CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yuling Ma,Airong Li,Cheng Wang
Metal-organic frameworks (MOFs) with a high specific surface area, an adjustable pore structure, and functionalized pore environment have a broad application prospect in gas adsorption and separation. In this work, a series of defective UiO-66 (UiO-66-monocarboxylic acid) samples were prepared by adding different monocarboxylic acids during the synthesis of UiO-66. UiO-66-monocarboxylic acid samples (UiO-66-formic acid, UiO-66-acetic acid, UiO-66-benzoic acid, UiO-66-acrylic acid, and UiO-66-cyanoacetic acid) had a high specific surface area (1200–1400 m 2 /g) and a good thermal stability (560 °C). In the desulfurization experiment of simulated flue gas (SO 2 /CO 2 /O 2 /N 2 , 0.3/10.0/5.5/84.2 vol%), the breakthrough time of UiO-66-cyanoacetic acid for SO 2 was higher (194 min/g), and the selectivity of SO 2 /CO 2 reached 33.8. Through optimizing the moles of cyanoacetic acid added, the breakthrough time of SO 2 on 18-UiO-66-cyanoacetic acid increased to 251 min/g. At a pressure of 1.0 bar and a temperature of 298 K, the adsorption capacity of SO 2 by 18-UiO-66-cyanoacetic acid reached 762.1 mg/g. In addition, the adsorption behavior of 18-UiO-66-cyanoacetic acid for SO 2 was considered as a combination of chemical and physical adsorption, and fractional chemisorption sites was provided by cyanoacetic acid.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2012
·Vol. 291
·期 4
·919-925
·
IF 2.331
Ambreen Jaweria,Yang Jinxian,Ye Xiaodong,Siddiq Mohammad
The temperature-induced phase transition of poly(2-ethyl-2-oxazoline) (PEtOx) aqueous solution under mixing with a series of small carboxylic acids has been studied by turbidity measurements and laser light scattering. It has been found that cloud point temperature ( T
cp ) of the PEtOx was changed to varying degrees depending upon the pH, ionic strength, molar ratio of acids to 2-ethyl-2-oxazoline unit, and carbon chain length of small carboxylic acids. Significant change in T
cp was observed in the case of hexanoic acid. At acidic pH, an increase in the molar ratio of hexanoic acid to the 2-ethyl-2-oxazoline unit gradually decreased the phase transition temperature of the polymer as compared to the T
cp of pure PEtOx. At original pH 6 (pH > p K
a ), T
cp shifts to higher value than that of pure PEtOx for lower molar ratios and decreased later on with increasing the molar ratio. The shift in the T
cp is described based on the differences in the driving force of phase transition, including hydrogen bonding between small carboxylic acids and PEtOx polymer and hydrophobic interaction.
研究领域:
高分子化学
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers of Medicine
·
2021
·Vol. 15
·期 6
·887-902
·
IF 4.592
Wu Xin,Wang Zongqi,Li Haiying,Xie Xueshun,Wu Jiang,Shen Haitao,Li Xiang,Wang Zhong,Chen Gang
Monocarboxylic acid transporter 1 (MCT1) maintains axonal function by transferring lactic acid from oligodendrocytes to axons. Subarachnoid hemorrhage (SAH) induces white matter injury, but the involvement of MCT1 is unclear. In this study, the SAH model of adult male Sprague-Dawley rats was used to explore the role of MCT1 in white matter injury after SAH. At 48 h after SAH, oligodendrocyte MCT1 was significantly reduced, and the exogenous overexpression of MCT1 significantly improved white matter integrity and long-term cognitive function. Motor training after SAH significantly increased the number of ITPR2 + SOX10 + oligodendrocytes and upregulated the level of MCT1, which was positively correlated with the behavioral ability of rats. In addition, miR-29b and miR-124 levels were significantly increased in SAH rats compared with non-SAH rats. Further intervention experiments showed that miR-29b and miR-124 could negatively regulate the level of MCT1. This study confirmed that the loss of MCT1 may be one of the mechanisms of white matter damage after SAH and may be caused by the negative regulation of miR-29b and miR-124. MCT1 may be involved in the neurological improvement of rehabilitation training after SAH.
