Foods
·
2023
·Vol. 12
·期 5
·1085
·
IF 5.2
Ziwen Zhang,Ran Han,Sixuan Chen,Feilin Zheng,Xinmiao Ma,Mingfei Pan,Shuo Wang
In this study, a rapid fluorescent and colorimetric dual-mode detection strategy for Hg2+in seafoods was developed based on the cyclic binding of the organic fluorescent dye rhodamine 6G hydrazide (R6GH) to Hg2+. The luminescence properties of the fluorescent R6GH probe in different systems were investigated in detail. Based on the UV and fluorescence spectra, it was determined that the R6GH has good fluorescence intensity in acetonitrile and good selective recognition of Hg2+. Under optimal conditions, the R6GH fluorescent probe showed a good linear response to Hg2+(R2= 0.9888) in the range of 0–5 μM with a low detection limit of 2.5 × 10−2μM (S/N = 3). A paper-based sensing strategy based on fluorescence and colorimetric analysis was developed for the visualization and semiquantitative analysis of Hg2+in seafoods. The LAB values of the paper-based sensor impregnated with the R6GH probe solution showed good linearity (R2= 0.9875) with Hg2+concentration in the range of 0–50 μM, which means that the sensing paper can be combined with smart devices to provide reliable and efficient Hg2+detection.Keywords:Hg2+;R6GH;dual mode;fluorescence;visualization
研究领域:
分析化学
·
环境科学
·
食品安全
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2014
·
IF 4.287
ChengCai Zeng,XiaoNi Shi,Bo Wu,Dong Zhang,WeiLu Zhang
A type of novel macromolecular colloid was prepared from gadolinium-based poly( l -succinimide) and gold nanoparticles (GNPs) with Au S covalent bonds. The colloid displayed improved stability in aqueous media and regular arrays in partial region. Moreover, these materials enhanced the contrast 9 times more than that of the corresponding uncoated Au compound when the Au mass content was only 0.15%. Therefore, these materials might have potential as dual-modality contrast agents for magnetic resonance imaging (MRI) and computed tomography (CT).
研究领域:
医学影像学
·
纳米医学
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DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2013
·Vol. 11
·期 1
·1-12
·
IF 0
Zhou Zhijun,Zhang Chunlei,Qian Qirong,Ma Jiebing,Huang Peng,zhang Xi,Pan Liyuan,Gao Guo,Fu Hualin,Fu Shen,Song Hua,Zhi Xiao,Ni Jian,Cui Daxiang
Background Gastric cancer is 2th most common cancer in China, and is still the second most common cause of cancer-related death in the world. Successful development of safe and effective nanoprobes for in vivo gastric cancer targeting imaging is a big challenge. This study is aimed to develop folic acid (FA)-conjugated silica coated gold nanoclusters (AuNCs) for targeted dual-modal fluorescent and X-ray computed tomography imaging (CT) of in vivo gastric cancer cells. Method AuNCs were prepared, silica was coated on the surface of AuNCs, then folic acid was covalently anchored on the surface of AuNCs, resultant FA-conjugated AuNCs@SiO 2 nanoprobes were investigated their cytotoxicity by MTT method, and their targeted ability to FR(+) MGC803 cells and FR(−) GES-1 cells. Nude mice model loaded with MGC803 cells were prepared, prepared nanoprobes were injected into nude mice via tail vein, and then were imaged by fluorescent and X-ray computed tomography (CT) imaging. Results FA-conjugated AuNCs@SiO 2 nanoprobes exhibited good biocompatibility, and could target actively the FR(+) MGC-803 cells and in vivo gastric cancer tissues with 5 mm in diameter in nude mice models, exhibited excellent red emitting fluorescence imaging and CT imaging. Conclusion The high-performance FA-conjugated AuNCs@SiO 2 nanoprobes can target in vivo gastric cancer cells, can be used for fluorescent and CT dual-mode imaging, and may own great potential in applications such as targeted dual-mode imaging of in vivo early gastric cancer and other tumors with FR positive expression in near future.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
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产品关联
DOI
PubMed
Nanoscale
·
2017
·Vol. 10
·期 7
·3130-3143
·
IF 7.367
Shaohua Zhang,Qian Huang,Lijuan Zhang,Hao Zhang,Yaobao Han,Qiao Sun,Zhenxiang Cheng,Huizhu Qin,Shixue Dou,Zhen Li
The vacancies in the semiconductor nanocrystals not only induce unique properties, but also provide spaces for engineering them with multifunctions by the introduction of other elements. Herein, the vacancy of Cu2−xSe nanoparticles was tuned by doping with magnetic ferric ions (Fe3+) at room temperature, and the position and intensity of the near-infrared localized surface plasmon resonance (LSPR) in the resultant nanostructure can be finely controlled by altering the feeding amount of Fe3+ ions. The results of the density-functional theory (DFT) calculations show that both doping and replacement reactions are favourable. Owing to its tunable near-infrared absorption and magnetic property, the obtained hybrid nanostructure was demonstrated to be a novel nanotheranostic agent for effective deep-tissue photoacoustic imaging, magnetic resonance imaging, and photothermal therapy of cancer.
