JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Ning Li,Xiaoyu Lu,Min Fang,Zhixia Qiu,Xijing Chen,LiLi Ren,Pingkai Ouyang,Guoguang Chen
Triacontanol (TA), a natural compound with various health benefits, is extensively used as a nutritional supplement. The therapeutic and nutraceutical applications of TA are limited due to its poor aqueous solubility. PEGylated triacontanol (PEGylated TA) was designed to improve the solubility and pharmacokinetics of TA. After PEGylation, the solubility (∼250 g·L–1 versus 9 × 10–14 g·L–1), body residence (MRT, 9.40 ± 2.03 h versus 2.59 ± 0.705 h, p < 0.001), and systemic exposure (AUC0–inf, 29.1 ± 5.33 μM·h versus 0.529 ± 0.248 μM·h, p < 0.001) of TA were all significantly increased compared to pristine TA. When intravenously administered (6.85, 22.8, and 68.5 μmol·kg–1) in rats, PEGylated TA exhibited a slow clearance (44.8 ± 8.62, 47.9 ± 5.18, and 46.9 ± 16.5 mL·h–1·kg–1), long elimination half-life (8.76 ± 0.96, 10.4 ± 1.66, and 11.1 ± 2.81 h), and abundant systemic exposure (AUC0–t, 155 ± 24.2, 523 ± 56.2, and 1709 ± 245 μM·h). Meanwhile, its metabolite TA showed a high AUC0–t (28.4 ± 5.14, 151 ± 25.4, and 797 ± 184 μM·h) and slow elimination (t1/2, 10.1 ± 2.03, 7.78 ± 1.74, and 6.82 ± 0.58 h). Our results demonstrated that PEGylated TA has superior pharmacokinetics, which enhanced its nutritional and pharmacodynamic potency, and thus warrants further investigations.
研究领域:
药理学
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营养学
·
药物化学
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产品关联
DOI
PubMed
高影响因子
Journal of Chemistry
·
2012
·
IF 0
Xiao Yan,Hai-Rong Pei,Tong-Bo Wang,Wen-Bo Liu,Xiao-Zheng Lan
Phase behavior of undecane-dodecane mixtures (n-C11H24-C12H26, C11-C12) in bulk and confined in SBA-15 (pore diameters 3.8, 7.8, and 17.2 nm) has been studied by differential scanning calorimetry. Phase diagram of the confined C11-C12 system shows dependence on pore size, indicating simple behavior compared with the bulk. In the three systems, melting points of the confined C11, C12 and the mixtures ( = 0.1–0.9) present a linear relation with the pore diameter from 3.8 to 17.2 nm. Melting behavior of the confined C11-C12 mixtures is closely as the confined C11, C12. Melting temperatures of the three systems have been fitted as a function of mole fraction .
研究领域:
材料科学
·
物理化学
✓ 已验证
产品关联
DOI
FLUID PHASE EQUILIBRIA
·
2023
·
IF 2.6
Shuo Yuan,Yi Liu,Jingwei Cui,Xiong Zheng
Hydrocarbons have wide applications in various industrial processes, and the knowledge of thermophysical properties is the foundation for their utilization. As an important thermophysical property, the thermal conductivity of fluids is vital in the evaluation of energy conversion quality, like heat transfer enhancement , thermodynamic cycle efficiency evaluation, etc. Therefore, obtaining accurate experimental data is of great importance for the utilization of hydrocarbons. Here, the thermal conductivities of liquid n-nonane and n-undecane were investigated using the transient hot-wire method (combined expanded uncertainty is 2.0 %) with a wide temperature and pressure range from 293.15 to 523.15 K and 0.1 to 15.0 MPa. For the convenience of engineering applications, a polynomial as a function of temperature and pressure was proposed to correlate the experimental data, the average absolute deviations between experimental data and fitted data are 0.29 % for n-nonane and 0.35 % for n-undecane, which indicates that the polynomial describes the experimental data well in the measured region. Meanwhile, the available literary data were collected and compared with our results, and good agreement was found between literary data and our results. This work is not only helpful for the industrial applications of hydrocarbons but also helps to understand the internal mechanism of the thermal conductivity of hydrocarbons.
