MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Jingjing Liu,Yan Zhang,Hongwei Yu,Weijia Li,Longfei Li,Yizhou Chen,Shikun Liu,Lixin Qiao,Jiale Kuang,Zetao Chen,Shuang Li,Qingjun Liu
Astringency, as a complex oral sensation, poses challenges for in-vitro detection and quantification due to the intricacy of its perception mechanism and the complexity of the astringent substances involved. To address this challenge, we developed a chitosan hydrogel-based sensor inspired by the human tongue. Mucins were embedded within the sensor to detect astringent polyphenols. When in contact with astringent phenolic compounds, the resulting precipitate aggregates entangle or block the pores, restricting ion conductivity within the sensor. Astringency detection is achieved using cyclic voltammetry. The tongue-inspired sensor can detect a wide range of tannic acid (1E −4 wt% - 5wt%), including the human sensory threshold for astringency, and construct a standard astringency quantification curve from the sensing data. It was demonstrated to revert the actual astringency sensing process by overall astringency detection and synergistic effect, simulating the in-vitro function of the tongue. In addition, the sensor provides insights for evaluating the optimal drinking time of open red wines based on astringency, offering a novel approach for wine astringency evaluation, demonstrating its potential for a variety of applications in the food and beverage industry.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 12.2
Wenli Tang,Daiwen Zhu,Qilong Zeng,Huan Zhong
Predicting the bioaccumulation of potent neurotoxic methylmercury (MeHg) in rice is essential for assessing and mitigating human exposure risks, particularly for Asians and infants. However, significant uncertainties lie in understanding and predicting MeHg accumulation in rice, partially due to the insufficient understanding of how rice plants regulate Hg biogeochemistry in soil-rice systems. Here, we conducted a pot experiment involving 32 commonly cultivated rice varieties under the same soil and ambient conditions. By analyzing MeHg contents in rice-paddy systems and amino acid profiles in grains, we demonstrate that rice varieties impact soil MeHg production through secreting differential root exudates and regulate MeHg uptake by modulating plant biomass and grain amino acids. Importantly, we provide evidence that rice cultivars impact MeHg accumulation by regulating the amounts of specific amino acids and antioxidant pigments, which quench reactive oxygen species and subsequently inhibit in vivo MeHg demethylation, reshaping tissue MeHg concentrations and MeHg translocation. Meanwhile, in vivo demethylation may serve as a primary source of grain inorganic Hg (IHg), which explains the positive correlation between grain MeHg and IHg. Our study underscores the critical yet overlooked role of plants in Hg transformations, offering valuable insights for elucidating MeHg bioaccumulation.
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Advanced Healthcare Materials
·
2026
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IF 11
Xueqiang Deng,Zhiqiang Li,Xuan Yi,Dong Ruan,Xiang Chen,Jun Luo
Osteoporosis poses a significant threat to human health and severely impairs patients' quality of life. Conventional pharmacological interventions are limited by poor patient compliance and suboptimal efficacy. Imbalanced macrophage polarization is a key driver in osteoporosis pathogenesis, and precise regulation toward the anti-inflammatory M2 phenotype represents a critical therapeutic target. A calcium-polyphenol network-functionalized black phosphorus nanosheet system (HCBP) is developed as a bone-targeted cascade-responsive nanoplatform. After intravenous administration, bone-targeting peptides mediate efficient accumulation in bone tissue. The system dissociates in the acidic osteoporotic microenvironment and releases phosphate ions, which combine with calcium ions to form bioactive calcium phosphate. HCBP alleviates inflammation, sustains M2 macrophage polarization, scavenges reactive oxygen species, enhances osteogenesis, and suppresses osteoclast differentiation. Transcriptomic analysis confirms regulation of the TNF-α/NF-κB, IL-17, and osteoclast differentiation pathways, together with inhibited glycolysis. This multifunctional strategy overcomes the limitations of single-target osteoporosis therapies and facilitates the clinical translation of nanomedicines for metabolic bone diseases.
