BIOCONJUGATE CHEMISTRY
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2024
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IF 4
Shu Li,Shibo Song,Xiaojing Liu,Xingjiao Zhang,Xueya Liang,Xin Chang,Daijun Zhou,Jianting Han,Yaoyan Nie,Chen Guo,Xiaojun Yao,Min Chang,Yali Peng
Aberrant canonical NF-κB signaling has been implicated in diseases, such as autoimmune disorders and cancer. Direct disruption of the interaction of NEMO and IKKα/β has been developed as a novel way to inhibit the overactivation of NF-κB. Peptides are a potential solution for disrupting protein–protein interactions (PPIs); however, they typically suffer from poor stability in vivo and limited tissue penetration permeability, hampering their widespread use as new chemical biology tools and potential therapeutics. In this work, decafluorobiphenyl-cysteine SNAr chemistry, molecular modeling, and biological validation allowed the development of peptide PPI inhibitors. The resulting cyclic peptide specifically inhibited canonical NF-κB signaling in vitro and in vivo, and presented positive metabolic stability, anti-inflammatory effects, and low cytotoxicity. Importantly, our results also revealed that cyclic peptides had huge potential in acute lung injury (ALI) treatment, and confirmed the role of the decafluorobiphenyl-based cyclization strategy in enhancing the biological activity of peptide NEMO–IKKα/β inhibitors. Moreover, it provided a promising method for the development of peptide-PPI inhibitors.
研究领域:
药理学
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分子生物学
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炎症研究
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药物开发
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肽化学
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DOI
PubMed
高影响因子
European Physical Journal Plus
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2024
·Vol. 139
·期 7
·1-9
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IF 2.8
Wang Zhaoyang,Yang Huawei,Qi Yonggang,Wang Lifei,Zou Jiawei
Abstract As unique class of specialty engineering plastics, the development and applications for poly(aryl ether)s is of utmost significance in energy field due to their outstanding heat resistance and mechanical properties in highly challenging environments. Thus, In this study, fluorinated poly(aryl ether) fiber membrane (FPAE-FM) is successfully prepared by electrospinning technology. Furthermore, FPAE-FM is paired with copper to construct a vertical contact-separated triboelectric nanogenerator (TENG). The open-circuit voltage is 75 V and the short-circuit current is 3 μA. The construction of fiber increases the surface roughness of FPAE-FM, which facilitates the generation of triboelectric charges and improve the surface charge density. Furthermore, SiO 2 is introduced into FPAE-FM, which not only improves the surface roughness of the fibers to a certain extent, but also builds charge trap at the interface between SiO 2 and FPAE for trapping triboelectric charges, reducing the charge dissipation and increasing the volume charge density. The collective augmentation of surface charge density and volume charge density synergistically enhances the triboelectric output performance, resulting in a remarkable surge in both the open-circuit voltage and short-circuit current of TENG, reaching 147 V and 11 μA, respectively. Overall, this study provides new materials and theoretical support for exploiting TENG with high-performance. Graphical abstract
研究领域:
材料科学
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能源工程
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DOI
高影响因子
PEDOSPHERE
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2024
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IF 5.2
Yue CAI,Lirong PU,Lianzhou SHEN,Xinghao WANG,Zhaoyue SUN,Guodong FANG,Dongmei ZHOU,Yunjiang YU,Juan GAO
Silica nanoparticles (nSiO 2 ) have attracted considerable attention in agricultural practices. However, their effects on polycyclic aromatic hydrocarbon (PAH) accumulation in plants remain largely unknown. Thus, this issue was tracked here with a 30-d pot experiment with foliar spraying different sizes of nSiO 2 (100 mg L -1 , 10 mL) on Amaranthus tricolor L. (amaranth). Results showed that 30 nm and 100 nm nSiO 2 increased phenanthrene (PHE) contents in amaranth leaves by 242% ± 88.4% and 158% ± 29.6%, respectively, which was more significant than 2 µm particles (96.0% ± 29.2%). Metabolomics indicated that compared to nSiO 2 , 2 µm SiO 2 more significantly boosted oxidative defense in amaranth leaves, enhanced cell membrane fluidity, and upregulated amino acid metabolism, glycolysis, and gluconeogenesis. In addition, the upregulation of discriminating metabolites was the most significant in 2 µm SiO 2 -treatment, followed by 100 nm and 30 nm. This is mainly because nSiO 2 promoted amaranth growth and decreased average PHE content per unit biomass, namely “dilute effect”. Thus, slighter metabolic disturbances were observed in 30 nm and 100 nm SiO 2 -treated group. The present study revealed the possibility of PAHs accumulation enhancement in vegetables with nSiO 2 foliar spayed. The results of this study provide theoretical guidance regarding to particle size selection for the safe agricultural application of nSiO 2 in PAHs-contaminated areas.
