COLLOIDS AND SURFACES B-BIOINTERFACES
·
2020
·
IF 4.389
Jing Hu,Shanshan Liu,Weijun Deng
Linalool is a main component in different naturally derived essential oils, and widely used in household, personal care, food and therapeutic formulations. However, the application is limited due to its high volatility and low stability. In this study, an effective encapsulation with high loading ratio was built up together with thermal-redox dual responsiveness and controlled release properties. The emulsified linalool droplets were modified with carbon-carbon double bonds, followed by the precipitation polymerization with thermal sensitive monomer, N-vinyl caprolactam. The average size and the loading ratio of the prepared linalool capsules were 1.4 μm and 50.41 wt%. The linalool capsules exhibited thermal-redox dual responsive properties and the antioxidant-antibacterial performance. Especially, responding to the stimuli mimicking practical circumstance, the synthesized capsules presented excellent bacteria inhibiting effect. This work may open a new path for fragrance and essential oil encapsulation, enlarging them as the green biological antibacterial agents in different applications.
研究领域:
材料科学
·
生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2023
·
IF 4.1
Hong Shen,Changwei Zhang,Chengzhang Wang,Jianxin Jiang,Fengxia Tang,Chuan Li,Hua Yuan,Xiaoran Yang,Zhenkai Tong,Yi Huang
Liposomes are considered the best nanocarrier for delivering cancer drugs such as chlorin e6 (Ce6) and paclitaxel (PTX). However, the poor stability and non-selectivity release of liposomes may severely limit their further applications. In this study, based on the characteristics of lutein (L) photo-response and orthoester (OE) acid-response, stable and dual-responsive liposomes (Dr-lips) have been prepared. The Dr-lips exhibited a spherical shape with a uniform size of approximately 58.27 nm. Moreover, they displayed a zeta potential ranging from −45.45 to −28.25 mV and showed excellent storage stability, indicating stable colloidal properties. Additionally, they achieved high drug encapsulation rates, with 92.27% for PTX and 90.34% for Ce6, respectively. Meanwhile, under near-infrared (NIR) light at 660 nm, Ce6 plays a key role in accelerating the photodegradation rate of lutein and PEG-OE-L while also enhancing tissue penetration ability. Additionally, Dr-lips loaded with Ce6 and PTX not only displayed excellent pH and photo dual-responsiveness for targeted delivering and releasing but also showed remarkable reactive oxygen species (ROS) generation capacity and impressive anti-tumor activity in vitro. Therefore, it provides a novel strategy for optimizing stability and enhancing their targeted drug delivery of liposome.
研究领域:
药剂学
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2024
·
IF 4.5
Yaxue Xie,Pingxiong Cai,Huining Xiao,Yuanfeng Pan
In this work, a dual-responsive hydrogel for sustainable release of drug was prepared using chitosan grafted with PBA as substrate to form semi-interpenetrating polymer networks (S-IPN) via free-radical crosslinking polymerization of acrylic acid in the presence of MBAA as a crosslinker and KPS as an initiator as well as Fe 3+ .ions introduced. The results from comprehensive characterization indicated that the as-prepared hydrogel possesses cavity structure with the pores of varying sizes, thus facilitating the accommodation of 5-fluorouracil as a model drug. In addition, the swelling behavior of the hydrogels in different pH buffers and glucose solutions was also investigated. As expected, the prepared hydrogels are pH and glucose responsive due to PAA and phenylboronic acid incorporated into the hydrogel, which enables the slow or sustainable release of drug. Moreover, the release processes were fitted with various kinetic models whereas the release was better described by Korsmeyer-Peppas model or the drug release is mainly governed by the release mechanism of the hydrogel is primarily driven by Fickian diffusion from a mechanical point of view. Hydrogel loaded with drug was found to have good antibacterial effects against E. coli and S. aureus, leading to the potential for various medical-related applications.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Tao Wang,Jingsong Cao,Linan Sun,Jingru Zhao,Yujie Fu
Paclitaxel (PTX), a natural diterpene alkaloid with potent anticancer activity, has been a focus of global research due to its complex structure, significant biological effects, unique mechanism of action, and limited natural availability. In this study, cellulose was used as the raw material to synthesize functionalized pH-responsive modified cellulose porous hydrogel microspheres (MCC/SA/MA-POSS-PTX) via inverse suspension polymerization, using sodium alginate (SA) as the pH-responsive material. Based on this using PTX as the template molecule, 4-VP as the functional monomer, N-isopropylacrylamide (NIPAM) as the thermosensitive monomer, cellulose-based PTX molecularly imprinted hydrogel microspheres (CDLMIHM-PTX) with dual pH and temperature responsiveness were prepared. The adsorption mechanism of the novel material was elucidated through a series of characterization and adsorption experiments. The CDLMIHM-PTX exhibited exceptional adsorption capacity (35.12 mg·g −1 ) and selectivity, as well as good reusability (6 of cycles). Specific enrichment of PTX from the crude extract of Taxus × media branches was achieved, increasing its content from 7.59 % to 55.98 %. This highlights the capability of CDLMIHM-PTX for targeted enrichment and separation of PTX from complex plant matrices, suggesting promising industrial applications. This work explores the construction of pH/temperature dual responsive cellulose-based molecularly imprinted hydrogel microspheres for the selective capture of target compounds, with potential for practical applications.