研究领域:
神经科学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2018
·
IF 2.011
Teng-Fei Zheng,Xue-Mei Tian,Shu-Li Yao,Chen Cao,Jin-Bao Cai,Sui-Jun Liu
Two Ln III complexes derived from one aromatic monocarboxylate ligand, namely [Tb 2 (mnba) 6 (H 2 O) 4 ] n ( 1 ) and [Dy 2 (mnba) 4 ( μ 3 -OH) 2 (H 2 O)] n ( 2 ) (Hmnba = m -nitrobenzoic acid), have been prepared by similar synthetic procedures and structurally characterized. Complex 1 contains two identical one-dimensional (1D) chains with the syn,syn -carboxylate as linkers, while complex 2 takes the 1D chain structure with μ 3 - - OH and carboxylate as bridge. Magnetic studies indicate that ferromagnetic interactions between intra-chain metal centers exist in 1 and 2 and only complex 2 exhibits field-induced slow magnetic relaxation behavior.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Fajie Hu,Danfeng Zhao,Rushuo Li,Yunqi Zhang,Tianyu Zhang,Xiubing Huang,Ge Wang
The hierarchical porous and chemical microenvironmental properties of Metal–Organic Frameworks (MOFs) have been emphasized in catalytic applications. In this work, after selectively removing ligands from frameworks of Ce-UiO-66 by monocarboxylic acid etching, they exhibit obvious mesoporous properties with essentially unchanged crystallinity. Distinguishing from other pore-making methods, the MOFs have abundant missing sites after etching, and Ni nanoparticles (NPs) can be efficiently anchored in the framework of defective Ce-UiO-66, resulting in the formation of Ce–O–Ni heterogeneous interfaces. The chemical environments of Ni NPs can be modulated through the Ce–O–Ni interfaces, and the metal–support interaction improves the charge densities between the active sites. The prepared catalysts showed high conversion and selectivity in the hydrogenation reaction of dicyclopentadiene, and also had good cycling performance. The present work provides new insights into the construction of hierarchical porous defective MOFs with abundant heterogeneous interfaces for hydrogenation reactions.
研究领域:
催化化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2022
·Vol. 29
·期 12
·6783-6796
·
IF 6.123
Yu Shimo,Zhao Xinfu,Zhang Jing,Liu Sijia,Yuan Zhipeng,Liu Xiaochan,Liu Benxue,Yi Xibin
High CO 2 concentration in atmosphere causes serious environmental issues, and carbon capture and storage technologies have attracted attention as a means to reduce the atmospheric CO 2 concentration. Metal-organic frameworks (MOFs) can potentially be used for CO 2 adsorption, but their poor stability and microporosity limit their applications. Herein, a novel strategy was proposed to combine a cellulose aerogel and hierarchically-porous MOFs (HP-MOFs) with larger pores. According to this strategy, a series of microcrystalline cellulose/HP-UIO-66-NH 2 hybrid aerogels (MC-HUN-X) was constructed by adding a modulator (monocarboxylic acid, MA), followed by the in-situ growth of HP-UIO-66-NH 2 on a cellulose aerogel. By adjusting the chain length of MA, the structure–function relationship between pore size and the CO 2 adsorption capacity of MC-HUN-X was explored. The results showed that the CO 2 adsorption capacity increased first and then decreased upon increasing the MOFs pore size, while the adsorption selectivity of CO 2 continuously increased. Among all samples, MC-HUN-4 with a moderate pore size had the highest CO 2 adsorption capacity (1.90 mmol/g at 298 K and 1 bar) and adsorption selectivity (13.02 and 2.40 for CO 2 /N 2 and CO 2 /CH 4 ). The combination with a cellulose aerogel endowed MC-HUN-X with excellent mechanical stability and reusability. Graphical abstract Cellulose/HP-UIO-66-NH 2 hybrid aerogel with larger aperture sizes of MOF showed excellent adsorption capacity and selectivity for CO 2 , and the combination with aerogel could effectively improve the mechanical stability and reusability.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Haoyang Yuan,Peifu Xiao,Fan Wang,Chen Guo,Shu Pan,Mai Jiang,Shicheng Hou,Yunong Sun,Yibo Wang,Yu Zhang,Tian Yin,Haibing He,Jingxin Gou,Xing Tang
Epithelial cell entrance and trans-epithelial transport are two essential processes that directly affect the efficacy of oral delivery of nanocarriers. Herein, a hydroxyethyl starch-based nanocapsule dual decorated with butyrate and octadecylamine (ODA) was first constructed to enhance transporter-mediated endocytosis and trans-epithelial transport, while reducing exenatide (EXT) loss during absorption. The epithelial barrier was then treated with linoleic acid (LA), which functioned as a cell membrane fluidity regulator. This treatment further improved oral delivery efficiency by lowering the energy cost of endocytosis through fluidizing of the cell membrane and increasing monocarboxylate transporter 1 (MCT1) expression on cell surfaces. The findings revealed that LA upregulated MCT1 expression by 3.26-fold, increased the cellular uptake of nanocapsules co-modified with butyrate and ODA by 4.52-fold, decreased ATP consumption for uptake in LA-pretreated Caco-2 cells to only 18.64 % of that in untreated Caco-2 cells, and increased their transcellular transport by 1.72-fold in a Caco-2/HT29-MTX-E12 co-culture monolayer. Therefore, the oral administration of EXT-loaded Bu-PEG-ODA NCs with LA significantly enhanced the oral bioavailability of EXT (Bu-PEG-ODA NCs group: 10.10 %, Bu-PEG-ODA NCs + LA group: 14.84 %), leading to a significant hypoglycemic effect with a 16.06 % relative pharmacological availability. This dosing strategy exhibited efficacious blood glucose control and pancreatic function recovery capabilities in the type 2 diabetes rat model. This study presents a unique co-optimization strategy based on two key processes in the oral absorption of nanocarriers, yielding significant advancements in the oral bioavailability of nanomedicines and improving their therapeutic efficacy.
