ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2016
·Vol. 408
·期 12
·3359-3367
·
IF 3.125
Wang Kun,Li Na,Lei Lei,Yang Xiao,Wang Zhibing,Li Dan,Zang Shuang,Zhang Hanqi,Yu Aimin,Zhang Ziwei
Dispersive liquid–liquid microextraction combined with collection of the extraction phase with the hollow fiber was applied to the extraction of estrogens from environmental water samples. 1-Undecanol with relatively lower toxicity was used as the extraction solvent. The hollow fiber was used to collect the extraction phase containing the analytes from the aqueous phase. Hollow fibers collecting the extraction phase were eluted with acetonitrile and the resulting eluate was analyzed by high performance liquid chromatography. Several parameters, including pH of sample, the type and volume of the extraction and dispersive solvent, salt concentration, extraction time, and collection time were optimized. Under the optimal experimental conditions, the limits of detection for estriol, 17α-estradiol, and ethynylestradiol were 4.58, 1.41, and 1.41 μg L –1 , respectively. When the present method was applied to the analysis of real water samples, the recoveries of estrogens at two spiked levels were in the range of 55.8–107.4 %. In this method, the separation of the extraction phase and aqueous phase becomes easy with no need for centrifugation, refrigeration-thaw, or any special device. The hollow fiber was commercially available and the collection procedure was easy to perform, which make the present method have potential for automation and wide promotion. Small sizes of pores on the walls of the hollow fibers can block large molecules, which makes the present method have the potential for the treatment of complex matrices.
研究领域:
分析化学
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环境科学
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PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
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2016
·Vol. 35
·期 1
·54-65
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IF 1.811
Chen Qi-jing,An Ze-sheng
A series of well-defined core cross-linked star (CCS) polymeric ionic liquids (PILs) were synthesized via a three-step approach. First, the styrenic imidazole-based CCS polymer (S-PVBnIm) was prepared by the RAFT-mediated heterogeneous polymerization in a water/ethanol solution, followed by the quaternization of S-PVBnIm with bromoalkanes and anion exchange. The CCS polymers were characterized by gel permeation chromatography (GPC), nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), and differential scanning calorimetry (DSC). The obtained CCS polymers were used as the effective emulsifiers for oil-in-water high internal phase emulsions (HIPEs). Multiple oils with different polarity including n -dodecane, undecanol, toluene and octanol were emulsified using 0.5 wt% S-PVBnIm aqueous solution under the acidic condition to form HIPEs with long-term stabilities. The excellent emulsification properties of CCS PILs were demonstrated by HIPE formation for a variety of oils. The properties of HIPEs in terms of emulsion type and oil droplet size were characterized by the confocal laser scanning microscopy (CLSM). The intriguing capability of CCS PILs to stabilize HIPEs of various oils holds great potentials for the practical applications.
研究领域:
聚合物化学
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材料科学
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胶体与表面化学
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高影响因子
MICROCHEMICAL JOURNAL
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2026
·
IF 5.1
Qing-nan Chen,Yun-e Bai,Yao Ma,Rui Liao,Lu-lu Wang,Shuang Hu,Jian- ping Gao
Latex-bearing plants have gained global attention, but few studies have been reported on Codonopsis pilosula (Franch.) Nannf.( C. pilosula ) latex. In this research, we established a UHPLC-MS/MS method to investigate the constituents in C. pilosula latex. Analysis revealed that the latex of C. pilosula contains alkaloids, terpenoids, and fatty acids, with fatty acids being one of the primary metabolites distinguishing the latex from above-ground (DS) and below-ground (DX) parts of C. pilosula. To evaluate the quality of C. pilosula latex, an approach of dispersive liquid-liquid microextraction with solidification of the floating organic drop (DLLME-SFO) methodology was developed to quantitatively analyze the contents of three fatty acids (palmitic, linoleic, and stearic) in the latex of C. pilosula . The ideal extraction conditions involve injecting 20 μL of dodecanol extractant into a 5 mL 10% NaCl solution at pH 3.0, followed by 20 min at 700 rpm. The three components mentioned above have enrichment coefficients ranging from 48 to 50. The quantification limits were between 0.23 and 0.25 μg/mL, and three components demonstrated good linearity in their respective linear ranges (R 2 > 0.995). The satisfied precision and recovery rates were 1.26 to 8.05% and 92.38 to 101.53%, respectively. By quantitatively analyzing the three fatty acid contents in the latex of C. pilosula , the results showed that palmitic and linoleic acids were able to successfully distinguish the latex of C. pilosula from different parts, which laid the foundation for the quality evaluation of C. pilosula , and provided a reference for the utilization of C. pilosula , a medicinal food source.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2025