研究领域:
材料科学
·
药物化学
·
植物化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
·
2013
·Vol. 51
·期 20
·1494-1504
·
IF 2.221
Yi Chen,Yuanqin Xiong,Chang Peng,Wenyong Liu,Yue Peng,Weijian Xu
Polyhedral oligomeric silsesquioxane hybrid temperature and pH double-responsive hydrogels with organic–inorganic co-crosslinked networks are synthesized by in situ , free-radical polymerization of N -isopropylacrylamide and dimethylaminoethyl methacrylate in the presence of both organic crosslinker N , N ′-methylenebis(acrylamide) (BIS) and inorganic crosslinker octavinyl polyhedral oligomeric silsesquioxane (OvPOSS) in tetrahydrofuran media. The resulting hydrogels (OR-OvP gels) display obvious temperature and pH double responsiveness, OvPOSS particles dispersed in polymer make a dominant effect on the properties of gels. With the increase of OvPOSS, the aggregation of particles on nano- or microscale happens and causes a considerable change on the properties of gels, such as the lower critical solution temperature and better compression strength. Specially, the interconnected microporous structure of gels ascribed to the microphase separation results in faster deswelling rate, which makes the gel become attractive. Besides, the crosslink by BIS intensifies the heterogeneity of gels significantly, which could also be used to adjust the properties of gels. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2013 , 51 , 1494–1504
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2019
·Vol. 7
·期 8
·3277-3286
·
IF 5.251
Jun Li,Zu-E. Hu,Xian-Ling Yang,Wan-Xia Wu,Xiu Xing,Bo Gu,Yan-Hong Liu,Na Wang,Xiao-Qi Yu
Dual stimuli-responsive camptothecin polymeric prodrugs (CPT Prodrugs) with grafted structures were designed via chemoenzymatic methods and combined with doxorubicin (DOX) for synergistic drug delivery to improve anticancer efficiency. The CPT Prodrugs loaded DOX with a high efficiency through the cooperative contribution of several interaction forces. The produced amphiphilic polymeric prodrugs loaded with DOX, referred to as DOX@CPT Prodrugs, formed homogeneous spherical micelles of appropriate sizes (sub-50 nm). The DOX@CPT Prodrug micelles showed excellent stability in release experiments under in vitro physiological conditions and maintained over 80% drug loading after 4 weeks when stored at 4 °C. Under weakly acidic pH and reduced glutathione (GSH) conditions, the DOX@CPT Prodrugs with high disulfide and tertiary amine content achieved synergistic release of the two loaded drugs and biodegraded into low-molecular-weight compounds. The cell experiments confirmed that the internalization of DOX@CPT Prodrugs into cancer cells was greatly improved by nearly 30% compared with that of free drugs. Furthermore, the synergistic drug delivery system exhibited superior anticancer efficiency with highly improved cell selectivity ratios (up to 127.0%) and greatly enhanced synergistic effects (up to 23.9%) benefiting from good long-term stability, better internalization by cells and sensitive pH and GSH dual-responsivity. In addition, the DOX@CPT Prodrugs with suitable sizes and good water solubility also exhibited a greater penetrability in the case of simulating solid tumors than the free drugs. These results demonstrate the potential of DOX@CPT Prodrugs as biodegradable, dual-responsive combination therapy nanocarriers for synergistic anticancer treatment.