研究领域:
环境科学
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农业科学
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植物生理学
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DOI
高影响因子
Biomaterials Science
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2025
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IF 5.7
Wenqing Zhang,Huawei Yang,Xu Zhang,Zhaoyang Wang,Shifang Luan
Hernia typically does not heal spontaneously. Large-pore patches, most notably polypropylene patches (PP patches), are the gold standard in hernia repair surgery. However, a single patch is insufficient for both anti-adhesion and tissue fusion, leading to complications such as organ adhesions. In this study, a chemically stable and biocompatible modified fluorinated poly(aryl ether) (FPAE-F) was prepared by grafting perfluoroalkyl groups onto a fluorinated poly(aryl ether) via nucleophilic aromatic substitution. A porous FPAE-F fiber film (eFPAE-F) was fabricated by electrospinning and combined with a PP patch to produce a modified fluorinated poly(aryl ether)/polypropylene (FPAE-F/PP) composite patch. The eFPAE-F layer of the composite patch, which faces the abdominal viscera, exhibits a water contact angle of 151.3 ± 1.2°. This superhydrophobic surface prevents protein adhesion, thereby inhibiting rapid fibroblast proliferation. The small pore size (3.22 ± 1.25 μm) of the eFPAE-F layer effectively impedes fibroblast infiltration while permitting the transport and metabolism of nutrients. In vivo experiments have demonstrated that the composite patch is a viable anti-adhesion material, resulting in no adhesions and low inflammation levels after 2 weeks. Due to its outstanding anti-adhesion properties, eFPAE-F/PP is expected to be applied in the field of hernia repair.
研究领域:
生物医学工程
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材料科学
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外科手术
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产品关联
DOI
PubMed
高影响因子
Advanced Science
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2025
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IF 14.1
Shuo Yang,Sizhe Tang,Yufeng Cai,Zhiming Ye,Xiangbin Zou,Xueyu Yuan,Yujie Song,Bing Li,Dongyan Tang,Ming Liu
Passive thermal-regulation strategies have become increasingly important due to the strain alleviated on power grids for temperature management. Designing a system capable of automatically switching between cooling and heating modes in response to changing ambient conditions presents several specific challenges that engineers and researchers are actively addressing. In this research, a CaCl 2 incorporated PNIPAM coated fluorinated poly(aryl ether) (FPAE) porous film with tunable reflectance is developed. The aim is to mitigate the reliance on active cooling systems, which consume significant amounts of energy. The moisture-temperature dual sensitive film exhibits a tunable reflectance range between 91.1% and 39.1% via phase change of the PNIPAM layer. Coupled with an infrared emissivity of 96.0%, a daytime cooling of 10 °C compared to the control experiment is achieved. Coating the film with a photothermal layer results in an adaptive Janus film that is capable of autonomous switching between heating and cooling, and demonstrates a heating of 22.5 °C in a cold environment. The facile preparation method, excellent cyclic stability, mechanical properties, and UL-94 V-0 rating enable promising applications of the smart film under diverse living environments.
研究领域:
材料科学
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环境科学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19
Guangsheng Zhang,Lishuai Zong,Jianhua Han,Changhong Xiao,Xiaoxu Wang,Yibo Wang,Haoran Liu,Lingmei Jiang,Xigao Jian,Jinyan Wang
With the advancement of the Internet of Things (IoT), 3D printing has emerged as a versatile fabrication platform for constructing 3D conformal electronics. However, developing photosensitive resins compatible with 3D printing that possess high thermal and moisture stability alongside low dielectric loss remains a challenge for fabricating complex, curved 3D circuits. Herein, a fluorine-rich poly(aryl ether) photosensitive material system, synthesized via quaternary copolymerization and blended with thiols to formulate inks for direct ink writing (DIW) is presented. The optimized inks demonstrate high thermal stability (glass transition temperature up to 247°C), robust mechanical strength (tensile strength of 69 MPa and elongation at break of 17%), and favorable dielectric properties (dielectric constant of 2.86 and dielectric loss of 0.0063 at 10 GHz). Leveraging the advantageous properties of the poly(aryl ether) photosensitive inks, it is successfully fabricated various functional, complex 3D structures with high thermal and moisture stability, including high-curvature conformal circuits. Furthermore, a 3D-printed high-frequency X-band antenna operating at 10.2 GHz, highlighting the practical applications of these fluorine-rich resin materials for advanced IoT devices is demonstrated. These results present a promising material concept and fabrication strategy for producing complex 3D-printed circuits applicable to a wide range of 3D conformal electronic devices.
