JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Huiwen Ren,Ruiqi Xie,Sheng Jian,Xiong Tong,Xian Xie,Zhihui Zhao,Xuelin Wei
The separation of spodumene and albite by the new collector 12-aminododecanoic acid (12-ADA) without an activator or depressant was investigated by single-mineral and artificially mixed-ore flotation test. The results showed that under the 12-ADA concentration of 314 mg/L, pH 5.0, and 10 °C, the recoveries of spodumene and albite were 12.85 % and 89.15 %, respectively. At the 12-ADA concentration of 114 mg/L, pH 4.5, and 10 ± 2 °C, Li 2 O grade of 4.56 % and recovery of 84.55 % were achieved. In addition, the interaction mechanism between minerals and 12-ADA was investigated. The results showed that 12-ADA could form an association complex, which could create hydrogen bonds with the Si-O bond on the albite surface through NH 2 , and form chemical bonds with Na through COOH. However, 12-ADA mainly adsorbed onto the spodumene surface through electrostatic attraction. With an increase in the concentration of 12-ADA, albite could preferentially adsorb 12-ADA as a monolayer, while the adsorption between spodumene and 12-ADA was small, when 12-ADA exceeded a certain amount, it became prone to multilayer adsorption. 12-ADA overcame the temperature limitation of traditional fatty acid reagents and had potential application value for the flotation of spodumene in cold areas. It also provided a theoretical basis for the research and development of low-temperature reagents for spodumene.
研究领域:
矿物加工工程
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材料科学与工程
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产品关联
DOI
高影响因子
METABOLIC ENGINEERING
·
2025
·
IF 6.8
Haixin Gao,Qiang Fang,Yanfen Bai,Chunyue Hu,Howard H. Chou
Biosynthesis of 12-aminododecanoic acid (ADDA) directly from biomass-derived sugars would enable a more sustainable process for manufacturing the engineering polymer Nylon 12. ADDA biosynthesis is currently hindered by the cytotoxicity of dodecanoic acid (DDA) to growing cells, and the accumulation of the overoxidized byproduct dodecanedioic acid (DDDA). In this study, these challenges were addressed by engineering an autoinducible system to better control in vivo DDA synthesis without impacting growth, and deleting aldehyde dehydrogenases and oxidases to reduce DDDA accumulation. As a result, a one-step fermentation process was established to synthesize ADDA from glucose and cellobiose. Finally, batch fermentation achieved 1035 mg/L ADDA and 5% yield, which is the highest titer and yield accomplished directly from sugar to date. This research contributes to the mechanistic understanding of microbial DDA, ADDA, and DDDA synthesis, as well as the goal of developing more sustainable processes for nylon production.
研究领域:
微生物学
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生物工程
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合成生物学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 42
·35991-35999
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IF 3.289
Jing Liu,Jing Liu,Dujuan Zhao,Naxin Ma,Yuxia Luan
Cytarabine (1-β-D-arabinofuranosylcytosine, Ara-C), an attractive medicinal treatment for myeloblastic leukemia, is subject to low oral bioavailability due to its weak membrane permeability and lipophilicity as well as its poor metabolic stability. Based on these considerations, we proposed a chemical linkage of cytarabine with lauric acid (LA), a long-chain fatty acid with 12 carbons, leading to a new prodrug, LA–Ara. The NH2 group of Ara-C is protected by conjugation and thus cannot not be deactivated by deamination; moreover, notably high liposolubility and penetrability were obtained. When dispersed in water, this new amphiphilic molecule can adopt a nanofiber configuration. It was found that LA–Ara molecules are stable in artificial biological media, indicating that the prodrug could be administrated orally. MTT assays on HL60 and K562 cells were performed, and the significantly higher cytotoxicity compared to the pure drug suggested that the prodrug has conspicuously superior antiproliferative activity. Following oral administration, the elimination half-life and bioavailability of the LA–Ara group dramatically increased to 6.6- and 32.8-fold of those of free Ara-C, respectively. It appears that this new prodrug could be an effective oral alternative treatment to Ara-C and supply a promising therapy index for leucocythemia.
