ENVIRONMENT INTERNATIONAL
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2026
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IF 10.2
Wei Shi,Yuanteng Sun,Kejia Liu,Ying Zhang,Lu Lu,Qian Zhou,Yuepu Pu,Rongli Sun,Lihong Yin
Decabromodiphenyl ethane (DBDPE), a widely used novel brominated flame retardant, has been increasingly detected across environmental matrices and human samples. Owing to its marked persistence and bioaccumulation potential, DBDPE was designated as a Substance of Very High Concern (SVHC) by the European Chemicals Agency in 2025. However, evidence regarding its potential reproductive hazards remains limited. Here, we systematically investigated the molecular mechanisms underlying DBDPE-induced spermatogenic disorder using an integrated approach that combines network toxicology, machine learning, and in vivo validation. Intersecting 564 DBDPE-associated targets with 1,743 NOA-related differentially expressed genes identified 33 overlapping candidates that may mediate DBDPE-induced spermatogenic disorder. Enrichment analyses implicated the HIF-1 signaling and gap junction pathways in DBDPE-induced spermatogenic disorder. Machine learning prioritized five core genes, including PRKACG, WDR5, AURKC, PFKP, and ASGR1, all of which were downregulated in NOA patients. Molecular docking demonstrated stable binding between DBDPE and these core targets. In vivo , DBDPE exposure disrupted testicular structure, reduced sperm concentration and motility, and decreased expression of the five core proteins, confirming the predicted mechanisms. Additionally, we proposed an adverse outcome pathway (AOP) framework describing key events leading to DBDPE-induced spermatogenic impairment. Collectively, our findings revealed the reproductive toxicity of DBDPE and provided a mechanistic foundation for developing strategies to safeguard male fertility.
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TOXICOLOGY AND APPLIED PHARMACOLOGY
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2022
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IF 4.46
Fengmin Ma,Yasong Luo,Yuqi Liu,Mai Zhang,Jiguo Wu,Lingyun Chen,Guoxia Zhang
The health risks of Decabromodiphenyl ethane (DBDPE) with its cardiovascular toxicity , liver toxicity and cytotoxicity had been generally acknowledged. However, the influence on gut microbiome and short-chain fatty acids (SCFAs) metabolism caused by DBDPE exposure remained unknown. In this study, three exposure groups (5, 50, 500 mg/L) and control group were used to investigate the effect of DBDPE by using simulator of the human intestinal microbial ecosystem (SHIME). 16S rRNA gene high-throughput sequencing illustrated that high dose DBDPE exposure increased the α -diversity of gut microbiota , while reduced the abundance of Firmicutes and Proteobacteria . In addition, the low dose (5 mg/L) DBDPE inhibited the increasing of SCFAs, but the medium and high dose (50 and 500 mg/L) DBDPE promoted the advancement, especially in ascending colon . Notably, DBDPE exposure lead a similar changing of acetic acid and butyric acid contents in different sections of the colon. This study confirmed the alternation of composition and metabolic function in gut microbial community due to DBDPE exposure, indicating an intestinal damage and appealing for more attention concentrated on the health effects of DBDPE exposure.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2023
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IF 11.4
Rui Hou,Siqi Zhang,Qianyi Huang,Lang Lin,Hengxiang Li,Jingxi Li,Shan Liu,Chengjun Sun,Xiangrong Xu
Ingestion is a major exposure route for hydrophobic organic pollutants in fish, but the microbial transformation and estrogenic modification of the novel plastic additives by the gut microbiota of fish remain obscure. Using an in vitro approach, we provide evidence that structure-related transformation of various plastic additives by the gastric and intestinal (GI) microbiota from crucian carp, with the degradation ratio of bisphenols and triphenyl phosphate faster than those of brominated compounds. The degradation kinetics for these pollutants could be limited by oxygen and cometabolic substrates (i.e., glucose). The fish GI microbiota could utilize the vast majority of carbon sources in a Biolog EcoPlate, suggesting their high metabolic potential and ability to transform various organic compounds. Unique microorganisms associated with transformation of the plastic additives including genera of Citrobacter, Klebsiella, and some unclassified genera in Enterobacteriaceae were identified by combining high-throughput genetic analyses and metagenomic analyses. Through identification of anaerobic transformation products by high-resolution mass spectrometry, alkyl-cleavage was found the common transformation mechanism, and hydrolysis was the major pathway for ester-containing pollutants. After anaerobic incubation, the estrogenic activities of triphenyl phosphate and bisphenols A, F, and AF declined, whereas that of bisphenol AP increased.