研究领域:
化学工程
·
热物理
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产品关联
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 18
·10024-10029
·
IF 3.049
Chunming Chen,Zhonghua Chen,Xingrong Zeng,Fei Yu
We herein report the preparation of phase change nanocapsules with undecanoic acid (UA) as the core and a styrene–butyl acrylate copolymer as the shell by miniemulsion polymerization using interfacial redox initiation. The morphology, particle size, thermal properties, and structure of the nanocapsules were characterized by transmission electron microscopy, differential scanning calorimetry, and thermogravimetric analysis. Further, the cotton fiber was dissolved in hydroxyl-functionalized ionic liquid 1-(3-chloro-2-hydroxypropyl)-3-methyl imidazolium chloride, and then the nanoencapsulated UA was immobilized on the cotton fiber by mixing the solution with the phase change nanocapsule emulsion. The desired thermoregulating fabrics were then recovered by vacuum suction filtration and drying, and their surface morphologies and thermoregulating properties were evaluated. The nanocapsules were found to be of a regular spherical shape with a diameter ranging from 90 to 110 nm, and they exhibit a phase change temperature of 29.3 °C. Finally, the prepared thermoregulating non-woven fabrics exhibited excellent thermal reliability, air permeability, and thermoregulating capability.
研究领域:
材料科学
·
纺织工程
✓ 已验证
DOI
高影响因子
JOURNAL OF DAIRY SCIENCE
·
2023
·
IF 3.5
Yanmei Xi,Sana Ikram,Tong Zhao,Yiwei Shao,Ruirui Liu,Fuhang Song,Baoguo Sun,Nasi Ai
ABSTRACT Flavor sensation is one of the most prevalent characteristics of food industries and an important consumer preference regulator of dairy products. So far, many volatile compounds have been identified, and their molecular mechanisms conferring overall flavor formation have been reported extensively. However, little is known about the critical flavor compound of a specific sensory experience in terms of oxidized off-flavor perception. Therefore, the present study aimed to compare the variation in sensory qualities and volatile flavors in full-fat UHT milk (FFM) and low-fat UHT milk (LFM) samples under different natural storage conditions (0, 4, 18, 25, 30, or 37°C for 15 and 30 d) and determine the main component causing flavor deterioration in the FFM and LFM samples using sensory evaluation, electronic nose, and headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS). In addition, the Pearson correlation between the volatile flavor components and oxidative off-flavors was analyzed and validated by sensory reconstitution studies. Compared with the LFM samples, the FFM samples showed a higher degree of quality deterioration with increased storage temperature. Methyl ketones of odd carbon chains (i.e., 2-heptanone, 2-nonanone, 2-undecanone, 2-tridecanone, and 2-pentadecanone) reached a maximum content in the FFM37 samples over 30 d storage. The combined results of the Pearson correlation and sensory recombination study indicated that 2-heptanone, 2-nonanone, and 2-undecanone conferred off-flavor perception. Overall, the present study results provide potential target components for detecting and developing high-quality dairy products and lay a foundation for specific sensory flavor compound exploration in the food industry.
