CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2024
·
IF 3.7
Chengwei Xu,Yifu Wang,Yan Yu,Lirong Li
The wettability has an important effect on coalescence performance of filter. In this paper, we utilized a commercial glass fiber filter as the substrate to prepared the Janus filter through dip-coating and electrospraying. The Janus filter exhibited a remarkable reduction in pressure drop, with only 2.8 kPa of wet pressure drop compared to 6.1 kPa for the original filter and 5.4 kPa for the oleophilic filter. Notably, the coating depth played a critical role in enhancing the coalescence performance of the Janus filter. Furthermore, when placing the Janus filter in reverse direction, its quality factor increased by 2.87 times, highlighting that orientation is an essential factor for coalescence performance of Janus filters. The results indicate great potential in the application of Janus filters for coalescence filtration.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
·
2018
·
IF 3.891
Yaran Yin,Chunying Zhu,Rongwei Guo,Taotao Fu,Youguang Ma
The dynamics of the gas-liquid two-phase flow are of great significance for the heat and mass transfer performance in a microreactor. In this paper, the flow pattern, void fraction and frictional pressure drop of gas-liquid two-phase flow of CO 2 and MEA/[Bmim][BF 4 ] aqueous solution accompanied by the chemical reaction in a 400 μm square microchannel were investigated experimentally by a high-speed camera and pressure sensor. Three kinds of flow regimes were observed: slug-bubbly flow, slug flow and slug-annular flow. The void fraction and frictional pressure drop in the slug flow regime were mainly investigated, and the applicability of models without consideration of the mass transfer proposed in the literature was assessed. Considering the effect of chemical absorption, two correlations were proposed with the Hatta number for predicting the two-phase void fraction and Chisholm parameter C , which showed good prediction performance.
研究领域:
化学工程
·
传热与传质
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Xin Wei,Yufeng Liu,Hua Zhou,Feng Chen,Hongxia Wang,Zhongli Ji,George G. Chase,Tong Lin
Oil aerosol usually causes air pollution, health issues, and corrosion to equipment. The removal of aerosol oil particles from the air is a crucial process in industrial production and daily life. Although fibrous filters have been a widely used material for the separation of oil aerosol from the air, it is still a challenge to separate submicrometer aerosol oil particles with both high filtration efficiency and low resistance. Herein, we report a novel approach to markedly reduce the pressure drop of a fibrous filter and simultaneously increase its aerosol filtration efficiency, only by surface treatment to make the filter have in-plane alternating superoleophilic and superoleophobic patterns. We used a spraying method to prepare superoleophobic and superoleophilic patterns on the filter. The best filtration results were achieved when two layers of the patterned filters that have superoleophobic and superoleophilic strips (both width, 5 mm) were stacked in a way that the opposite wetting surfaces contacted each other between the layers. The filter showed a much-reduced filtration resistance and the pressure drop (4.16 kPa) at the pseudo-steady state being at least 45% lower when compared to the two-layer controls with a homogeneous surface wettability (i.e., untreated surface, superoleophobicity, and superoleophilicity). It also showed higher filtration efficiency (98.37% for small oil mists and 99.99% for large oil mists) and over two times higher quality factor (0.99 kPa–1 for small oil mists and 2.27 kPa–1 for large oil mists). The asymmetric wettability leads to the formation of unobstructed channels for the air stream to penetrate through the filter matrix, leading to a low resistance with improved oil capture efficiency. The pattern strip width showed an effect on filtration performance. This unexpected finding may provide a novel approach to designing high-performance, low energy consumption, and long-life coalescence filters.
研究领域:
材料科学
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环境工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Expert Opinion on Drug Delivery
·
2024
·
IF 5
Zhutian Zhang,Qian Ma,Zhaoxing Dai,Jiaxu Hong,Jifeng Gu,Rong Shi,Jianjiang Xu,Yaling Ma,Xinghuai Sun,Jianguo Sun
Background Glaucoma is one of the major irreversible blinding eye diseases in the world. Reducing intraocular pressure (IOP) is the primary treatment option, and taking eye drops daily is the common method. However, short drug duration and poor bioavailability of eye drops may lead to unsatisfied therapeutic effects and inadequate patient compliance.Methods A brimonidine-loaded silicone rubber insert (BRI@SR@PT) was prepared by loading brimonidine into a surface-modified silicone rubber ring, followed by polydopamine/thermoplastic polyurethane coatings. The physical properties, in vitro cytocompatibility and drug release of BRI@SR@PT were investigated. The BRI@SR@PT was administrated in the conjunctival sac of rabbit eyes, and its in vivo drug release, IOP-lowering efficacy and biosafety were assessed.Results The BRI@SR@PT presented great thermal stability and excellent elasticity. The BRI@SR@PT was able to release BRI sustainably for 28 days with little toxicity in vitro. Compared to BRI eye drops, the BRI@SR@PT effectively lowered IOP for 21 days based on the sustained BRI release with great biosafety when administrated in conjunctival sac of rabbit eyes in a noninvasive fashion.Conclusions The conjunctival sac insert (BRI@SR@PT), as a promising drug-delivery platform, may provide a sustained IOP-lowering treatment for patients with ocular hypertension or glaucoma, without the need for invasive procedures.
