APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
De-Rui Kong,Yu-Ying Xin,Xian-Fa Zhang,Zhao-Peng Deng,Li-Hua Huo,Shan Gao
The development of a non-enzymatic electrochemical sensor possessing well dual-sensing to H 2 O 2 and glucose remains challenging due to less report. Herein, spinel CoCr 2 O 4 nanoparticles with small size were synthesized by sol–gel reaction, which were then simply mixed with commercial graphene under ultrasonic to obtain uniformly dispersed CoCr 2 O 4 /Graphene composite. They were deposited onto the surface of bare glassy carbon electrode (GCE) through a common drop-coating method. The CoCr 2 O 4 /Graphene/GCE sensor firstly achieves highly dual-sensing to H 2 O 2 and glucose in 0.1 M NaOH solution. At 0.4 and 0.55 V, its sensitivities to H 2 O 2 and glucose can separately reach up to 1168.6 and 1722.5 μA mM −1 cm −2 , and the corresponding detection limits are as low as 18 nM and 12 nM. These key indexes are the best among reported dual-functional spinel oxide-based electrodes. This excellent electrochemical sensing ability stems from its large electrode active area, good conductivity, and the synergism between graphene and CoCr 2 O 4 nanoparticles with mixed redox couplings, which provides an efficient platform for dual-sensing detection. In addition, the modified electrode can accurately determine glucose in human tears, rat serum and orange juice, as well as H 2 O 2 in milk whey, mouthwash and disinfectant, thus predicting its good application prospects.
研究领域:
电化学传感器
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材料科学
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分析化学
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Yongyun Mao,Zhipeng Mei,Lanfeng Liang,Bingpu Zhou,Yanqing Tian
In this work, we presented the robust and magnetically recoverable dual sensor particles that are capable of real-time monitoring of dissolved oxygen (DO) and glucose concentrations in aqueous solutions. The dual sensor consists of glucose oxidase-functionalized polyethylenimine-coated Fe 3 O 4 particles (Fe 3 O 4 @PEI-GOD) and sub-micro-sized Fe 3 O 4 -modified poly(Platinum porphyrin- co -Styrene) ((PtTFPPMA-PS)@Fe 3 O 4 ) fluorescent spheres. The dual sensing functions originate from the cascade catalysis amplification driven by the recyclable Fe 3 O 4 @PEI-GOD particles and glucose oxidase consumption of oxygen in the process of glucose oxidation. Consequently, the (PtTFPPMA-PS)@Fe 3 O 4 fluorescent spheres exhibited higher fluorescence intensity due to the effective alleviation of fluorescence quenching effect raised from the decrease of DO. The remarkable fluorescence intensity-changing characteristics of the solutions facilitate convenient identification of oxygen concentrations and glucose concentrations even with naked eyes. Thanks to the magnetically recoverable superiority, the recycle study proved that the multifunctional particles could be repeatedly utilized without significant catalytic activity loss after 10 cycles. Interestingly, the sensing film comprising the (PtTFPPMA-PS)@Fe 3 O 4 fluorescent spheres can also be applied to the unsteady pressure measurement and unsteady air flow visualization due to its remarkable light intensity-changing features.
研究领域:
生物化学
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材料科学
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医学检测
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产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Shuxian Zhang,Xiaoying Wang,Xiaofei Wang,Xiaoxuan Fan,Keshuai Liu,Yuping Sa,Gidion Wilson,Xueqin Ma,Guoning Chen
α-Glucosidase plays a direct role in the metabolic pathways of starch and glycogen, any dysfunction in its activity could result in metabolic disease. Concurrently, this enzyme serves as a target for diverse drugs and inhibitors, contributing to the regulation of glucose metabolism in the human body. Here, an integrated analytical method was established to screen inhibitors of α-glucosidase. This step-by-step screening model was accomplished through the biosensing and affinity chromatography techniques. The newly proposed sensing program had a good linear relationship within the enzyme activity range of 0.25 U mL −1 to 1.25 U mL −1 , which can quickly identify active ingredients in complex samples. Then the potential active ingredients can be captured, separated, and identified by an affinity chromatography model. The combination of the two parts was achieved by an immobilized enzyme technology and a microdevice for reaction, and the combination not only ensured efficiency and accuracy for inhibitor screening but also eliminated the occurrence of false positive results in the past. The emodin, with a notable inhibitory effect on α-glucosidase, was successfully screened from five traditional Chinese medicines using this method. The molecular docking results also demonstrated that emodin was well embedded into the active pocket of α-glucosidase. In summary, the strategy provided an efficient method for developing new enzyme inhibitors from natural products.
