial polymerization in this work. Among the series of J-MIPs, the selected J-MIP 3 showed fast binding kinetics (∼40 s) towards the target pollutant. The theoretical and instrumental analysis suggested that the electrostatic interaction, hydrogen bond and hydrophobic reaction constituted the dominant mechanism for J-MIP 3 's recognition of target pharmaceutical. Selectivity and robustness tests indicated that the synthetic method was promising in practical application. Finally, the feasibility of the J-MIP 3 fixed-bed column in the rapid removal of propranolol (PRO) from hospital effluents was successfully demonstrated. Compared to the activated carbon fixed-bed column, the J-MIP 3 fixed-bed column showed at least 7-fold enhancement in its treatment efficiency. To the best of our knowledge, this is the first time that the accelerated mass transfer and fast removal of the pharmaceutical from wastewater have been achieved by the synthetic receptor with asymmetric structure. We believe the present study will open new avenues for the development of multi-functional molecularly imprinted polymers as well as Janus materials in environmental science.
研究领域:
环境科学
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材料科学
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生物医药工程
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产品关联
DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2022
·
IF 11.072
Yanan Shao,Xiaodong Li,Longbo Jiang,Xue Wei,Yanlan Zhao,Xuwu Chen,Shuai Li
UV/chlorine as an advanced oxidation process (AOPs) has been employed to treat contaminants. However, current research has primarily focused on drinking water and sewage treatment . This paper investigated the degradation of ciprofloxacin (CIP) by UV/chlorine treatment in hospital urine components that contain a higher concentration of iodine (I − ). The results indicated that the characteristic ions (HCO 3 − , SO 4 2− , and NH 4 + ) and I − in hospital urine inhibited CIP removal. In contrast, the characteristic ion, Cl − ion promoted this degradation reaction. Surprisingly, microgram levels of I − strongly inhibited CIP degradation. The characteristic ions can reduce the contribution of hydroxyl radicals (HO•) and reactive chlorine species (RCS). I − can decrease the contribution rate of HO• while slightly increasing the contribution of other radical oxidation in phosphate buffer solution (PBS) ascribed to the formation of HOI and reactive iodine species (RIS). Three degradation pathways have been proposed based on the main transformation products : hydroxylation , electron transfer , and halogen substitution. The piperazine ring of CIP was the main reactive group, and the N2, C10, C16, and C13 atoms were identified as reaction sites. Preliminary toxicity analysis suggested that the toxicity of hospital hydrolyzed urine containing iodine was higher than that of PBS.
研究领域:
环境科学
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水处理
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化学工程
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毒理学
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 2
·1-9
·
IF 5.7
Yang Qiaoli,Wu Dan,Aziz Ayesha,Deng Sangsang,Zhou Lei,Chen Wei,Asif Muhammad,Wang Shenqi
The development of a novel colorimetric method is reported, using vB_YepM_ZN18 phages along with AuPt nanozyme for the sensitive detection of Y. pseudotuberculosis. The phage used in this work has been extracted from hospital sewer water and is highly specific toward Y. pseudotuberculosis . The synthesized AuPt NPs possess peroxidase-like activity, which is suitable in the development of nanozyme based detection system. Furthermore, phages@MB and AuPt@phages are added into the bacterial samples for co-incubation, forming an intercalated complex. The magnetic separation and absorbance analysis of enzymatic reaction are carried out for the detection of targeted bacteria. The proposed method has a limit of detection of 14 CFU/mL, a wide linear range from 2.50 × 10 1 ~ 2.50 × 10 7 CFU/mL and the assay completion time is 40 min. Benefitting from the outperformance of this sensor, we have successfully employed the developed sensing platform for the detection of Y. pseudotuberculosis in food industry and hospital specimens. Graphical Abstract
研究领域:
生物技术
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分析化学
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微生物学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）