研究领域:
材料科学
·
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2021
·
IF 12.479
Yang Tian,Wen-Li Jiang,Wen-Xin Wang,Guo-Jiang Mao,Yongfei Li,Chun-Yan Li
The reduced coenzymes (NADH and NADPH) are an important product in energy metabolism and closely related to the occurrence and development of cancer. So it is necessary to use a powerful detection tool to visualize NAD(P)H in energy metabolism of tumor cells and find a new strategy to improve cancer treatment based on NAD(P)H. Herein, a novel multifunctional probe (Cy-N) is synthesized with good near-infrared fluorescence (NIRF) response to NAD(P)H and the photoacoustic (PA) and photothermal properties are successfully activated by NAD(P)H. The probe is successfully applied in visualizing NAD(P)H in energy metabolism of tumor cells and imaging NAD(P)H in bacteria. Moreover, the probe can be used to image NAD(P)H in energy metabolism of tumor-bearing mice by dual-modal imaging (NIRF and PA). More importantly, in terms of the role of NAD(P)H in energy metabolism, the photothermal therapy (PTT) is activated by NAD(P)H and a novel strategy of enhanced PTT is proposed by injecting glucose. As far as we know, this is the first probe to detect NAD(P)H in energy metabolism through dual-modal imaging, and also the first probe to activate PTT based on NAD(P)H, which will provide important information of the diagnosis and treatment of cancer.
研究领域:
生物化学
·
医学影像学
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2016
·Vol. 45
·期 13
·5484-5491
·
IF 4.177
Bo Li,Xudong Wang,Yali Guo,Anam Iqbal,Yaping Dong,Wu Li,Weisheng Liu,Wenwu Qin,Shizhen Chen,Xin Zhou,Yunhuang Yang
A one-step hydrothermal method was developed to fabricate Fe3O4–carbon dots (Fe3O4–CDs) magnetic–fluorescent hybrid nanoparticles (NPs). Ferric ammonium citrate (FAC) was used as a cheap and nontoxic iron precursor and as the carbon source. Moreover, triethylenetetramine (TETA) was used to improve the adhesive strength of CDs on Fe3O4 and the fluorescence intensity of CDs. The prepared water-soluble hybrid NPs not only exhibit excellent superparamagnetic properties (Ms = 56.8 emu g−1), but also demonstrate excitation-independent photoluminescence for down-conversion and up-conversion at 445 nm. Moreover, the prepared water-soluble Fe3O4–CDs hybrid NPs have a dual modal imaging ability for both magnetic resonance imaging (MRI) and fluorescence imaging.
