Journal of the Mechanical Behavior of Biomedical Materials
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2020
·
IF 3.372
Xiaoduo Zhao,Namachivayam Karthik,Dangsheng Xiong,Yuntong Liu
The biocompatible high-performance material PEEK (polyetheretherketone) is an attractive implant material, however, its hydrophobicity and high friction coefficients severely hinder its biomedical applications . Thus, it is inferred from the recent advances in surface modification technology, achieving the biomimetic natural joint lubrication systems on PEEK still remains a challenge. In view of the above, herein we proposed a novel two-step strategy to fabricate a “soft (dual cross-linked hydrogel) layer-hard (PEEK) substrate” texture that mimics the structure and function of soft cartilage on the hard basal bone in joints. At first, a layer of acrylic acid-co-acryl amide (AA-AM) hydrogel is anchored to the PEEK substrate through UV-initiated polymerization. In the second step, hydrogel coated PEEK substrate is immersed in ferric nitrate solution to create the secondary cross-linkage between Fe 3+ and –COOH groups in the hydrogel. As a result, the consequential top-coat hydrogel layer not only transforms the surface wettability (hydrophobic to hydrophilic) but also provides scratch resistance to the underlying PEEK substrate. The modified specimens display low friction coefficients in water under different load conditions. In addition, the obtained surface exhibits a certain self-repairing ability due to its unique physically reversible network structure. Therefore, this work provides a promising strategy for broadening the use of PEEK in orthopedic implants .
研究领域:
生物医学工程
·
材料科学
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产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Yikun Ji,Mingjun Zou,Kaige Yan,Bin Liu,Shujuan Liu,Qian Ye,Feng Zhou
In this study, a novel ionic liquid-functionalized dual cross-linked hydrogel was developed via ring-opening reaction grafting ionic liquid. The hydrogel matrix containing epoxy groups was first synthesized via a one-pot polymerization reaction of acrylic acid, acrylamide, methylene diarylamide and glycidyl methacrylate, followed by the introduction of Fe 3+ ions to improve its mechanical strength, and then the ionic liquid MIm-Br with amino group was grafted onto the hydrogel matrix by amino-epoxy ring-opening reaction. The resulting ionic liquid-functionalized hydrogel exhibited excellent hydrophilicity and anti-adhesion properties, achieving an antibacterial rate exceeding 98 % against two species of bacteria and a removal rate of over 95 % for two types of algae. The synergistic effect of the hydrogel and the ionic liquid was responsible for these efficient antibacterial and antifouling properties. The hydrogel's high hydrophilicity and low adhesion confer them excellent anti-adhesion effects for bacteria and alga. Meanwhile, the positively charged imidazole ring of MIm-Br interacts with the negatively charged bacterial cell membranes through electrostatic adsorption, altering the cell's membrane permeability and causing leakage of intracellular substances. Moreover, the ionic liquid-functionalized hydrogel exhibited significantly improved swelling properties, water retention and water lubrication performance, enhancing its utility.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2020
·Vol. 11
·期 18
·3169-3178
·
IF 5.342
Chenxi Yu,Huichang Gao,Qingtao Li,Xiaodong Cao
Injectable hydrogels have shown great potential for cartilage tissue engineering as three-dimensional cell culture scaffolds, owing to their similarity to the extracellular matrix (ECM), which endows them with the ability to match irregular defects, minimally invasive properties and convenience for cell transplantation and proliferation. However, injectable hyaluronic acid (HA) hydrogels have limited applications in cartilage tissue engineering due to their poor mechanical properties and fast enzymatic degradation. In this study, a double cross-linked (DC) hydrogel was designed and prepared by combining the Diels–Alder click reaction and a phenyl boronate ester bond, in which the DA reaction provides mechanical properties and the phenyl boronate bond provides versatility, such as injectability, adhesion and anti-degradation. Compared with the single cross-linked hydrogel, the DC hydrogel not only possessed good injectability and pH responsiveness, but also had repeatable strength and durability. In addition, in vitro cell experiments indicated that the injectable DC hydrogel was capable of supporting cell loading and proliferation, thus being a promising candidate for repairing cartilage defects.