研究领域:
药理学
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肿瘤学
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药物化学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Jingna Liu,Liu Cui,Yuying Shi,Qiong Zhang,Yuangong Zhuang,Peng Fei
In this study, docosanoic acid, a very long chain fatty acid , was used to modify pectin, and the products were incorporated with carboxylmethyl cellulose (CMC) to prepare a hydrophobic composite. Results of structural characterisation showed that docosanoic acid was grafted to pectin through the esterification reaction, and the highest grafting ratio was 7.89 %. After grafting with docosanoic acid, the emulsifying activity and stability of pectin were significantly enhanced from 1.23 × 10 −2 and 9.27 % to 4.78 × 10 −2 and 26.73 %. Moreover, when modified pectin was blended with CMC instead of native pectin, the hydrophobicity of the composite membranes increased significantly. In detail, the highest contact angle of the composite membrane incorporated with modified pectin was 97.6°, which was much higher than that with native pectin (68.9°). As the grafting ratio of pectin increased, the water vapor permeability of the composite membranes significantly increased, while the water absorption decreased. Furthermore, the mechanical properties and transparency of the composite membranes could be improved by grafting docosanoic acid into pectin. All the results indicated that incorporating docosanoic acid possibly helped improve the comprehensive properties of the composite membranes based on polysaccharides and expand their application in food packaging.
研究领域:
食品科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL PHYSICS LETTERS
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2024
·
IF 2.8
Xiaoqing Weng,Xudong Zhang,Pengpeng Ai,Qian Chen,Richard M. Kasomo,J. Viridiana García-Meza,Hongqiang Li,Yingxin Chen,Shaoxian Song
Sodium oleate (NaOL) is commonly employed as a traditional organic collector during the flotation process of phosphate ore. However, the residual NaOL in mineral processing wastewater not only poses a great threat to the environment, but also reduces the qualities of subsequent flotation products. In this study, an effective adsorbent graphene oxide/polyethyleneimine (GP) composite hydrogel was prepared and applied for the adsorption of NaOL. The successful association between GO and PEI was elucidated through various characterizations. Further to that, the adsorption performance was systematically determined through adsorption isotherm, adsorption kinetics, co-existing ions and reusability experiments. The results clearly demonstrated that the adsorption behavior of NaOL could be well described by both pseudo-second-order (PSO) kinetic and Langmuir isotherm models. GP composite hydrogel was able to achieve superior NaOL adsorption with an excellent adsorption capacity (295.95 mg/g) and a quick kinetic (120 min). The existence of competitive ions, such as CO 3 2− , SO 4 2− and PO 4 3− , had a negative effect on NaOL adsorption. The mechanism investigation suggested that chemical adsorption and hydrogen bonds were central and played imperative roles for the adsorption of NaOL on GP composite hydrogel. Overall, the current work provides a valuable reference for the efficient adsorption of NaOL.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
Journal of Water Process Engineering
·
2025
·
IF 6.7
Yujia Tang,Zhenchu Dan,Hui Sun,Xinyue Hu
In environmental settings, perfluorinated compounds are characterized by low concentrations and heterogeneous distributions, which reduce their mass transfer efficiency, rendering conventional treatment technologies largely ineffective. This study examines perfluorododecanoic acid (PFDoDA) as a representative perfluorinated compound, employing solubilizing agents such as Tween80, sodium lauryl sulfate (SLS), and cocamidopropyl betaine to investigate the transfer characteristics and mechanisms of PFDoDA from non-aqueous to aqueous phases. SLS demonstrated the highest efficacy, enhancing the solubility to 2.684 mg/L, an increase by a factor of 6.8. Mechanistically, PFDoDA is solubilized within the micellar core and palisade layer of SLS. The electrocatalytic oxidation process effectively degrades the PFDoDA-rich solubilized solution. The electro-catalytic oxidation system achieved a removal rate exceeding 99 % for PFDoDA over five cycles. Radical quenching experiments and electron paramagnetic resonance (EPR) analysis identified the predominant role of superoxide anions, effectively removing PFDoDA with the assistance of hydroxyl radicals, singlet oxygen and sulfate radical. The degradation pathways of major intermediate products of PFDoDA and solvents were proposed, along with a toxicity assessment. This research is the first to report the combination of surfactants with electro-catalytic oxidation as a promising approach for the removal of perfluorinated compounds.