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2017
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IF 6.035
Kuibo Zhang,Shoutao Gong,Baolin Zhao,Yanxiang Liu,Naeem Akhtar Qaisrani,Lingdong Li,Fengxiang Zhang,Gaohong He
Inadequate hydroxide conductivity of anion exchange membrane (AEM) is one of the obstacles restricting practical application of anion exchange membrane fuel cell. In this work, we report the design, fabrication and properties of AEMs based on bent-twisted non-coplanar block copolymer . The bent-twisted polymer backbone creates high free volume size so that hydroxide ion transport is facilitated. The free-volume effect can also facilitate microphase separation due to enhanced chain segment motion. With the free-volume holes working synergistically with microphase-separation enabled ion channels, the membrane showed a high conductivity (35 mS cm −1 at room temperature) at a relatively low ion exchange capacity (IEC, 1.25 meq g −1 ); it also exhibited a good dimension stability, the swelling ratio being 4.7% at room temperature and kept virtually unchanged with temperature because of relatively low IEC. A H 2 /O 2 fuel cell employing the fabricated AEM yielded a high power density (262 mW cm −2 at 50 °C). Our work opens up a new route to fabrication of highly conductive AEM with relatively low IEC.
研究领域:
材料科学
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燃料电池工程
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2017
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IF 2.843
Zhigeng Chen,Haohao Huang,Shijing Yan,Zhanping Zheng,Shumei Liu,Yanchao Yuan,Jianqing Zhao,Yi Fu
A new approach to synthesize fluorine-containing graphene oxide (FCGO) was proposed, in which a less toxic reagent was used rather than fluorine gas or anhydrous hydrogen fluoride. The dielectric and mechanical properties of polyimide composites were improved by incorporating a small amount of FCGO. FCGO served as not only nanofiller to lower the dielectric constant of PI films but also inorganic toughening particles to improve the toughness of PI films. The dielectric constant of PI films with 0.6 wt % FCGO was decreased from 3.33 for pure PI to 2.34. In addition, both the tensile strength and Young’s modulus of PI films with 0.6 wt % FCGO were increased to 141 MPa and 4.95 GPa from 118 MPa and 2.81 GPa for pure PI, respectively. In addition, its tensile energy to break was enhanced to 31.6 MJ/m3 from 20.8 MJ/m3.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
TALANTA
·
2018
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IF 4.244
Yarong Li,Pengpeng Lu,Jincheng Cheng,Xiaoliang Zhu,Wang Guo,Lijun Liu,Qiang Wang,Chiyang He,Shaorong Liu
A new microporous β -cyclodextrin polymer (MP-CDP) was prepared for the simultaneous solid-phase extraction (SPE) of bisphenol F (BPF), bisphenol A (BPA) and bisphenol AF (BPAF). The MP-CDP was characterized by Fourier transform infrared spectroscopy, solid-phase 13 C nuclear magnetic resonance, thermo-gravimetric analysis, scanning electron microscopy, and nitrogen adsorption and desorption analysis. Results indicated that the MP-CDP had micron-level particle size, microporous structure, a high BET surface area, and a high product yield. Adsorption tests showed that the MP-CDP sorbent had high adsorption ability and fast binding kinetics for bisphenols . Moreover, the MP-CDP presented high extraction efficiencies, high enrichment factor, good reusability and good batch-to-batch reproducibility for SPE of bisphenols. Based on the MP-CDP sorbent, a SPE-HPLC-UV method was developed and successfully applied to simultaneously detect three bisphenols in water samples and orange juice with the recoveries of 95.7–106.3% (RSD = 2.0–5.2%) for BPF, 92.9–107.0% (RSD = 1.5–5.1%) for BPA, and 96.0–103.5% (RSD = 1.7–5.0%) for BPAF, respectively. The limit of detection (S/N = 3) and the limit of quantification (S/N = 10) for all bisphenols in these samples were 0.15 ng/mL and 0.5 ng/mL, respectively. The new MP-CDP can be potentially utilized as a good sorbent for simultaneous SPE of trace bisphenols in environmental water samples and beverages.