研究领域:
生物材料学
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组织工程学
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再生医学
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产品关联
DOI
高影响因子
MACROMOLECULES
·
2018
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IF 5.914
Hailong Fan,Jiahui Wang,Zhaoxia Jin
We demonstrate a facile and universal strategy in the fabrication of dual-cross-linked (DC) single network hydrogels with high toughness, “nonswellability”, rapid self-healing, and versatile adhesiveness based on polymer–tannic acid (TA) multiple hydrogen bonds. Two widely used hydrogels, physically cross-linked poly(vinyl alcohol) and chemically cross-linked polyacrylamide, have been transformed to TA-based DC hydrogels by dipping the corresponding aerogels into TA solution. The second cross-link via multiple polymer–TA hydrogen bonds effectively suppresses the crack propagation, resulting in both DC gels with high mechanical strength. But these two TA-based DC hydrogels go through different deformation mechanisms during the stretching based on analyzing their stress–strain curves using the Mooney–Rivlin equation. Moreover, these DC hydrogels are swelling-resistant, with strong toughness, good self-recoverability, rapid self-healing, and versatile adhesiveness. This work provides a simple route to fabricate multifunctional DC hydrogels, hopefully promoting their applications as biomedical materials.
研究领域:
材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yue Liu,Jian Wang,Pu Hou,Zunchang Gao,Yang Liu,Jianing Zhao,Pengfei Huo
Hydrogel electrolytes have the dual functions of electrolyte and separator and combine the advantages of liquid and solid electrolytes, making them one of the most ideal candidates for supercapacitors and sensors. However, hydrogel electrolytes are prone to deactivate when the operating temperature is too low. Therefore, dual cross-linked hydrogels with chemical bonds and multiple noncovalent interactions were prepared at room temperature using activated modified lignin. Dual cross-linked hydrogel had excellent mechanical performance and fatigue resistance, whose tensile elongation could reach 700 %. Because the hydrogel contained a concentrated alkaline solution, the electrolyte achieved excellent freezing resistance and a high ionic conductivity of 0.345 S cm −1 (−40 ℃, 0.044 S cm −1 ). Supercapacitors assembled with the hydrogel electrolyte demonstrated a high specific capacitance of 210 F g −1 (−40 ℃, 176 F g −1 ) at 1.0 A g −1 . Furthermore, the hydrogel electrolyte exhibited good electrochemical properties not only in alkaline environments but also in neutral and acidic conditions. The hydrogel could also act as a flexible sensor with a sensitivity of 1.34 within a 100 % strain, making it a promising material for wearable sensors to monitor joint activities in the human body.
研究领域:
材料科学
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能源技术
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
DESALINATION
·
2025
·
IF 9.8
Hui Yang,Baozhong Ma,Shuyang Shi,Jiancheng Yu,Yubo Liu,Zhihe Cao,Chengyan Wang,Yongqiang Chen
Extracting rubidium from brine is critical for addressing the rubidium supply challenge. Ion exchange is an effective method for rubidium recovery, but practically, it faces the challenge that the adsorbent powder is too fine for column operation. Herein, hydrogel beads (AWP@AlG&PVA) were innovatively synthesized through dual crosslinking between sodium alginate and CaCl₂, as well as polyvinyl alcohol and boric acid, incorporating ammonium phosphotungstate (AWP) as the active component, and were employed as adsorbents for rubidium extraction from high-salinity brine. The mercury intrusion pore measurement confirmed that the prepared AWP@AlG&PVA is a porous material, with the majority of pores being large pores. Through systematic adsorption experiments, over 90 % of rubidium was adsorbed from the simulated solution under optimal conditions. The coexisting K + interfered with rubidium adsorption, while Na + , Ca 2+ , and Mg 2+ had no apparent influence. Adsorption kinetic study revealed that Rb adsorption adhered to the pseudo-first-order kinetic model. The adsorption isotherms of AWP@AlG&PVA on Rb + accord with the Freundlich model. XPS and SEM-EDS analyses indicated that the adsorption mechanism was ascribe to ion exchange between NH 4 + and Rb + . Remarkably, the adsorbent exhibited excellent regeneration performance, retaining over 71.3 % of its adsorption ability after undergoing six sequential adsorption-desorption cycles in actual brine. This research suggested that the AWP@AlG&PVA beads address the challenges posed by fine powder and high solubility and are a feasible material for Rb adsorption from high-salinity brine.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
POLYMER
·
2025
·
IF 4.5