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Journal of Future Foods
·
2026
·
IF 10.6
Danfei Liu,Yuyang Chen,Xiaoxuan Li,Wenxuan Zhou,Changfan Zhang
This study developed a multifunctional freshness indicator film based on black wolfberry anthocyanins (BWA) and a Houttuynia essential oil Pickering emulsion for monitoring pork freshness. The film was fabricated using a polyvinyl alcohol/guar gum blend system via a casting method, followed by screen-printing of a chitosan-stabilized Houttuynia essential oil Pickering emulsion onto its surface. The film showed improved mechanical strength (tensile strength up to 32.35 MPa) and ammonia-responsive color change from purplish-red to bluish-green during 4 °C pork storage, correlating with TVB-N (17.73 mg/100g) and TVC (5.98 lg CFU/g) by day 6. Structural analyses (SEM, FTIR, XRD) confirmed hydrogen bonding and enhanced film compactness. A ResNet18 model trained on 305 film images achieved 97.3% classification accuracy and was integrated into a PyQt5-based visual platform. This work integrates natural pigments, antibacterial Pickering emulsions, and deep learning for real-time meat freshness monitoring. However, the film's color stability under prolonged storage and its sensitivity to environmental humidity require further optimization. Future studies should focus on scaling up production and validating the system for diverse meat products under varying storage conditions.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Mengru Li,Wei Zhang,Yuan Huang,Xiaoying Zhang,Wuernisha Kadeer,Leihong Mao,Yuqian Jiang,Rong Tsao,Yao Tang
The production of raisins by freeze-drying (FD) generates large volumes of water removed from fresh grapes, which contains antioxidant-active substances and volatile aromatic compounds. The migration pattern of those compounds and their interaction with water during dynamic FD was investigated, and results revealed that the free and weakly bound water in grape tissues gradually reduced as internal pores formed. Through high-performance liquid chromatography characterization, the concentration of total phenolic compounds in the recovered water peaked around 3 mg/L at 60 h, alongside the identification of key volatile compounds such as linalool and ethyl butyrate. The migration of these compounds was closely linked to the moisture decrease in the grapes, suggesting that the water sublimation facilitated the transfer of beneficial compounds to the recovered water. This study provides theoretical foundation for utilizing recovered water as value-added resource in food industry.
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Frontiers in Plant Science
·
2022
·
IF 6.627
Su Xuexia,Bai Cuihua,Wang Xianghe,Liu Huilin,Zhu Yongcong,Wei Leping,Cui Zixiao,Yao Lixian
Fruit color is a decisive factor in consumers’ preference. The bright red color of litchi fruit is associated with its high anthocyanin; however, poor fruit coloration is a major obstacle in litchi plantation. The role of spraying mineral nutrient salts such as KH2PO4, KCl, K2SO4, and MgSO4 on litchi pericarp pigmentation was examined by a field trial, and the relation between human visual color preference versus pericarp pigments and hue-saturation-brightness (HSB) color parameters was investigated. K2SO4-sprayed litchi fruit gained the maximum popularity for its attractive red color. Spray of K and Mg salts decreased the buildup of yellowish pigments, but increased the accumulation of red ones, with the exception of slightly reduced anthocyanins in KH2PO4-sprayed fruit, by regulating the activities of enzymes involved in anthocyanidin metabolism and decreasing pericarp pH, leading to varied pericarp pigment composition. K2SO4 spray generated the highest percentage of cyanidin-3-glucoside over all pigments in pericarp. Correlation analysis shows the percent of cyanidin-3-glucoside, superior to anthocyanin concentration and HSB color parameters, was a reliable indicator to fruit color preference. This work demonstrates that spray of suitable mineral salt can regulate pericarp pigment profile, and is an effective approach to improve fruit pigmentation and promote its popularity.