研究领域:
药剂学
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眼科医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nutrients
·
2022
·Vol. 14
·期 11
·2332
·
IF 6.706
Meng-Ling Zhang,Qian Yang,Yan-Di Zhu,Ya-Di Zhang,Rui Zhang,Jian Liu,Xiao-Yan Zhao,Qin-Yu Dang,Dong-Xu Huang,Ming-Yuan Zhang,Yu-Chen Wei,Zhuo Hu,Xia-Xia Cai,Li-Fang Gao,Yang Shan,Huan-Ling Yu
In this study, we aimed to evaluate the effect of Nobiletin (NOB) on the placenta of Sprague–Dawley (SD) rats that had undergone reduced uterine perfusion pressure (RUPP) surgery and to evaluate the safety of NOB intervention during pregnancy. The results showed that NOB alleviated placental hypoxia, attenuated placental cell apoptosis, and inhibited placental damage in RUPP rats. No side effect of NOB intervention during pregnancy was observed. BeWo cell lines with P53 knockdown were then constructed using lentiviral transfection, and the P53 signaling pathway was found to be essential for NOB to reduce hypoxia-induced apoptosis of the BeWo cell lines. In summary, NOB attenuated hypoxia-induced placental damage by regulating the P53 signaling pathway, and those findings may contribute some insights into the role of NOB in placental development and the prevention of placental-related diseases.Keywords:Nobiletin;placenta;hypoxia;RUPP;P53 signaling pathway
研究领域:
药理学
·
妇产科学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 42
·22269-22279
·
IF 11.301
Kangli Xu,Jixia Deng,Rui Lin,Heng Zhang,Qinfei Ke,Chen Huang
Nonwovens are widely applied in the air filtration field for their multi-layered fibrous structures and interconnected pores. Despite their intensive use, conventional microfiber nonwovens usually suffer from low filtration efficiencies due to their large pore size, while most nanofiber nonwovens are still confined within the laboratory due to the difficulties of reconciling the comprehensive requirements (such as low pressure drop, high fluffiness, strength and long-term reliability) raised from practical applications. Herein, we report a simple and scalable method that can generate more nanofibrils in a para-aramid microfiber nonwoven without interfering with the three-dimensional nonwoven structure. The success of this method relies on treating the whole nonwoven, rather than individual fibers, with phosphoric acid to trigger a surface fibrillation process of para-aramid microfibers. The structural reinforcement from microfibers, in combination with the enlarged surface area and the reduced pore size brought by nanofibrils, improves the filtration efficiency of the fibrillated nonwoven by 84.7% and maintains the pressure drop at an ultralow value of 3.5 Pa. Further synthesis and loading of a novel catalyst (CuO–CeO2) onto the nonwoven demonstrates a higher catalyst-loading capacity after fibrillation. The resulting nonwoven filter shows high elimination rates against a variety of solid and gaseous pollutants (including particulate matter, carbon monoxide and toluene), and is applicable at both room and elevated temperatures. We believe that the generation of nanofibrils in microfiber nonwovens and the subsequent loading of catalysts will find extensive utility in the purification of industrial emissions, automobile exhausts and indoor air.