Jiarui Wang,Jijun Wei,Fan Zhang,Xiaona Huang,Xiaotong Dong,Hang Jiang,He Zhang,Yungang Bai,Kun Xu,Pixin Wang
The excellent salt tolerance of ionic electrostatic and chemical double cross-linking hydrogels (D-IEC gel) was demonstrated using cationic hyperbranched poly(amido amine) as both electrostatic and chemical cross-linking junctions in an electrolyte solution. The D-IEC gel can be synthesized in NaCl concentrations ranging from 0 to 4.5 mol/L, while the single ionic electrostatic cross-linking hydrogel containing linear cationic monomers (SL-IEC gel) cannot form when the salt concentration exceeds 0.6 mol/L. Notably, the elastic modulus (G’) of the D-IEC gel, formed in a 4.5 mol/L NaCl solution, decreased slightly from 28.00 kPa (in distilled water) to 24.01 kPa––yielding a G’ retention rate of 85.75%, which is nearly 27 times higher than that of conventional IEC gels. Additionally, the D-IEC gel exhibited a self-healing efficiency of up to 90%. From practical applications, the G’ values of the D-IEC gel synthesized in a 3.5 wt% NaCl aqueous solution (similar to seawater) and in distilled water were measured, revealing a retention rate of 87.61%, significantly outperforming conventional IEC gel (3.18%). These findings indicate that the D-IEC gel, with its salt tolerance and self-healing capabilities, is a promising candidate for industrial materials, even in highly concentrated electrolyte solutions. Their exceptional performance is attributed to the structural stability of the hyperbranched polymer in an electrolyte solution and the dynamic irreversibility of ionic electrostatic cross-linking owing to the high charge density of the hyperbranched units.
研究领域:
材料科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
Applied Materials Today
·
2024
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IF 7.2
Lu Guo,Yibo Liang,Junchi Ma,Haoyang Song,Yang Cai,Chenglong Li,Yan Shang,Cai Long,Changsheng Liu,Yongquan Qing
Flexible wearable strain sensors possess extensive applicability in wearables, electronic skin, and environmental monitoring. However, these sensors face challenges in maintaining stable sensing performance when exposed to harsh environments, as mechanical damage and liquid corrosion can lead to localized degradation, micro-cracks, and even macroscopic cracks. Herein, we present an integrated wearable collaborative strain sensor (IWCSS), achieved by applying the superhydrophobic layer on conductive double-cross-linked hydrogel surface. This IWCSS, once severed, can simultaneously restore its sensing performance and superhydrophobicity after 16 h at 25 ℃, attributing to the synergistic effect of reversible bonds—amide, borate ester and metal coordination bond—that drive molecular self-healing. Additionally, with a sensing coefficient of 0.8 and a response time of 70 ms, the IWCSS's superhydrophobic layer serves as a shield against aqueous infiltration and corrosive liquids, ensuring stable sensing and accurate monitoring of human movements in harsh environments. Our design strategy paves the way for developing wearable sensor materials with enhanced reliability in demanding operating environments.
研究领域:
材料科学
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生物医学工程
·
传感技术
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materiomics
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2024
·
IF 8.4
Chunlin Liu,Le Jiang,Fenglin Zhao,Qin Hu,Yingge Zhang,Xiaodan Sun,Lianxin Peng
Despite their importance as components for flexible electronics, most stretchable hydrogels suffer from incomplete recovery after deformation, are prone to failure upon long-term repeated stretching, and cannot be exploited at subzero temperatures because of the freezing of their constituent water. Consequently, strategies for circumventing these drawbacks are highly sought after. This study describes the synthesis of a doubly (chemically and physically) crosslinked hydrogel from gelatin and methacrylic acid and demonstrates the suitability of this material for the fabrication of high-performance stretchable and environment-resistant supercapacitors and strain sensors. The performance of this supercapacitor (areal capacitance = 1210.2 mF cm −2 at a current density of 1 mA cm −2 , maximum energy density = 158.8 μW h cm −2 , maximum power density = 659.5 μW cm −2 ) was superior to that of most of integrated supercapacitors reported to date and was hardly affected by stretchable, low temperatures, bending, ice-cold water and strong acid/alkali solutions or long-term storage. Additionally, a strain sensor based on the above hydrogel was capable of accurately capturing human body motions when affixed to skin and recognising mouse movement (even in humid environments) after implantation into mouse legs. Our work may pave the way to high-performance stretchable and environment-resistant wearable electronics.
