EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2017
·
IF 3.756
Shichao Du,Yan Wang,Songgu Wu,Bo Yu,Peng Shi,Lin Bian,Dejiang Zhang,Jie Hou,Jingkang Wang,Junbo Gong
Crystal engineering strategy was applied to develop new solid forms of lamotrigine . Two novel cocrystals of lamotrigine forming with 4,4′-bipyridine (2:1) and 2,2′-bipyridine cocrystal (1:1.5) were successfully obtained by neat grinding and liquid assisted grinding. The novel cocrystals were fully characterized and confirmed by X-ray diffraction, thermal and spectroscopic analysis. DXRxi Raman microscope was also used to identify the cocrystals. The factors such as solvent and the structure of coformers which influenced the cocrystal formation were discussed. Furthermore, the novel cocrystals were both obtained by slurry crystallization . Process analytical technologies including focused beam reflectance measurement and attenuated total reflectance Fourier Transform Infrared were applied to investigate the cocrystallization process and the mechanism. HPLC analysis showed that the dissolution rate and the solubility of the two novel cocrystals were both improved.
研究领域:
药学
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晶体工程
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DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Yaning Gao,Yin Wang,Hui Sun
The control of the morphology and nanostructure of soft nanomaterials self-assembled from amphiphilic polymers has attracted significant attention. In this study, various nanostructures including bowl-shaped nanoparticles with controlled openings, round Yuanbao-shaped assemblies, nanowires and butterfly shaped twin nanosheets are formed by manipulating the self-assembly pathway of an amphiphilic homopolymer. The amphiphilic (poly( N -(2,2′-bipyridyl-4-acrylamide), PBPyAA) with bipyridine pendants is designed and synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization, which can self-assemble into bowl-shaped nanoparticles with controlled openings by solvent switch method at different initial concentrations. In addition, core–shell nanostructures are obtained taking advantage of the coordination between bipyridine and Fe 2+ . Upon annealing in ethanol, butterfly shaped twin nanosheets with thickness of about 10 nm are formed by controlling the cooling rate, while round Yuanbao-shaped assemblies are formed by naturally cooling. Revealing into the formation mechanism of the butterfly shaped twin nanosheets, a fusion induced assembly process of nanowires is observed. Overall, various nanostructures are obtained by manipulating the self-assembly pathways of a bipyridine containing amphiphilic homopolymer.
研究领域:
材料科学
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高分子化学
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纳米技术
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
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IF 8.456
Jinbiao Shi,Jianling Zhang,Tongling Liang,Dongxing Tan,Xiuniang Tan,Qiang Wan,Xiuyan Cheng,Bingxing Zhang,Buxing Han,Lifei Liu,Fanyu Zhang,Gang Chen
Metal–organic frameworks (MOFs) have attracted increased research attention in photocatalysis due to their great potential in light harvest and conversion. However, the organic transformations as photocatalyzed by MOFs under mild conditions yet remain a challenge. Herein, three bipyridyl-containing cadmium–organic frameworks Cd(dcbpy) (dcbpy = 2,2′-bipyridine-5,5′-dicarboxylate), Cd(bdc)(bpy) (bdc = 1,4-benzenedicarboxylate; bpy = 2,2′-bipyridyl), and Cd(bdc)(2Me-bpy) (2Me-bpy = 4,4′-dimethyl-2,2′-bipyridyl) were synthesized for the first time. The bpy-containing Cd-MOFs have strong light harvest abilities and suitable photocatalysis energy potentials, making them highly active and selective for the photo-oxidation of benzylamine to N-benzylbenzaldimine under mild conditions, i.e., using atmospheric air as oxidant, at room temperature, and in the absence of any photosensitizer or cocatalyst. It provides an efficient, economical, and green way for the direct oxidation of amines to produce imines.
