WATER RESEARCH
·
2015
·
IF 5.528
Zhaobing Li,Zhi Chen,Yingying Xiang,Li Ling,Jingyun Fang,Chii Shang,Dionysios D. Dionysiou
Bromate formation in bromide-containing water through the cobalt (Co)-mediated activation of peroxymonosulfate (PMS) was investigated. Increasing the PMS dosage and the cobalt dosage increased the formation of bromate and bromate yields of up to 100% were recorded under the test conditions. The bromate yield increased to a maximum as the pH rose from 2.7 to 6 before decreasing by over 90% as the pH rose further from 6 to above 9. The bromate formation is a two-step process involving free bromine as a key intermediate and bromate as the final product. In the first step, apart from the known oxidation of bromide to free bromine and of free bromine to bromate by sulfate radicals (SO 4 − ), Co(III) produced from the oxidation of Co(II) by PMS and SO 4 − also oxidizes bromide to free bromine. The contribution of Co(III) to the bromate formation was verified with the addition of methanol and EDTA, a radical scavenger and a Co(III) ligand, respectively. In the presence of methanol, free bromine formation increased with increasing Co(II) dosage but no bromate was detected, indicating that Co(III) oxidized bromide to form free bromine but not bromate. In the presence of both EDTA and methanol, no free bromine or bromate was detected, as Co(III) was stabilized by EDTA to form the Co III EDTA – complex, which could not oxidize bromide. Mathematical simulation further suggested that Co(III) outweighed SO 4 − to oxidize bromide to free bromine. On the other hand, SO 4 − is essential for the oxidation of free bromine to bromate in the second step. In real water, the presence of NOM significantly decreased the bromate formation but caused the brominated organic DBP formation with high quantity. This is the first study to demonstrate the significant bromate formation in the Co/PMS system and the substantial contribution of Co(III) to the formation.
研究领域:
环境科学
·
化学
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DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Xiao-Feng Li,Tingting Yuan,Haixia Xu,Xuan Xin,Guanglei Zhao,Hui Wu,Xinglong Xiao
Puerarin, an important isoflavonoid from the edible root of Pueraria lobata, shows multiple bioactivities but suffers from low bioavailability. In this study, a new whole-cell catalytic method for acylation modification of puerarin was developed. Among the 12 strains tested, Aspergillus oryzae showed the highest catalytic activity and selectively catalyzed acylation of puerarin at the 6″-hydroxyl group. The organic solvents used significantly influenced the catalytic efficiency of the cells. In the green solvent 2-methyltetrahydrofuran, the reaction showed high substrate conversion (92.5%) and regioselectivity (95.8%), with results similar to those with tetrahydrofuran (94.2% and 98.5%, respectively) under optimal conditions. The monoester products showed higher liposolubility in comparison to puerarin, and those with C3–C8 fatty acid chain lengths showed evidently improved antioxidant activity toward erythrocyte hemolysis. Considering the operational stability of the cells and efficiency of the scaled-up reactions, this method is efficient and cost effective, with promising applications in the health food industry.
研究领域:
药理学
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生物化学
·
食品科学
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DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2015
·
IF 2.912
Shangde Sun,Bingxue Hu,Fei Qin,Yanlan Bi
Feruloylated acylglycerols (FAGs) are the lipophilic derivatives of ferulic acid. In this work, soybean oil (SBO) and the mixed fatty acids (MFA) were selected as fatty acyl donors, and reacted with glyceryl monoferulate (GMF) to prepare FAGs in ionic liquids (ILs). Effect of various reaction parameters (time, temperature, enzyme concentration, and substrate ratio) and ILs on the GMF conversion and the reaction selectivity for FAGs formation were investigated. Response surface methodology (RSM) based on a 3-level-4-factor Box–Behnken experimental design was employed to evaluate the inactive effect of reaction parameters. For the esterification of GMF with MFA, the maximum GMF conversion (98.9 ± 0.9%) and FAG yield (88.9 ± 0.6%) were achieved in [C10mim]PF6. However, for the transesterification of GMF with SBO, the maximum GMF conversion (94.3 ± 0.7%) and FAG yield (83.8 ± 1.0%) were obtained in [C12mim]PF6. High FAG selectivities (∼0.90) were also obtained using SBO or MFA as acyl donors.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2025
·Vol. 48
·期 4
·e70154
·
IF 2.8
Tianai Zhang,Jiaqi Guo,Weiyang Sun,Xinyi Huang,Zilong Zhang,Yuming Jin,Zifan Hu,Shi Qiu,Xiaoli Zou