研究领域:
环境科学
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化学工程
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DOI
高影响因子
FLUID PHASE EQUILIBRIA
·
2018
·
IF 2.197
Xiangyang Liu,Chenyang Zhu,Feng Yang,Chao Su,Maogang He
An experimental study on the isobaric molar heat capacities of ethyl nonanoate and ethyl dodecanoate was performed at temperatures between 303 K and 393 K and at pressures between 0.1 MPa and 25.2 MPa. An increase of isobaric molar heat capacity with temperature increase was observed, and temperature was found to have a greater effect on isobaric molar heat capacity than pressure. Then the isobaric molar heat capacity data of 18 saturated fatty acid methyl and ethyl esters in literature were selected, to get a general correlation for the isobaric molar heat capacity of saturated fatty acid alkyl esters. The average absolute relative deviation and the maximum deviation of the present correlation from experimental data are lower than 0.70% and 3.82%, respectively. At last, to test the predictive ability of the proposed correlation, the heat capacities of ethyl nonanoate and ethyl dodecanoate were calculated. The average absolute relative deviation and the maximum deviation from our experimental results are 0.88% and 2.10%, respectively.
研究领域:
物理化学
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热力学
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产品关联
DOI
高影响因子
DRUG DELIVERY
·
2019
·
IF 3.829
Yanfei Tao,Fei Yang,Kuiyu Meng,Dongmei Chen,Yujuan Yang,Kaixiang Zhou,Wanhe Luo,Wei Qu,Yuanhu Pan,Zonghui Yuan,Shuyu Xie
In our previous study, enrofloxacin-loaded docosanoic acid solid lipid nanoparticles (SLNs) could be effectively delivered to cells in vitro. In this study, its properties and exploitation as possible oral and intramuscular sustained release formulations for pigs were studied after being made into suspension. The re-dispersed time and sedimentation rate of the nanosuspension were 55 s and 1, respectively. It showed good stability when stored away from light and sustained release in pH = 7.4 PBS buffer. The suspension exhibited no irritation at the injection site and good palatability. Compared with commercial injection and soluble powder, the nanosuspension increased the bioavailability of enrofloxacin by 1.63 and 2.38 folds, and extended the mean residence time (MRT) of the drug from 11.27 and 12.33 to 37.76 and 35.15 h after intragastric and intramuscular administration, respectively. These results suggest that docosanoic acid SLN suspension (DAS) might be a promising oral and intramuscular sustained release formulation to enhance the pharmacological activity of enrofloxacin.
研究领域:
兽医学
·
药物递送系统
·
药剂学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2019
·
IF 0
Yanan Sun,Yuwei Wu,Chaoran Yu,Li Zhang,Gang Song,Zhiyi Yao
We report nanoscale pyrenyl excimers induced by the self-assembly of a pyrene-based fluorescent probe, 12-pyren-1-yldodecanoic acid (PyDA), for rapid detection of 2,4,6-trinitrotoluene (TNT) in aqueous media. Under the optimized conditions, the sensing nanosystem exhibited fast response and high selectivity and sensitivity for the detection of TNT. Especially, it could distinguish TNT from TNP, which is the major interferent in most circumstances. The detection limit is as low as 5.0 × 10–9 M. It also can be used for qualitatively and quantitatively monitoring TNT in real samples.
研究领域:
纳米技术
·
分析化学
·
环境科学
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产品关联
DOI
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2020
·
IF 2.888
Zemin Yuan,Guanjia Zhao,Xing Zhang,Jianguo Yin,Suxia Ma
Physical fuel surrogate is always necessary to be proposed to match physical properties such as liquid density, viscosity and surface tension of the real bio-aviation kerosene for the characteristics of their spray performance. Thus, it is crucial to determine the related thermophysical properties over a wide temperature range for a further development of the fuel spray system. Therefore, binary surrogates of n-decane with ethyl decanoate and ethyl dodecanoate were proposed and their thermophysical properties were investigated in the present work. The liquid density was obtained using a U-tube densimeter in the temperature range between (293.15 and 433.15) K. The liquid kinematic viscosity and surface tension were investigated simultaneously by surface light scattering (SLS) method in the temperature range from (313 to 423) K. Additionally, the refractive index was measured by a refractometer in the temperature range from (278.15 to 358.15) K. Furthermore, correlations for these properties were developed as the function of mole fraction and temperature. The relative deviations of experimental liquid density, kinematic viscosity, surface tension and refractive index from those calculated according to the correlations were within the range of ±0.2%, ±2%, ±1% and ±0.08%, respectively.
研究领域:
化学工程
·
热力学
·
燃料科学
·
航空航天工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）