研究领域:
药剂学
·
生物医学工程
·
糖尿病治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Lubrication Science
·
2019
·Vol. 32
·期 1
·1-9
·
IF 1.682
Mingjin Fan,Shuai Zhang,Lin Ma,Yu Lu,Jia Ai,Xin Du,Wenjing Sun,Desuo Yang,Feng Zhou,Weiming Liu
In this work, a series choline monocarboxylate ionic liquids ([Ch][MA] ILs) were synthesized. The physicochemical properties and lubricating efficiency of the ILs on copper and aluminum discs were systematically investigated. At the same time, their ecotoxicity was explored on aquatic organisms. In comparison with 1-butyl-3-methyl imidazolium tetrafluoroborate (L-B104), which is a kind of traditional IL, [Ch][MA] ILs exhibited excellent lubricating properties and low toxicities, thus can be considered as environmentally friendly lubricants in tribology.
研究领域:
材料科学
·
环境科学
·
生物学
✓ 已验证
DOI
高影响因子
Catalysis Science & Technology
·
2014
·Vol. 5
·期 1
·549-555
·
IF 4.76
Feng Cui,Guangci Li,Xuebing Li,Mohong Lu,Mingshi Li
The carbon-covered aluminas were prepared by using different monocarboxylic acids as carbon sources to modify active alumina, and then were used as supports to prepare supported CoMo catalysts for hydrodesulfurization (HDS) of 4,6-dimethyldibenzothiophene (4,6-DMDBT). These monocarboxylic acid molecules can be readily converted to carbon species by thermal decomposition in a nitrogen atmosphere and deposited on an alumina surface. The carbon species can then effectively weaken the interaction between active metals and alumina, which improves the migration and growth of surface Mo species. This result further affected the morphology and orientation of surface sulfur species, that is, the slab length and stacking number of the MoS2 slabs, which closely relates to HDS activity. Since the surface Mo species supported on the alumina modified with acetic acid consisted of the MoS2 slabs with the shortest lengths, leading to the presence of more easily reducible sulfur species during the reaction, the corresponding catalyst exhibited the highest HDS activity for 4,6-DMDBT. In addition, the stacking numbers for all of the catalysts were relatively low, which hindered the adsorption of 4,6-DMDBT on the brim sites of the MoS2 stacks, and thus the HDS reaction mainly occurred through the direct desulfurization route.