研究领域:
药学
·
肿瘤学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Li-Jing Zhu,Hai-Ming Song,Gang Wang,Zhi-Xiang Zeng,Qun-Ji Xue
Dual pH- and thermo-responsive polysulfone (PSf) membranes with three-dimensionally interconnected networks are fabricated by introducing poly(acrylic acid- co - N -isopropylacrylamide) (P(AA-NIPAm)) into the membrane surfaces and pore walls during membrane formation via a vapor-liquid induced phase separation (V-LIPS) process. After introducing the copolymers of P(AA-NIPAm), the fabricated membranes exhibit impressive open network pores on the surfaces, meanwhile their cross-sectional structure turns from classical asymmetric finger-like structure into bi-continuous nanopores throughout the whole thickness of membrane, due to high solution viscosity and low mass transfer rate of VIPS process. Furthermore, pure water permeation tests show that the pure water permeation ( L p ) and the molecular weight cutoff (MWCO) of the fabricated PSf/P(AA-NIPAm) membranes increases sharply as the solution pH decreases from 12.5 to 1.5 and the feed temperature increases from 25 to 50 °C, attributing to the increasing pore size. With the decreasing mass ratio of AA to NIPAm, the pH-responsive coefficient decreases, while the temperature- responsive coefficient increases. In particular, for the fabricated membrane with the mass ratio of AA to NIPAm of 3 to 2, L p changes from ∼16.0 to ∼821.4 L m −2 h −1 bar −1 and MWCO increases from ∼223.1 to ∼1493.2 kDa, as the filtration experiments are operated with feed pH and temperature of 12.5/25 °C and 1.5/50 °C respectively. The results proposed in this study provide a novel mode for design and development dual responsive porous membranes in situ, which will enable good separation of various materials and expand the scope of membrane applications.
研究领域:
材料科学
·
分离技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMISTRY OF MATERIALS
·
2021
·
IF 9.811
Ying Liu,Yi Lei,Luqin Hua,Jianlei Lu,Kaojin Wang,Chuanzhuang Zhao
The introduction of anisotropicity is the key step of developing stimuli-responsive polymer hydrogels into intelligent devices. Among these anisotropic materials, hydrogels with oriented structures have attracted tremendous attention. However, most of oriented hydrogels are fabricated through aligning nanofillers or microchannels with external fields. In this work, instead of adding inert materials, we report a facile method to fabricate temperature and pH dual-responsive hydrogels with orientated polymer chains. The hydrogels are based on the interpenetrating network (IPN) of poly(acrylic acid) (PAAc) and poly(acrylamide) (PAAm), which can form temperature- and pH-switchable hydrogen bonds (H-bonds). The two polymerized networks are synthesized sequentially, which allows the application of a stretching force on the primary PAAm network and to “memorize” the orientation through the photopolymerization of the secondary PAAc network. Thanks to the aligned polymer chains and the oriented H-bonds, the obtained gels (i.e., PINSIA) exhibit anisotropic volume phase transition in response to temperature and pH. Due to the bilayer structure generated by the photopolymerization, the directions of the internal stresses of these two layers, that is, the bottom and top layer of the PINSIA gels, are perpendicular, driving the gels to form helices when tailored into narrow strips. Furthermore, the helical structure can be programmed by changing the cutting angle and the width of the gel strip and regulated by switching pH and temperature. This work provides a facile method to construct anisotropic hydrogels that can deform into programmable shapes, which could inspire the design and fabrication of smart hydrogels with potential applications as actuators, information carriers, etc.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Biomedical Nanotechnology
·
2022
·Vol. 18
·期 2
·571-580
·
IF 3.641
Zhou Shuwen,Zheng Xinmeng,Chen Jun,Xu Yiyang,Du Xuancheng,Wang Cheng,Cui Pengfei,Qiu Lin,Jiang Pengju,Ni Xinye,Wang Jianhao
Intranasal administration, which can bypass the blood–brain barrier (BBB), is widely recognized as a promising strategy for high-efficiency drug delivery to the brain. Herein, for the purpose of effectively delivering drugs to the brain via intranasal administration, glutathione
(GSH)-modified gellan gum (GSH-GG) with ion/temperature dual responsive properties was synthesized and encapsulated on galanthamine hydrobromide (GH)-loaded liposomes (GH-Lipo) for effective GH delivery to the brain (GH-Lipo@GSH-GG). Our results demonstrated that GSH-GG greatly decreased the
gelation temperature of GG from 44.0 °C to 22.1 °C without compromising its ion responsiveness. Moreover, GSH-GG had a good protection ability for GH-loaded liposomes without affecting its drug release. Most importantly, the finally obtained GH-Lipo@GSHGG showed acceptable targeted
delivery of GH to the brain upon in vivo administration. Therefore, this formulation can be employed as a potential delivery system in nasal-to-brain delivery.
