JOURNAL OF APPLIED POLYMER SCIENCE
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2024
·Vol. 141
·期 13
·e55146
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IF 2.7
Qin Liu,Lan Xu
In this study, the gold nanoparticles (Au NPs) are capped with a novel, well-defined double hydrophilic block copolymer, poly (ethylene glycols)-block-poly(mono-2-(methacryloyloxy) ethyl succinate) (PEG-b-PSEMA). The PEG-b-PSEMA, with long side chains and relatively narrow dispersity index, is successfully prepared by aqueous electrochemically mediated atom transfer radical polymerization using a PEG-Br macroinitiator (M n ≈2000 g mol −1 ). By simply mixing PEG-b-PSEMA and Au precursor before adding reductants, coulombic interactions occur between the Au precursor and the carboxylate group of the PSEMA, as a result dense Au NPs are formed. This enables the Au NPs to remain dispersed even in the presence of temperature variations, pH adjustments, and incubation in organic solvents. Au NPs were endowed by PEG-b-PSEMA with more remarkable catalytic activity in organic solvents of 4-nitrophenol into 4-aminophenol than by sodium citrate (Au@citrate) and MeO-PEG-OH (Au@PEG). In addition, PEG-b-PSEMA-stabilized Au NPs (Au@PEG-b-PSEMA) were also tested for the dye degradation property against Rhodamine-B in only pH 10 basic solution, and over 99% of dye degradation can be achieved in 9 min. PEG-b-PSEMA induces coulombic interactions with Au NPs, providing outstanding stability for catalytic applications in organic or specific acidic-base environments.
研究领域:
材料科学
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化学
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产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2013
·Vol. 31
·期 4
·691-701
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IF 1.27
Tan Lin,Xing Jin-xing,Cao Fu-hu,Chen Li-juan,Zhang Chong,Shi Rong-hua,Wang Yan-mei
A series of double-hydrophilic double-grafted PMA- g -PEG/PDMA copolymers, which contained poly(methacrylate) (PMA) as backbone, poly(ethylene glycol) (PEG) and poly( N,N -dimethylacrylamide) (PDMA) as side chains synthesized successfully by using reversible addition-fragmentation chain transfer (RAFT) polymerization and atom transfer radical polymerization (ATRP), were used as physical coatings for the evaluation of protein-resistant properties by capillary electrophoresis (CE). Electroosmotic flow (EOF) measurement results showed that the PMA- g -PEG/PDMA copolymer coated capillaries could suppress electroosmotic mobility in a wide pH range (pH = 2.8–9.8) and EOF mobility decreased with the increase of copolymer molecular mass and PDMA content. At the same time, protein recovery, theoretical plate number of separation and repeatability of migration time demonstrated that antifouling efficiency was improved with the increase of molecular mass and PEG content.
研究领域:
高分子化学
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生物医学工程
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材料科学
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DOI
高影响因子
Nanoscale
·
2017
·Vol. 10
·期 4
·2115-2127
·
IF 7.367
Guang-Yu Pan,Hao-Ran Jia,Ya-Xuan Zhu,Fu-Gen Wu
Developing biocompatible and photodegradable photothermal agents (PTAs) holds great promise for potential clinical applications in photothermal cancer therapy. Herein, a new PTA was innovatively constructed by conjugating the hydrophobic near-infrared (NIR) heptamethine cyanine molecule IR825-NH2 with a double hydrophilic block copolymer methoxypoly(ethylene glycol)5k-block-poly(L-aspartic acid sodium salt)10 (abbreviated as PEG-PLD) via amine-carboxyl reaction. The as-designed PEG-PLD(IR825) was amphiphilic and could self-assemble into polymeric nanomicelles in aqueous solutions. Benefiting from the chemical conjugation strategy, PEG-PLD(IR825) nanomicelles realized a considerably high drug loading rate (∼21.0%) and substantially avoided the premature release of IR825 during systemic circulation. Confocal imaging revealed that the nanomicelles mainly located at mitochondria and endoplasmic reticulum after cellular internalization. In vitro photothermal therapy demonstrated the excellent cancer killing efficiency of PEG-PLD(IR825) nanomicelles due to their high light-to-heat conversion efficiency upon NIR laser irradiation. In addition, PEG-PLD(IR825) nanomicelles showed polarity-sensitive fluorescence at ∼610 nm (under 552 nm excitation) and 830 nm (under 780 nm excitation), which was especially useful for both in vitro visible fluorescence imaging and in vivo near-infrared fluorescence imaging-guided photothermal therapy (PTT). At the in vivo level, PEG-PLD(IR825) nanomicelles exhibited an excellent tumor-homing ability and a long retention time in tumor tissues as evidenced by the in vivo fluorescence imaging results. The desirable properties of PEG-PLD(IR825) nanomicelles ensured their effective tumor ablation during PTT treatment. More importantly, the PEG-PLD(IR825) nanomicelles underwent degradation after laser irradiation, which ensured their post-treatment biosafety. Therefore, the nanomicelles are promising to serve as an efficient and safe PTA for imaging-guided photothermal cancer therapy.
