CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yuan Cao,Yao Wu,Yiming Huang,Hongping Xiang,Lanyue Zhang
4D printing, combining the advantages of 3D printing and stimuli-responsive materials, provides a precise and rapid fabrication method for complex-shaped smart objects. In this study, the photoisomerization characteristic of azobenzene is used to develop 4D printable resins composed of azobenzene-based acrylates (AZO) and other acrylate compounds, which can be UV-cured and 3D printed into objects with photo and thermal dual responsiveness. UV-curing kinetics reveal that AZO competes with the photoinitiator for photons during photopolymerization, reducing the generation of reactive oxygen species and subsequently affecting the mechanical properties of UV-cured resin. The optimum content of AZO in 4D printing resins is 0.5 wt%, producing 3D printed objects with excellent mechanical properties, including a maximum stress of 25.2 MPa and a strain of 100 %. This ensures the successful formation of complex-shaped objects in the 3D printing process. Moreover, the objects printed with this photosensitive resin demonstrate exceptional shape memory capabilities, achieving a 100 % shape recovery ratio over three cycles of thermal stimulation. The printed openwork spheroid with a concave shape can successfully revert to its original form after 48 s of irradiation with 365 nm UV light. The degree of shape recovery can be precisely controlled by adjusting the UV irradiation time and position. Therefore, these photo/thermal dual-responsive 4D objects show great application prospects in medical devices and smart materials.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2020
·
IF 4.389
Jing Hu,Shanshan Liu,Weijun Deng
Linalool is a main component in different naturally derived essential oils, and widely used in household, personal care, food and therapeutic formulations. However, the application is limited due to its high volatility and low stability. In this study, an effective encapsulation with high loading ratio was built up together with thermal-redox dual responsiveness and controlled release properties. The emulsified linalool droplets were modified with carbon-carbon double bonds, followed by the precipitation polymerization with thermal sensitive monomer, N-vinyl caprolactam. The average size and the loading ratio of the prepared linalool capsules were 1.4 μm and 50.41 wt%. The linalool capsules exhibited thermal-redox dual responsive properties and the antioxidant-antibacterial performance. Especially, responding to the stimuli mimicking practical circumstance, the synthesized capsules presented excellent bacteria inhibiting effect. This work may open a new path for fragrance and essential oil encapsulation, enlarging them as the green biological antibacterial agents in different applications.
研究领域:
材料科学
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生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 41
·15451-15457
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IF 8.067
Xi-Zhu Zhang,Wen-Jing Zhu,Zhong-Xi Yang,Yi Feng,Lin-Lin Fan,Guang-Gang Gao,Hong Liu
The sensitive and selective detection of ethylenediamine (EDA) has great significance due to its threat to environment and human health. Herein, a rationally designed polyoxometalate–viologen complex (1) has been demonstrated, in which the viologen molecules are hydrogen bonded to Dawson-type polyoxoanions. When complex 1 is in the atmosphere of EDA, the chromic intensity or Raman signals present proportional response to EDA concentrations. In particular, a very low detection limit of 0.1 ppb can be obtained for 1 based on its Raman signal output, which is the most sensitive complex than the reported EDA sensors. Also, high selectivity is observed for 1 when other amine molecules coexist as interfering compounds. According to the structural analysis and comparative experimental results, the highly sensitive and selective chromic or Raman response can be ascribed to the existence of viologen in the crystal lattice, which can not only accept electrons from EDA but also effectively accelerate the electron transfer to polyoxometalate. This work affords a novel concept for the design of highly sensitive and dual response polyoxometalate-based sensors by virtue of viologen-boosting electron transfer.