研究领域:
环境科学
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分析化学
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材料科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2017
·
IF 3.582
Jiaqi Xu,Qilang Lin,Yan Yu,Dongyang Chen,Zhuoliang Ye
Linear fluorinated poly(arylene ether)s with and without pendent allyl groups (CFPAE and FPAE) were successfully polymerized from decafluorobiphenyl at room temperature . The subsequent SN 2 nucleophilic substitution of the remaining F atom on CFPAE and FPAE with sodium 4-hydroxybenzenesulfonate yielded SCFPAE and SFPAEs in one simple step under mild conditions. The chemical structures of the polymers were confirmed by 1 H NMR and FT-IR. The ion exchange capacity (IEC), inherent viscosity, water uptake, swelling ratio, proton conductivity , mechanical property, thermal stability, and oxidative stability of the SFPAEs were characterized. The experimental results revealed that the IEC of the SFPAEs can be facilely controlled by the loading amount of sodium 4-hydroxybenzenesulfonate in the reaction mixture. The SFPAE-20 with an IEC of 2.0 mmol g −1 exhibited an in-plane proton conductivity of 106 mS cm −1 at 30 °C, higher than that of Nafion N212. More importantly, the SFPAEs showed significantly enhanced oxidative stabilities compared to sulfonated non-fluorinated analogs in literature. While there was still a trade-off between proton conductivity and mechanical strength as often seen for homogeneous systems, the SFPAEs were demonstrated to be promising candidates for proton exchange membranes .
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
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2022
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IF 5.546
Zhaoyang Wang,Bo Jiang,Yunhe Zhang,Xuefeng Li,Yongpeng Wang,Yingshuang Shang,Haibo Zhang
The rapid development of high-speed communication networks (for example, 5G) has imposed more stringent requirements on the comprehensive performance of low dielectric constant (low- k ) polymeric materials, as an important member of which, fluoropolymer has gained much attention. In this study, a series of cross-linkable fluorinated poly(aryl ether)s with different phenylethynyl content have been synthesized through nucleophilic substitution reaction, then their polymeric films have been prepared and thermally cross-linked via phenylethynyl groups. Thermal, mechanical and dielectric properties of the films are systematically compared. Due to the presence of F atoms and cross-linked structure in polymer chains, these polymeric films exhibit remarkable dielectric properties with the lowest dielectric constant < 2.4 and dissipation factor < 0.003 at frequency from 100 Hz to 1 MHz. Moreover, the dielectric performance shows impressive temperature independence before 200 °C. Excellent mechanical properties of the films have been corroborated by the DMA data of Young’s modulus > 1.50 GPa and modulus retention rate > 70%. It is noteworthy that polymeric films possess very low dielectric constant and dielectric loss at high frequency of 10 GHz, of which the lowest values can reach 2.47 and 0.0018, respectively. The polymeric films constructed in this study have shown great application prospects in the field of high-speed communication.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2022
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IF 10.53
Tao Ban,Maolian Guo,Yajie Wang,Yiyang Zhang,Xiuling Zhu
Fabrication of aromatic proton exchange membrane (PEM) with excellent conductivity and stability is a long-standing challenge. Here, we propose an aromatic PEM containing multiple sulfonated alkyl side chains (SAFPAEK-x and SAFPAEF-x), and then implement an ideal strategy to address the trade-off between conductivity and stability by optimizing the side chain length and main chain polarity. Specifically, the synthesized PEMs achieve an efficient proton transport (proton conductivity >0.124 S cm −1 at 80 °C) under the synergistic effect of multiple pendant sulfonate groups and a pronounced microphase separation structure. Meanwhile, regulating the polarity of the hydrophobic domain via introducing fluorinated structures can effectively suppress the swelling behavior, so that SAFPAEF-x display excellent dimensional stability (swelling ratio <10% at 80 °C). The theoretical calculations of molecular models and ex-situ experiments demonstrate that appropriate increases in side chain length and main chain polarity lead to noticeably improved radical stability of aromatic PEMs. Finally, the laboratory-assembled direct borohydride fuel cell using our rationally designed PEMs reaches the highest peak power density of 191.17 mW m −2 at room temperature, outperforming the Nafion 115 (95.87 mW m −2 ) under the same conditions. Therefore, this membrane design strategy stimulates great potential in designing high-performance aromatic PEMs for fuel cells.
研究领域:
材料科学
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能源化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）