Sustainability
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2021
·Vol. 14
·期 1
·21
·
IF 3.251
Shuangshuang Zhang,Wenhui Zhang,Yazhen Wan
To remedy the widespread chromium (Cr) pollution in the environment, this study mainly used the ultrasonic-assisted co-precipitation and precipitation methods to prepare FeS-modified Fe-Al-layered double hydroxide (FeS/LDH) composite material. The experimental results showed that FeS/LDH has higher removal efficiency of Cr in aqueous solution and stronger anti-interference ability than unmodified LDH. Under the same reaction conditions, the removal efficiency of total Cr(Cr(T)) using LDH was 34.85%, and the removal efficiency of Cr(VI) was 46.76%. For FeS/LDH, the removal efficiency of Cr(T) and Cr(VI) reached 99.57% and 100%, respectively. The restoration of Cr(T) and Cr(VI) by FeS/LDH satisfied the Langmuir adsorption isotherm. The maximum adsorption capacity of Cr(T) and Cr(VI) achieved 102.9 mg/g and 147.7 mg/g. The efficient removal of Cr by FeS/LDH was mainly based on the triple synergistic effect of anion exchange between Cr(VI) and interlayer anions, redox of Cr(VI) with Fe2+and S2−, and co-precipitation of Fe3+and Cr3+.Keywords:chromium;FeS/LDH;double reduction;anti-interference;co-precipitation
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2019
·Vol. 136
·期 37
·47946
·
IF 2.188
Xiao Ma,Jiangtao Liu,Lei Lei,Hong Yang,Zhongli Lei
Stimulus-responsive polymeric nanoparticles have great potential as nanocarriers. Here, triple-stimuli-responsive core-crosslinked (CCL) micelles were developed that were convenient for drug delivery by taking advantage of dual-redox and UV light synergistic triggers. Amphiphilic block copolymers methoxy poly(ethylene glycol)- b -poly(3-azido-2-hydroxy-propyl methacrylate- co - ο -nitrobenzyl methacrylate) [mPEG- b -P(GMA-N 3 - co -NBM)] were synthesized via atom transfer radical polymerization and ring-opening reaction of ethylene oxide; these block copolymers can spontaneously self-assemble into noncrosslinked (NCL) micelles. Afterward, CCL micelles were prepared using an alkyne-functionalized crosslinking agent. Furthermore, the CCL micelles showed an excellent Nile Red dye molecule encapsulation, light and dual-redox-responsive performance, and increasing release rate of the dye as the concentration of glutathione and light irradiation increased. The triple-stimuli-responsive CCL micelles showed excellent stability and controllable release compared to NCL micelles. Therefore, we have developed a new smart nanocarrier, and the triple-stimuli-responsive CCL micelles could also be a potential delivery system in cancer therapy. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47946.
研究领域:
材料科学
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生物医学工程
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药剂学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
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2021
·
IF 9.776
Jinlei Peng,Ying Liu,Miao Zhang,Fangjun Liu,Liwei Ma,Cui-Yun Yu,Hua Wei
Facile engineering of β-cyclodextrin (β-CD)-based supramolecular nanocontainers with simultaneous enhanced extracellular stability and efficient intracellular biosignals-triggered destabilization generally suffers from multistep synthesis and tedious purification process, thus remains a significant challenge for the scale-up production and clinical translation of β-CD-based supramolecular nanomedicine . To address these issues, we reported in this study a one-pot preparation of dual-redox sensitive, stabilized supramolecular nanocontainers for potential programmable drug release by self-crosslinking of a multifunctional β-CD unit that integrates a host cavity for oxidation-mediated reversible complexation with ferrocence (Fc) guest molecule and lipoic acids (LAs)-decorated primary and secondary faces for reversible in-situ crosslinking by the reducible disulfide links. The resulting doxorubicin (DOX)-loaded nanoparticles showed, on one hand, enhanced colloidal stability and high DOX loading capacity with a drug loading content (DLC) of approximately 11.3% due to the crosslinked structure, and on the other hand, a programmable destruction of the supramolecular micelles triggered by a simultaneous adoption of intracellular glutathione (GSH) and reactive oxygen species (ROS) toward a complete structural destruction for promoted drug release with enhanced therapeutic efficiency. Notably, an optimized DOX-loaded micelle formation, DOX@CL P1 showed greater cytotoxicity with an IC 50 of 2.94 ± 0.25 μg/mL than free DOX (6.00 ± 0.56 μg/mL) in Bel-7402 cancer liver cells, but a significantly reduced side effect relative to free DOX in L02 normal liver cells. In vivo animal study in Bel-7402 tumor-bearing BALB/c mice further confirmed prolonger elimination half-life time, efficient tumor accumulation, enhanced therapeutic efficiency and compromised systemic toxicity of this micelle construct. Therefore the multifunctional CD unit developed in this study offers an extremely straightforward and robust strategy with respect to dual-redox responsive, stabilized supramolecular nanocontainers with potential programmable controlled release properties for clinical translations.