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Chu Zhou,Yanfu Chen,Dang Cheng
Micro packed bed reactors (MPBRs) operated by feeding with two immiscible liquids are of increasing importance in the chemical, biochemical, and energy industries. Herein, the impact of the channel- to particle-diameter ratio (N) on the liquid–liquid mass transfer and pressure drop in MPBRs is experimentally investigated. The experimental results reveal that both the overall volumetric liquid–liquid mass transfer coefficient (kLa) and pressure drop per unit length (ΔP/Lc) increase with the total flow rate (Qtot) for MPBRs of low to high N. The wall effects depend on Qtot, and the larger the Qtot, the more significant the wall effects. At small values of Qtot, kLa decreases slightly with N and increases marginally with the organic- to aqueous-phase flow rate ratio (φ); ΔP/Lc increases inappreciably with N and φ. At large values of Qtot, kLa declines significantly with N and increases appreciably with φ; ΔP/Lc increases significantly with N and φ. Correlations for calculating kLa and ΔP/Lc of the MPBRs are developed, yielding predictions that are in reasonably good agreement with the corresponding experimental data.
研究领域:
化学工程
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生物化学工程
·
能源工程
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2023
·
IF 4.9
Jingyi Zhao,Jian Xiong,Yun Ning,Jiansong Zhao,Zhipeng Wang,Linhui Long,Haibing He,Jingxing Gou,Tian Yin,Xing Tang,Yu Zhang
Glaucoma is a chronic disease that requires lifelong treatment, whereas, discomfort caused by frequent medication may affect the quality of life. Moreover, the therapeutic efficacy of traditional local administration was unsatisfactory due to the rapid ocular clearance mechanism and the ocular barrier. Herein, a triple crosslinked micelle-hydrogel lacrimal implant with low polymer content was fabricated for localized and prolonged therapy of glaucoma. Latanoprost and timolol were simultaneously entrapped in the PEG-PLA micelles with high encapsulation efficiency and further loaded into the triple crosslinked hydrogel, facilitating a double sustained release of drugs. Subsequently, the implant was constructed by a unique molecular orientation fixation technology, which enables the implant to be fixed in the lacrimal duct. The triple crosslinked micelle-hydrogel lacrimal implant manifested a distinguished physicochemical characterization to sustain the release of latanoprost and timolol. In vitro release experiment demonstrated the duration of two drugs was extended for up to 28 days. The in vivo test of elevated intraocular pressure (IOP) in a rabbit model revealed that the IOP-lowering effects were sustained longer than 28 days as expected. The relative pharmacological availability (PA) of lacrimal implants was 5.7 times greater than that of the eye drops. The results of the studies on ocular irritation and histological examination demonstrated the good safety of the lacrimal implant. In conclusion, the triple crosslinked micelle-hydrogel lacrimal implant could effectively lower the IOP with splendid compatibility, demonstrating the promising prospect in the long-term noninvasive treatment of glaucoma.
研究领域:
药剂学
·
眼科医学
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生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Gas Science and Engineering
·
2025
·
IF 5.5
Chenyang Lin,Yijun Wang,Yihang Liu,Takeshi Hagio,Baowen Zhou,Xinling Li,Zhen Huang
Direct air capture (DAC) is a technology that captures low concentrations of CO 2 directly from the air. In recent years, amine-modified solid adsorbents have been widely utilized to facilitate an efficient CO 2 capture process. In industrial applications, the significant pressure drop reduced by powder accumulation results in economic losses for fans. However, previous studies on monoliths have failed to simultaneously satisfy the industrial requirements for both adsorption capacity and mechanical strength. In this work, a novel honeycomb monolith was proposed to address this issue. The seven uniformly distributed channels effectively reduced pressure drop, while the wall thickness satisfied the mechanical strength requirements under industrial application conditions. And the structure was optimized by using activated carbon. After high-temperature treatment, the new pore formed in the space previously occupied by the activated carbon. Through the secondary loading approach, the amine loading was comparable to the powder. Compared with the monoliths without activated carbon, the pore volume significantly increased (from 5.31 % to 96.26 %). The pore volume of 20AC-SiO 2 -M reached 0.84 cm 3 g −1 . At 35 °C and 400 ppm, 20AC-SiO 2 -M exhibited the best CO 2 adsorption capacity (1.94 mmol/g) and the fastest CO 2 adsorption rate (0.0395 mmol/(g.min)). Additionally, the structure strength (1.46 MPa) and pressure drop losses (0.002 psi) were tested, and both parameters met the requirements for industrial applications.