A growing concern has been raised about human exposure to phthalates and bisphenols, while data is limited regarding the accumulation of these endocrine disrupting chemicals at the target tissue. In this study, a novel, simple, and sensitive method was successfully developed for the simultaneous determination of nine phthalate monoesters and nine bisphenols in human prostate tissue samples. A solid–liquid extraction procedure was applied following ultra-high performance liquid chromatography tandem mass spectrometry analysis. The detection and quantification limits were in the range of 4.12 × 10 −3 to 0.370 ng/g and 1.38 × 10 −3 to 1.23 ng/g, respectively. The average spiked recoveries varied from 71.4% to 102%, with relative standard deviations ≤ 10%. Finally, this method was applied to 76 human prostate tissue samples. Four phthalate monoesters (mono-ethyl phthalate, mono- iso -butyl phthalate, mono- n -butyl phthalate, and mono-benzyl phthalate) were detected with the highest frequency of 98.68%, followed by other five phthalate monoesters (71.05% ∼ 94.74%), bisphenol S (72.37%), and bisphenol A (57.89%). Five bisphenols were not detected in any tissue sample. The concentrations of detected phthalate monoesters and bisphenols ranged from 1.12 × 10 −3 to 1.86 × 10 2 ng/g and 6.08 × 10 −3 to 39.0 ng/g, respectively, with standard errors ranging from 3.25×10 −3 to 4.64 ng/g. Besides, a positive correlation for the concentration of seven phthalate monoesters and bisphenol A could be observed between tissue and urine, which indicates that these metabolites in urine can serve as noninvasive biomarkers to evaluate the true exposure level of prostate tissue. This study provides data and information on exposure to phthalate monoesters and bisphenols in human prostate tissue and the association with their urinary metabolites, supporting further studies of pollutant exposure and prostate disease.
研究领域:
环境科学
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医学
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毒理学
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 2
·1-9
·
IF 5.3
Xie Hui,Xie Sihui,Jiang Li,Lei Chenghong
Ce-MOFs with ferrocenedicarboxylic acid ligands (Ce-FcDC) as a bifunctional nanozyme exhibited high peroxidase (POD)-mimicking activity and superoxide dismutase (SOD)-mimicking activity. H 2 O 2 was produced from catalytic hydrolysis of peroxymonosulfate (PMS) using Ce-FcDC as a catalyst. The growth of E. coli and S. aureus were synergistically and more effectively suppressed by PMS in the presence of Ce-FcDC, in comparison with the sole use of PMS or Ce-FcDc. Under the catalysis of Ce-FcDC as the POD-mimicking nanozyme, PMS could be activated by Ce-FcDC to produce SO 4 •− and •OH and H 2 O 2 from the hydrolysis of PMS was further derivatized to O 2 •− and •OH. Ce-FcDC as the SOD-mimicking nanozyme causes O 2 •− to form H 2 O 2 . The generation of O 2 •− and •OH were confirmed using p-benzoquinone and isopropanol alcohol as the scavengers. The resulted SO 4 •− , O 2 •− , and •OH from combination of PMS with Ce-FcDC as an activator may have key roles for suppressing the growth of E. coli and S. aureus . This strategy could be an effective approach for suppressing the growth and preventing infections or pollutions of some other microbial cells as well. Graphical abstract
研究领域:
微生物学
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生物化学
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材料科学
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DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2022
·
IF 9.224
Zheng-Meng Jiang,Fang-Fang Wang,Jie Liu,Tian-Qing Huang,Hu Zhang,E-Hu Liu
The conversion of diester-diterpenoid alkaloids (DAs) into monoester-diterpenoid alkaloids (MAs) is an effective method to reduce the toxicity of Aconiti Lateralis Radix Praeparata (Fuzi in Chinese, ALRP), a popular traditional Chinese medicine. In the present study, deep eutectic solvents (DESs) were first utilized to simultaneously detoxify ALRP and extract aconitum alkaloids by gas bath thermostatic oscillator-assisted extraction. The effects of extraction parameters, including the extraction time, water content of DESs, temperature, liquid/solid ratio, and pH, on the extraction of MAs were evaluated by single-factor experiments, and the optimal condition was further optimized using response surface methodology. The results indicated that betaine-urea (Bet-Ure, 1:2 mol/mol) was the most appropriate DES to hydrolyze highly toxic DAs into less toxic MAs and improve the extraction efficiency of aconitum alkaloids in one step. The detoxification mechanism study showed that alkaline DESs had an excellent efficiency for DA hydrolysis and MA extraction, and the MA-extraction efficiency enhanced with the increase in pH. Compared with the conventional extraction, the newly developed detoxification process maximized the hydrolysis of DAs and exhibited a higher MA-extraction efficiency (1.913 mg/g vs 0.155 mg/g). The DES-based method offered an ecofriendly, simple, and feasible detoxication strategy for ensuring the safe and effective use of ALRP.