研究领域:
材料科学
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环境科学
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化学传感器
✓ 已验证
DOI
高影响因子
Nanomaterials
·
2024
·Vol. 14
·期 24
·2022
·
IF 4.4
Qiongmei Mai,Yu Lu,Qianyu Cai,Jianglong Hu,Yunyou Lv,Yonglan Yang,Liqiang Wang,Yuezhao Zhou,Jie Liu
Sclerotinia sclerotiorumis one of the fungi that cause plant diseases. It damages plants by secreting large amounts of oxalic acid and cell wall-degrading enzymes. To meet this challenge, we designed a new pH/enzyme dual-responsive nanopesticide Pro@ZnO@Pectin (PZP). This nanopesticide uses zinc oxide (ZnO) as a carrier of prochloraz (Pro) and is encapsulated with pectin. When encountering oxalic acid released bySclerotinia sclerotiorum, the acidic environment promotes the decomposition of ZnO; at the same time, the pectinase produced bySclerotinia sclerotiorumcan also decompose the outer pectin layer of PZP, thereby promoting the effective release of the active ingredient. Experimental data showed that PZP was able to achieve an efficient release rate of 57.25% and 68.46% when pectinase was added or under acidic conditions, respectively. In addition, in vitro tests showed that the antifungal effect of PZP was comparable to that of the commercial Pro (Pro SC) on the market, and its efficacy was 1.40 times and 1.32 times that of the Pro original drug (Pro TC), respectively. Crucially, the application of PZP significantly alleviated the detrimental impacts of Pro on wheat development. Soil wetting experiments have proved that PZP primarily remained in the soil, thereby decreasing its likelihood of contaminating water sources and reducing potential risks to non-target organisms. Moreover, PZP improved the foliar wettability of Pro, lowering the contact angle to 75.06°. Residue analyses indicated that PZP did not elevate prochloraz residue levels in tomato fruits compared to conventional applications, indicating that the nanopesticide formulation does not lead to excessive pesticide buildup. In summary, the nanopesticide PZP shows great promise for effectively managingSclerotinia sclerotiorumwhile minimizing environmental impact.
研究领域:
植物病理学
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环境科学
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产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2023
·
IF 4.1
Hong Shen,Changwei Zhang,Chengzhang Wang,Jianxin Jiang,Fengxia Tang,Chuan Li,Hua Yuan,Xiaoran Yang,Zhenkai Tong,Yi Huang
Liposomes are considered the best nanocarrier for delivering cancer drugs such as chlorin e6 (Ce6) and paclitaxel (PTX). However, the poor stability and non-selectivity release of liposomes may severely limit their further applications. In this study, based on the characteristics of lutein (L) photo-response and orthoester (OE) acid-response, stable and dual-responsive liposomes (Dr-lips) have been prepared. The Dr-lips exhibited a spherical shape with a uniform size of approximately 58.27 nm. Moreover, they displayed a zeta potential ranging from −45.45 to −28.25 mV and showed excellent storage stability, indicating stable colloidal properties. Additionally, they achieved high drug encapsulation rates, with 92.27% for PTX and 90.34% for Ce6, respectively. Meanwhile, under near-infrared (NIR) light at 660 nm, Ce6 plays a key role in accelerating the photodegradation rate of lutein and PEG-OE-L while also enhancing tissue penetration ability. Additionally, Dr-lips loaded with Ce6 and PTX not only displayed excellent pH and photo dual-responsiveness for targeted delivering and releasing but also showed remarkable reactive oxygen species (ROS) generation capacity and impressive anti-tumor activity in vitro. Therefore, it provides a novel strategy for optimizing stability and enhancing their targeted drug delivery of liposome.
研究领域:
药剂学
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肿瘤学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Tao Wang,Jingsong Cao,Linan Sun,Jingru Zhao,Yujie Fu
Paclitaxel (PTX), a natural diterpene alkaloid with potent anticancer activity, has been a focus of global research due to its complex structure, significant biological effects, unique mechanism of action, and limited natural availability. In this study, cellulose was used as the raw material to synthesize functionalized pH-responsive modified cellulose porous hydrogel microspheres (MCC/SA/MA-POSS-PTX) via inverse suspension polymerization, using sodium alginate (SA) as the pH-responsive material. Based on this using PTX as the template molecule, 4-VP as the functional monomer, N-isopropylacrylamide (NIPAM) as the thermosensitive monomer, cellulose-based PTX molecularly imprinted hydrogel microspheres (CDLMIHM-PTX) with dual pH and temperature responsiveness were prepared. The adsorption mechanism of the novel material was elucidated through a series of characterization and adsorption experiments. The CDLMIHM-PTX exhibited exceptional adsorption capacity (35.12 mg·g −1 ) and selectivity, as well as good reusability (6 of cycles). Specific enrichment of PTX from the crude extract of Taxus × media branches was achieved, increasing its content from 7.59 % to 55.98 %. This highlights the capability of CDLMIHM-PTX for targeted enrichment and separation of PTX from complex plant matrices, suggesting promising industrial applications. This work explores the construction of pH/temperature dual responsive cellulose-based molecularly imprinted hydrogel microspheres for the selective capture of target compounds, with potential for practical applications.