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MACROMOLECULAR RAPID COMMUNICATIONS
·
2021
·Vol. 43
·期 3
·2100643
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IF 5.734
Tianmeng Liu,Hong Huang,Yan Wang,Junrong Yu,Zuming Hu
Nature has provided many delicate strategies for optimizing the structural characteristics of biological materials. One such strategy is the strengthening and toughening of matrix materials by aduandant and hierarchically arranged non-covalent crosslinking. However, efficient strengthening and toughening of high-performance aromatic polymers by non-covalent bonds has rarely been reported yet. Herein, we report the preparation and characterizations of a metal coordination bonds crosslinked polybenzimidazole (PBI) network. By optimizing the synthetic parameters, the strength of copper ion (Cu 2+ ) crosslinked PBI is improved from 87.8 to 218.4 MPa, and the toughness is increased from 19.4 to 111.9 MJ m −3 , corresponding to increments of 148.7 % and 476.8 %, respectively, which surpass all previously reported non-covalent bonds crosslinked high-performance polymers. PBI with varied chain flexibility are then synthesized to deeply understand the stregnening and toughening mechanism. In addition, the glass transition temperature of PBI is dramatically increased by 75 °C after Cu 2+ crosslinking. Moreover, the chemical recycling of PBI from crosslinekd network, and the development of a novel high-temperature resistant or high-temperature rewritable anti-counterfeiting films based on Cu 2+ crosslinked PBI are also demonstrated. This study is expected to shed light on design principle for future supramolecularly crosslinked and recyclable high-performance polymers.
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PROGRESS IN ORGANIC COATINGS
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2019
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IF 3.42
Shiai Xu,Junlan Li,Junhao Shen,Hong Wang,Gaimei Pei
It is of practical significance to prolong the service life of the silk screen plate used for screen printing by a simple method. To our knowledge, no attempt has been made to coat silk screen stencil film with polybenzimidazole (PBI) to improve its abrasion resistance against squeegee in order to prolong the service life of the silk screen plate. In this study, the synthesized PBI with 2,6-disubstituted benzimidazole structure was coated on the silk screen stencil film by solution casting, and its effect on the morphology, roughness and abrasion resistance of stencil film was investigated by scanning electron microscope, atomic force microscope and Taber abrasion tester. The abrasion resistance of the silk screen stencil films with 1 and 19 μm thick PBI coating is improved by 18.6% and 87.6% compared with that of pure stencil film, respectively. The stencil film undergoes two wear stages: the first stage with a larger mass loss is characterized by the wear of photosensitive film; and the second one with a relatively smaller mass loss is characterized by the wear of both photosensitive film and silk screen. The thickness of PBI coating has an important effect on the substrate strength and surface properties of films during the wear, thus resulting in changes in the abrasion resistance of stencil films. It shows that 8 μm thick PBI coating is enough to protect the stencil film from wear.
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Energy Storage Materials
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2016
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IF 0
Yuang Zhang,Bingtao Tang,Lingjuan Wang,Rongwen Lu,Defeng Zhao,Shufen Zhang
The development of phase change materials (PCMs) with fire resistance is important to improve the application security. Series of novel hybrid materials were synthesized by the simple composite process of phase change polyurethane with flame retardants . The polyurethane functions as phase change segment for thermal energy storage as well as supporting materials of flame retardants. The structure and properties of obtained materials were characterized by FT-IR, DSC , XRD , TG and limiting oxygen index (LOI). The latent heat of the composite reached 86.69 J/g, and the LOI reached 21.3, which indicated that the composite materials had good fire resistance and high thermal energy storage density. Simultaneously, the obtained materials also demonstrated excellent form-stable properties and thermal stability. Judicious application of the novel form-stable PCMs has opened up a rich field of energy materials with enhanced performance in fire resistance and energy storage.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2025
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IF 8.4
Lumei Xie,Hongli Liu,Xinyue Hu,Jiacheng Xu,Bingdi Chao,Jie Wang,Lujia Sun,Xiyao Liu,Niya Zhou,Luming Sun,Hongbo Qi,Xin Luo
Decabromodiphenyl ethane (DBDPE), a newly emerging brominated flame retardant (BFR), has garnered increasing attention due to its high production volumes and widespread usage, prompting worries about its possible impacts on human well-being. Prior investigations have highlighted the substantial toxicity of DBDPE to the thyroid, liver, and cardiovascular systems, yet its effects on fetal growth and development remain inadequately understood. This investigation aims to elucidate the underlying mechanisms and consequences of DBDPE exposure on fetal growth and development through both in vivo and in vitro models. Pregnant mice were administered DBDPE orally at doses of 0, 0.05, 0.5, and 5 mg/kg bw/day. Results revealed that gestational DBDPE exposure caused placental damage, resulting in fetal growth restriction (FGR). A significant reduction in the phosphorylation level of AIFM1 Ser116 in placental trophoblasts was observed, specifically correlating with the activation of oxeiptosis. Metabolomic and transcriptomic analyses further suggested that DBDPE exposure disrupts the oxidative phosphorylation (OXPHOS) pathway, thereby impairing mitochondrial function. Notably, treatment with MitoQ, a mitochondria-targeted antioxidant, effectively reversed DBDPE-induced oxeiptosis in placental trophoblasts, alleviating the negative effects of DBDPE on placental damage and FGR. Mechanistically, the mitochondrial dysfunction induced by gestational DBDPE exposure initiates oxeiptosis in placental trophoblasts, exacerbating placental injury and ultimately leading to FGR. In summary, this study integrates the roles of environmental pollutants, oxeiptosis, and mitochondrial dysfunction, offering new insights into the toxicological mechanisms by which DBDPE and other emerging pollutants impact fetal growth and development.