研究领域:
生物化学
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药物开发
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分析化学
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产品关联
DOI
PubMed
高影响因子
CELLULOSE
·
2020
·Vol. 27
·期 15
·8923-8935
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IF 4.21
Sun Longfei,Wang Fei,Jiang Jingjing,Liu Hangcheng,Du Binglei,Li Mingze,Liu Yixin,Li Minghua
Sodium alginate (SA), as the eco-friendly and human-safe biomass material not only can achieve effective dispersion of graphene nanoplatelets (GnPs), but also improve the interaction between GnPs and cellulose macromolecules. Based on this, a flexible and wearable GnPs/cellulose strain sensor with a special 2 × 2 double rib knitted fabric structure (KFGS) was prepared by a simple dip-coating method that could be used on a large scale. The KFGS exhibited dual sensing performance with high sensitivity (25.32 kPa −1 at 3 kPa pressure, gauge factor 32.62 at 25% tensile strain), stretchability (ε > 25%) and dynamic stability (signal drift < 6% after 300 cycles). Its potential application prospects were also predicted by the monitoring of human movement and physical parameters through a wireless Bluetooth connection.
研究领域:
材料科学
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生物医学工程
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纺织科学
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Jiashang Chen,Jin Huang,Hui Fang,Hemi Qu
Colorimetric gas sensors show promise as selective detectors for gas chromatography (GC), but their application has been limited by the irreversibility of their responses. This study presents the successful hyphenation of colorimetric gas sensors with GC, overcoming this limitation through a novel approach that refreshes the sensor’s reaction area with controlled movement, enabling the generation of reversible GC peaks. The sensors, based on acid–base indicators, such as chlorophenol red and bromocresol green, were integrated with a capillary GC column and evaluated for amine detection. Performance testing revealed satisfactory sensitivity, linearity, and reproducibility, with the colorimetric sensors demonstrating superior selectivity for amines compared to flame ionization detectors (FID). Moreover, a dual-sensor array, combined with a pattern recognition algorithm, enabled effective discrimination between various amine compounds. This work establishes a promising, cost-effective alternative for portable GC systems, enhancing selectivity and improving the capability of field vapor analysis.
CAS / MDL:
研究领域:
分析化学
·
传感器技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jian Cheng,Hang Zhou,Ziran Yu,Hai Ren,Xiaoyu Sun,Huayu Wu,Shikuo Li
The smart therapy is a big challenge to the wound healing caused by bacterial infections for avoiding the antibiotic abuse. Herein, a visible light driven polyacrylamide/trehalose/Cu-Tetrakis (4-carboxyphenyl) porphyrin/bromothymol blue (CuTCPP) hydrogel with dual-sensing capabilities and on demand photodynamic therapy was synthesized by an in-situ polymerization method. The CuTCPP in the hydrogel can harvest the light for the generation of reactive oxygen species (ROS). The wound infection can be real-time monitor not only by the on-site pH variations, but also the electrophysiological signals. The sterilization efficacy of the CuTCPP hydrogel was achieved as high as 10 7 CFU mL −1 under visible light irradiation (λ ≥ 420 nm, 30 min). Remarkably, in vivo infection on mouse displayed that the photodynamic effect of CuTCPP hydrogel was much better than that of the control experimental. Importantly, the release of ROS during the wound healing can be adjusted on demand. And the hydrogel displayed good tissue adhesion, self-repairing and good biocompatibility as well. The photodynamic mechanism was investigated via the fluorescence, ESR spectra and the charge density difference analysis. Such intelligent hydrogel provided important insights for the development of precise theragnostic platforms to advanced interventions in critical wounds.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Ying-ying Hu,Caiyue Gao,Xiao-qin Wu