研究领域:
食品科学
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感官评价
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 17
·9327-9333
·
IF 2.936
Lei Meng,Jian-Hang Yin,Yaqing Yuan,Na Xu
A novel ratiometric fluorescence strategy is developed for specific detection of folic acid (FA) by using 11-mercaptoundecanoic acid protected gold nanoclusters (AuNCs@MUA). In this design, the fluorescence color of the probe can be switched among red, pink, violet and blue by varying the concentration of FA. AuNCs@MUA possesses strong fluorescence peaking at 612 nm (R-signal) and FA exhibits blue emissive auto-fluorescence at 446 nm (B-signal), showing a large emission shift of ∼170 nm. When AuNCs@MUA approaches FA through electrostatic binding, the R-signal decreases while the B-signal increases with titration of FA. Based on the above phenomenon, a radiometric analysis platform is constructed for FA target detection, with a wide linear response range from 0 to 20 μM, and an excellent detection limit of 26 nM. This new ratiometric strategy exhibits low background, and wide signal changes in a low concentration range, which presents obvious advantages over most previous FA detections based on single-responsive fluorescence methods. Furthermore, the proposed method is successfully applied to determine FA in human serum samples.
研究领域:
分析化学
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生物医学工程
·
分子生物学
✓ 已验证
DOI
高影响因子
PEST MANAGEMENT SCIENCE
·
2024
·
IF 3.8
Xin-Yue Zhang,Wen-Hao Han,Feng-Bin Zhang,Jun-Xia Wang,Shu-Sheng Liu,Xiao-Wei Wang
BACKGROUND The whitefly Bemisia tabaci is one of the world's foremost agricultural pests. Recently, we found that a wild relative of tobacco ( Nicotiana benthamiana ) demonstrates remarkable attractiveness and nearly 100% lethality towards whiteflies. Therefore, it can act as a dead-end trap crop for whitefly control in the field. However, the underlying mechanism of the significant attractiveness of N. benthamiana towards whiteflies is unclear. RESULTS Binary-choice assays and olfactory experiments showed that compared to common tobacco ( N. tabacum ), the volatile of N. benthamiana has a greater attraction to whiteflies. Then we analyzed and compared volatiles from these two Nicotiana species by thermal desorption-gas chromatography–mass spectrometry (TD-GC–MS). We identified 16 chemical compounds that are more abundant in N. benthamiana than in N. tabacum. Seven compounds were further tested with olfactometer assays and we found that, among them, undecane strongly attracted whiteflies. Further experiments revealed that even 0.005 μg mL −1 undecane is attractive to whiteflies. We also silenced the genes that may influence the biosynthesis of undecane and found the production of undecane decreased after silencing NbCER3 , and that N. benthamiana plants with less undecane lost their attraction to whiteflies. In addition, we found that applying 0.005 μg mL −1 undecane on yellow sticky traps can increase the number of stuck insects on the traps by ≈40%. CONCLUSION Undecane from the volatile of N. benthamiana is a critical chemical signal that attracts whiteflies and NbCER3 involved in the biosynthesis of undecane. Undecane may be used to improve the efficiency of yellow sticky traps for whitefly control. © 2024 Society of Chemical Industry.
研究领域:
农业昆虫学
·
植物科学
·
化学生态学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2023
·
IF 10.9
Yinghao Wu,Jinming Wei,Xiaolu Shi,Wenjie Zhao
In the marine environment, the protective coatings face serious corrosion and biofouling problem, limitations, and challenges that made self-healing coatings unable to perform both anti-corrosion and anti-biofouling dual-function at the same time. Here we constructed the corrosion resistance and anti-biofouling self-healing coating by integrating nano-containers into the coating matrix, the 2-Undecylimidazoline (ULM) acted as a corrosion inhibitor and anti-biofouling dual-functional agent which was loaded on the natural container attapulgite (ATP). To obtain high healing efficiency, a fluidity-driven self-healing silicone oil coating was thickened by fibrous ATP to enhance its stability, which played a key role in the self-healing and long-term corrosion resistance. The self-healing time of ULM@ATP reinforced oil coating was 4 s at least in the air and up to 30 s in the 1 M HCl solution. Meanwhile, the ULM@ATP can significantly enhance the corrosion resistance of the self-healing coating, with the best effect achieved when the content of ULM@ATP was 5 wt.%. The impedance modulus of ULM@ATP-2 still reached 1.62 × 10 8 Ω cm 2 after 480 immersion in 3.5 wt.% NaCl solution, which is 3 orders of magnitude high than pure Oil coating (2.17 × 10 5 Ω cm 2 ). The restructure of the ATP network and the release of ULM could largely inhibit the corrosion of metal. The continuous open circuit potential of the composite coating performed the potentially infinite self-healing capacity. The self-healing performances of the composite coating in strong acid and base solutions exhibited high environmental suitability. This anti-corrosion and anti-biofouling (the surface coverage of adhered chlorella decreased 96.88%) dual-function strategy of self-healing coatings could be also realized by many other porous nano-materials or function modifications. The self-healing performances of the composite coating in strong acid and base solutions exhibited high environmental suitability. This anti-corrosion and anti-biofouling dual-function strategy of self-healing coatings could be also realized by many other porous nano-materials or function modifications. The rapid response self-healing coating possessed anti-biofouling and active self-healing functions and showed wide application under more service environments.