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Yuting Fan,Qingyu He,Chao Gan,Zhen Wen,Jiang Yi
The interactions between bovine α-lactalbumin and procyanidin B2 were fully investigated by spectroscopic methods and molecular docking. This study hypothesized that ALA could spontaneously interact with procyanidin B2 to form protein-based complex delivery carrier. Far UV CD and FTIR data demonstrated ALA’s secondary structures were altered and intrinsic fluorescence quenching suggested ALA conformation was changed with procyanidin B2. Calorimetric technique illustrated ALA-procyanidin B2 complexation was a spontaneous and exothermic process with the number of binding site (n, 3.53) and the binding constant (K b , 2.16 × 10 4 M −1 ). A stable nano-delivery system with ALA can be formed for encapsulating, stabilizing and delivering procyanidin B2. Molecular docking study further elucidated that hydrogen bonds dominated procyanidin B2 binding to ALA in a hydrophobic pocket. This study shows great potential in using ALA as protein-based nanocarriers for oral delivery of hydrophilic nutraceuticals, because procyanidin B2-loaded ALA complex delivery systems can be spontaneously formed.
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FOOD CHEMISTRY
·
2023
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IF 8.8
Lei He,Qian Hu,Liyang Wei,Xuliyang Ge,Ning Yu,Ying Chen
An integrated metabolomics approach based on UPLC-QTOF-MS and HS-SPME-GC-orbitrap-MS was performed to investigate the dynamic changes of metabolite profiling in chickpeas, red speckled kidney beans, and mung beans during soaking. There were 23, 23, 16 non-volatile metabolites, and 18, 21, 22 volatile metabolites were identified as differential metabolites in chickpeas, red speckled kidney beans, and mung beans during soaking, respectively. These metabolites mainly included flavonoids, lysophosphatidylcholines (LPCs), lysophosphatidylethanolamines (LPEs), fatty acids, alcohols, aldehydes, and esters. The key time points responsible for the significant changes in metabolites and quality of the three pulses were 4, 8, and 24 h of soaking. Results revealed that the variations of some metabolites could attribute to oxidation and hydrolysis reactions. These results contribute to a better understanding of how soaking affects pulses quality, and provide useful information for determining soaking time according to nutritional and sensory requirements of their final products or dishes.
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FOOD RESEARCH INTERNATIONAL
·
2023
·
IF 8.1
Lei He,Qian Hu,Jiukai Zhang,Ranran Xing,Yongsheng Zhao,Ning Yu,Ying Chen
Black soybeans are extensively planted and consumed in China due to their high nutritional value and numerous health benefits. However, very few is known about the characteristic metabolites of black soybeans from different geographical origins in China. In the present study, 31 black soybean samples were collected from 11 main producing provinces in China. A combined metabolomics approach using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) and gas chromatography coupled to an Orbitrap mass analyzer (GC-orbitrap-MS) was performed for the first time to comprehensively investigate the metabolite variability among the black soybeans from different geographical origins. A total of 48 differential non-volatile metabolites and 14 differential volatile metabolites were identified based on orthogonal partial least squares discriminant analysis (OPLS-DA) coupled with analysis of variance (ANOVA). Higher procyanidin B1, procyanidin B2, epicatechin, malonylated isoflavones, and β -pinene were observed in Gansu black soybeans. Guangxi black soybeans had higher amounts of linoleic acid and its oxidation products of hexanal and pentane. The black soybeans from Xinjiang and Yunnan were found to have higher delphinidin-derived anthocyanins, gamma-glutamyl peptides, and aromatic hydrocarbons. The characteristic metabolites of black soybeans from other geographical origins were also clarified. This study indicated that the integrated untargeted metabolomic approach can be a powerful tool to provide knowledge for developing specialty black soybeans.
