CHEMOSPHERE
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2019
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IF 5.108
Jiyuan Jin,Zhihao Chen,Xiaojie Song,Bingdang Wu,Guoyang Zhang,Shujuan Zhang
Quinones are components of electron transport chains in photosynthesis and respiration. Acetylacetone (AA), structurally similar to benzoquinone (BQ) for the presence of two identical carbonyl groups, has been reported as a quinone-like electron shuttle. Both BQ and AA are important chemicals in the aquatic environment. However, little information is known about their interactions if co-existed. We found here that AA significantly enhanced the conversion of BQ. By analyzing the evolution of chemical concentration, solution pH, dissolved oxygen, and the final products, the interactions between AA and BQ were elucidated. The reactions between BQ and AA generated oxygen but ultimately led to the reduction of solution pH and dissolved oxygen. The reactions proceeded faster under indoor lighting condition than in the dark. The formation of semiquinone radicals is believed as the primary step. The secondary AA-derived radicals might be strongly oxidative or reductive, depending on the concentration of dissolved oxygen. Insoluble humus was generated in the mixture of BQ and AA. These results suggest that the presence of AA might interfere with photosynthesis and respiration through the interactions with quinones.
研究领域:
环境科学
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生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
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2023
·
IF 2.9
Zhixing Wang,Peng Liu,Peng Ye,Sheng Dai,LuYing Liu,Ping Yang
Dopamine has been widely used for surface modification of cardiovascular medical devices as it forms films on most substrates that provide functional groups for surface chemical modification. However, under oxidative stress, the phenolic hydroxyl group on dopamine can undergo reversible transformation into phenol-semiquinone-quinone, which can cause cytotoxicity and immunotoxicity. In this study, we measured the effects of semiquinone on the behavior of vascular wall cells and inflammatory cells under oxidative stress via ultraviolet irradiation with a hydrogen peroxide diluent. Na2S2O3 was used as a stabilizer to obtain a semiquinone-rich poly-dopamine film, then phenol-semiquinone-quinone ratio on its surface was evaluated at three irradiation-oxidation time points. We found that the poly-dopamine film with ultraviolet irradiation in hydrogen peroxide solution for 15 min had the highest semiquinone occupancy of 19.18%. In the experimental group irradiated for 15 min, endothelial cells were cultured statically for 3 days and the number of surface adherent endothelial cells in the group with added semiquinone stabilizer was reduced to 73% of that in the group without stabilizer, indicating that semiquinone rich surface inhibits adhesion and proliferation of endothelial cells; Smooth muscle cells were cultured statically for 3 days, and the number of adherent smooth muscle on surfaces without stabilizer was reduced to 75% of that on surfaces with stabilizer added, indicating that semiquinone rich surfaces promote smooth muscle proliferation. These results demonstrate that semiquinone can adversely affect the repair effect after implantation of cardiovascular materials. Therefore, our study provides a reference for the application and optimization of dopamine in cardiovascular implant materials.
研究领域:
生物医学工程
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细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Danping Wu,Quan Chen,Min Wu,Peng Zhang,Liping He,Yihui Chen,Bo Pan
The reactivity of pyrogenic carbon has attracted a great deal of research attentions recently. The oxygen-containing structures are rich on the surface of biochars, and involved in accepting and donating electrons during the interactions between biochar and organic contaminants . In this work, the species and content of oxygen-containing functional groups on biochar surface were regulated through chemical modification, and batch sorption/degradation experiments were carried out for rhodamine B (RhB). Based on the comparison of surface functional groups, biochars produced below 200 °C mediated RhB degradation through phenol hydroxyl group, while semiquinone and carboxylic acid groups were the main reaction active sites for biochars produced at higher than 500 °C. Considering that various biochar properties play roles in mediating organics degradation , the strategies in manipulating biochar properties should be carefully considered.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2025
·
IF 11.3
Xiaowen Chen,Kun Li,Haizhen Bian,Shan Zhang,Xueqi Ma,Li Fang,Wei Jiang,Caiqing Yan,Lin Du
The interactions between different emission sources have significant impacts on secondary organic aerosol (SOA) formation and related environmental effects. Biomass burning and biogenic emissions could interact with each other; however, the formation, composition, and health effects of SOA from such mixtures remain poorly understood. Here, we investigated the interactions and atmospheric evolution of mixed biomass burning-derived guaiacol and biogenic α -pinene using an oxidation flow reactor (OFR), coupled with aerosol size distribution, offline iodometry-mass spectrometry, and dithiothreitol (DTT) assays. The results show that the mixed SOA yield shifted from suppression (at low hydroxyl radicals (OH) exposure) to enhancement (at high OH exposure), driven by low-volatility organics and subsequent enhanced gas-particle partitioning of intermediates. Fresh guaiacol SOA exhibited higher oxidative potential (OP) due to redox-active C 7 quinones and methoxy-hydroquinones, whereas the declining total peroxide of α -pinene SOA was attributed to the oxidative degradation. The OP of aged mixed SOA surpassed predicted values, which may be linked to the C 15 -C 17 quinone-terpenoid adducts and C 7 toxic products stabilizing semiquinone radicals, thereby facilitating sustained reactive oxygen species (ROS) generation. This study revealed that biogenic emissions amplify the health risks of biomass-burning emissions.
研究领域:
环境健康学
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大气化学
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气溶胶科学
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氧化应激
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呼吸毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENT INTERNATIONAL
·
2025
·
IF 9.7
Zirui Liu,Dehua Ma,Qiang Cheng,Aroob Abid,Shuaijie Zhao,Chenyi Li,Qingzhuo Niu,Min Zheng
p- Benzoquinone analogues, a class of ubiquitous oxidation byproducts, are increasingly detected in effluents from various oxidative treatment systems. While halogenated derivatives have received substantial research attention, the ecotoxicological impacts of non-halogenated analogues—particularly in vivo —remain poorly characterized. This study systematically compared the toxicity of 2,6-dichloro- p -benzoquinone (2,6-DCBQ) and 2,6-dimethyl- p -benzoquinone (2,6-DMBQ) using zebrafish embryos. 2,6-DMBQ exhibited comparable lethality to 2,6-DCBQ (48 h EC 50 = 221.72 vs. 169.17 μg/L), with developmental malformations of cardiac edema and notochord malformation mainly emerging in juvenile fish at 250 μg/L. Exposure to 2,6-DCBQ of 2.5 μg/L and 2,6-DMBQ of 25 μg/L induced significant oxidative stress, elevating reactive oxygen species (ROS) levels and upregulating antioxidant enzymes of total superoxide dismutase, catalase, and glutathione peroxidase. PCR gene chip analysis showed that 23 oxidative stress-related genes were coordinately upregulated in both treatment groups. Co-exposure with N-acetylcysteine (20 μM) or Na 2 SO 3 (Na 2 SO 3 : p -BQs = 10:1) synergistically mitigated toxicity of 2,6-DCBQ and 2,6-DMBQ at 250 μg/L, restoring morphological and biochemical endpoints to control levels. Electron paramagnetic resonance confirmed semiquinone radicals and hydroxyl radicals as key drivers of ROS amplification. These findings establish radical-mediated mechanisms as critical toxicological pathways and inform risk management strategies for quinoid byproducts in water treatment systems.
研究领域:
环境毒理学
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水处理化学
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分子生态毒理学
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发育毒理学
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自由基生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）