研究领域:
环境科学
·
材料科学
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化学工程
·
吸附分离
·
碳捕集与封存
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Miaomiao Zhu,Yankang Deng,Yong Zheng,Xuan Hu,Wenxuan Xu,Ranhua Xiong,Chaobo Huang
Recently, the demand for healthcare products especially wearable smart masks is increasing. The biosafety and degradability of smart masks are crucial for human health and environmental protection. However, the development of biodegradable and biocompatible fibrous membranes with high filtration efficiency and low pressure drop is still a challenge. How to realize the collaborative improvement between air filtration efficiency and pressure drop of the nanofibrous membrane is still a challenge. Here, a tribo-charge enhanced and biodegradable nanofibrous membranes (TCB NFMs) with highly fluffy structure for air filtration and self-powered respiration monitoring systems is reported for the first time. The filtration efficiency and pressure drop of the prepared membranes for 0.3 µm NaCl particulates is 99.971% and 41.67 Pa. The TCB NFMs based smart mask possesses a series of satisfactory and excellent characteristics, such as self-powered, biodegradable, biocompatible, high filtration efficiency, and low pressure drop, which is highly promising for application in air filtration systems and intelligent wearable respiration monitoring systems.
研究领域:
材料科学
·
环境科学
·
医疗技术
·
可穿戴设备
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Yibo Liu,Chao Jia,Han Zhang,Haiyang Wang,Pan Li,Luna Jia,Feng Wang,Pengfei Zhu,Hao Wang,Lu Yu,Feipeng Wang,Lingxiao Wang,Xin Zhang,You Sun,Bo Li
Particulate matter of 0.3 μm in diameter (PM0.3) poses a serious threat to the environment and human beings. Ultrathin and -light nanofibrous filters with excellent filtration properties can significantly prevent the detrimental effects of these particles. Here, we develop free-standing polyamide PA-66 ultrafine nanofiber papers for PM0.3 filtration using effective and scalable blow and electro-blow spinning techniques. The smallest average fiber diameter is 61.7 nm, which is 2–3 orders of magnitude smaller than that of conventional textiles. Poly(ethylene terephthalate) nonwovens are selected to fabricate free-standing nanofiber papers of various polymers, including polyamide, poly(methyl methacrylate), poly(vinylpyrrolidone), and poly(ethylene oxide) owing to the smooth surfaces of the nonwovens. This underlying principle can be used to create similar free-standing nanofiber papers from other commodity polymers in the future. Mechanisms of capturing particulate matter with different nanofiber morphologies are discussed. Salt and oil particulates are used to characterize the filtration properties. PA-66 papers are promising reusable filters owing to their mechanical particle-capture mechanism. The blow-spun PA-66 papers show filtration performance of 98.75% efficiency and a pressure drop of 125.44 Pa owing to the “slip” effect caused by the ultrasmall diameter. In the electro-blow spinning process, a supplementary voltage supply is conducive to separating nanofiber bundles into random-oriented nanofibers. Electro-blown spun papers possess an ultrahigh efficiency of 99.99% with a reduced areal density of 0.9 g m–2. These PA-66 papers can be used in a variety of applications, such as reusable personal protective equipment, industrial waste gas treatment, and central ventilation purification systems.
研究领域:
材料科学
·
环境工程
·
纳米技术
·
过滤技术
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Qibin Wang,Zungui Shao,Jian Sui,Ruimin Shen,Ruixin Chen,Zeqian Gui,Yude Qi,Wenzhengyi Song,Guoxin Li,Yifang Liu,Gaofeng Zheng
Preparing bio-based air filtration membrane through green electrospinning strategy is a vital approach to alleviating environmental and energy crises. However, the development of related biomaterials and method for regulating membrane structure are still lacking. In this study, ethyl cellulose (EC) bimodal nanofibrous membrane was prepared by electrospinning using ethanol and water as solvents to achieve high-performance air filtration. A new strategy for bimodal fiber molding based on molecular weight modulation was proposed. The EC polymer chains with medium molecular weights were subject to the highest degree of inhomogeneity of solvent intrusion, and there were significant differences in viscous forces “microscopically”, leading to the formation of bimodal structure by inhomogeneous stretching of the jet. The well-defined bimodal structure endowed EC membrane with excellent air filtration performance. The filtration efficiency for PM 0.3 , pressure drop, quality factor were 99.11 %, 42.2 Pa, and 0.112 Pa −1 , respectively. Compared to the commonly used zein, EC cost just 12.77 %, and its solution had a 50 % longer shelf life, making it a more desirable biomaterial. This work will facilitate the application of more biomaterials in air filtration, promote the green fabrication of high-performance air filtration membranes, and realize sustainable development.
研究领域:
材料科学
·
环境科学
·
化学工程
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）