·
IF 2.8
Xun Zhan,Jian Chen,Yanhua Kang,Zhaozhe Yang,Guomin Wu,Zhenwu Kong
In the application of waterborne coatings, enhancing the water resistance and mechanical properties of coating films derived from waterborne coatings has been a critical challenge in need of urgent resolution. To tackle this issue, we propose an innovative strategy that involves surface modification of cellulose nanocrystals (CNC) using long-chain alkyl alcohols and the preparation of polyurethane composite films with excellent hydrophobicity by compounding the modified CNC (C-CNC) with waterborne polyurethane (WPU). Using a custom mold, we achieved surface hydrophobic functionalization. This study delves into the impact of CNC on the hydrophobic composite film, particularly focusing on its contribution to film morphology, thermal properties, and mechanical properties, significantly enhancing its hydrophobicity. Experimental results demonstrate that the mold with a rough surface constructs numerous rough and porous structures on the coating film surface, significantly enhancing its hydrophobicity. Notably, the C 28 –CNC/WPU composite film prepared using octacosanol-modified CNC exhibits the best hydrophobicity, with a water contact angle reaching 122.80°. This strategy of preparing hydrophobic coating films through a simple and effective method not only overcomes limitations of waterborne coatings in terms of water resistance and mechanical properties but also holds significant potential for environmentally friendly coatings, offering new insights for waterborne coating development.
研究领域:
材料科学
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化学工程
·
涂层技术
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高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2025
·Vol. 26
·期 9
·4337
·
IF 4.9
Xianxin Zhu,Zihan Wu,Xunzhi Deng,Ze Liao,Ruozhong Wang,Zhoufei Luo
Strigolactones (SLs) are key hormones regulating branching and tillering in rice, impacting plant architecture and yield. A rapid, sensitive, and environmentally friendly method using dispersive liquid–liquid microextraction based on the solidification of floating organic droplets (DLLME-SFO), coupled with ultra-high-performance liquid chromatography and tandem mass spectrometry (UHPLC-MS/MS), has been developed for the determination of three SLs (strigol, orobanchol, and 5-deoxystrigol). The DLLME-SFO method integrates one-step low-temperature extraction and enrichment. The DLLME-SFO conditions were optimized through a single-factor experimental design. Under the best-tested conditions, the developed method exhibited excellent linearity, with the coefficient of determination (R2) values greater than 0.9993. The recoveries ranged from 83% to 96%, with precision values ranging from 4.5% to 12.4%. The limits of detection (LODs) varied from 0.6 to 1.2 pg/g fresh weight, indicating the high sensitivity of the method. Additionally, a novel assay protocol for the quantification of SLs in rice in response to nitrogen and phosphorus stress conditions was applied.
研究领域:
植物学
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分析化学
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Min Wang,Yajie Yue,Xiaoning Wei,Jinyuan Zhang,Xinyuan Bi,Liyan Jia,Xu Jing
Strobilurin fungicides are widely used pesticides globally; however, their residues pose a risk to environmental safety and human health. This study aimed to develop a rapid and green method for detecting strobilurin fungicide residues. Chitosan and magnetic deep eutectic solvent-based emulsive liquid-liquid microextraction method combined with high-performance liquid chromatography was developed to determine strobilurin fungicides in water samples. A high-concentration oil-in-water emulsion containing chitosan solution and extractant was formulated, followed by the addition of samples to form a low-concentration oil-in-water emulsion to complete the rapid pretreatment, therefore solving the limitation of emulsive liquid-liquid microextraction in the inapplicability of extractants. Traditional microextraction required toxic solvents and complex equipment to facilitate the dispersion of extractants, whereas this study used only chitosan solution to aid in emulsifying extractants. The new green magnetic deep eutectic solvent synthesized by tetraoctylammonium bromide, ferric chloride, and oleic acid was used instead of toxic extractants. An external magnetic field assisted the extractant phase collection, which shortened the separation time. Under optimal conditions, the recovery of this method was 83.3 %–107.4 %, the limit of detection was 0.0010–0.0021 mg L −1 , and the coefficient of determination was >0.994. This rapid, green, simple, and efficient chitosan-based microextraction method could detect strobilurin fungicide residues in water samples because of its enhanced compatibility with hydrophobicity extractants.