研究领域:
材料科学
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药物化学
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植物化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2024
·
IF 4.5
Yaxue Xie,Pingxiong Cai,Huining Xiao,Yuanfeng Pan
In this work, a dual-responsive hydrogel for sustainable release of drug was prepared using chitosan grafted with PBA as substrate to form semi-interpenetrating polymer networks (S-IPN) via free-radical crosslinking polymerization of acrylic acid in the presence of MBAA as a crosslinker and KPS as an initiator as well as Fe 3+ .ions introduced. The results from comprehensive characterization indicated that the as-prepared hydrogel possesses cavity structure with the pores of varying sizes, thus facilitating the accommodation of 5-fluorouracil as a model drug. In addition, the swelling behavior of the hydrogels in different pH buffers and glucose solutions was also investigated. As expected, the prepared hydrogels are pH and glucose responsive due to PAA and phenylboronic acid incorporated into the hydrogel, which enables the slow or sustainable release of drug. Moreover, the release processes were fitted with various kinetic models whereas the release was better described by Korsmeyer-Peppas model or the drug release is mainly governed by the release mechanism of the hydrogel is primarily driven by Fickian diffusion from a mechanical point of view. Hydrogel loaded with drug was found to have good antibacterial effects against E. coli and S. aureus, leading to the potential for various medical-related applications.
研究领域:
材料科学
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药学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Li-Jing Zhu,Hai-Ming Song,Gang Wang,Zhi-Xiang Zeng,Qun-Ji Xue
Dual pH- and thermo-responsive polysulfone (PSf) membranes with three-dimensionally interconnected networks are fabricated by introducing poly(acrylic acid- co - N -isopropylacrylamide) (P(AA-NIPAm)) into the membrane surfaces and pore walls during membrane formation via a vapor-liquid induced phase separation (V-LIPS) process. After introducing the copolymers of P(AA-NIPAm), the fabricated membranes exhibit impressive open network pores on the surfaces, meanwhile their cross-sectional structure turns from classical asymmetric finger-like structure into bi-continuous nanopores throughout the whole thickness of membrane, due to high solution viscosity and low mass transfer rate of VIPS process. Furthermore, pure water permeation tests show that the pure water permeation ( L p ) and the molecular weight cutoff (MWCO) of the fabricated PSf/P(AA-NIPAm) membranes increases sharply as the solution pH decreases from 12.5 to 1.5 and the feed temperature increases from 25 to 50 °C, attributing to the increasing pore size. With the decreasing mass ratio of AA to NIPAm, the pH-responsive coefficient decreases, while the temperature- responsive coefficient increases. In particular, for the fabricated membrane with the mass ratio of AA to NIPAm of 3 to 2, L p changes from ∼16.0 to ∼821.4 L m −2 h −1 bar −1 and MWCO increases from ∼223.1 to ∼1493.2 kDa, as the filtration experiments are operated with feed pH and temperature of 12.5/25 °C and 1.5/50 °C respectively. The results proposed in this study provide a novel mode for design and development dual responsive porous membranes in situ, which will enable good separation of various materials and expand the scope of membrane applications.
研究领域:
材料科学
·
分离技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2019
·Vol. 7
·期 8
·3277-3286
·
IF 5.251
Jun Li,Zu-E. Hu,Xian-Ling Yang,Wan-Xia Wu,Xiu Xing,Bo Gu,Yan-Hong Liu,Na Wang,Xiao-Qi Yu
Dual stimuli-responsive camptothecin polymeric prodrugs (CPT Prodrugs) with grafted structures were designed via chemoenzymatic methods and combined with doxorubicin (DOX) for synergistic drug delivery to improve anticancer efficiency. The CPT Prodrugs loaded DOX with a high efficiency through the cooperative contribution of several interaction forces. The produced amphiphilic polymeric prodrugs loaded with DOX, referred to as DOX@CPT Prodrugs, formed homogeneous spherical micelles of appropriate sizes (sub-50 nm). The DOX@CPT Prodrug micelles showed excellent stability in release experiments under in vitro physiological conditions and maintained over 80% drug loading after 4 weeks when stored at 4 °C. Under weakly acidic pH and reduced glutathione (GSH) conditions, the DOX@CPT Prodrugs with high disulfide and tertiary amine content achieved synergistic release of the two loaded drugs and biodegraded into low-molecular-weight compounds. The cell experiments confirmed that the internalization of DOX@CPT Prodrugs into cancer cells was greatly improved by nearly 30% compared with that of free drugs. Furthermore, the synergistic drug delivery system exhibited superior anticancer efficiency with highly improved cell selectivity ratios (up to 127.0%) and greatly enhanced synergistic effects (up to 23.9%) benefiting from good long-term stability, better internalization by cells and sensitive pH and GSH dual-responsivity. In addition, the DOX@CPT Prodrugs with suitable sizes and good water solubility also exhibited a greater penetrability in the case of simulating solid tumors than the free drugs. These results demonstrate the potential of DOX@CPT Prodrugs as biodegradable, dual-responsive combination therapy nanocarriers for synergistic anticancer treatment.