研究领域:
材料科学
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生物医学工程
·
能源技术
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
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2020
·Vol. 44
·期 23
·9903-9911
·
IF 3.288
Xueqin Zhang,Ruqing Zhang,Shu Wu,Ying Sun,Hong Yang,Baoping Lin
An ideal hydrogel for biomedical engineering or flexible devices should have excellent properties, especially high stretchability, strength, resilience and self-healing ability to withstand cyclic loading and damage. The formation of hydrogels by physically and chemically dual-crosslinked structures is a powerful method to improve the strength and resilience. Here, we have designed a physically and chemically dual-crosslinked (PCDC) hydrogel with sodium dodecyl sulfate-stearyl methacrylate (SDS-C18) micelles as physical crosslinkers, amphiphilic polyether modified polysiloxane terminated by isocyanoethyl methacrylate (SiPU) nanoparticles as chemical crosslinkers, and acrylamide (AM) as the monomer. The prepared PCDC hydrogels have a tensile strength of more than 130 kPa and a tensile elongation at break value of over 710%, and can quickly recover their original state in cyclic tensile and cyclic compression tests, exhibiting excellent stretchability, strength and resilience. Based on the hydrophobic interaction mechanism, remarkable self-healing properties of the hydrogels were achieved, allowing re-adhesion of cut surfaces without any external stimulus.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Wenjie Zhong,Wenao Liao,Lingcong Xu,Niezhenghao He,Ke Xu,Caiyuan Liu,Fei Wang,Wei Zhang,Jiang Hu,Haowen Cui
Diabetes-induced oxidative stress can lead to poor bone defect healing, severely affecting the quality of life for patients. Studies show that improving the microenvironment and promoting bone formation can effectively accelerate the healing of bone defects. However, traditional local drug delivery methods face various challenges during the treatment process. Therefore, this study develops a novel hydrogel (HLBP) loaded with natural protein polysaccharides (LBP) extracted from goji berries, aiming to enhance the healing of diabetic bone defects. The hydrogel is composed of freeze-dried polyvinyl alcohol (PVA) and photocrosslinked poly (ethylene glycol) diacrylate (PEGDA). This hydrogel exhibits excellent biocompatibility. Additionally, it demonstrates effective loading capacity for the LBP. LBP's bioactivity enables ROS scavenging and promotes bone regeneration at defect sites. In vitro, experimental results show that HLBP significantly reduces ROS levels and enhances osteogenic differentiation ability and cell viability of human bone marrow mesenchymal stem cells. In vivo studies using BKS-db diabetic mice show that HLBP implantation at bone defects achieves over 80% healing, highlighting its strong healing potential. This method effectively avoids potential toxicity from systemic drug administration and significantly promotes regeneration at the bone defect site, providing a new strategy for treating diabetic bone defects.
研究领域:
生物材料学
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再生医学
·
糖尿病研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2021
·
IF 12.479
Yang Yuan,Shihong Shen,Daidi Fan
Burn wounds are one of the most destructive skin traumas that cause more than 180000 deaths each year. Patients with large, irregular burn wounds suffer from slow healing. Dynamic burn wounds have special requirements for hydrogel dressing due to their high frequency movement. To focus on dynamic burn wounds, we designed a novel double cross-linked hydrogel prepared by Schiff base and catechol-Fe 3+ chelation bond. The unique double cross-linked structure of the hydrogel resulted in better physicochemical properties and enhanced efficacy. The enhanced physicochemical properties, such as faster gelation time (52 ± 2 s), stronger mechanical property (535 kPa of G’), enhanced adhesive strength (19.3 kPa) and better self-healing property, made the hydrogel suitable for dynamic wounds. The excellent shape adaptability (97.1 ± 1.3% of recovery) made the hydrogel suitable for wounds with irregular shapes. The hydrogel exhibited not only biodegradability during the wound healing process but also superior inherent antibacterial activity (100% killing ratio) and hemostatic property. The results showed that the hydrogel shortened the healing time of burn wounds to 13 days, and accelerated the reconstruction of skin structure and function. This double cross-linked multifunctional hydrogel is a promising candidate as a dynamic burn wound dressing.
研究领域:
生物材料学
·
创伤修复
·
医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）