Hui Yu,Xiaojing Chen,Jie Cai,Dongdong Ye,Yuxiao Wu,Peifeng Liu
Long-term antibacterial medical dressings can prevent infection as skin wounds heal. In this study, we used the hydrophobic antibacterial drug amoxicillin as a model to prepare drug-loaded nanomicelles using a film dispersion–hydration method, and drug-loaded nanomicelles were coaxially electrospun into nanofiber to create a novel nanomicelle-in-nanofiber (NM-in-NF) drug delivery system. Scanning electron microscopy and transmission electron microscopy were used to characterize the morphology of nanomicelles and nanofibers. Thermal property of as-prepared samples was tested using differential scanning calorimetry. The drug release behavior, cytotoxicity, and antibacterial properties of NM-in-NFs were examined in vitro to evaluate the system’s potential to be used in the treatment of skin wounds. Experimental results indicated that the novel NM-in-NF system had dual controlled release effect, which greatly reduced burst release and prolonged effective drug duration. Moreover, NM-in-NFs was also found to be safe and non-toxic, with a broad-spectrum antibacterial activity. It thus could potentially be used in long-term antibacterial medical dressings to treat skin wounds.
The multifunctional chemicals with structural diversity are particularly attractive for various applications. In this study, we present a series of surfactants featuring the chemical structure of quaternary pyridinium salts (QPSs), wherein two types of alcohol fragrance molecules are linked to QPSs via ester bonds and acetal moieties. These profragrances exhibit multifunctional properties, including exceptional surface activity, antibacterial capability, and effective fragrance release performance. A notable feature of this system is their dual-controlled release of the perfume mixture of two different alcohols. In this context, the surface tension of the QPS was determined with the critical micelle concentration (CMC) ranging from 0.0313–0.4349 mmol L–1 and a γ-CMC value of 19.4–26.1 mN m–1. The minimum inhibitory concentration (MIC) tests demonstrated significant antibacterial properties, particularly against Gram-positive bacteria. Gas chromatography with headspace solid-phase microextraction was employed to test the release performance of profragrances in both the solution and the surface of cotton. The controlled release of individual fragrance alcohols under alkaline conditions resulted in a long-lasting scent, while the simultaneous release of two flavors was achieved under acidic conditions. Moreover, the QPSs were shown to be an effective fragrance delivery system for textiles.
Polyaniline (PANI) chains with different lengths were grafted onto the surface of hollow mesoporous silica spheres (HMSs) by in situ chemical oxidative polymerization. In the cargo-loading experiments, HMSs-PANI(L) with long PANI chains was unsuitable to load Doxorubicin (DOX) hydrochloride molecules because of channel blockage. In contrast, the oligomer of PANI chains served as the gate, and when grafted onto HMSs (HMSs-PANI(S)), they simply manipulated the “opening” or “closing” of mesopores through the doping mechanism of PANI chains. Utilizing the different states of PANI chains led to the different interaction forces between PANI chains and cargo molecules, and HMSs-PANI(S) can effectively load different cargo molecules. When stimulated by using an acid, the acid-controlled release behaviors of DOX and Rhodamine 6G (R6G) were achieved. When stimulated by using an acid, alkaline controlled release behavior was also observed by loading indomethacin (IND) molecules.
Bio-based hydrogel containing cyclodextrins (CDs) is of a promising polymer material that could display many advantages including wide availability, sustainability, biocompatibility and biodegradability , especially the inherent encapsulation ability with hydrophobic substance. To obtain these, the electrostatic and host-guest interactions were introduced and a hydrogel with three-dimensional double network structures was built. For preparing a spherical biopolymer cage, hydroxyethyl cellulose (HEC) and modified chitosan (HACC) were cross-linked by a one-pot reaction. The existence of HACC in this hydrogel provides a positive charge core to attract negative host molecule of sulfobutylether- β -cyclodextrin (SEB- β -CD). The loading amount of SEB- β -CD were determined by the method of weight increment and photometric titration, respectively, and an average content of active SEB- β -CD in our prepared hydrogel is more than 50%, much higher than the grafting of CD on biopolymers materials through chemical reaction. By the host-guest interaction, hydrophobic molecule of PP could adsorb rapidly in our prepared hydrogel and sustain-release in aqueous solution. Through ion-exchange interaction, different negative ions were studied for obtaining a control release of SEB- β -CD, which is to achieve the purpose of rapid release of hydrophobic guest molecule.
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