研究领域:
材料科学
·
海洋工程
·
防腐蚀技术
✓ 已验证
DOI
高影响因子
Materials
·
2024
·Vol. 17
·期 7
·1570
·
IF 3.1
Luchao Yan,Yang Wang,Shijian Lu,Zhipeng Zhu,Lingling Xu
With the fast development of the cold chain transportation industry, the traditional refrigeration method results in significant energy consumption. To address the national call for energy saving and emission reduction, the search for a new type of energy storage material has already become a future development trend. According to the national standard GB/T28577 for the classification and basic requirements of cold chain logistics, the temperature in frozen logistics is typically below −18 °C. In this study, n-undecane with a phase change temperature of −26 °C is chosen as the core material of microcapsules. Poly(methyl methacrylate) is applied as the shell material, with n-undecane microcapsules being prepared through suspension polymerization for phase change cold storage materials (MEPCM). Using characterization techniques including SEM, DSC, FTIR, and laser particle size analysis, the effects of three types of emulsifiers (SMA, Tween-80, Tween-80/span-80 (70/30)), SMA emulsifier dosage, core–shell ratio, and emulsification rate on the thermal performance and micro-surface morphology of n-undecane/PMMA microcapsules were studied. The results indicate that when comparing SMA, Tween-80, and Tween-80/span-80 (70/30) as emulsifiers, the dodecane/PMMA microcapsules prepared with SMA emulsifier exhibit superior thermal performance and micro-surface morphology, possessing a complete core–shell structure. The optimal microstructure and the highest enthalpy of phase change, measuring 120.3 kJ/kg, are achieved when SMA is used as the emulsifier with a quantity of 7%, a core-to-wall ratio of 2.5:1, and an emulsification speed of 2000 rpm. After 200 hot and cold cycles, the enthalpy of phase change decreased by only 18.6 kJ/kg, indicating the MEPCM thermal performance and cycle life. In addition, these optimized microcapsules exhibit favorable microstructure, uniform particle size, and efficient energy storage, making them an excellent choice for the refrigeration and freezing sectors.
研究领域:
材料科学
·
能源工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INSTRUMENTATION SCIENCE & TECHNOLOGY
·
2019
·
IF 1.118
X.-C. Fan,Q. Wang
A highly sensitive arginine sensor based on optical fiber surface plasmon resonance (SPR) and 11-mercaptoundecanoic acid (MUA) was studied and implemented in this work. The method of modifying the mercaptoundecanoic acid molecule on the surface of the sensing area was proposed initially by using molecular self-assembly technology in order to complete the detection of arginine. The detection principle is a hydrogen bond-based aggregation between mercaptoundecanoic acid and arginine. The close alignment of the mercaptoundecanoic acid molecules allows the aggregation of arginine to affect changes within the surrounding local refractive index. This aggregation was selective for the arginine molecules. The sensor probe has a detection limit of 0.005 μM and a sensitivity of up to 1474 nm/μM. The entire detection system, including the probe, has the advantages of being low cost, small in size, easy to operate, and uses low power. This approach has the potential to be developed as a mobile and fast-detection method.