研究领域:
材料科学
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化学
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2021
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IF 7.312
Jiancong Pan,Biaowen Wei,Hengxin Xie,Jun Feng,Shijun Liao,Xiuhua Li,Yigang Yu
Hexyl-modified series-connected bipyridine and 1,4-diazabicyclo[2.2.2]octane (DABCO) di-cations functionalized anion exchange membranes (QPPO-DP and QPPO-DABCO respectively) for electrodialysis (ED) were prepared via reactions of brominated poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) and the self-designed quaternization agents containing mono-ionic bipyridine and DABCO moieties. These agents are precursors to the combinations of different di-cations and hydrophobic side chains. QPPO-DP (thickness: 95 μm) and QPPO-DABCO (thickness: 70 μm) with similar functionalization degrees were characterized in terms of ion exchange capacity (IEC), water uptake (WU), swelling ratio (SR), thermal and mechanical stabilities, morphology, area resistance ( R m ), transport number ( t - ) and limiting current density. QPPO-DP and QPPO-DABCO give IECs of 2.27 and 2.63 mmol g −1 respectively owing to the different unit masses of the di-cations. The conjugated aromatic bicyclic structure of bipyridine di-cations offers QPPO-DP higher WU than that of QPPO-DABCO. The relatively weaker hydrophilicity of DABCO di-cations ensures QPPO-DABCO moderate WU, superior R m and t - (2.77 Ω cm 2 and 0.949). Thus, QPPO-DABCO displays more excellent ED performances than those of commercial AMX under the same ED conditions, including current efficiency of 89.58%, salt flux of 81.39 mg m −2 s −1 and reasonable energy consumption of 1.76 kWh kg −1 NaCl, revealing its potential in ED application.
研究领域:
材料科学
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环境工程
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DOI
高影响因子
Science China-Chemistry
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2025
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IF 9.7
Fan Huahua,Wang Runjia,Zhang Li,Liu Minghua
The G-quartet, a hydrogen-bonded macrocycle formed by cation-templated assembly of guanosine derivative, plays a vital role in areas ranging from structural biology to supramolecular chemistry and nanotechnology. Herein, we show a zinc-terpyridine derivative (Ftpy) that could form complex with various guanosine phosphates, exhibiting relatively weak circularly polarized luminescence CPL (dissymmetry factor, g lum ≈ 1 × 10 −3 ). Interestingly, when Ag + ions are involved, significantly boosted circularly polarized luminescence (CPL) is obtained in the assemblies of Ftpy with GTP, which the g lum can reach to 0.15. In contrast, no significant difference is observed in the presence of other cations (Na + , K + , Rb + , NH 4 + , Cu 2+ , and Sr 2+ ). It reveals that CPL signal is amplified due to the formation of G-quartet in the presence of Ag + ions, which further hierarchically self-associate into helically stacked supramolecular aggregates with the cooperation and π - π of Ftpy, contributing to the expression of chirality information. Furthermore, the co-assemblies of Ftpy/GTP/Ag + exhibit an enantioselective recognition of enantiomeric penicillamine by CPL spectra. This work provides a straightforward avenue to fabricate supramolecular assemblies with strong CPL based on G-quartet formation.
研究领域:
超分子化学
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纳米技术
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结构生物学
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2016
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IF 4.758
Yunsheng Dong,Tianqi Liu,Xuejuan Wan,Hang Pei,Lisi Wu,Youwei Yao
A bipyridine-based colorimetric/fluorometric chemosensor (LBD) was designed and prepared via a facile one-step synthesis with high yield, and the obtained chemosensor exhibited a specific detection performance toward Al 3+ in DMSO/H 2 O solution (7:3, v/v, 10 mM HEPES, pH 7.4) with relative low interference of other common metal cations. As a colorimetric sensor, the absorbance peak centered at 315 nm and 400 nm enhanced after the addition of Al 3+ , while the absorbance peak centered at 275 nm and 344 nm gradually decreased. Distinctive colorimetric transition of LBD from colorless to light yellow was also clearly discerned. Simultaneously, a significant turn-on fluorescence response of LBD at 495 nm and an apparent fluorescence emission variation from non-fluorescent to strong bright cyan was also observed by naked eye, which can be ascribed to the inhibited C = N isomerization and photo-induced electron transfer (PET) in LBD after the addition of Al 3+ . A stoichiometric complexation of 1:1 molar ratio between LBD and Al 3+ was confirmed and the detection limit of LBD was found to be 9 nM.