研究领域:
环境科学
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分析化学
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PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Xian Cheng,Yan-Ju Lu,Sheng-Nan Li,Ya-Zhou Xu,Pan-Pan Li,Jing Wang,Shi-Chao Xu,Yan Gu,Liang-Wu Bi,Yu-Xiang Chen
Fungicide residues in food can pose serious hazards to humans. The aim of this study was to establish a new method of semistable emulsion assisted dispersive liquid–liquid microextraction (DLLME) for the preconcentration and determination of fungicide residues in juice samples. In this study, Gum Acacia (GA) was selected as the dispersive agent and decanoic acid was adopted as the extractant in aqueous sample. Based on that, a semistable emulsion was induced to facilitate the extraction of target analytes and automatic phase separation. The mechanistic analysis results revealed that the formation of the semistable emulsion was attributed to the mild emulsification of GA with a high molecular weight. Besides, the semistable emulsiont allowed the automatic phase separation in DLLME for the first time. Moreover, the novel method was optimized for detecting fungicide residues and exhibited good linearity (R2 ≥ 0.995), precision (≤16.2 %), matrix effect (≤9.8 %), method recovery (84.0–103.6 %), as well as a low limit of detection (0.5–2.5 μg·L −1 ) and quantitation (1–5 μg·L −1 ). In conclusion, this method can be employed to effectively measure fungicide residues in juice samples (orange, grape, carrot and peach). Furthermore, this method can be considered as an effective DLLME alternative for the automatic pretreatment of samples, exhibiting a promising application prospect in food safety.
研究领域:
分析化学
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食品安全
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环境科学
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高影响因子
ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Li Chen,Yibo Yan,Changbao Hong,Xiangting Wei,Jianhua Xiong,Chuixiu Huang,Xiantao Shen
Background Simultaneous determination of different natures of analytes is of great significance for saving sample volumes and simplifying analytical procedures. However, sample preparation for the simultaneous extraction of polar and non-polar analytes represents a challenge in sample preparation. Inspired by the successive liquid-phase microextraction (sLPME) method for acidic and basic analytes that we previously developed, we first proposed an efficient successive electromembrane extraction (sEME) system by adjusting the acidity of the donor solution and using binary organic solvents for extraction of polar and non-polar targets from biological samples in this work. Results We performed a detailed optimization of the sEME system. Here, carnitine (C0) and acylcarnitines were selected as model analytes since the demand increased especially in metabolomics studies. The combination of 2-nonanone and 2-nitrophenylpentyl ether (NPPE) was selected as supported liquid membranes (SLMs), and trichloroacetic acid (TCA) 100 % (v/v) was added to donor solution to adjust the acidity of the donor solution after the first sEME process (sEME-1). The recoveries of the targets in blood and urine were 47%–119% and 54%–118%, respectively. Moreover, the sEME systems were evaluated by liquid chromatography tandem mass spectrometry (LC-MS/MS) from biological samples. The limit of detection (LOD) and limit of quantitation (LOQ) of analytes were 0.03–1.33 ng mL −1 and 0.09–4.42 ng mL −1 , respectively. Significance sEME enabled the extraction of polar and non-polar analytes from the same sample under optimal extraction conditions for all target analytes, which provided ideas for efficient sEME of exogenous and endogenous analytes from biological samples for forensic, clinical, and epidemiological studies.
研究领域:
分析化学
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生物医学
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PubMed
高影响因子
ANALYTICAL LETTERS
·
2024
·
IF 1.6
Yelu Wu,Weiyang Tang,Jian-Liang Zhou,Tian Xie
3,4-Dihydroxybenzaldehyde (DHB) is a highly effective water-soluble compound in the traditional Chinese medicine Salvia miltiorrhiza Bge. Which demonstrates clear therapeutic effects against a variety of diseases. Therefore, the development of a selective approach for the separation of 3,4-dihydroxybenzaldehyde is of great significance. In this study, electro-driven extraction combined with multi-stage extraction technology was employed for the first time to separate 3,4-dihydroxybenzaldehyde from S. miltiorrhiza Bge. Decoction (Recovery ≥ 46.09%). Five long-chain fatty alcohols were selected as the supported liquid membrane (SLM) in the electro-driven extraction. Factors influencing extraction efficiency, including pH, voltage, and extraction time, were optimized using a design of experiments. Under the optimal conditions, the linearity of 3,4-dihydroxybenzaldehyde ranged from 0.01 to 100 μg·mL−1), with limits of detection (LOD) and quantification (LOQ) of 5 and 17 ng·mL−1, respectively. The precision of electro-driven liquid membrane extraction for 3,4-dihydroxybenzaldehyde was below 8.42%. This paper reports novel electro-driven liquid membrane extraction for selectively isolating 3,4-dihydroxybenzaldehyde from S. miltiorrhiza Bge.