研究领域:
材料科学
·
医学影像
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
Polymers
·
2019
·Vol. 11
·期 2
·220
·
IF 3.164
Lingyun Wang,Meiying Huang,Hao Tang,Derong Cao,Yu Zhao
Fluorescent magnetic nanoparticles (NPs) utilized for imaging hold great promise for biomedical applications, but it remains a challenging task. Here, we report novel dual-modality NPs using an aggregation-induced emission (AIE)-active and near-infrared (NIR) emissive dye (TPAS) and magnetic Fe3O4as the core, and biocompatible polymer Pluronic F-127 as the encapsulation matrix by self-assembly procedures. The obtained fluorescent-magnetic AIE NPs have both high fluorescence quantum yield (13.8%) at 700 nm and high magnetic saturation value. With good photostability and biocompatibility, the resulting NPs show effective MRI ability, but also a stain in cytoplasm with a strong NIR fluorescent signal.Keywords:dual-modality;AIE;MRI;bioimaging
研究领域:
材料科学
·
生物医学工程
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2022
·
IF 11.322
Wenwen Li,Min Sang,Shuai Liu,Bochao Wang,Xufeng Cao,Guanghui Liu,Xinglong Gong,Lingyun Hao,Shouhu Xuan
Soft actuators with large deformation and high stability in response to multi-stimuli are highly demanded in biomimetic applications. However, most of the present actuators driven by a single stimulus often exhibit low performance and high energy consumption. In this work, a sandwich structural soft actuator (MPDMS/MXene/PTFE) which possesses electrothermal/magnetic coupling actuation is fabricated by combining magnetic NdFeB/Polydimethylsiloxane (MPDMS) composite layer, MXene film, and PTFE tape together. Due to the large difference of thermal expansion coefficient between MPDMS film and PTFE tape, the soft actuator shows a wonderful electrothermal actuation and the bending deformation can reach to as high as 353° under a 3 V power supply. The excellent electrical conductivity of MXene component endows the sandwich film with good thermal management performance, thus the soft MPDMS/MXene/PTFE sandwich films can be applied in the thermal treatment of body and thermal imaging. Most importantly, the soft actuator also exhibits a typical magnetic biomimetic actuation and the programmable actuation performance of the dragonfly actuator can be demonstrated by both experiments and finite element simulations. Eventually, the electrothermal/magnetic coupling actuation is successfully applied in an intelligent crawling robot to overcome the traditional inchworm movement simulation.
研究领域:
材料科学
·
仿生学
·
软体机器人
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产品关联
DOI
高影响因子
Science of Advanced Materials
·
2021
·Vol. 13
·期 7
·1364-1373
·
IF 1.474
Zhang Yumei,Pei Ruina,Luo Tao
ABSTRACT
The development of nanomaterials, especially the development of multi-modality imaging nanoprobe technology has become a reality for tumor imaging diagnosis. In this study, the gadolinium ion chelating agent (2,2′,2′′-(10-(2-(2, 5-dioxopyrrolidin-1-oxyl)-2
oxoethyl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-tri)triacetic acid) (DOTA-NHS) and polyethylene glycol (PEG)-modified targeting ligand PEG-folic acid (FA) were grafted onto the PEG-modified fifth-generation polyamide-amine dendrimer (P5-NH2), which were undertaken as standards
to wrap gold nanoparticles. Then, remaining amino group was acetylated to acquire Gd–Au DENPS-FA nanoparticles. Biocompatibility and cytotoxicity of nanoparticles were analyzed while characterizing them. The cases with unidentified tumors (mass diameter >4.5 cm) of abdominal or pelvic
origin were selected and used for clinical study of computed tomography (CT)/magnetic resonance imaging (MRI) dual-modality abdominal tumors. In the test, average particle size of Gd-Au DENPs-FA nanoparticles was 4.2 nm, and they had good water solubility and stability in aqueous solution.
When concentration of Au+ nanoparticles increased, the cell morphology remained normal, only a small number of round cells appeared, and the cell activity remained above 80%. GD-Au DENPs-FA nanoparticles had a good targeting specificity for KB cells with high folate receptor expression.
During 6–24 hours of injection, the signal at the tumor site of the patient was enhanced markedly, namely the targeted gold nanoparticles were bound to the tumor tissue and the metabolic rate was slow. Based on this material, CT/MRI imaging could be performed in the patient’s body
and further used for the early diagnosis of abdominal tumors.