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ENERGY & FUELS
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2017
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IF 3.091
Wenfeng Li,Yingjie Li,Yong Chen,Qingnan Liu,Yingzhou Lu,Hong Meng,Chunxi Li
Carbon-based materials are a kind of promising sorbent for the desulfurization of fuel oils, especially for polycyclic aromatic sulfur heterocycles (PASHs), and development of new sorbents is of great significance. In this paper, six alkynyl carbon materials (ACM-1 to ACM-6) were prepared for the first time through mechanochemical reaction of calcium carbide with six full halogenated hydrocarbons, i.e., CCl4, C2Cl6, C2Cl4, C6Cl6, C6Br6, and C14H4Br10, respectively. Their carbon content and specific surface areas (SSAs) were analyzed, and their adsorption performance for thiophenic sulfurs was studied. The ACMs are mesoporous materials with relatively high SSAs and favorable adsorptive performance for PASHs with the order of DBT > BT > 3-MT. Their adsorptivity is virtually consistent with the SSA values and follows the order of ACM-6 > ACM-5 > ACM-4 > ACM-1 > ACM-3 > ACM-2. ACM-6 has the highest SSA (712 m2 g–1) and saturated adsorbance of 21.1 mg-S·g–1 for DBT in octane, as well as 6 mg-S·g–1 for real diesel. As a whole, ACM-6 represents the best ADS sorbent among all mesoporous carbon materials and may be applicable for real oils after some further modification.
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Journal of Environmental Sciences
·
2017
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IF 2.865
Yingjie Li,Wenfeng Li,Qingnan Liu,Hong Meng,Yingzhou Lu,Chunxi Li
For the first time, a series of alkynyl carbon materials (ACMs) were prepared via the mechanochemical reaction of CaC 2 with six polyhalogenated precursors, namely CCl 4 , C 2 Cl 6 , C 2 Cl 4 , C 6 Cl 6 , C 6 Br 6 , and C 14 H 4 Br 10 (ACM-1, ACM-2, ACM-3, ACM-4, ACM-5, and ACM-6, respectively) and used for the adsorptive removal of mercury from aqueous solutions. Based on preliminary investigations, the adsorption of mercury on ACM-5 was studied in depth. Specifically, the effect of pH on mercury adsorptivity , adsorption kinetics, thermodynamics, isotherms, and recyclability was studied. The adsorptivity of mercury on ACMs was found to be closely related to the hydrocarbon precursor, specific surface area of sorbent , and the alkynyl content. ACM-5 showed the best performance and is among the best raw carbonaceous sorbents reported so far, with a Langmuir saturated adsorption capacity of 191.9 mg g − 1 . The promising mercury adsorption performance mainly arises from the strong Lewis soft acid–soft base interactions between the alkynyl groups and mercury ions. The adsorption isotherms could be satisfactorily correlated with the Langmuir equation. The results show that the ACMs can be used as efficient sorbents for the removal of mercury and may also be useful for the adsorption of other heavy metals.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2025
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IF 6.1
Jianwei Cui,Liting Zhou,Xuehan Ding,Hui Ye,Tianyou Wang,Wen Qi
Decabromodiphenyl ethane (DBDPE) is a kind of commonly used novel brominated flame retardants, and widely exists in environments. DBDPE could be enriched in the liver, but its effects on lipid metabolism in liver and underlying mechanisms remain largely unknown. In the present study, firstly, we investigated the impact of DBDPE on the liver in rats and L02 cells. We found that DBDPE exposure could induce lipid metabolism disorders, up-regulate the expressions of Notch pathway genes, and promote Arrestin domain containing protein 1-mediated microvesicles (ARMMs)-derivation. Subsequently, siRNAs were used to inhibit the Notch pathway and the ARMMs-derivation in L02 cells respectively. It demonstrated that inhibition of Notch or ARMMs-derivation could reverse the lipid accumulation induced by DBDPE, and the inhibition of ARMMs-derivation could suppress the activation of the Notch pathway. Extracellular vesicles from L02 cells exposed to DBDPE co-culture with L02 cells confirmed that ARMMs can directly activate the Notch signaling pathway and induce lipid accumulation. In conclusion, our study is the first to explore the role of ARMMs in lipid metabolism disorders caused by environmental pollutants. We found that exposure to DBDPE increases the levels of ARMMs, which directly activates the Notch signaling pathway and triggers disruptions of liver lipid metabolism.