研究领域:
分析化学
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材料科学
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DOI
高影响因子
LUMINESCENCE
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2020
·Vol. 35
·期 4
·601-607
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IF 1.855
Xiao Liu,Dong Chen,Chenchen Wang,Nianjuan Tian,Zhiqiang Li,Ying Zhang,Zhi-Jun Ding
Highly selective detection of Bacillus anthrax spores has attracted worldwide attention because Bacillus anthrax spores not only are harmful to the health of human beings and animals, but also can be used as biological warfare agents. Here, we report a simple platform by mixing EuCl 3 ·6H 2 O and sodium polyacrylate in aqueous solution and further investigate its luminescence response towards Bacillus anthrax biomarker dipicolinic acid (DPA) as a turn-on luminescence probe. Importantly, our probe has good sensitivity, lower detection limit, excellent selectivity as well as great anti-interference ability due to the great luminescence enhancement of Eu 3+ . Moreover, a test paper is constructed to realize the purpose of portable detection. These results indicate that our probe is an excellent candidate for sensing DPA.
研究领域:
生物化学
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分析化学
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微生物学
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DOI
PubMed
高影响因子
JOURNAL OF COORDINATION CHEMISTRY
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2019
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IF 1.685
Jun Wang,Jinyi Liu,Tianyu Lan,Liduo Chen,Libo Wang
Two new hyperbranched bispyridylamine ligands and multinuclear chromium complexes were synthesized with 1.0 G hyperbranched macromolecules, 2-chloropyridine, 2-chloro-4-methylpyridine and CrCl3(THF)3 as raw materials. The structures of hyperbranched ligands and chromium complexes were characterized by UV, FT-IR, 1H NMR, ESI-MS, and elemental analysis. These hyperbranched chromium complexes were evaluated as catalyst precursors by using MAO as activator in the oligomerization of ethylene. Effects of reaction temperature, reaction pressure, Al/Cr molar ratio, concentration of catalyst, solvent, and the structure of catalysts on the catalytic activity and product selectivity were investigated. The oligomerization results showed that with increase of reaction temperature, reaction pressure, and Al/Cr molar ratio, the catalytic activity increased and then decreased; the catalytic activity continuously decreased as the amount of catalyst increased. The products were mainly based on C6 and C8. Under optimized conditions, the catalytic system of hyperbranched NNN/Cr(III)/MAO led to activity of 1.26 × 105 g/(mol·Cr·h) and 63.34% selectivity for C6 and C8.
研究领域:
化学
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材料科学
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DOI
高影响因子
EUROPEAN POLYMER JOURNAL
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2020
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IF 3.862
Yanyan Wang,Xiaoteng Jia,Erik B. Berda,Jiaxin Zhao,Xincai Liu,Danming Chao
Multicolor electrochromic polymers have attracted great attention and interest owing to their potential applications in multicolor displays, intelligent electronic devices, and smart visualized sensors. Herein, we prepared new electrochromic polysiloxanes by chemically coupling oligoaniline groups with cathodically colouring viologen and/or anodically colouring phenothiazine groups, respectively. Due to the combined effect and synergistic effect of paired anodically colouring oligoaniline and cathodically colouring viologen, the resulting polysiloxane exhibits multicolor electrochromic behavior switching from purple to transparent grey, to light green, finally to blue. As the oligoaniline units coupled with anodically colouring phenothiazine groups, the resultant polysiloxane also demonstrates multicolor electrochromic behavior changing from transparent grey to light green, to gray-blue, to brown and finally black purple. Furthermore, good switching durability has also been revealed during the electrochromic measurements, because of their robust network molecular structure and covalent bonding to the substrate.