研究领域:
生物医学工程
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癌症治疗
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纳米技术
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材料科学
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产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
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2012
·Vol. 213
·期 20
·2192-2200
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IF 2.361
Xiao-Hui Dai,Chun-Yan Hong,Cai-Yuan Pan
A novel double-hydrophilic block copolymer P(MEO 2 MA- co -OEGMA)- b -PAMA has been successfully synthesized by two-step RAFT polymerization. Then, the amino groups of PAMA blocks in the copolymers react with 1-pyrenecarboxaldehyde via a “Schiff-base” reaction, and the resulting copolymers are self-assembled to form spherical micelles in aqueous solution. Because the “Schiff-base” linkage is pH sensitive, the release rate of pyrene depends upon the pH of solution. Complete release is achieved at pH 1, and the control release is much faster at pH 5.5 than that at pH 7.4. With progress of pyrene release, the micelles are disassembled gradually and disappeared completely at last. This double-hydrophilic copolymer is a promising candidate of drug carrier for the aldehyde- containing hydrophobic drugs.
研究领域:
高分子化学
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药剂学
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纳米医学
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生物材料
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药物递送系统
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DOI
高影响因子
COLLOID AND POLYMER SCIENCE
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2015
·Vol. 293
·期 12
·3517-3526
·
IF 1.865
He Naipu,Lu Zhenwu,Zhao Weigang
Double hydrophilic protein-polymer hybrids were successfully prepared by “grafting-to” method. Sodium polyacrylate (PANa) with an activated end group was prepared using acrylic acid as initial monomer by atom transfer radical polymerization (ATRP) in the water/DMF mixture at pH 7.8. Then, the activated end group of PANa directly covalently binds to the primary amino groups of the lysine of bovine serum albumin (BSA) in phosphate buffer solution (PBS) at pH 7.4. BSA-PANa hybrids were characterized by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and matrix-associated laser desorption/ionization time-of-flight mass spectra (MALDI-ToF MS). UV-vis spectrometer, transmission electron microscopy (TEM), and dynamic light scatter (DLS) were used to study their self-assembly in PBS at different pH. The resulting BSA-PANa hybrids were pH-responsive. They were found to form spherical structures with narrow distribution in PBS at pH 7.4. In PBS at pH 2.5, fewer spherical particles with broad distribution were visible. Meanwhile, spherical particles had a very thin wall with thickness of 10 nm.
The table of contents (ToC) The resulting BSA-PANa hybrids were found to be pH-responsive. The self-assembly aggregates were found to form spherical structures with a diameter of approximately 100 nm phosphate buffer solution (PBS) at pH 7.4. In PBS at pH 2.5, the diameters of spherical particles varied between 80 and 200 nm. Meanwhile, spherical particles had a very thin wall with thickness of 10 nm.
研究领域:
材料科学
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聚合物化学
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生物物理
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DOI
高影响因子
DESALINATION
·
2012
·
IF 2.59
Lei Ling,Yuming Zhou,Jingyi Huang,Qingzhao Yao,Guangqing Liu,Peixin Zhang,Wei Sun,Wendao Wu
In an attempt to control Ca 3 (PO 4 ) 2 , CaCO 3 , and CaSO 4 deposits in industrial recycling water systems, an acrylic acid (AA)-allyloxy poly(ethylene glycol) polyglycerol carboxylate (APEG-PG-COOH) copolymer was synthesized as a nonphosphorus inhibitor. The synthesized polymer was characterized by 1 H NMR. The performance of PAA/APEG-PG-COOH on inhibition of Ca 3 (PO 4 ) 2 , CaCO 3 and CaSO 4 precipitation was studied through static scale inhibition tests. It was shown that PAA/APEG-PG-COOH exhibited excellent ability to control inorganic minerals, with approximately 100% CaSO 4 inhibition and 99.89% Ca 3 (PO 4 ) 2 inhibition at levels of 3 and 6 mg/L PAA/APEG-PG-COOH, respectively. PAA/APEG-PG-COOH also displayed ability to prevent the formation of CaCO 3 scales. The effects on formation of Ca 3 (PO 4 ) 2 , CaCO 3 and CaSO 4 were investigated with combination of Scanning electronic microscopy (SEM), Transmission electron microscopy (TEM), and X-ray powder diffraction (XRD) analysis, respectively.
研究领域:
环境化学
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材料科学
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工业水处理
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高分子化学
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腐蚀与防护
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矿物结垢控制
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DOI
高影响因子
危险品化学品经营许可证（带存储）