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MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 1
·1-12
·
IF 5.833
Zhang Haipin,Song Huijia,Tian Xuemeng,Wang Yue,Hao Yi,Wang Wenting,Gao Ruixia,Yang Wan,Ke YuShen,Tang Yuhai
A synergistic imprinting strategy of covalent and non-covalent interactions is proposed to prepare magnetic molecularly imprinted polymers (DI-MMIPs) for highly selective separation of procyanidin B2 (PC) from grape seed samples. Dopamine and 3-amino-phenylboronic acid as cooperative functional monomers endow the imprinted sites with synergistic tailoring. Benefiting from the synergistic effect, the DI-MMIPs exhibit enhanced imprinting performance with high adsorption capacity (27.71 mg g −1 ), fast kinetic equilibrium time (within 30 min), outstanding selectivity (IF = 5.8, SC > 3.2), and satisfactory regeneration ability. In addition, the DI-MMIPs possess good magnetism, uniform morphology with typical core-shell structure, and stable crystallization. Furthermore, the established DI-MMIPs coupled with HPLC-UV (~ 280 nm) method has a wide linearity range of 0.05–200 μg mL −1 with correlation coefficient of 0.9997, high recoveries (> 93.1%) with RSDs from 2.9 to 5.5%, and low LOD (0.0008 μg mL −1 ). Consequently, this work provides an effective and easily tailored way to fabricate magnetic imprinted nanomaterials with both rapid recognition rate and high selectivity and thus holds great promise to realize the extraction and detection of PC from real samples. Graphical abstract
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Taotao Dai,Jun Chen,David Julian McClements,Ti Li,Chengmei Liu
Procyanidins are reported to inhibit α-glucosidase, which may be a useful attribute for developing functional foods that control post-prandial blood sugar levels. At present, the nature of the molecular interaction between procyanidins and α-glucosidase is poorly understood. In this study, spectroscopic analyses and computer simulations were used to investigate the interactions between α-glucosidase and B-type procyanidin dimer (BPD). Our results suggest that BPD binds to α-glucosidase through a combination of hydrophobic and hydrophilic interactions. This hypothesis was based on measurements of the intrinsic fluorescence quenching, conformational changes, and surface hydrophobicity of the α-glucosidase after binding. Thermodynamic analysis suggested that α-glucosidase had one binding site for BPD and that the interaction was spontaneous. Homologous modeling of α-glucosidase was used to provide information about the precise nature of the molecular interactions. Molecular docking analysis suggested that BPD formed hydrogen bonds and hydrophobic interactions with α-glucosidase when it bound to its active site. This research offers new insights into the mechanism of interaction between procyanidins and α-glucosidase, which may be useful for the development of functional foods to tackle type 2 diabetes.
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FOOD RESEARCH INTERNATIONAL
·
2018
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IF 3.52
Qian Li,Chengmei Liu,Ti Li,David Julian McClements,Yinxin Fu,Jiyan Liu
Epidemiological studies had indicated that the incidence of colorectal cancer is inversely correlated to the consumption of proanthocyanidins (PAs). In this study, five PAs fractions isolated from Choerospondias axillaris fruit peels with different mean degree of polymerization (mDP) were characterized and their antiproliferative effects on Caco-2 cells were investigated. MALDI-TOF-MS results indicated that PAs fractions were composed of procyanidins with DP up to 13-mers. All PAs fractions induced dose and time-dependent reductions of Caco-2 cell viability. The IC 50 values of PAs fractions with increasing mDP were 240 ± 16.0, 143 ± 9.53, 87.0 ± 3.55, 44.3 ± 4.89, and 42.8 ± 2.20 μg/mL after 24 h incubation, respectively. The observed reduction in Caco-2 cell viability was due to apoptosis via the activation of caspase-9, caspase-3, caspase-8 and the elevation of intracellular ROS generation. Moreover, the extent of the reduction in cell viability after exposure to PAs fractions was positively correlated with their mDP and galloylation. These results indicate that Choerospondias axillaris peel is a potential source of natural chemopreventive agents for the treatment of colorectal cancer.
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危险品化学品经营许可证（带存储）