研究领域:
中药化学
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分离纯化技术
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药用植物研究
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高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2026
·
IF 12.4
Yu Han,Guohua Ma,Kai Zhang,Runcai Xu,Ning Xin,Jingtong An,Ning Wang,Yantao Li
Lipid nanoparticles (LNPs) have emerged as a powerful nanoplatforms contributing to the success of mRNA vaccines. However, the rational design of lipid structures and the optimization of LNP composition, especially via metal-based adjuvants to boost extrahepatic delivery and immune responses, represent a promising yet technically challenging strategy. Herein, we developed a Zn(II)-adjuvanted imidazole-based LNP system that integrates rational lipid design with metal-coordinated self-assembly to achieve synergistic enhancement in delivery and immunogenicity. Initially, a library of 28 imidazole-based ionizable lipids was synthesized and screened, identifying A10–1 LNPs with a well-balanced lipid composition and high transfection efficiency. Furthermore, Zn 2+ coordination with the imidazole headgroup imparts Zn-A10–1 LNPs with enhanced structural stability and delivery performance, leading to improved cellular uptake, efficient endosomal escape, and preferential accumulation in the spleen. These attributes contributed to the robust activation of bone marrow-derived dendritic cells (BMDCs), induced memory T cell responses, and elevated proinflammatory cytokine secretion. In a melanoma model, vaccination with Zn-A10–1 LNPs markedly suppressed tumor progression and promoted the infiltration of OVA-specific CD8 + T cells. Overall, this study underscores the potential of Zn(II)-coordinated LNPs as effective nanoplatforms for extrahepatic mRNA vaccine delivery, offering a promising strategy for the mRNA-based vaccine design and immunotherapies.
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高影响因子
Science Advances
·
2026
·Vol. 12
·期 11
·
IF 13.9
Zhangqin Shi,Mingming Fang,Jing Zhang,Qinghui Zeng,Wei Hao,Yongteng Dong,Zhu Liu,Xubing Dong,Xinyang Yue,Zheng Liang
Although energy density and cycling stability remain central to lithium metal battery (LMB) research, particularly in solid-state systems, two critical yet underappreciated challenges are wide-temperature operability and recyclability. These key parameters are fundamentally governed by electrolyte design. Here, we introduce a persistent-range hydrogen-bonded (PHB) gel polymer electrolyte (GPE) for LMBs. Constructed via continuous hydrogen-bonding interactions between perfluorinated branches and ─NH─ groups on fluorinated polyurethane backbones, this dynamic network architecture synergizes seemingly incompatible properties: chemically cross-linked–level mechanical robustness and chemical stability, alongside physically cross-linked–level dynamicity and ionic conductivity (8.6 mS cm −1 in regular carbonate electrolytes). The resulting PHB-GPE endows Li-metal pouch cells with stable cycling across a −60° to 100°C temperature range. Moreover, PHB-GPE exhibits recyclability potential, enabling the reuse of the Li salt and polymer at the end of battery life. These findings provide transformative insights into designing multifunctional GPE structures for next-generation LMBs, addressing both performance and sustainability imperatives.
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高影响因子
ACS Applied Bio Materials
·
2020
·
IF 0
Shanguo Zhang,Xiaojie Wang,Jia Man,Jianyong Li,Xiaoyang Cui,Chuanwei Zhang,Weichen Shi,Donghai Li,Song Zhang,Jianfeng Li
The protective effects of histone deacetylase (HDAC) inhibitors were highlighted in the treatment of kidney diseases, especially acute kidney injury (AKI). However, the currently available HDAC inhibitor cannot be delivered to the kidney properly because of its poor solubility in aqueous solutions. Therefore, calcium alginate (Ca-ALG) microspheres were proposed as microcarriers for the delivery of HDAC inhibitors in this study. First, Ca-ALG microspheres with high sphericity were obtained by a single-emulsion microfluidic strategy. Then, we selected suitable Ca-ALG microspheres for HDAC inhibitor loading by analyzing the swelling ratio and the release property using different parameters. Besides, thermal stimulation will change the drug release property of Ca-ALG microspheres in in vitro experiments. Furthermore, the HDAC inhibitor-loaded microspheres were delivered to the kidney by renal subcapsular injection for evaluating the treatment effects in mice with ischemia-reperfusion-induced AKI. The in vivo results showed that the HDAC inhibitor-loaded Ca-ALG microspheres could effectively reduce the renal regional inflammatory response and macrophage infiltration. Taken together, we proposed a promising therapy with an effective kidney-targeted drug delivery for the treatment of AKI.
研究领域:
药理学
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肾病学
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生物医学工程
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药物递送系统
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DOI
PubMed
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