研究领域:
医学影像学
·
纳米生物学
·
肿瘤学
✓ 已验证
DOI
高影响因子
Advanced Optical Materials
·
2025
·
IF 7.2
Junyan Li,Hao Lei,Kanghong Wang,Xianyao Li,Zhuo Chen,Sang Lam,Xin Tu,Ka Lok Man,Chun Zhao
The advancement of optoelectronic sensing synapse devices, which integrate multiple sensory modalities and achieve the efficiency of biological vision systems, is crucial for the field of artificial vision systems. This work incorporates CdSe/CdSe x S 1-x quantum dots with In 2 O 3 semiconductor into a heterojunction via low-cost fully solution-based process to endow the synaptic transistor with dual-modality of lights and electricity. Optoelectronic synaptic transistors exhibit sensitivity to a broad spectrum of light, encompassing wavelengths ranging from 395 to 808 nm, in addition to their responsiveness to electrical signals. The efficiency of information processing is therefore improved by integration of senses. Additionally, by doping lithium ions into the dielectric layer, the gate capacitance is increased by over ten times and significantly improved the devices channel modulation and retention characteristics. An artificial visual perception demo based on the Quantum Dot-Enhanced synaptic ransistors (QDET) is well presented to showcase their practical application in pattern recognition and QDETs offer a promising platform for energy-efficient, high-performance neuromorphic systems.
研究领域:
材料科学
·
神经科学
·
电子工程
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产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2022
·
IF 7.033
Nan Ding,Yao Lu,Robert J Lee,Chang Yang,Lei Huang,Jian Liu,Guangya Xiang
Rationale and objective Receptor-targeted delivery of imaging and therapeutic agents can lead to enhanced efficacy for both. Multimodality imaging offers unique advantages over traditional single modality imaging. Tumor marker folate receptor (FR)-targeted fluorescent paramagnetic bimodal liposomes were synthesized to co-deliver paramagnetic and fluorescence agents for magnetic resonance (MR) and optical bimodal imaging contrast enhancement.Materials and methods Fluorescent and paramagnetic bimodal liposomes were synthesized with a mean diameter of 136 nm and a low polydispersity index. The liposomes incorporated folate-PEG3350-CHEMS for FR targeting, Gd(III)[N,N-Bis-stearylamidomethyl-N’-amidomethyl]diethylenetriamine tetraacetic acid (Gd-DTPA-BSA) for MR contrast, and calcein for fluorescence. To determine the specificity and efficiency of delivery, the liposomes were evaluated in FR-positive KB and HeLa cells and FR-negative A549 cells, which were analyzed by fluorescence microscopy, magnetic resonance imaging (MRI), and flow cytometry (FCM).Results FR-specific and efficient cellular uptake of the FR-targeted bimodal liposomes was confirmed by fluorescence microscopy and by FCM. The mean fluorescence intensity (MFI) of KB cells treated with FR-targeted liposomes was 45× that of cells treated with nontargeted liposomes, and 18× that of cells treated with FR-targeted liposomes and excess folic acid (FA). The MFI of HeLa cells treated with targeted liposomes was 33× that of nontargeted liposomes, and was 16× that of the mixture of targeted liposomes and free FA. In contrast, the MFI of A549 cells treated with FR-targeted liposomes was nearly the same as those treated with nontargeted liposomes. The T1-weighted MR images of HeLa and KB cells incubated with FR-targeted liposomes had much higher signal intensity than those treated with nontargeted liposomes or free Gd-DTPA. Furthermore, the FR-targeting effect could be blocked by excess free FA.Conclusion FR-targeted fluorescent paramagnetic bimodal liposomes provided a novel platform for bimodal tumor imaging and theranostic delivery.
研究领域:
医学影像学
·
药剂学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 25
·2101567
·
IF 18.808
Changjian Chen,Yixi Zhuang,Xinya Li,Feiyan Lin,Dengfeng Peng,Dong Tu,An Xie,Rong-Jun Xie
Mechanoluminescence (ML) is one of the most important routes to realize remote sensing of stress distribution, but has never been used in temperature sensing. Traditionally, stress sensing and temperature sensing are separately realized through different methods in multifunctional sensors, which definitely makes the structure more complicated. In this work, the remote stress–temperature dual-modal sensing is proposed by using the double-lanthanide-activated ML material SrZnSO:Tb,Eu, where the stress is read by the integral intensity of ML and the temperature is displayed by the green to red emission ratio ( I Tb / I Eu ) of ML in one material. The dual sensing mode in SrZnSO:Tb,Eu enables building of a new imaging system, providing a facile, reliable, and more sensitive way to remotely visualize the distribution of stress and temperature. It opens up a novel approach to develop advanced artificial skins with simplified structures in human–machine interfaces, structural health monitoring, and biomedical engineering applications.
研究领域:
材料科学
·
生物医学工程
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）