Environmental pollution is a hot topic of concern for countries around the world. Therefore, {[Ni(NDC)(phen)(H 2 O)]• n ( Ni-1 , NDC = 2,6-naphthalenedicarboxylic acid, phen = o-phenanthroline), a 1D Ni-MOF, was synthesized using the solvothermal method as an electrochemical-fluorescence dual sensor for detecting phenylenediamine isomers. By the difference in the position of the reduction peaks, it is possible to distinguish between isomers while detecting them. The electrochemical behavior of the Ni-1 /GCE sensing phenylenediamine isomers was analyzed by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The LODs of o-PDA, m-PDA and p-PDA were 2.567 μM, 1.984 μM and 0.4003 μM in the detection range of 5–50 μM, respectively. Ni-1 was highly stable in aqueous solution (H 2 O), so it was dissolved in H 2 O to fabricate the Ni-1 /H 2 O fluorescence sensor. Ni-1 /H 2 O exhibited Stern-Volmer quenching constants of 6.080 × 10 4 M −1 , 2.086 × 10 3 M −1 , and 6.417 × 10 3 M −1 for o-PDA, m-PDA, and p-PDA, respectively. In addition, this dual sensor still shown excellent immunity to interference under the organic interferents. This work provides an efficient, convenient, and sensitive dual sensing method for the detection and differentiation of phenylenediamine isomers, which is of great significance for the detection of aromatic amines in the fields of wastewater discharge, environmental protection, and food safety.
研究领域:
环境科学
·
材料科学
·
分析化学
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电化学
·
荧光传感
✓ 已验证
产品关联
DOI
高影响因子
Advanced Science
·
2022
·Vol. 9
·期 12
·2104738
·
IF 17.521
Ying Ye,Yuancai Ge,Qingwen Zhang,Meiling Yuan,Yu Cai,Kang Li,Yang Li,Ruifeng Xie,Changshun Xu,Danfeng Jiang,Jia Qu,Xiaohu Liu,Yi Wang
Contact lenses have become a popular health-monitoring wearable device due to their direct contact with the eyes. By integrating biosensors into contact lenses, real-time and noninvasive diagnoses of various diseases can be realized. However, current contact lens sensors often require complex electronics, which may obstruct the user's vision or even damage the cornea. Moreover, most of the reported contact lens sensors can only detect one analyte. Therefore, an optical-based dual-functional smart contact lens sensor has been introduced to monitor intraocular pressure (IOP) and detect matrix metalloproteinase-9 (MMP-9), both of which are key biomarkers in many eye-related diseases such as glaucoma. Specifically, the elevated IOP is continuously monitored by applying an antiopal structure through color changes, without any complex electronics. Together with the peptide modified gold nanobowls (AuNBs) surface-enhanced Raman scattering (SERS) substrate, the quantitative analysis of MMP-9 at a low nanomolar range is achieved in real tear samples. The dual-sensing functions are thus demonstrated, providing a convenient, noninvasive, and potentially multifunctional sensing platform for monitoring health and diagnostic biomarkers in human tears.
研究领域:
生物医学工程
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眼科
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纳米技术
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生物传感器
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产品关联
DOI
PubMed
高影响因子
COMPOSITES COMMUNICATIONS
·
2023
·
IF 8
Ling Wang,Hao Wang,Wei Xiao,Qiancheng Wan,Jiefeng Gao
Wearable piezoresistive sensors possessing outstanding flexibility and breathability have aroused growing interests of researchers due to their promising applications in wearable electronics, health monitoring, etc. The development of waterproof and oil-proof piezoresistive sensors that respond to both tensile and compressive strains is still a great challenge. Herein, a two-step dip-coating method, i.e., ion reduction assisted phase separation and subsequent fluorination, is used to prepare amphiphobic rubber foam composites (ARFC). The ARFC shows excellent photothermal and electro-thermal conversion performance. The ARFCs with high electrical conductivity can be served as both strain and pressure sensors, demonstrating a dual sensing mode. The ARFC exhibits a relatively low detection limit (1%), wide working range (0–150%) and a gauge factor of 34.2 under 100%–150% strain. Also, the strain/pressure sensor exhibits outstanding cyclic sensing performance and can realize real-time monitoring of different body motions. Its amphiphobicity and dual sensing mode further broaden the application in smart wearable electronics.
研究领域:
材料科学
·
电子学
·
可穿戴技术
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）