研究领域:
材料科学
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化学工程
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显示技术
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
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2022
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IF 9.231
Xiaodan Ding,Waqas Ahmad,Jizhong Wu,Yawen Rong,Qin Ouyang,Quansheng Chen
In this work, an ultrasensitive ciprofloxacin (CIP) detection strategy has been established based on copper (Cu 2+ ) ions-induced strong charge transfer in poly acrylic acid (PAA) functionalized upconversion nanoparticles (UCNPs)/2,2-bipyridine (bipy) system. The positively charged Cu 2+ ions electrostatically adhere to the surface of the PAA-UCNPs and deactivate the fluorescence via a charge transfer process. The bipy in this hybrid system controls the aggregation by chelating in proximity to the Cu 2+ center. Due to the strong affinity between pyridone oxygen and carboxy oxygen, CIP coordinates in high stoichiometry with the bipy-Cu complex as compared to the PAA-UCNPs, causing the trapped fluorescence to be released in an amount equivalent to the target concentration. Under the optimum assay conditions, a good calibration plot (0.05–1000 ng/mL) was acquired with a detection limit of 0.13 ng/mL. The satisfactory recoveries (85.93–96.87%) for real prawn and fish samples were further validated by enzyme-linked immunoassays (P > 0.05).
研究领域:
分析化学
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食品安全
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纳米技术
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2018
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IF 6.042
Shuo Wu,Wenjuan Tu,Yanqiu Zhao,Xiuyun Wang,Jie Song,Xinlan Yang
A ruthenium(II) bipyridyl derivative photoelectrochemical probe, Ru-1, is synthesized and coupled with TiO2 nanoparticles (Ru-1/TiO2) for the specific recognition and highly sensitive photoelectrochemical (PEC) detection of Hg2+ in a series of biofluids. The probe is designed with a chromophore, a thiocyanate recognition unit, a π-conjugated photoelectron-transfer pathway, and a phosphonate anchor. TiO2 nanoparticles with strong affinity to phosphonate and suitable conduction band energy are used as intermediate layers to increase the Ru-1 adsorption amount and amplify the photocurrent response. Under irradiation, the Ru-1/TiO2/fluorine-doped tin oxide (FTO), with strong visible light-harvesting capacity, aqueous stability, and efficient photoelectron transfer, shows a high and stable photocurrent response. In the presence of Hg2+, however, the specific Hg2+ and NCS coordination changes the photophysical properties of Ru-1, imposing the probe with a wider band gap, a weaker absorbance, and a poorer photoelectron and hole separation efficiency, thus resulting in a significant photocurrent decrease. On the basis of the Hg2+-induced photocurrent change, the Ru-1/TiO2/FTO shows good selectivity and high sensitivity toward the PEC detection of Hg2+, with wide linear ranges from 10–12 to 10–7 and 10–7 to 10–3 g/mL, and a low limit of detection of 0.63 pg/mL. The PEC probe is recyclable and accurate for selective detection of Hg2+ in urine, serum, and cell extracts. The whole analysis can be completed within 15 min. These good analytical performances indicate that the PEC method might have great potential for the onsite detection of small molecules in biosystems.
研究领域:
分析化学
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环境科学
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生物医学
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DOI
PubMed
高影响因子
Nanomaterials
·
2021
·Vol. 11
·期 11
·2886
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IF 5.076
Chao Bai,Shi He,Huai-Ming Hu,Hui Zeng,Feng Zou,Ji-Jiang Wang
A europium(III) hybrid material Eu(tta)3bpdc-SiO2@mTiO2(Htta = 2-thenoyltrifluoroacetone, H2bpdc = 2,2′-bipyridine-3,3′-dicarboxylic acid) was successfully designed and synthesized by the covalent grafting complex Eu(tta)3bpdc to SiO2@mTiO2core–shell nanosphere. The FT-IR, PXRD, XPS, TEM, HRTEM, SAED, TGA and PL were performed to characterize these materials. The results indicate that core–shell nanosphere structure and anatase crystallites of SiO2@mTiO2are retained well after grafting the europium complex. Hybrid material Eu(tta)3bpdc-SiO2@mTiO2displays uniform nanosphere structure, bright red color and long lifetime, which can serve as a multicolor emission material modulated by using Al3+ions via the cation exchange approach under a single-wavelength excitation. To the best of our knowledge, this work is the first multicolor emissive sensor for Al3+ions based on the lanthanide hybrid material.Keywords:lanthanide hybrid materials;SiO2@mTiO2core–shell nanosphere;bipyridine derivative;multicolor luminescence
研究领域:
材料科学
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化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）