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JOURNAL OF SOILS AND SEDIMENTS
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2025
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IF 3
Jin Meiqing,Sun Yuanchao,Chai Bing,Wang Minghu,Wu Yuping,Wu Weihong,Zhou Qingwei,Qiu Linlin,Du Jia,Fu Li
Purpose Decabromodiphenyl ethane (DBDPE) and lead (Pb), two prevalent contaminants in e-waste dismantling areas, pose significant threats to soil ecosystem health. However, the ecotoxicological effects of their co-exposure on soil invertebrates remain poorly characterized. Methods Avoidance behavior, survival rate, and growth-inhibition assays were performed to assess the combined toxic effects of DBDPE and Pb on earthworm ( Eisenia fetida ) in an artificial soil system over exposure periods of 7–21 d. Responses from multiple biochemical biomarkers, including superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), glutathione S-transferase (GST), and acid phosphatase (ACP) were also measured, and the data were integrated by the biomarker response index (BRI). Interaction between Pb and DBDPE on BRI was further analyzed by calculation of effect addition index (EAI). Results Avoidance behavior emerged as the most sensitive endpoint and exhibited concentration-dependent escalation under co-exposure conditions. While individual exposure to DBDPE (0–0.75 mg/kg) induced negligible impacts on growth and mortality, its combination with Pb (1000 mg/kg) resulted in significant synergistic effects. Similarly, biochemical biomarkers—including SOD, CAT, MDA, GST, and ACP—showed markedly greater alterations in co-exposure groups compared to single DBDPE treatments. The BRI revealed only slight alterations in biological health across most treatments. The EAI values indicated that antagonistic effects dominated the interaction between DBDPE and Pb. Conclusion Our findings demonstrated significant variation in biomarker sensitivity to pollutant exposure. Notably, short-term sub-lethal co-exposures may elicit synergistic effects on avoidance, growth, and mortality, revealing a time-concentration toxicity dependency. These results provide novel insights into the interaction between heavy metals and organo-pollutants and highlight the ecological hazards posed by emerging brominated flame retardants (e.g., DBDPE) in heavy metal-contaminated soil systems.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Fei Zhu,Xianwen Yan,Sai Zhang,Bohao Lv,Wenqiang Qiao,Zhiyuan Wang
Epoxy resins (EPs) have gained increasing attention due to their excellent properties, but endowing EPs with high mechanical properties and migration resistance while maintaining flame retardancy remains a challenge. This study addresses this challenge by developing novel oligomeric flame retardants (PB-O and PB-E), synthesized via a Heck cross-coupling reaction of polybutadiene (PB) with decabromodiphenyl oxide (DBDPO) or decabromodiphenyl ethane (DBDPE). Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) show these additives reduce EP curing temperatures and enhance char formation at elevated temperatures. UL-94 and microscale combustion calorimetry (MCC) tests confirm exceptional flame retardancy: composites with 5 phr PB-O/PB-E achieve V-1/V-0 ratings (vs. pure EP), with peak heat release rates (PHRR) reduced by 40.3%/40.0% for enhancing fire safety. Synergistic rigid-flexible effects (phenyl groups and PB chains) endow composites with outstanding mechanical properties: impact strength increases by 557% (PB-O)/524% (PB-E), flexural strength rises by 51.5%/49.2% versus unmodified EP. Migration rates of 5 phr PB-O/PB-E in EP composites show 0 after 84 h (5 phr PB@DBDPO/PB@DBDPE: 4.2%/4.0%) by migration tests. Hence, this work provides an integrated strategy to develop multifunctional oligomeric brominated flame retardants for EPs, which simultaneously improve flame retardancy, mechanical properties, and migration resistance to align with increasingly rigorous industrial requirements.
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