研究领域:
催化化学
·
能源化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2018
·Vol. 24
·期 12
·2962-2970
·
IF 5.16
Pengfei Yang,Fangxin Mao,Yongsheng Li,Qixin Zhuang,Jinlou Gu
Graphical Etch a sketch : A simple and efficient monocarboxylic acid etching (MAE) strategy was developed to prepare hierarchical porous UiO-66, which inherits excellent stability from its parent material and the pore parameters can be controlled by adjusting the monocarboxylic acid concentration and reaction temperature. A new monocarboxylic acid etching (MAE) strategy was developed for transforming chemically stable Zr-based metal-organic frameworks (MOFs) of UiO-66 to their hierarchical porous counterpart. The key design element was based on the incomplete replacement of bridging ligands in MOFs by monocarboxylic acids (MAs), leading to the departure of partial ligands and metal clusters to create mesopores in MOFs. A series of MAs with different acidity and carbon chain length were tested, and propionic acid (PA) was screened to be the suitable choice. The textural features including pore size distribution, specific surface area, and pore volume of the obtained products can be controlled by adjusting the MA concentration and reaction temperature. The obtained hierarchical porous MOFs inherited excellent stability from their parent materials. Additionally, the MAE strategy was universal to construct hierarchical porous Zr-based MOFs, and it was expanded to etch UiO-66 derivatives. The excellent adsorption behavior of the resultant hierarchical porous Zr-based MOFs over two enzymes with different size was also successfully exemplified, demonstrating their application potentials with bulky molecules involved.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
THERIOGENOLOGY
·
2024
·
IF 2.4
Xiu-Li Zhang,Zhi-Yong An,Gao-Jie Lu,Tuo Zhang,Cheng-Wei Liu,Meng-Qi Liu,Qing-Xin Wei,Lin-Hu Quan,Jin-Dan Kang
Oocytes and embryos are highly sensitive to environmental stress in vivo and in vitro. During in vitro culture, many stressful conditions can affect embryo quality and viability, leading to adverse clinical outcomes such as abortion and congenital abnormalities. In this study, we found that valeric acid (VA) increased the mitochondrial membrane potential and ATP content, decreased the level of reactive oxygen species that the mitochondria generate, and thus improved mitochondrial function during early embryonic development in pigs. VA decreased expression of the autophagy-related factors LC3B and BECLIN1 . Interestingly, VA inhibited expression of autophagy-associated phosphorylation-adenosine monophosphate-activated protein kinase (p-AMPK), phosphorylation-UNC-51-like autophagy-activated kinase 1 (p-ULK1, Ser555), and ATG13, which reduced apoptosis. Short-chain fatty acids (SCFAs) can signal through G-protein-coupled receptors on the cell membrane or enter the cell directly through transporters. We further show that the monocarboxylate transporter 1 (MCT1) was necessary for the effects of VA on embryo quality, which provides a new molecular perspective of the pathway by which SCFAs affect embryos. Importantly, VA significantly inhibited the AMPK-ULK1 autophagic signaling pathway through MCT1, decreased apoptosis, increased expression of embryonic pluripotency genes, and improved embryo quality.
研究领域:
生殖生物学
·
分子生物学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Brain Sciences
·
2024
·Vol. 14
·期 4
·327
·
IF 2.7
Yuhan Wu,Hui Hu,Weiwei Liu,Yun Zhao,Fang Xie,Zhaowei Sun,Ling Zhang,Huafeng Dong,Xue Wang,Lingjia Qian
Lactate has emerged as a key player in regulating neural functions and cognitive processes. Beyond its function as an energy substrate and signal molecule, recent research has revealed lactate to serve as an epigenetic regulator in the brain. However, the molecular mechanisms by which lactate regulates spatial memory and its role in the prevention of cognitive disorders remain unclear. Herein, we injected L-lactate (10 μmol/kg/d for 6 d) into the mouse’s hippocampus, followed by the Morris water maze (MWM) test and molecular analyses. Improved spatial memory performances were observed in mice injected with lactate. Besides, lactate upregulated the expression of synaptic proteins post-synaptic density 95 (PSD95), synaptophysin (SYP), and growth associated protein 43 (GAP43) in hippocampal tissues and HT22 cells, suggesting a potential role in synaptic transmission and memory formation. The facilitative role of monocarboxylate transporter 2 (MCT2), a neuron-specific lactate transporter, in this process was confirmed, as MCT2 antagonists attenuated the lactate-induced upregulation of synaptic proteins. Moreover, lactate induced protein lactylation, a post-translational modification, which could be suppressed by MCT2 inhibition. RNA sequencing of lactated-injected hippocampal tissues revealed a comprehensive gene expression profile influenced by lactate, with significant changes in genes associated with transcriptional progress. These data demonstrate that hippocampal lactate injection enhances spatial memory in mice, potentially through the upregulation of synaptic proteins and induction of protein lactylation, with MCT2 playing a crucial role in these processes. Our findings shed light on the multi-faceted role of lactate in neural function and memory regulation, opening new avenues for therapeutic interventions targeting cognitive disorders.
研究领域:
神经科学
·
认知科学
·
分子生物学
·
表观遗传学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）