研究领域:
药学
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肿瘤学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Guoping Li,Mingliang Pei,Peng Liu
Carbon quantum dots (CQDs) show promising potential for tumor imaging owing to their unique superior fluorescent properties. However, the small particle size limits their practical application. Here, pH/reduction dual-responsive comet-shaped PEGylated CQD-DOX conjugate prodrug, DOX-Hy-CQD-SS-PEG with DOX content of 28.5%, was designed with the hydrophobic acid-labile DOX conjugated CQDs as comet nucleus and the few hydrophilic bioreducible detachable PEG brushes as comet tails. The comet-shaped DOX-Hy-CQD-SS-PEG prodrug could self-assemble into unique micelles with mean diameter of 127 nm. The DOX-Hy-CQD-SS-PEG micelles possessed excellent pH/reduction dual-responsive drug release with low drug leakage of 9% in 150 h. Furthermore, the fluorescent CQDs was recovered after DOX release and de-PEGylation, demonstrating their potential application for real-time response of therapy.
研究领域:
纳米医学
·
药物递送系统
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
·
2013
·Vol. 51
·期 20
·1494-1504
·
IF 2.221
Yi Chen,Yuanqin Xiong,Chang Peng,Wenyong Liu,Yue Peng,Weijian Xu
Polyhedral oligomeric silsesquioxane hybrid temperature and pH double-responsive hydrogels with organic–inorganic co-crosslinked networks are synthesized by in situ , free-radical polymerization of N -isopropylacrylamide and dimethylaminoethyl methacrylate in the presence of both organic crosslinker N , N ′-methylenebis(acrylamide) (BIS) and inorganic crosslinker octavinyl polyhedral oligomeric silsesquioxane (OvPOSS) in tetrahydrofuran media. The resulting hydrogels (OR-OvP gels) display obvious temperature and pH double responsiveness, OvPOSS particles dispersed in polymer make a dominant effect on the properties of gels. With the increase of OvPOSS, the aggregation of particles on nano- or microscale happens and causes a considerable change on the properties of gels, such as the lower critical solution temperature and better compression strength. Specially, the interconnected microporous structure of gels ascribed to the microphase separation results in faster deswelling rate, which makes the gel become attractive. Besides, the crosslink by BIS intensifies the heterogeneity of gels significantly, which could also be used to adjust the properties of gels. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2013 , 51 , 1494–1504
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2021
·
IF 9.811
Ying Liu,Yi Lei,Luqin Hua,Jianlei Lu,Kaojin Wang,Chuanzhuang Zhao
The introduction of anisotropicity is the key step of developing stimuli-responsive polymer hydrogels into intelligent devices. Among these anisotropic materials, hydrogels with oriented structures have attracted tremendous attention. However, most of oriented hydrogels are fabricated through aligning nanofillers or microchannels with external fields. In this work, instead of adding inert materials, we report a facile method to fabricate temperature and pH dual-responsive hydrogels with orientated polymer chains. The hydrogels are based on the interpenetrating network (IPN) of poly(acrylic acid) (PAAc) and poly(acrylamide) (PAAm), which can form temperature- and pH-switchable hydrogen bonds (H-bonds). The two polymerized networks are synthesized sequentially, which allows the application of a stretching force on the primary PAAm network and to “memorize” the orientation through the photopolymerization of the secondary PAAc network. Thanks to the aligned polymer chains and the oriented H-bonds, the obtained gels (i.e., PINSIA) exhibit anisotropic volume phase transition in response to temperature and pH. Due to the bilayer structure generated by the photopolymerization, the directions of the internal stresses of these two layers, that is, the bottom and top layer of the PINSIA gels, are perpendicular, driving the gels to form helices when tailored into narrow strips. Furthermore, the helical structure can be programmed by changing the cutting angle and the width of the gel strip and regulated by switching pH and temperature. This work provides a facile method to construct anisotropic hydrogels that can deform into programmable shapes, which could inspire the design and fabrication of smart hydrogels with potential applications as actuators, information carriers, etc.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）