研究领域:
中药学
·
植物化学
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产品关联
DOI
高影响因子
TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2023
·
IF 3.8
Jia-min Gong,Xiao-lei Yi,Jia-hong Liang,Zhen-zhong Liu,Zuo Du
Phthalate esters (PAEs), accompanied by phthalate monoesters as hydrolysis metabolites in humans, have been widely used as plasticizers and exhibited disruptive effects on the endocrine and metabolic systems. The present study aims to investigate the inhibition behavior of PAEs and phthalate monoesters on the activity of the important hydrolytic enzymes , carboxylesterases (CESs), to elucidate the toxicity mechanism from a new perspective. The results showed significant inhibition on CES1 and CES2 by most PAEs, but not by phthalate monoesters, above which the activity of CES1 was strongly inhibited by DCHP, DEHP, DiOP, DiPP, DNP, DPP and BBZP, with inhibition ratios exceeding 80%. Kinetic analyses and in vitro-in vivo extrapolation were conducted, revealing that PAEs have the potential to disrupt the metabolism of endogenous substances catalyzed by CES1 in vivo . Molecular docking results revealed that hydrogen bonds and hydrophobic contacts formed by ester bonds contributed to the interaction of PAEs towards CES1. These findings will be beneficial for understanding the adverse effect of PAEs and phthalate monoesters.
研究领域:
生物化学
·
毒理学
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产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Qiuyan Lin,Na Zheng,Qirui An,Zhifei Xiu,Xiaoqian Li,Huicheng Zhu,Changcheng Chen,Yunyang Li,Sujing Wang
Phthalate monoesters (mPAEs) possess biological activity that matches or even exceeds that of their parent compounds, phthalate esters (PAEs), negatively impacting humans. Indoor dust is the main carrier of indoor pollutants. In this study, indoor dust samples were collected from 46 households in Changchun City, Jilin Province, in May 2019, and particulate and flocculent fibrous dust was used as the research target to analyze the concentration and compositional characteristics of mPAEs, primary metabolites of five significant PAEs. The influence of factors such as architectural features and living habits in residential areas on exposure to mPAEs was explored. Ten suspected enzyme genes along with two metabolic pathways with the ability to degrade PAEs were screened using PICRUSt2. The results showed that the total concentrations of the five mPAEs in the indoor dust samples were particulate dust (11.49–78.69 μg/g) and flocculent fibrous dust (21.61–72.63 μg/g), respectively. The molar concentration ratio (R C ) of mPAEs to corresponding PAEs significantly differed among chemicals, with MMP/DMP and MEP/DEP sporting the highest R C values. Different bacterial types have shown distinct influences against mPAEs and PAEs. Enzyme function and metabolic pathway abundance had a significant effect on the concentration of some mPAEs, mPAEs are most likely derived from microbial degradation of PAEs.
研究领域:
环境科学
·
微生物学
·
公共卫生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Dami Li,Yaoyao Zhang,Xing Qiao,Shangde Sun
Resveratrol monoesters, synthesized by esterifying with lipophilic groups, excel in lipophilicity, antioxidant activity, and bioavailability. This study selectively acylated resveratrol at 3-OH and 4’-OH using lipozyme RMIM (from Rhizomucor miehei ). Seven 3-resveratrol monoesters (3-RC 2:0 – 18:0 ) and seven 4’-RC 2:0 – 18:0 were prepared, purified and identified. Their antioxidant capacity and bioaccessibility were innovatively studied, focusing on substitution and acyl chain length effects. Results showed that 3-RC 2:0 – 18:0 consistently outperformed 4’-RC 2:0 – 18:0 in SET assays for antioxidant activity. Notably, 4’-RC 2:0 – 8:0 performed better oxygen radical absorption capacity than 3-RC 18:0 . 3-RC 2:0 even showed better ABTS radical scavenging capacity than Trolox and TBHQ. 3-RC 2:0 /RC 4:0 displayed higher antioxidant efficacy than medium- and long-chain counterparts, excluding 3-RC 16:0 . In the gastric and intestinal phases, 4’-RC 2:0 – 18:0 showed slightly higher retention due to enhanced lipophilicity compared to 3-RC 2:0 – 18:0 . RC 2:0 /RC 12:0 – 18:0 showed better retention properties during digestion. In summary, 3-RC 2:0/16:0 exhibited exceptional antioxidant capacity and digestive stability. These findings suggest resveratrol derivatives' potential in lipid-based foods, pharmaceuticals, and cosmetics.