研究领域:
药学
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纳米医学
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肿瘤治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Chemistry
·
2022
·
IF 7.613
Miao Zhang,Shuang Li,Jinlei Peng,Ying Liu,Fangjun Liu,Fengmin Zhong,Shengsong Tang,Qian Ning,Cui-Yun Yu,Hua Wei
Nanocarriers with reversibly crosslinked structures provide one solution to the in vivo stability versus high therapeutic efficiency dilemma, however, generally suffer from a diluted condition-required synthetic approach for crosslinking. To address this issue, we reported herein multivalent cyclic template-directed synthesis of polycyclodextrin (polyCD)-based nanocarriers. The adopted multivalent cyclic template with great stability and steric hindrance resulted in a relatively high preparation concentration of 1.0 mg/mL for crosslinking. The synthesized dual-redox responsive polyCD-based crosslinked micelles showed enhanced colloidal stability, a high drug loading content (DLC) of 17.8% for doxorubicin (DOX), and intracellular complete destruction for promoted DOX release with enhanced anticancer efficiency in vivo . This study therefore not only reported the use of a multivalent cyclic polymer as a novel template for the production of polyCDs-based crosslinked micelles and ring-like colloids at a relatively high concentration, but also demonstrated great potential of the developed (polyCD)-based nanocarriers for enhanced chemotherapy.
研究领域:
药剂学
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生物医学工程
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材料科学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Yang Kang,Xin Ju,Li-Sheng Ding,Sheng Zhang,Bang-Jing Li
A dual redox and biorelevant triggered supramolecular system is developed through noncovalent supramolecular inclusion interactions between the ferrocene (Fc) modified on camptothecin (CPT) and β-cyclodextrin (β-CD) at the end of methoxy polyethylene glycol (mPEG). With these two segments, a stable noncovalent supramolecular structure, i.e., mPEG-β-CD/Fc-CPT, can be formed, and then self-assembled into micellar structures in water. Interestingly, these supramolecular micelles showed uniform sphere structure, high and constant drug loading content, hyper-fast redox-responsive drug release, and exhibited equal cellular proliferation inhibition toward A549 cancer cells. The cytotoxicity evaluation of mPEG-β-CD also indicated good biocompatibility. In vivo results revealed the mPEG-β-CD/Fc-CPT nanoparticles had higher in vivo efficacy without side effects. It is anticipated this supramolecular complex may serve as a new kind of promising alternative for drug delivery systems.
研究领域:
生物化学
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药剂学
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纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Catalysis Science & Technology
·
2022
·Vol. 12
·期 15
·4763-4775
·
IF 6.177
Ting Zhu,Ran Wang,Ziteng Chen,Feng Ji,Yuan Dong,Ming Yang
The problem of safe and efficient storage and transportation of hydrogen energy limits the large-scale development of the “hydrogen economy”. The liquid organic hydrogen storage technology is based on reversible catalytic hydrogenation and dehydrogenation reactions of unsaturated compounds to achieve safe and efficient storage and release of hydrogen. Heterogeneous catalysts with excellent catalytic capacity and stability should be developed to drive the reactions. However, it is a challenge to develop these catalysts. We fabricated a series of RuPd-based and supported catalysts following two different methods, and the catalytic hydrogenation and dehydrogenation activities of these catalysts were systematically investigated. The experiment results implied that the Pd2.5Ru2.5/H2 (double reduction method) catalyst exhibited catalytic hydrogenation rates that were similar to those of Pd2.5Ru2.5/L (when reduced by NaBH4). The former exhibited much better catalytic dehydrogenation rates than the latter. The Pd2.5Ru2.5/H2 catalyst also exhibited much better catalytic recyclability than the Pd2.5Ru2.5/L catalyst, and the conclusion was arrived at by conducting 10 cycles of hydrogenation–dehydrogenation tests. The relationship between the catalytic performances and the catalyst's properties was further investigated using a combination of H2-TPR, NH3-TPD, XPS, and TEM techniques. The characterization results revealed that the double reduction process could be used to enhance the extent of electronic interaction of the RuPd active sites with the support, and more numbers of strong acidic sites and active sites could be generated. Furthermore, DFT calculations also revealed that 8H-NPCZ and 4H-NPCZ formed stable adsorption structures on the Ru3Pd3/Al2O3(100) surface, facilitating catalytic reactions. Notably, the reaction energies of Ru3Pd3/Al2O3(100) were 1.16 eV, 1.42 eV, and 1.63 eV, indicating that the dehydrogenation process (8H-NPCZ → 4H-NPCZ and 4H-NPCZ → NPCZ) occurred easily. All the above-mentioned characteristics make the Pd2.5Ru2.5/H2 catalyst an excellent catalyst for hydrogenation and dehydrogenation and endow it with outstanding catalytic capacity and recyclability.
研究领域:
材料科学
·
催化化学
·
能源存储技术
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2020
·Vol. 11
·期 13
·2360-2369
·
IF 5.342
Yefei Tian,Miao Lei,Luke Yan,Feifei An
Drug delivery systems developed from zwitterionic polymers have intriguing antifouling properties. Combining these with stimuli-responsiveness, we fabricated a new type of zwitterionic nanogel with dual redox-labile properties by copolymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) and a diselenide bond-containing crosslinker through reflux precipitation polymerization. Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-based nanogels show high protein adsorption resistibility and colloidal stability at high salt concentrations. By incorporation of diselenide bonds into polymer networks, the nanogels are endowed with unique dual redox-labile properties that lead to their efficient degradation into short polymers either in a reducing environment (GSH) or in an oxidative environment (H2O2). Nanogels loaded with anticancer drugs (doxorubicin, DOX) display a finely controlled release behavior and low leakage of DOX under physiological conditions (15.0% in 24 h), but rapid and sufficient release under reducing conditions (88.3% in 24 h) or under oxidative conditions (82.2% in 24 h). Cell viability assays reveal that the blank nanogels have no cytotoxicity within a wide concentration range, while DOX-loaded nanogels present a significant inhibitive effect against tumor cells.
研究领域:
药学
·
纳米技术
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）