研究领域:
生物化学
·
传感技术
✓ 已验证
DOI
高影响因子
Nanoscale
·
2015
·Vol. 7
·期 39
·16372-16380
·
IF 7.394
Jian Sun,Fan Yang,Xiurong Yang
A novel and convenient one-pot but two-step synthesis of fluorescent gold nanoclusters, incorporating glutathione (GSH) and 11-mercaptoundecanoic acid (MUA) as the functionalized ligands (i.e. AuNCs@GSH/MUA), is demonstrated. Herein, the mixing of HAuCl4 and GSH in aqueous solution results in the immediate formation of non-fluorescent GSH–Au+ complexes, and then a class of ∼2.6 nm GSH-coated AuNCs (AuNCs@GSH) with mild orange-yellow fluorescence after several days. Interestingly, the intense orange-red emitting ∼1.7 nm AuNCs@GSH/MUA can be synthesized within seconds by introducing an alkaline aqueous solution of MUA into the GSH–Au+ complexes or AuNC@GSH solution. Subsequently, a reliable AuNC@GSH/MUA-based real-time assay of acid phosphatase (ACP) is established for the first time, inspired by the selective coordination of Fe3+ with surface ligands of AuNCs, the higher binding affinity between the pyrophosphate ion (PPi) and Fe3+, and the hydrolysis of PPi into orthophosphate by ACP. Our fluorescent chemosensor can also be applied to assay ACP in a real biological sample and, furthermore, to screen the inhibitor of ACP. This report paves a new avenue for synthesizing AuNCs based on either the bottom-up reduction or top-down etching method, establishing real-time fluorescence assays for ACP by means of PPi as the substrate, and further exploring the sensing applications of fluorescent AuNCs.
研究领域:
分析化学
·
生物传感
·
纳米材料
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2020
·
IF 4.049
Yujie Zhang,Hui Zhong,Zi'ang Cao,Shouyong Zhou,Dabing Zhang,Renling Lu,Haifeng Han,Mingliang Zhang,Hongdeng Qiu
The present work described two triacontyl-bonded silica adsorbents containing different polar embedded groups ( i.e. amide- and carbamate-type) for high performance liquid chromatography, which were prepared by covalent surface modification of silica gel with respective pre-synthesized polar-embedded triacontyl (C30) silane. The acylimidazole-mediated method was used for the first time for the synthesis of amide-type alkyl silane, while the carbamate-type silane was obtained via an improved solvent-free procedure. A conventional C30 stationary phase was also developed on the same silica substrate in the similar manner, which was used as a reference column for comparison of the unique mechanisms facilitated and/or furnished by the polar groups. The successful immobilization of the designed C30 species was confirmed by infrared spectroscopy and elemental analysis. In further comparison with an amide-embedded octadecyl (C18) two other conventional C18 stationary phases of different surface chemistry, detailed chromatographic characterization of the C30 series stationary phases was performed in terms of surface density, hydrophobicity, aromatic selectivity, shape selectivity and water tolerance using a diversified range of analytes, including homologous alkylbenzenes, isomeric polycyclic aromatic hydrocarbons, carotenes, congeners of polychlorobiphenyls, aromatic amines, phenolic compounds, estrogens and nucleosides. A high resemblance between the chromatographic behaviors of the two polar-modified C30 stationary phases was observed, meanwhile they demonstrated noticeable differences from non-polar C30 stationary phase. The polar-embedded C30 phases showed satisfactory performance towards the solutes of interest in the studied conditions. The beneficial synergy of the polar groups and the triacontyl chains enabled these polar-enhanced C30 stationary phases to address challenging separation tasks with high selectivity.
研究领域:
分析化学
·
色谱技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）