研究领域:
食品科学
·
营养学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2016
·
IF 2.687
R. Xu,H.T. Gao,F. Zhu,W.X. Cao,Y.H.M. Yan,X. Zhou,Q. Xu,W.L. Ji
This research was mainly focused on the effects of food emulsifier on the bioavailability of six priority controlling phthalate acid esters (PAEs) for the further accurate assessment of their toxic effects, using the corresponding phthalate acid monoesters (PAMEs) in rats urine as biomarkers. Glycerin monostearate was chosen as typical food emulsifier. A method was established to determine PAMEs in urine from rats either in experimental group (integrated gavaged with glycerin monostearate and PAEs) or in control group (gavaged with PAEs only), by using solid-phase extraction (SPE) coupled with ultra performance liquid chromatography tandem mass spectrometry (SPE–UPLC–MS/MS). Extraction recoveries were more than 75% for all the PAMEs; the calibration curve was linear in the range of 1.0–1000.0 ng/mL with R 2 > 0.995; the limits of detection (LOD) were 0.30 ng/mL–0.50 ng/mL. In addition, by analysing quality control (QC) urine samples in 3 days, it showed that the method was precise and accurate, for the intra-day and inter-day RSD within 16%, and the accuracy more than 82%. Internal exposure amount of all PAEs in experimental group was significantly higher than that in control group with p values of less than 0.05 except for butyl benzyl phthalates (BBP) ( P = 0.07). The bioavailability of all PAEs ranged from 5.03% to 109.35% with the presence of food emulsifiers glycerin monostearate, observably higher than that without glycerin monostearate (1.12% to 54.39%). It indicated that food emulsifiers increased the bioavailability of PAEs and may lead to potential food safety risk, which should bring awareness and be further studied.
研究领域:
毒理学
·
分析化学
·
食品安全
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产品关联
DOI
PubMed
高影响因子
TENSIDE SURFACTANTS DETERGENTS
·
2019
·Vol. 56
·期 3
·244-251
·
IF 0.748
Yaning Shi,Yonghong Zhao,Guangliang Zhang,Qingbin Dong
Lauryl phosphate monoester was synthesized from the starting materials lauryl alcohol and phosphoric acid without catalysts. Subsequently, the crude product was purified by recrystallization and characterized by Fourier transform infrared (FT-IR) and nuclear magnetic resonance ( 31 P-NMR). From the results, it was apparent that the synthesized material was the desired target product. Lauryl monoester potassium phosphate reduced the surface tension of water to 25.08 mN/m at a critical micelle concentration (CMC) of 0.569 mmol/L. It showed a low contact angle and had a low surface tension, indicating a good hydrophilicity. Lauryl monoester potassium phosphate also showed excellent antistatic properties, however its emulsifying ability was not good. The size of the aggregates of lauryl monoester calcium phosphate in aqueous solution was 220 nm and their morphology was spherical.
研究领域:
化学合成
·
材料科学
·
表面化学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Shengyuan Ye,Yang Cheng,Zheng Guo,Xingguo Wang,Wei Wei
This study aimed to prepare single-component LNPs with sugar alcohol fatty acid monoesters for temperature-controlled release. In total, 20 kinds of lipids with a series of sugar alcohol head groups (ethylene glycol, glycerol, erythritol , xylitol and sorbitol) and fatty acyl tails (12:0, 14:0, 16:0 and 18:0) were synthesised via lipase-catalysed esterification . Their physicochemical properties and upper/lower critical solution temperature (LCST/USCT) were analysed. Two groups of mixed lipids, 78 % ethylene glycol lauric acid monoester + 22 % sorbitol stearic acid monoester (LNP-1) and 90 % ethylene glycol lauric acid monoester + 10 % xylitol myristic acid monoester (LNP-2), had LCST/USCT of approximately 37 °C, which formed empty LNPs using the emulsification−diffusion method. These two mixed lipids were prepared for LNPs loaded with curcumin , showing high encapsulation (>90 %), mean particle sizes of approximately 250 nm and low polydispersity index (≤0.2). These lipids have the potential for tailor-made LNPs achieving thermo-responsivity in delivering bioactive agents and drugs.
研究领域:
药剂学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）