研究领域:
药剂学
·
神经科学
✓ 已验证
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Zhimei Wei,Qingyu Lin,Jie Yang,Shengru Long,Gang Zhang,Xiaojun Wang
Dual temperature- and pH-sensitive materials used as drug carriers have attracted a particularly high level of interest. However, it is limited by low sensitivity to changes in conditions because of large size and low specific surface area. In this work, novel dual temperature- and pH-sensitive poly( N -isopropylacrylamide- N -methylolacrylamide acrylic acid) (PNIPAm-NMA-AAc) ultrafine fibres were successfully prepared by radical copolymerisation, electrospinning and thermal chemical treatment. The PNIPAm-NMA-AAc ultrafine fibres were characterized by Fourier transform infrared (FTIR), proton nuclear magnetic resonance ( 1 H NMR), spectroscopy UV–visible spectroscopy, scanning electron microscopy (SEM) and cell counting kit-8 (CCK-8) assay. The uniformity and small size of PNIPAm-NMA-AAc ultrafine fibres with LCST range from 31 °C to 43 °C were used to drug carrier because of good thermal stability, no cytotoxic. Curcumin as a model drug was well distributed in PNIPAm-NMA-AAc ultrafine fibres. In addition, analysis of curcumin release at different pH values and temperatures confirmed that the PNIPAm-NMA-AAc ultrafine fibres are responsive to both temperature and pH. The maximum amount of curcumin released was 98.47% ± 1.87%. In addition, the release mechanism of curcumin-based PNIPAm-NMA-AAc ultrafine fibres was shown to conform to Fickian diffusion (r 2 ≥ 0.95). These results indicated that dual-responsive PNIPAm-NMA-AAc ultrafine fibres are promising as drug carriers.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Materials Today Communications
·
2022
·
IF 3.662
Lianlian Yang,Junhong Ling,Nan Wang,Yongjun Jiang,Yuqing Lu,Li-Ye Yang,Xiao–kun Ouyang
Here, glycidyl methacrylate (GMA) was used for modification of carboxymethyl chitosan (CMCS). The double bond on the side group of CMCS was polymerized and cross-linked with N-N′-bis(acryloyl) cysteamine (BAC), containing a disulfide bond, and modified with folic acid (FA) to obtain nanogels for the targeted delivery of doxorubicin (DOX). Effectiveness of DOX delivery and release were subsequently investigated. The drug encapsulation efficiency (EE) and loading capacity (LC) of DOX were 94.77 ± 0.83% and 15.6 ± 0.12%, respectively. The particle size of the GCMCS-FA-DOX nanoparticles loaded with DOX was 220.4 ± 38.4 nm. The experimental results showed that GCMCS-FA-DOX had a high glutathione and pH response performance. GCMCS-FA-DOX showed an improved inhibitory effect on tumor cell proliferation compared to free DOX. GCMCS-FA-DOX significantly improved the efficiency of drug uptake by cells, and the cytotoxicity of GCMCS-FA-DOX in HCT-116 tumor cells was higher than that in HepG-2 tumor cells.
研究领域:
药学
·
生物材料
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2025
·
IF 6.3
Danyang Li,Shizhen Zhao,Yuanpeng Cai,Hui Liu
Single chemotherapy lacked controllability, while smart-responsive hydrogel could deliver drug to specific sites in response to different external stimuli. Hyaluronic acid–Chitosan–Thioketal@Chlorin e6 (HA-CS-TK@Ce6) hydrogel with dual response of ROS and hyaluronidase (HAase) was synthesized by electrostatic interaction force. HA-CS-TK@Ce6 hydrogel loaded with chemotherapeutic drug doxorubicin (DOX) and photosensitizer Ce6 successfully achieved the combined anticancer effect of chemotherapy and photodynamic therapy. Experimental results demonstrated that releasing efficiency of the hydrogel toward DOX could reach 90.6 % in pH = 5 H 2 O 2 solution with HAase at T = 40 ℃. Moreover, HA-CS-TK@Ce6 hydrogel was capable of stimulating Ce6 to produce massive ROS under 650 nm laser irradiation, thus leading to breakage of ROS-cleavable TK and realizing degradation of hydrogel. It was worth mentioning that laser confocal results indicated that MCF-7 cells could successfully uptake Ce6 and DOX, which further proved that HA-CS-TK@Ce6 hydrogel could achieve efficient photodynamic-chemotherapeutic treatment. Therefore, dual-responsive HA-CS-TK@Ce6 hydrogel with excellent biocompatibility and degradability enabled selective and intelligent release of DOX, which would be prospective to improve therapeutic effect of cancer through chemo-photodynamic therapy.
研究领域:
生物材料学
·
肿瘤治疗学
·
药剂学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）